抗癌研究最新文献

{"title":"Retrospective Analysis of the Effect of Auricular Acupuncture on Pain and Gastrointestinal Motility Recovery After Laparoscopic Surgery for Colorectal Cancer","authors":"Xiaofan Li, Ni Yang, Lei Yu, Lingzhi Nie, Zhixin Xue, Yan-Chuan Pu, Min-feng Wu, Junyan Wang","doi":"10.26689/par.v7i3.4982","DOIUrl":"https://doi.org/10.26689/par.v7i3.4982","url":null,"abstract":"Objective: To investigate the effect of auricular acupuncture on postoperative pain and gastrointestinal motility recovery after laparoscopic surgery for colorectal cancer. Methods: The clinical data of patients who underwent laparoscopic radical surgery for colorectal cancer in our hospital from April 2020 to December 2021 were collected. Based on the inclusion and exclusion criteria, 76 patients were included in the retrospective analysis. Depending on whether they received auricular acupuncture or not, the patients were divided into two groups: 46 patients in the experimental group (auricular acupuncture) and 30 patients in the control group. The differences between the two groups were analyzed. Results: The time to first flatus of the experimental group was significantly shorter than that of the control group (52.2 ± 7.36 h versus 66.3 ± 7.83 h; P < 0.001). Similarly, the time to first defecation of the experimental group was significantly shorter than that of the control group (76.3 ± 7.76 h versus 86.1 ± 10.79 h; P < 0.001). The time to first fluid intake of the auricular group was significantly shorter than that of the control group (90.4 ± 8.92 h versus 107.3 ± 9.66 h, P < 0.001). Compared with the control group, the experimental group scored significantly lower on the visual analogue scale on postoperative days 2 and 3 (P < 0.001). Conclusion: Auricular acupuncture is an effective traditional Chinese medicine external treatment method. It can promote gastrointestinal motility recovery in patients after laparoscopic radical surgery for colorectal cancer and also reduce postoperative pain and discomfort. Furthermore, this therapy is easy to operate and well-accepted by patients. Therefore, it should be strongly promoted in clinical practice.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43047462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of CST1 in Promoting Gastric Cancer Metastasis and Analysis of Its Mechanism","authors":"Jianfei Wu, Xinmei Hu, Xinyu Peng, Xiuqin Zhang, Jianjun Zhang, Peng Liu","doi":"10.26689/par.v7i3.4861","DOIUrl":"https://doi.org/10.26689/par.v7i3.4861","url":null,"abstract":"Objective: To elucidate the role and mechanism of cysteine protease inhibitor SN (CST1) in promoting the metastasis of gastric cancer. Methods: (1) Firstly, 6 pairs of cancer and paracancer tissue samples from gastric cancer patients without distant metastasis and 5 pairs of cancer and paracancer tissue samples from gastric cancer patients with peritoneal metastasis were collected for transcriptome sequencing. Statistical analysis was performed on the sequencing results to identify significantly upregulated differential genes. (2) Another 75 pairs of cancer and paracancer tissue samples were collected from gastric cancer patients, and the protein and total RNA of gastric cancer tissue samples were extracted. Western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to detect the expression of CST1 protein and messenger RNA (mRNA) in gastric cancer and adjacent tissues. (3) The total protein and total RNA of AGS, BGC823, HGC-27, MGC803, MKN45, SGC7901, and SNU-1 gastric cancer cells and normal gastric mucosal epithelial cells GES-1 were extracted. Western blot and qRT-PCR were used to detect CST1 protein and mRNA expression. Results: (1) The significantly upregulated differential gene CST1 was screened, and the expression of CST1 in gastric cancer tissues was significantly higher than that in adjacent tissues. (2) Compared with normal gastric mucosal epithelial cells GES-1, the expression of CST1 in gastric cancer cell lines was upregulated, and the expression of CST1 in HGC-27 and SNU-1 was relatively low, while the expression of CST1 in AGS and MKN45 was relatively high. At the same time, a stable cell line of HGC-27 overexpressing CST1 and MKN45 knocking down CST1 was successfully constructed. (3) Overexpression or knockdown of CST1 did not significantly change the proliferation ability of gastric cancer cells, but can promote the migration and invasion of gastric cancer cells. (4) CST1 may promote the metastasis of gastric cancer cells by activating the epithelial–mesenchymal transition (EMT) signaling pathway. Conclusion: CST1 gene promotes the migration of gastric cancer cells, and we found through animal experiments that CST1 can affect the metastasis and invasion function of gastric cancer and is negatively correlated with the level of E-cadherin.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46677070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between NLRP3 Inflammasome and GP73 Levels and Hepatitis B Cirrhosis with Esophageal Varices Rupture","authors":"Y. Li, Yifei Lv, F. Xi, Ying Gao","doi":"10.26689/par.v7i3.4905","DOIUrl":"https://doi.org/10.26689/par.v7i3.4905","url":null,"abstract":"Objective: To investigate the correlation between NOD-like receptor family protein 3 (NLRP3) inflammasome and Golgi protein 73 (GP73) levels and hepatitis B cirrhosis with esophageal varices (EV) rupture. Methods: The subjects of this study were 145 patients with hepatitis B cirrhosis and varices who were treated in our hospital in recent years. Endoscopic examination was performed on the patients. The patients were divided into two groups according to whether there was EV rupture: rupture group and non-rupture group. The correlation between plasma NLRP3 and GP73 levels and hepatitis B cirrhosis with EV rupture was analyzed. Results: Through observation, comparing the levels of NLRP3 and GP73 between the two groups, the levels of NLRP3 and GP73 were significantly higher in the rupture group than in the non-rupture group (P < 0.05). Logistic regression analysis showed that NLRP3 and GP73 levels and Child-Pugh classification were related risk factors of hepatitis B cirrhosis with EV rupture. Conclusion: NLRP3 inflammasome and GP73 levels are closely related to hepatitis B cirrhosis with EV rupture. The corresponding evaluation aids in predicting EV rupture and bleeding in patients with hepatitis B cirrhosis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42060470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the Effect of Integrated Medical and Nursing Care in Patients with Pulmonary Tuberculosis Combined with Lung Cancer","authors":"W. Yuan, Yuanyuan Lu, Mi Zhang, Min Zheng, X. Luan, Yanling Feng, Linlin Chai","doi":"10.26689/par.v7i3.4847","DOIUrl":"https://doi.org/10.26689/par.v7i3.4847","url":null,"abstract":"Objective: To explore the effect of integrated medical and nursing care in patients with pulmonary tuberculosis combined with lung cancer. Methods: From August 2021 to August 2022, 60 patients with pulmonary tuberculosis combined with lung cancer were admitted. All patients were diagnosed with pulmonary tuberculosis according to the Guidelines for the Diagnosis and Treatment of Pulmonary Tuberculosis and with lung cancer by pathology. The patients were randomly divided into two groups, with 30 cases in each group. The control group received daily nursing care, whereas the study group received integrated medical and nursing care. The sputum conversion rate, tumor remission rate, and quality of life of patients were observed and analyzed. Results: The item function score and symptom function score of the observation group were higher than those of the control group (P < 0.05); the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05); the sputum conversion rate of the observation group was significantly higher than that of the control group (P < 0.05). Conclusion: For patients with pulmonary tuberculosis combined with lung cancer, the application of integrated medical and nursing care can help consolidate the treatment effect and improve the quality of life of patients; thus, it is worthy of promotion and application.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69072566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Evaluation of Potential Ligands of Cancer Cells for Surfactin from Bacillus spp.","authors":"Mahmuda Akhter Akhi, U. T. Ferdous, M. Fakruddin, Suvamoy Datta, Md. Asaduzzaman Shishir","doi":"10.26689/par.v7i3.4918","DOIUrl":"https://doi.org/10.26689/par.v7i3.4918","url":null,"abstract":"Cancer is one of the most prevalent diseases worldwide, which causes significant morbidity and mortality. Designing and developing a potential anti-cancer drug is an active field of research worldwide. Microorganisms have been considered a potential source of anti-cancer drugs. One such microbe-derived compound is surfactin, which shows potential anti-cancer activities. In this study, we evaluated the binding potential of surfactin with several cancer cell ligands via an in-silico approach. Hence, molecular docking studies were performed to test the binding potential of surfactin against four targets. The analyses revealed that surfactin from Bacillus sp. can bind with the targeted ligands (coenzyme A, D-leucine, glycerol, and (R)-3-hydroxytetradecanal) with significant affinity. Surfactin showed the highest binding affinity (-7.7 kcal mol-1) to coenzyme A among the targeted ligands. These results may be useful for developing anti-cancer drugs. Nevertheless, further experimental studies are needed to investigate the ligand binding capacity and anti-cancer potential of such surfactin-like molecules.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41451457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric Comparative Analysis of Volumetric Modulated Arc Therapy and Intensity-Modulated Radiation Therapy in Cervical Cancer","authors":"R. He","doi":"10.26689/par.v7i3.4937","DOIUrl":"https://doi.org/10.26689/par.v7i3.4937","url":null,"abstract":"Objective: To carry out dosimetric comparison between volumetric modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) in cervical cancer. Methods: 50 postoperative cervical cancer patients were included in this study. The patients were admitted for treatment from January 2021 to January 2022. VMAT and IMRT plans were designed for each patient to analyze the dose distribution in the target area of the two treatment techniques. Results: Comparing the monitor unit for single treatment (638.21 ± 116.21 MU) and time of single treatment (143.21 ± 23.14 s) in the observation group and the monitor unit for single treatment (932.14 ± 74.11 MU) and time of single treatment (223.14 ± 17.26 s) in the control group, there was significant difference (P < 0.05); there was also significant difference (P < 0.05) between the normal tissue (bladder and rectum) of the observation group and that (bladder and rectum) of the control group. Conclusion: VMAT is more effective in cervical cancer, and it has a certain protective effect on normal tissues in patients and can reduce the radiation dose.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43679172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Analysis of Patients with Cervical Cancer After Adequate Radiotherapy and Surgery","authors":"W. Mi","doi":"10.26689/par.v7i3.4975","DOIUrl":"https://doi.org/10.26689/par.v7i3.4975","url":null,"abstract":"Objective: To explore the effect of giving adequate radiotherapy before surgery on the recovery of patients with cervical cancer. Methods: An experimental study was carried out in Aviation General Hospital (hereafter referred as our hospital) from March 2022 to March 2023. Fifty patients with cervical cancer were retrospectively analyzed. The patients underwent surgery 15–20 days after adequate external radiotherapy, and the clinical effect was analyzed. Results: The symptoms of the patients were relieved, among which contact bleeding and irregular vaginal bleeding completely resolved in 27 patients and 19 patients, respectively; although intermittent vaginal bleeding persisted in 3 patients, the symptom improved compared with before treatment; for 1 patient, the treatment was ineffective, as there was no significant improvement in symptoms. For patients with stage IB2 cancer, the tumor reduction rate after treatment was about 50%–70%, but the reduction in 2 patients was insignificant. Conclusion: Cervical cancer is a serious condition. Adequate radiotherapy before surgery has a significant effect. It reduces the difficulty of surgery and creates an opportunity for patients to undergo surgery, thus improving the treatment effect. Therefore, it is worthy of clinical promotion.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":"229 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41266361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Pelvic Peritoneum Closure Combined with Extraperitoneal Colostomy in Laparoscopic Surgery for Low Rectal Cancer","authors":"H. Yao, Jipan Liu, Cai-Hong Sun, Chengjun Wang, Yun Li, Li Li, Binde Zhao, Jia Liu","doi":"10.26689/par.v7i3.4869","DOIUrl":"https://doi.org/10.26689/par.v7i3.4869","url":null,"abstract":"Background: In the treatment of colorectal cancer, laparoscopic surgery has seen a significant amount of success. Reducing the risk of postoperative complications and improving patients’ quality of life can be accomplished by appropriately employing pelvic peritoneal repair and sigmoid colostomy when appropriate. Objective: To compare fusion closure of pelvic peritoneum combined with extraperitoneal colostomy with non-closure of pelvic peritoneum combined with intraperitoneal colostomy in patients with low rectal cancer who had permanent colostomy. Methods: Low rectal cancer patients admitted to Hengshui People’s Hospital for permanent colostomy were evaluated. The participants were divided into two groups: an observation and a control group. All 30 cases in the observation group underwent pelvic peritoneum closure and extraperitoneal colostomy, while the other 30 cases in the control group underwent intraperitoneal colostomy. The C-reactive protein (CRP) levels of the participants in both groups were evaluated for 6 months to 2 years (24 h before, 24 h after, 48 h after, 96 h after surgery). Results: Comparing the colostomy operative time, time to  first passage of flatus postoperatively, time to first defecation postoperatively, length of hospital stay, laboratory indicators, stoma-related complications, colostomy function, etc., the colostomy operative time significantly differed between the two groups (P < 0.05); the observation group did considerably better than the control group in terms of stoma-related complications and bowel movement control 6 months after surgery (P < 0.05); and although serum CRP levels increased in both groups 48 h after surgery, the difference was significant (P < 0.05). Conclusion: Extraperitoneal colostomy can improve the quality of life of patients with permanent stoma and reduce the occurrence of stoma-related complications. Thus, this technique is worthy of promotion in clinical practice.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43018151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Traditional Chinese Medicine Syndrome Types and Influencing Factors of Asthmatic Bronchitis in Children","authors":"Miao Ren, Shijie Luo","doi":"10.26689/par.v7i3.4910","DOIUrl":"https://doi.org/10.26689/par.v7i3.4910","url":null,"abstract":"Objective: To explore the correlation between traditional Chinese medicine (TCM) syndrome types and the influencing factors of asthmatic bronchitis in children, as well as to provide clinical syndrome differentiation basis and reference for the treatment of children with asthmatic bronchitis. Methods: The clinical data of 197 inpatients with asthmatic bronchitis in our hospital from March 2021 to March 2022 were collected, referring to “Zhu Futang Practical Pediatrics” (7th Edition, 2002) and “Chinese Medicine Industry Standards – Standards for Diagnosis and Efficacy of Pediatric Diseases and Syndromes of Traditional Chinese Medicine” (1994, State Administration of Traditional Chinese Medicine) for diagnosis, classification, and analysis of TCM syndrome types and the influencing factors of asthmatic bronchitis in children. Results: (i) cold asthma syndrome contributed to the majority of TCM syndrome types of pediatric asthmatic bronchitis; (ii) gender had a great influence on TCM syndromes types in children with asthmatic bronchitis, and the differences among the TCM syndrome types were statistically significant (P < 0.05); (iii) there was no significant difference in the distribution of TCM syndrome types of pediatric asthmatic bronchitis among different age groups (P > 0.05); (iv) birth status had no effect on the distribution of TCM syndrome types of pediatric asthmatic bronchitis (P > 0.05); (v) no significant correlation was observed between the mode of delivery and the distribution of TCM syndrome types in children with asthmatic bronchitis (P > 0.05); (vi) children with cold asthma syndrome, heat asthma syndrome, and mixed cold and heat syndrome were not breastfed, and there was no significant difference in the feeding methods of children with mixed deficiency and excess syndrome (P > 0.05); (vii) no significant correlation was observed between the TCM syndrome types of pediatric asthmatic bronchitis and family history of asthma/allergy (P > 0.05); (viii) a significant correlation was observed between different TCM syndrome types and history of drug and food allergy (P < 0.05); (ix) normal or high eosinophil percentage was commonly observed in children with asthmatic bronchitis, and there was no significant difference among the different TCM syndrome types (P > 0.05). Conclusion: The TCM syndrome types of pediatric asthmatic bronchitis are related to gender, feeding history, allergy history, and other factors, which may be influencing factors of the TCM syndrome types of pediatric asthmatic bronchitis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47742102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Mitochondrial Function of Ovarian Granulosa Cells on In Vitro Fertilization and Embryo Transfer Outcomes in Obese Polycystic Ovary Syndrome Patients","authors":"Jing Wang, Yan Gao, Hongli Wu, Gaijing Wang, J. Cui, Jinjin Qin, Lulu Wang, Yakun Zhao, Rui Li","doi":"10.26689/par.v7i3.4780","DOIUrl":"https://doi.org/10.26689/par.v7i3.4780","url":null,"abstract":"Objective: To investigate the effect of abnormal ovarian granulosa cell metabolism on in vitro fertilization and embryo transfer (IVF-ET) outcomes in obese polycystic ovary syndrome (PCOS) patients. Methods: Patients with PCOS who met the study criteria were screened according to the inclusion criteria. A total of 32 patients with obese PCOS were recruited into the study group, and 39 patients with non-obese PCOS were recruited into the control group. The general data (age, body mass index, and years of infertility), insulin resistance index (HOMA-IR), follicle-stimulating hormone (FSH), luteinizing hormone (LH), granulosa cell mitochondrial function, and IVF-ET outcome of patients in the study group and control group were retrospectively analyzed. Results: The differences in age and years of infertility between the study group and the control group were insignificant (P > 0.05), and the body mass index (BMI) of the study group and control group was 30.5 ± 1.24 kg/m2 and 22.3 ± 1.12 kg/m2, respectively, in which the difference was statistically significant (P < 0.05); the HOMA-IR of the study group was significantly higher than that of the control group (P < 0.05); the reactive oxygen species (ROS) in the study group was significantly higher than that in the control group (P < 0.05), and the ATP content in the study group was significantly lower than that in the control group (P < 0.05); comparing the FSH and LH levels between the two groups, the difference was not statistically significant (P > 0.05); the rate of IVF-ET failure was significantly higher in the study group than in the control group. Conclusion: PCOS is a complex endocrine disorder, and obesity is one of the independent risk factors for the development of PCOS.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46566495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}