抗癌研究最新文献_第7页

A Comprehensive Analysis of a Case of Internal Carotid Artery Stenting 颈内动脉支架置入术1例综合分析

抗癌研究 Pub Date : 2022-07-28 DOI: 10.26689/par.v6i4.3917

Mengxue Sun, Jun Wang, Yamei Wang

引用次数: 0

Using Pegaspargase in Combination with Chemotherapy in the Treatment of Lymphoma 聚乙二醇天冬氨酸联合化疗治疗淋巴瘤

抗癌研究 Pub Date : 2022-07-27 DOI: 10.26689/par.v6i4.4050

Y. Miao

引用次数: 0

An Evaluation of the Clinical Efficacy and Safety of Ixazomib for Relapsed/Refractory Multiple Myeloma 伊沙佐米治疗复发/难治性多发性骨髓瘤的临床疗效和安全性评价

抗癌研究 Pub Date : 2022-07-27 DOI: 10.26689/par.v6i4.4180

Lan Li, Weihua Zhang

{"title":"An Evaluation of the Clinical Efficacy and Safety of Ixazomib for Relapsed/Refractory Multiple Myeloma","authors":"Lan Li, Weihua Zhang","doi":"10.26689/par.v6i4.4180","DOIUrl":"https://doi.org/10.26689/par.v6i4.4180","url":null,"abstract":"Objective: To investigate the clinical efficacy and safety of ixazomib in the treatment of relapsed/refractory multiple myeloma (RRMM). Methods: The clinical data of 20 patients with RRMM admitted to the hospital from January 2020 to January 2022 were analyzed retrospectively. All patients were treated with ixazomib-based chemotherapy regimen (IRD regimen 13 cases; ID regimen 7 cases). The objective response rate (ORR) and adverse events (AEs) were observed. Results: All 20 patients received two to seven courses of treatment, in which the median was three courses. One patient had CR, four patients had VGPR, seven patients had PR, two patients had SD, and six patients had PD. The ORR was 60.00% (12/20), and 25.00% (5/20) of them had VGPR or more. The ORR of patients with previous treatment lines ? 3, ISS stage III, and high-risk cytogenetic was lower than that of patients with previous treatment lines < 3, ISS stage I/II, and low-risk cytogenetics. The main AEs include anemia, thrombocytopenia, neutropenia, nausea and vomiting, diarrhea, constipation, and respiratory tract infection, most of which are grade I/II. Conclusion: Ixazomib is effective in the treatment of RRMM in some patients, and the AEs are controllable. Patients who had received less than 3 lines of treatment in the past, with ISS stage I to II and low-risk cytogenetics had better treatment effect.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47880266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy and Childbirth After Sertoli-Leydig Cell Tumor Resection: A Case Study and Literature Review Sertoli Leydig细胞肿瘤切除术后的妊娠和分娩：病例研究和文献综述

抗癌研究 Pub Date : 2022-07-27 DOI: 10.26689/par.v6i4.4092

Li-jun Mu, Lihong Zhu

{"title":"Pregnancy and Childbirth After Sertoli-Leydig Cell Tumor Resection: A Case Study and Literature Review","authors":"Li-jun Mu, Lihong Zhu","doi":"10.26689/par.v6i4.4092","DOIUrl":"https://doi.org/10.26689/par.v6i4.4092","url":null,"abstract":"Objectives: To explore the clinical manifestations and pathological features in the biopsy of ovarian Sertoli-Leydig cell tumor, as well as to improve the clinical understanding of the disease. Methods: A case of pregnancy and childbirth after Sertoli-Leydig cell tumor resection was retrospectively analyzed. The patients’ clinical data were collected, including the clinical manifestations, postoperative biopsy results, auxiliary examination results, immunohistochemical results, treatment, and prognosis of the patient. Results: (1) SLCT occurred unilaterally; (2) according to the International Federation of Obstetrics and Gynecology (FIGO), the clinical staging was stage IA; according to the pathological classification of malignant tumors, it was grade ? (moderately differentiated); (3) a healthy female live baby was delivered. Conclusion: Such tumors are rare low-grade malignancies and are even rarer in pregnancy. An increase in preoperative testosterone levels with positive ultrasonography results can be used to assist diagnosis; however, postoperative biopsy pathology remains the “gold standard” for the diagnosis of SLCTs. The definite diagnosis of SLCTs is of great significance for surgical planning and prognostic evaluation.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44319577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Discussion on TCM Treatment and the Pathogenesis of Membranous Nephropathy in Primary Nephrotic Syndrome 原发性肾病综合征膜性肾病的中医治疗及病机探讨

抗癌研究 Pub Date : 2022-07-27 DOI: 10.26689/par.v6i4.4173

Xin Li, Genping Lei

{"title":"A Discussion on TCM Treatment and the Pathogenesis of Membranous Nephropathy in Primary Nephrotic Syndrome","authors":"Xin Li, Genping Lei","doi":"10.26689/par.v6i4.4173","DOIUrl":"https://doi.org/10.26689/par.v6i4.4173","url":null,"abstract":"Objective: To investigate the TCM treatment principle of membranous nephropathy and its effect. Methods: A total of 56 patients were selected from the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine. They were then divided into the control group (western medicine standard therapy) and the study group (Qidi Gushen prescription), with 28 patients in each group. The treatment effect, treatment safety, and patients’ satisfaction were observed and compared between the two groups. Results: The results showed that the treatment effect of the study group was 96.43%, which was significantly better compared with the control group (75.00%) (p < 0.05); in terms of safety, the probability of adverse events was 7.14% in the study group and 32.14% in the control group, in which the difference was statistically significant (p < 0.05); in addition, the study group’s satisfaction with the treatment measures was significantly higher than that of the control group (p < 0.05). Conclusion: In treating membranous nephropathy, traditional Chinese medicine can be tailored to its pathogenesis, which is not only beneficial to the treatment effect, but also has a high safety profile.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41567089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Analytical Model of Brain Tumor Based on Swarm Robotics 基于群体机器人的脑肿瘤分析新模型

抗癌研究 Pub Date : 2022-07-27 DOI: 10.26689/par.v6i4.4196

Mohamed Abbas

{"title":"A Novel Analytical Model of Brain Tumor Based on Swarm Robotics","authors":"Mohamed Abbas","doi":"10.26689/par.v6i4.4196","DOIUrl":"https://doi.org/10.26689/par.v6i4.4196","url":null,"abstract":"A tumor is referred to as “intracranial hard neoplasm” if it grows near the brain or central spinal vessel (neoplasm). In certain cases, it is possible that the responsible cells are neurons situated deep inside the brain’s structure. This article discusses a strategy for halting the progression of brain tumor. A precise and accurate analytical model of brain tumors is the foundation of this strategy. It is based on an algorithm known as kill chain interior point (KCIP), which is the result of a merger of kill chain and interior point algorithms, as well as a precise and accurate analytical model of brain tumors. The inability to obtain a clear picture of tumor cell activity is the biggest challenge in this endeavor. Based on the motion of swarm robots, which are considered a subset of artificial intelligence, this article proposes a new notion of this kind of behavior, which may be used in various situations. The KCIP algorithm that follows is used in the analytical model to limit the development of certain cell types. According to the findings, it seems that different KCIP speed ratios are beneficial in preventing the development of brain tumors. It is hoped that this study will help researchers better understand the behavior of brain tumors, so as to develop a new drug that is effective in eliminating the tumor cells.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43348182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Effectiveness of Decitabine Combined with a Half-Dose Priming Regimen in the Treatment of Elderly Patients with Acute Myeloid Leukemia 地西他滨联合半剂量启动方案治疗老年急性髓系白血病的疗效研究

抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.3999

Ying Gao, Lan Li, Xingxing Hu, Y. Miao

{"title":"A Study on the Effectiveness of Decitabine Combined with a Half-Dose Priming Regimen in the Treatment of Elderly Patients with Acute Myeloid Leukemia","authors":"Ying Gao, Lan Li, Xingxing Hu, Y. Miao","doi":"10.26689/par.v6i3.3999","DOIUrl":"https://doi.org/10.26689/par.v6i3.3999","url":null,"abstract":"Objective: To investigate the clinical effects of combining decitabine with a half-dose priming regimen in the treatment of elderly patients with acute myeloid leukemia. Methods: This study was conducted in Shaanxi Provincial People’s Hospital from January 2019 to January 2022. Sixty patients were recruited as the research subjects. The patients received different treatments and were randomly divided into two groups, with 30 cases in each group, one of which was treated with conventional priming regimen (control group), and the other was treated with decitabine combined with a half-dose priming regimen (study group). The two groups were compared and analyzed in terms of the effectiveness of treatment. Results: The rate of symptom relief in the study group was 96.67%, which was significantly higher than that in the control group (76.67%) (p < 0.05). Before treatment, there was no significant difference in the quality-of-life scores between the two groups, with p > 0.05. The patients in the study group had significantly longer disease-free survival and overall survival than those in the control group, with p < 0.05. The effectiveness of treatment in the study group was also better. Conclusion: The use of decitabine in combination with a half-dose priming regimen for the treatment of elderly patients with acute myeloid leukemia is effective in improving patients’ quality of life, relieving symptoms, and prolonging their survival.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45347924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Efficacy of Lenalidomide Combined with Cyclophosphamide and Dexamethasone in the Treatment of Multiple Myeloma 来那度胺联合环磷酰胺和地塞米松治疗多发性骨髓瘤的临床疗效

抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.3998

Y. Miao

引用次数: 0

A Summary of Lei Genping’s Experience in the Treatment of Chronic Nephritis 雷根平治疗慢性肾炎经验总结

抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.3884

Yue Zhang, Genping Lei

引用次数: 0

Inhibition of RNaseH2A Induces Fas-Regulated Programmed Cell Death in Hepatoma Cells 抑制RNaseH2A诱导fas调控的肝癌细胞程序性死亡

抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.4011

Xiaowei Chang, Yu Cai, P. Yan, Wujun Li

{"title":"Inhibition of RNaseH2A Induces Fas-Regulated Programmed Cell Death in Hepatoma Cells","authors":"Xiaowei Chang, Yu Cai, P. Yan, Wujun Li","doi":"10.26689/par.v6i3.4011","DOIUrl":"https://doi.org/10.26689/par.v6i3.4011","url":null,"abstract":"Objective: To screen clinically significant potential drug targets in liver cancer and to study the function and potential molecular mechanisms of this target protein in the development of liver cancer. Methods: By using the clinical database GEPIA to find genes that are differentially expressed in liver cancer compared to normal tissues, we further screened the genes that are highly expressed in hepatocellular carcinoma and have clinical prognostic relevance. Heat maps were used to sort these genes according to their clinical prognostic relevance, so as to screen for the target gene of interest. The characteristics of target gene expression and clinical prognosis in hepatocellular carcinoma were studied. The target gene was knocked down through siRNA, and cell proliferation experiments and apoptosis experiments were used to verify the importance of the target gene in the occurrence and development of liver cancer. Finally, we elucidated the potential molecular mechanism of the target gene’s function in liver cancer based on the mutual regulatory relationship between the target gene and key apoptosis genes. Results: 1482 genes were significantly underexpressed in liver cancer, and 725 genes were significantly overexpressed in liver cancer, of which RNaseH2A was significantly overexpressed in liver cancer and had a significant clinical prognosis. Knockdown of RNaseH2A inhibited the proliferation of hepatocellular carcinoma cells and induced apoptosis. Knockdown of RNaseH2A induced the high expression of Fas, a key gene for apoptosis, and liver cancer usually features low expression of Fas. After hepatocellular carcinoma cells that were knocked down of RNaseH2A continued were subject to Fas knockdown, hepatocellular carcinoma cell proliferation and apoptosis returned to normal levels. Conclusion: The high expression of RNaseH2A regulates the low expression of Fas, a key gene for apoptosis, thereby inhibiting apoptosis, promoting cell proliferation, and participating in the development of liver cancer.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44397497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0