抗癌研究最新文献

{"title":"Analysis of Humanistic Nursing Care in Regulating the Emotion, Satisfaction, and Sleep Quality of Inpatients with Hematologic Neoplasms","authors":"Xiaoyun Wang","doi":"10.26689/par.v6i5.4288","DOIUrl":"https://doi.org/10.26689/par.v6i5.4288","url":null,"abstract":"Objective: To explore the clinical application value of humanistic nursing care in the treatment of hematologic neoplasm inpatients. Methods: Fifty-two patients with hematologic neoplasms admitted to a hospital from May 2019 to February 2022 were selected as the research subjects. According to a random number table, they were divided into two groups: the control group (n = 25, routine clinical nursing) and the observation group (n = 27, humanistic nursing care). The negative emotion score, nursing satisfaction, and sleep quality were compared between the two groups under different nursing modes. Results: The SAS and SDS scores before and after nursing were compared between the two groups. There was no significant difference between the two groups before nursing (p > 0.05). However, the SDS and SAS scores in the two groups after nursing were lower than those before nursing, in which the observation group was slightly lower than the control group, and the difference was statistically significant (p < 0.001). In terms of nursing satisfaction, it was as high as 96.29% in the observation group, whereas in the control group, the satisfaction rate was only 72.00%; the PSQI scores were compared between the two groups before and after nursing, and there was no significant difference between the two groups before nursing (p > 0.05). However, the PSQI scores and total score of the observation group after nursing were lower than those of the control group (p < 0.001). Conclusion: In the clinical treatment of patients with hematologic neoplasms, the implementation of humanistic nursing care can significantly improve patients’ anxiety, depression, other negative emotions, sleep quality, and nursing satisfaction, all of which have significance in promoting the prognosis of patients and improving their quality of life.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46825432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Acute Emerging Infectious Disease Symptom Monitoring","authors":"Qing Zhang, Qiongfen Li","doi":"10.26689/par.v6i5.4195","DOIUrl":"https://doi.org/10.26689/par.v6i5.4195","url":null,"abstract":"In recent years, the risk of acute emerging infectious diseases has increased significantly due to changes in environmental conditions and social factors, posing a serious threat to public health security and human health. The general susceptibility of the population and the unpredictability and increasing infectiousness of emerging infectious diseases reflect the inadequacy of the existing infectious disease surveillance system for timely detection and screening of emerging infectious diseases, often leading to a certain scale of epidemic outbreaks that seriously harm humans before being detected passively. This is a literature review on symptom surveillance of acute emerging infectious diseases at home and abroad, emphasizing on the subject matter and development of symptom surveillance of emerging infectious diseases, so as to provide a scientific basis for the establishment and improvement of symptom surveillance of acute emerging infectious diseases.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41446663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploration of the Treatment of Spontaneous Progressive Hemopneumothorax in Young People","authors":"Duo Zhang, Q. Guo, Xuguang Zhang, Haibo Wang","doi":"10.26689/par.v6i5.4222","DOIUrl":"https://doi.org/10.26689/par.v6i5.4222","url":null,"abstract":"Objective: To explore an effective treatment for spontaneous progressive hemopneumothorax in young people. Methods: Thirty-four young patients with spontaneous progressive hemopneumothorax from January 2018 to December 2019 were selected to be included in the control group for retrospective analysis; from January 2020 to December 2021, 69 young patients with spontaneous progressive hemopneumothorax were selected to be included in the study group. The control group was treated with double-port thoracoscopic bullectomy, whereas the study group was treated with single-port thoracoscopic bullectomy. The intraoperative blood loss, operation time, tube retention time, VAS score, postoperative air leakage, and 1-year recurrence of the patients in the two groups were observed and analyzed. Results: The perioperative conditions of the patients in the study group, including intraoperative bleeding loss, operation time, tube retention time, and VAS scores, were 15.12 ± 1.36, 54.69 ± 18.78, 2.14 ± 0.98, and 3.25 ± 0.14, respectively. The perioperative conditions of the patients in the control group, including intraoperative bleeding loss, operation time, tube retention time, and VAS scores, were 22.69 ± 2.01, 55.36 ± 19.01, 4.21 ± 1.01, and 5.36 ± 0.45, respectively; other than the operation time, the differences in intraoperative blood loss, tube retention time, and VAS scores between the two groups were statistically significant (p < 0.05); after the surgery, two patients in the study group had postoperative air leakage, accounting for 2.90% and another two patients had recurrence one year after the surgery, accounting for 2.90%; on the other hand, three patients in the control group had postoperative air leakage, accounting for 8.82%, and two patients had recurrence one year after the surgery, accounting for 5.88%. However, ?2 test showed that p > 0.05. Conclusion: Treatment of spontaneous progressive hemopneumothorax in young people is better with single-port thoracoscopic bullectomy than with two-port thoracoscopic bullectomy, which effectively reduces intraoperative bleeding. The pain level is significantly better with single-port thoracoscopic bullectomy than with two-port thoracoscopic bullectomy, and the prognosis of patients is good with a low probability of recurrence for both, single- and two-port thoracoscopic bullectomy.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49611755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Bortezomib in Combination with Dexamethasone in the Treatment of Primary Multiple Myeloma","authors":"Y. Miao","doi":"10.26689/par.v6i5.4221","DOIUrl":"https://doi.org/10.26689/par.v6i5.4221","url":null,"abstract":"Objective: To study the clinical efficacy of bortezomib combined with dexamethasone in the treatment of primary multiple myeloma. Methods: Seventy patients with primary multiple myeloma treated in Shaanxi Provincial People’s Hospital between January 2020 and January 2021 were divided into two groups, a control group and a study group, using the random number table method; 35 patients in the control group were treated with conventional treatment, and the other 35 patients in the study group were treated with bortezomib combined with dexamethasone. The patients’ clinical outcomes, clinical indices, satisfaction, and adverse reactions were compared between the two groups. Results: There were significant differences (p < 0.05) in the indices between the two groups of patients treated with different treatment modalities for primary multiple myeloma. Conclusion: The use of bortezomib combined with dexamethasone for patients with primary multiple myeloma can effectively improve the treatment outcomes, clinical indices, patient satisfaction, and adverse reactions; hence, it is worthy to be widely promoted in clinical practice.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47310134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of Circulating Tumor Cells in Evaluating the Effect of Chemotherapy in Advanced Non-Small Cell Lung Cancer","authors":"Xuguang Zhang, Shaoyong Dong, Zhenqing Sun","doi":"10.26689/par.v6i5.4227","DOIUrl":"https://doi.org/10.26689/par.v6i5.4227","url":null,"abstract":"Objective: To explore the value of circulating tumor cells in evaluating the effect of chemotherapy for advanced non-small cell lung cancer. Methods: Sixty-two patients with advanced non-small cell lung cancer who received chemotherapy in the Affiliated Hospital of Hebei University from January 2018 to December 2021 were selected as the research subjects. The positive rate of CTCs after two weeks of chemotherapy and four weeks of chemotherapy as well as the evaluation of imaging efficacy were observed and analyzed. Results: Based on the clinical data of the patients, the positive rate of CTCs in male patients was 77.78%, that in female patients was 80.77%, that in patients ? 60 years old was 78.13%, that in patients < 60 years old was 76.67%, that in squamous cell carcinoma was 79.31%, that in adenocarcinoma was 78.79%, and that in highly differentiated, moderately differentiated, and poorly differentiated + undifferentiated CTCs was 66.67%, 84.21%, and 90.91%, respectively; there was no statistical difference in the general data. The positive rate of CTCs was 88.71% before chemotherapy and 66.13% after two weeks of chemotherapy, in which the difference was statistically significant; the positive rate of CTCs four weeks after chemotherapy was 59.68%, which was statistically significant compared with that before chemotherapy; however, there was no significant difference between two weeks after chemotherapy and four weeks after chemotherapy. After chemotherapy, 35 patients had CR+PR, 19 patients had SD, and 8 patients had PD. The proportions of CR+PR, SD, and PD in the imaging evaluation results were 56.45%, 30.65%, and 12.90%, respectively. After kappa consistency test, it was found that the consistency was good. Conclusion: CTCs can be used as one of the indicators to evaluate the effect of chemotherapy for advanced non-small cell lung cancer. The results are consistent with those of imaging evaluation. The detection of CTCs can be widely used as one of the clinical indicators.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43701670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Correlation Analysis of Postoperative Hypercoagulability and Peripheral Circulating Tumor Cells in Patients with Lung Cancer","authors":"Xuguang Zhang, Duo Zhang, Hefei Li","doi":"10.26689/par.v6i4.4091","DOIUrl":"https://doi.org/10.26689/par.v6i4.4091","url":null,"abstract":"Objective: To explore the correlation between peripheral circulating tumor cells and hypercoagulability in patients with lung cancer after surgery. Methods: From January 2017 to December 2021, 89 patients with lung cancer who were treated in the Affiliated Hospital of Hebei University were selected as the research subjects, and a retrospective analysis was conducted to analyze and observe the D-dimer (DD), fibrinogen (FIB), and platelet (PLT) levels in peripheral blood, as well as detect peripheral CTC. Results: There were statistical differences in TMN staging, tumor metastasis, and lymph node metastasis in the clinical data, but there were no statistical differences in gender, smoking history, and pathological classification. After retrospective analysis and comparison of the patients, the DD (mg/ml), FIB (g/L), and PLT (×109/L) levels of the CTC positive group were 3.41 ± 0.58, 3.98 ± 0.87, and 367.26 ± 34.98, respectively; the CTC negative group’s DD (mg/ml), FIB (g/L), and PLT (×109/L) levels were 0.89 ± 0.49, 1.06 ± 0.45, and 234.69 ± 35.69, respectively, and the differences were statistically significant. The factors affecting the prognosis of patients included TMN staging and CTC; the number of CTC positives in the death group was significantly higher than that in the survival group, and there was a statistical difference between the groups. Gender, age, smoking history, pathological type, and surgical resection had no effect on the prognosis of patients. Among the enrolled patients, the survival rate was 71.91%. Conclusion: CTC-positive patients have a higher probability of hypercoagulability after surgery and are prone to tumor metastasis; thus, CTC can be used as a judgment index for the prognosis of patients.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44348782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Level of Circulating Tumor Cells in Patients with Non-Small Cell Lung Cancer and Its Relationship with Tumor Markers","authors":"Rongfang Liu, Ben Li, Xuguang Zhang","doi":"10.26689/par.v6i4.4093","DOIUrl":"https://doi.org/10.26689/par.v6i4.4093","url":null,"abstract":"Objective: To explore the level of circulating tumor cells in patients with non-small cell lung cancer and its relationship with tumor markers. Methods: Fifty patients with NSCLC admitted to a hospital from March 2019 to February 2022 were retrospectively selected as the research subjects; their clinical data were sorted out and analyzed. All patients were examined for CTCs. According to their levels, the patients were divided into a positive group (30 cases, ? 4%) and a negative group (20 cases, < 4%). The positive rate of peripheral CTCs in patients with different gender, age, and pathological types of NSCLC, the positive rate of peripheral CTCs in patients with different staging of NSCLC, and the relationship between serum CEA, CA125, CYFRA21-1, and peripheral CTCs were analyzed and observed. Results: There was no significant difference in gender, age, and pathological type between the positive group and the negative group. There was also no significant difference in the T staging, N staging, and M staging between the positive group and the negative group. However, there was significant difference in the clinical staging of the positive group and the negative group. The CEA, CA125, and CYFRA21-1 of the positive group were 7.45 ± 1.26, 38.56 ± 4.12, and 5.01 ± 1.36, respectively, whereas those of the negative group were 5.12 ± 1.22, 32.69 ± 4.01, and 3.87 ± 1.25, respectively. The comparison between the two groups was statistically significant. Conclusion: CTCs provide the possibility of detecting cancer before the use of imaging methods, guide treatment in combination with other tumor markers, monitor postoperative treatment, and predict patients’ outcome.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41633269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the CT Features of Primary Spontaneous Pneumothorax and Its Application Value","authors":"Duo Zhang, Kuo Xiao","doi":"10.26689/par.v6i4.4094","DOIUrl":"https://doi.org/10.26689/par.v6i4.4094","url":null,"abstract":"Objective: To explore the performance characteristics of CT examination in primary spontaneous pneumothorax (PSP) and the effect of pleurodesis on patients with PSP. Methods: Sixty-four patients with PSP, who received medical care in the Affiliated Hospital of Hebei University from January 2017 to December 2021, were selected as the research subjects, of which 40 were male and 24 were female patients. All 64 patients were examined by X-ray and CT; the density, enhancement, and morphology of the pneumothorax were observed and analyzed, and the classification of pneumothorax was done. Results: The clinical analysis of 64 patients with PSP showed that the number of cases with unilateral pneumothorax was 42, accounting for 65.63%, whereas the number of cases with bilateral pneumothorax was 22, accounting for 34.37%. Among the cases of unilateral pneumothorax, the number of cases with left pneumothorax was 26, accounting for 61.90%, whereas the proportion of cases with right pneumothorax was 38.10%. When examined by CT, the diagnostic coincidence rate of 64 patients with PSP was 73.44%; using X-ray examination, the diagnostic coincidence rate of 64 patients with PSP was 92.19%. Conclusion: The detection accuracy of CT is higher than that of X-ray examination, which may improve the treatment effect in PSP, ensure the accuracy of findings, and facilitate follow-up treatment as well as the effect of postoperative analysis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45845732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Doses of BDNF on Postoperative Cognitive Function in Aged Rats Undergoing Abdominal Surgery","authors":"Yu-ming Zhang, Hui Wang, Kaihang Lu, J. Wang, Ning Bai","doi":"10.26689/par.v6i4.4224","DOIUrl":"https://doi.org/10.26689/par.v6i4.4224","url":null,"abstract":"Objective: To investigate the effects of different doses of BDNF on postoperative cognitive function in aged rats undergoing abdominal surgery. Methods: 72 aged healthy male SD rats of SPF grade were selected. According to the random number table method, the rats were randomly divided into the control group, model group, low dose BDNF injection group, and high dose BDNF injection group, with 18 rats in each group. The model group, low dose group, and high dose group underwent abdominal surgery after anesthesia, and 5?L/time of BDNF was intranasally administered to the rats in the low dose and high dose groups 6 hours after abdominal surgery, of which the dose of the low dose group was 0.1 g/L, while that of the high dose group was 0.2 g/L. The drug was administered alternately through both nostrils, with an interval of 2 minutes each time, for 5 times. The control group did not undergo surgery after anesthesia. The escape latency and swimming distance of the four groups of rats were compared before surgery, the first day, the third day, and the seventh day after surgery; similarly, the BDNF protein expression level in the hippocampus of the four groups of rats was compared on the first day, the third day, and the seventh day after surgery. Results: The escape latency and swimming distance of the control group were not statistically significant on the first day, the third day, and the seventh day after surgery, p > 0.05; the escape latency and swimming distance of the model group, low dose group, and high dose group on the first day, the third day, and the seventh day after surgery were statistically significant, p < 0.05. Before surgery, the escape latency and swimming distance of the four groups were not statistically significant, p > 0.05; on the first day, the third day, and the seventh day after surgery, the escape latency and swimming distance of the model group > low dose group > high dose group > control group, p < 0.05. The BDNF protein expression level in the hippocampus of the control group on the first day, the third day, and the seventh day after surgery showed no statistical significance p > 0.05; the expression level of BDNF protein in the hippocampus of the model group, low dose group, and high dose group on the first day, the third day, and the seventh day after surgery was statistically significant, p < 0.05. On the first day, the third day, and the seventh day after surgery, the expression level of BDNF protein in the hippocampus of the model group < low dose group < high dose group < control group, p < 0.05. Conclusion: Compared with 0.1 g/L of BDNF, 0.2 g/L of BDNF can improve the postoperative cognitive function of aged rats undergoing abdominal surgery.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47040603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Serum TSH, Ultrasound, and Enhanced CT in Papillary Thyroid Carcinoma with Lymph Node Metastasis","authors":"Meiqing He, Xixi Zhang, Hui Li, Tianshu Wang","doi":"10.26689/par.v6i4.4199","DOIUrl":"https://doi.org/10.26689/par.v6i4.4199","url":null,"abstract":"Objective: To explore the diagnostic value of serum TSH, ultrasound, and enhanced CT in papillary thyroid carcinoma with lymph node metastasis. Methods: 168 patients who underwent thyroidectomy in Shaanxi Provincial People’s Hospital from January 2020 to December 2021 were selected as the research subjects. Based on the pathological nature (benign or malignant), they were divided into two groups, with 86 patients in the control group and 82 patients in the study group. Based on whether the pathology was accompanied with lymph node metastasis, the PTC group was divided into a lymph node metastasis group and a non-lymph node metastasis group, with 51 and 31 patients in the respective groups. Retrospective analysis was conducted to observe and analyze the pathological results of the thyroid nodules’ thyroid ultrasound results, neck enhanced CT results, and thyroid function test serology results. Results: Compared with the PTC group, there were significant differences in TR classification, ultrasonic lymph nodes, and enhanced CT lymph nodes, but no significant differences in the course of disease, nodule distribution, and the number of nodules between the benign nodule group and PTC group; in the comparison of lymph node metastasis using ultrasound and enhanced CT, the number of patients with ultrasound lymph nodes without abnormal metastasis in the non-metastasis group was 28, while that of the metastasis group was 21; the number of patients with abnormal metastasis in the non-metastasis group was 3, while that of the metastasis group was 30. The number of patients with a single node without metastasis and metastasis was 14 and 8, respectively, whereas the number of patients with multiple nodes without metastasis and metastasis was 17 and 43, respectively. There were statistically significant differences in the number of ultrasound lymph nodes and nodules, but no statistically significant differences in TR classification, enhanced CT lymph nodes, nodules distribution, and disease course. Conclusion: Serum TSH can be used to identify the nature (benign and malignant) of thyroid nodules, and enhanced CT is better than ultrasound when evaluating complex lesions. It can be used as a supplement to ultrasound based on clinical context.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41485646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}