抗癌研究最新文献

{"title":"History and Development of Zhuang Medicine Shallow Needling from Bone Needle, Pottery Needle, and Bronze Needle to Electroacupuncture","authors":"Yun Zhang, Yuying Lan","doi":"10.26689/par.v7i2.4791","DOIUrl":"https://doi.org/10.26689/par.v7i2.4791","url":null,"abstract":"Zhuang medicine shallow needling has a long history and plays a significant role in Chinese medicine. With the development of medical treatment in China, there is a constant improvement in the use of needles. Bone needles have been modified to pottery needles, bronze needles, and electroacupuncture. From this long development history, there are some improvements in terms of material and technology. By analyzing and comparing the primitive and current acupuncture instruments used in China and their therapeutic effects, it can be seen that China’s medical treatment is constantly improving and will continue to improve with technology.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45169924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of N-Terminal Pro B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Homocysteine Levels in Predicting Cardiovascular Events in Chronic Heart Failure Patients After Discharge","authors":"Qianqian Yu, Linya Zhao, Yinyin Chen, Qing Zhao","doi":"10.26689/par.v7i2.4788","DOIUrl":"https://doi.org/10.26689/par.v7i2.4788","url":null,"abstract":"Objective: To investigate the value of N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) levels in predicting cardiovascular events (CV) in patients with chronic heart failure (CHF). Methods: A total of 63 patients with CHF admitted to our hospital between June 2019 and July 2021 were selected. Their NT-proBNP, hs-CRP, and Hcy levels were detected at discharge, and a 12-month follow-up was done after their discharge to collect clinical data. The collected data were inclusive of data from 21 CHF patients with cardiovascular disease and 42 CHF patients without cardiovascular disease. The effect of NT-proBNP, hs-CRP, and Hcy levels on the occurrence of CV was analyzed. Results: The levels of NT-proBNP, hs-CRP, and Hcy in the group with cardiovascular disease were significantly higher than those in the group without cardiovascular disease (P < 0.05); the levels of serum NT-proBNP, hs-CRP, and Hcy at discharge had certain value in predicting short-term CV in CHF patients (P < 0.05). Conclusion: NT-proBNP, hs-CRP, and Hcy levels can be used to predict CV in CHF patients, thus having clinical application value.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42353572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Hypovitaminosis D Status and Hyperactivation of IL-6/STAT3 Signaling in Clear Cell Renal Cell Carcinoma","authors":"J. Ji, Deqiang Gu, Jing-yang Guo, Weijuan Liang, Xue Zhao, Lin Li, Song Li","doi":"10.26689/par.v7i2.4763","DOIUrl":"https://doi.org/10.26689/par.v7i2.4763","url":null,"abstract":"Objective: To analyze serum vitamin D levels in patients with clear cell renal cell carcinoma (ccRCC) by flow cytometry and to investigate the relationship between hypovitaminosis D status and hyperactivation of IL-6/STAT3 signaling in ccRCC. Methods: Eighty patients diagnosed with ccRCC by our oncology department from January 2019 to December 2021 were selected as study subjects, and the control subjects were selected from patients who were receiving health check-up from our hospital (matched according to case group:control group, 1:2), with 160 healthy patients. All serum samples collected from the case-control subjects were allowed to stand for 1–2 hours, centrifuged at 3000 rpm for 10 minutes, and stored in a -80°C refrigerator, from which they were removed and thawed to measure 25-hydroxyvitamin D (25(OH)D) and interleukin 6 (IL-6) levels. Results: The blood calcium level of patients in the cancer group was significantly lower than that of patients in the non-cancer group, and the difference was statistically significant (P < 0.05). The IL-6 level of the cancer group was significantly higher than that of the non-cancer group. In high vitamin D state, the IL-6 level of the non-cancer group was higher than that of the cancer group, and the average concentration of IL-6 in both the cancer group and the non-cancer group was significantly higher in low vitamin D state compared with high vitamin D state (P < 0.05); the correlation between hypovitaminosis D status and renal Ki-67 was found to be positive. Conclusion: The results showed that serum IL-6 levels were elevated in the cancer group and circulating serum 25(OH)D levels were negatively correlated with IL-6 levels. In addition, signal transducer and activator of transcription 3 (STAT3) signaling in RCC tissues was activated in ccRCC patients and in those with low vitamin D status among the cancer group and was higher than that in those with high vitamin D status. These results suggest that hypovitaminosis D status in ccRCC patients is associated with activated IL-6/STAT3 signaling and the activation of tumor proliferation markers proliferating cell nuclear antigen (PCNA), cyclin D1, and Ki-67.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48355892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Serum microRNA-372-3p and Glucose Transporter 4 Levels and Insulin Resistance in Gestational Diabetes Mellitus","authors":"Jinjin Qin, Chenyuan Cao, Yakun Zhao, Jing Wang, Hongli Wu, Bei-bei Wang","doi":"10.26689/par.v7i2.4776","DOIUrl":"https://doi.org/10.26689/par.v7i2.4776","url":null,"abstract":"Objective: To observe the changes in insulin resistance in patients with gestational diabetes mellitus (GDM) based on the detection of serum microRNA-372-3p and glucose transporter protein 4 (GLUT4) levels. Methods: We conducted a retrospective cohort study of 42 patients who were diagnosed with GDM and hospitalized in our hospital during the period from January 2017 to December 2021 and another 42 patients who had normal pregnancy during the same period by collecting their clinical data. We analyzed their serum microRNA expression profiles and miR-372-3p levels to study the relationship between GDM and insulin resistance. Results: The relative expression of miR-372-3p in the serum of patients in the GDM group was significantly higher than that of patients in the control group, but the GLUT 4 level of the GDM group was significantly lower than that of the control group (P < 0.05). Compared with the control group, the GDM group had significantly higher levels of fasting blood glucose (FBG), fasting insulin (FINS), 2-hour postprandial blood glucose (2h-BG), total cholesterol (TC), triglyceride (TG), and homeostatic model assessment for insulin resistance (HOMA-IR) index but significantly lower homeostasis model assessment of ?-cell function (HOMA-?) index (P < 0.05). The relative expression of miR-372-3p in serum was independently and positively correlated with HOMA-IR, while the level of GLUT4 was independently and negatively correlated with HOMA-IR (P < 0.05). Conclusion: Glycosylated hemoglobin test in the early stages of pregnancy (12–13 weeks of gestation) is important to ensure the health of pregnant women and fetuses. The screening and intervention for elevated glucose in pregnant women act as a guideline for the treatment of GDM. Patients with insulin resistance and related complications such as hyperinsulinemia and hypoglycemia should be given priority.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46186306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Postprandial Blood Glucose, Fasting Insulin, and Glycated Hemoglobin Levels and Early Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus","authors":"Xing-xia Fan, Zhe Li","doi":"10.26689/par.v7i2.4797","DOIUrl":"https://doi.org/10.26689/par.v7i2.4797","url":null,"abstract":"Objective: To investigate the relationship between postprandial blood glucose (PBG), fasting insulin (FINS), and glycated hemoglobin (HbA1c) levels and early diabetic nephropathy in patients with type 2 diabetes. Methods: 96 cases of type 2 diabetes mellitus treated in our hospital from May 2021 to May 2022 were selected as the research subjects. The patients were divided into two groups according to the urinary albumin excretion rate (UAER), with 53 cases in the type 2 diabetes group (UAER < 30 ?g/min) and 43 cases in the early diabetic nephropathy group (30 ?g/min ? UAER < 300 ?g/min). PBG, FINS, and HbA1c levels were detected in 87 healthy patients. Results: The levels of PBG, FINS, and HbA1c in the early diabetic nephropathy group were higher than those in the control group (P < 0.01) and the type 2 diabetes group (P < 0.01). Conclusion: PBG, FINS, and HbA1c are factors affecting the occurrence of diabetic nephropathy in patients with type 2 diabetes; thus, controlling the levels of PBG, FINS, and HbA1c can effectively prevent the occurrence of diabetic nephropathy in type 2 diabetes mellitus.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69072555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Infection in Nephrotic Syndrome","authors":"Xijie Zheng, Yanli Gou, Jiandong Li, Hang Chen, Youlan Gong, Shanshan Guo","doi":"10.26689/par.v7i2.4838","DOIUrl":"https://doi.org/10.26689/par.v7i2.4838","url":null,"abstract":"Objective: To determine the risk factors of infection in patients with nephrotic syndrome. Methods: A retrospective study was conducted on 155 patients with nephrotic syndrome under our department from January 2019 to December 2019. Among them, 43 cases had infection, and the rate of infection was 27.74%. The risk factors of infection were analyzed. Results: Among the 155 patients with nephrotic syndrome, 43 cases developed infection, including 3 cases of upper respiratory tract infection (6.98%), 33 cases of lower respiratory tract infection (76.74%), 3 cases of skin infection (6.97%), 3 cases of urinary tract infection (6.97%), and 1 case of facial nerve infection (2.32%). Compared with the group without infection, the group with infection had lower serum albumin and immunoglobulin G (IgG) levels as well as higher serum creatinine and 24-hour urinary protein levels (P < 0.05). Multivariate logistic regression analysis showed that decreased serum albumin (odds ratio [OR] = 1.14; P < 0.01) and IgG (OR = 1.1; P < 0.144) were independent risk factors for infection. Conclusion: Respiratory infection is the most common infection in nephrotic syndrome, and the decrease in serum albumin and IgG are independent risk factors for infection.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41421673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application Effect of Medium-Length Peripheral Catheter in Critically Ill Patients Undergoing Hepatobiliary Surgery","authors":"Xiao-hua Song, Xiaoyan Liu, Xiaomei Liu, Xi Chen","doi":"10.26689/par.v7i2.4778","DOIUrl":"https://doi.org/10.26689/par.v7i2.4778","url":null,"abstract":"Objective: To investigate the effect of using peripheral medium-length catheters in critically ill patients undergoing hepatobiliary surgery. Methods: A retrospective analysis of the nursing experience and effect of using medium-length catheters for infusion in 102 critically ill patients undergoing hepatobiliary surgery from March 2021 to April 2022 was conducted. Results: All 102 patients had successful catheter placement with no catheter-associated infections, blockage, decannulation, or breakage. However, four cases had blood oozing from the puncture site, but it resolved after changing the dressing. Conclusion: Medium-length catheters are superior to traditional infusion tools in terms of benefit; thus, they deserve to be widely promoted in clinical practice.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43940797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposed Solution to the Interference of IgG?-Type M Protein on LDL-C Detection","authors":"Chaoyong James Yang, Yangjinqi Yu, Shuxin Liang, Haige Zhao, Na An","doi":"10.26689/par.v7i2.4736","DOIUrl":"https://doi.org/10.26689/par.v7i2.4736","url":null,"abstract":"Objective: To explore the interference of monoclonal immunoglobulin (M protein) on the detection of serum LDL-C in patients with multiple myeloma, improve the understanding of this matter, determine and establish the correct method, and provide more accurate clinical results through this case. Methods: A case was selected for analysis by the direct method. Results: The interference of IgG?-type M protein on LDL-C detection could not be completely eliminated by the enzymatic method. Conclusion: IgG-type type M protein affects the detection of LDL-C by the enzymatic method; thus, light reagents can be used with the direct method for detection.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48609360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Protective Effect of the Ethanolic Extract of Rosa laevigata Michx. Fruit on Rats with Mesangial Proliferative Glomerulonephritis Based on NLRP3 Inflammasome Pathway","authors":"J. Ji, Zhao Bi, Ling Tian, X. Fan, Limin Zhang, Song Li","doi":"10.26689/par.v7i1.4761","DOIUrl":"https://doi.org/10.26689/par.v7i1.4761","url":null,"abstract":"Objective: To investigate the effect of the ethanolic extract of Rosa laevigata Michx. fruit on rats with mesangial proliferative glomerulonephritis based on the NLRP3 inflammasome pathway. Methods: Thirty Wistar rats were divided into three groups, a blank control group, a diabetic nephropathy (DN) model group, and an ethanolic extract intervention group, according to the random number table method, with 10 rats in each group. One day before the experiment, basic feeding was initiated for all the rats; the changes in activity and weight of each group of rats were observed and recorded after 7 d, and a rat model of renal function injury was established after 1 d. Results: Compared with the control group, the model group had significantly higher kidney/body ratio, 24 h urine protein, serum creatinine (SCr), blood urea nitrogen (BUN), glomerular mesangial cell (GMC) count, and extracellular matrix (ECM) positive area ratio (P < 0.05); the same indicators were  significantly lower in the intervention group than in the model group (P < 0.05). The NLRP3 inflammasome pathway in renal intrinsic cells was activated in the intervention group. The overactivation of NLRP3 inflammasome is known to promote interleukin (IL)-1? release, which was inhibited in the intervention group. Conclusion: The ethanolic extract of Rosa laevigata Michx. fruit has a protective effect on renal intrinsic cells and may be related to NLRP3 inflammasome pathway, suggesting that the fruit of Rosa laevigata Michx. has a potential role in protecting renal intrinsic cells from inflammatory damage. NLRP3 inflammasomes are involved in the development of various chronic inflammatory diseases, such as acute and chronic glomerulonephritis and renal fibrosis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45472186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Restoration and Fixation of Lateral Femoral Wall Fracture","authors":"Muhammad Atta Ul Mustafa, Ling Shang, S. Bano, M. Moneruzzaman, Ning Bin","doi":"10.26689/par.v7i1.4753","DOIUrl":"https://doi.org/10.26689/par.v7i1.4753","url":null,"abstract":"Hip fractures, especially intertrochanteric fractures, are more common with aging. After decades of progress, it is a general consensus to carry out internal fixation for this group of patients. However, the recent focus is on unstable intertrochanteric fractures to ensure better prognosis and prevent internal fixation failure. The lateral femoral wall, as a novel concept, is often disregarded. Many scholars have recognized that the lateral wall of the proximal femoral plays a crucial role in the stability of internal fixation for intertrochanteric fractures. In this paper, the historical evolution, definition, clinical significance, injury classification, choice of internal fixation, and possible prognosis of lateral femoral wall fracture are reviewed in order to provide clinicians strong evidence of treatment strategies.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49155910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}