An Evaluation of the Clinical Efficacy and Safety of Ixazomib for Relapsed/Refractory Multiple Myeloma

Objective: To investigate the clinical efficacy and safety of ixazomib in the treatment of relapsed/refractory multiple myeloma (RRMM). Methods: The clinical data of 20 patients with RRMM admitted to the hospital from January 2020 to January 2022 were analyzed retrospectively. All patients were treated with ixazomib-based chemotherapy regimen (IRD regimen 13 cases; ID regimen 7 cases). The objective response rate (ORR) and adverse events (AEs) were observed. Results: All 20 patients received two to seven courses of treatment, in which the median was three courses. One patient had CR, four patients had VGPR, seven patients had PR, two patients had SD, and six patients had PD. The ORR was 60.00% (12/20), and 25.00% (5/20) of them had VGPR or more. The ORR of patients with previous treatment lines ? 3, ISS stage III, and high-risk cytogenetic was lower than that of patients with previous treatment lines < 3, ISS stage I/II, and low-risk cytogenetics. The main AEs include anemia, thrombocytopenia, neutropenia, nausea and vomiting, diarrhea, constipation, and respiratory tract infection, most of which are grade I/II. Conclusion: Ixazomib is effective in the treatment of RRMM in some patients, and the AEs are controllable. Patients who had received less than 3 lines of treatment in the past, with ISS stage I to II and low-risk cytogenetics had better treatment effect.