生物化学进展(英文)最新文献_第4页

Desmarestia anceps Montagne (Phaeophyceae) against Colorectal Cancer Cells: Cytotoxic Activity and Proapoptotic Effects 对大肠癌细胞的细胞毒活性及促凋亡作用

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.126019

R. Frassini, D. Steffens, S. Moura, C. Aguzzoli, A. P. Martins, P. Colepicolo, M. Fujii, N. Yokoya, C.M.P. Pereira, Ana Cláudia Phillipus, M. Falkenberg, J. P. Henriques, M. Roesch-Ely

引用次数: 0

Phytochemical Analysis and Bioactivity Screening of Primary and Secondary Metabolic Products of Medicinal Plants in the Valleys of Medina Region Saudi Arabia 沙特阿拉伯麦地那地区山谷药用植物初级和次级代谢产物的植物化学分析及生物活性筛选

生物化学进展(英文) Pub Date : 2022-01-01 DOI: 10.4236/abc.2022.124009

Safa Alsaedi, G. Aljeddani

引用次数: 4

Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds 新型噻唑偶氮染料及其配位化合物的合成、表征及生物活性研究

生物化学进展(英文) Pub Date : 2021-09-26 DOI: 10.4236/abc.2021.115013

T. Aiyelabola

{"title":"Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds","authors":"T. Aiyelabola","doi":"10.4236/abc.2021.115013","DOIUrl":"https://doi.org/10.4236/abc.2021.115013","url":null,"abstract":"The present work describes the synthesis of a novel heterocyclic azo dye \u0000by general diazonization of \u00002-amino-4,5-dimethylthiazole followed by the diazo- coupling \u0000of the resulting diazonium ion with 5-methyl-2-(propan-2-yl)phenol to obtain ligand L. This was \u0000characterized using Fourier-transformed infrared and electronic \u0000spectrophotometry. Ligand L was further coordinated with five metal ions, M:L, 1:2 [M = Cu(II), Mn(II), Zn(II), Ni(II) and Co(II)]. The coordination \u0000compounds obtained were characterized by electronic, IR spectrophotometry, \u0000magnetic susceptibility and percentage metal analyses. The results obtained suggested \u0000that a thiazoylazo dye was obtained as ligand L. It was proposed that \u0000two molecules of the solvent coordinated to the metal ion in addition with the \u0000ligands to give an octahedral geometry for copper(II), manganese(II) and \u0000nickel(II) complexes. On the other hand, square planar geometry was suggested for zinc(II) and cobalt(II) complexes. The anti-infla- mmatory \u0000activity of the ligand and coordination compounds was evaluated using four in vitro-based \u0000assays viz: xanthine oxidase and \u0000lipoxygenase inhibition assay, membrane stability and protein denaturation \u0000assay. The synthesized compounds generally exhibited good anti-inflammatory \u0000activity in all the assays carried out. \u0000However, the reference standards, in this instance, were more effective \u0000in the case of xanthine oxidase, lipoxygenase and protein denaturation \u0000inhibitory assays. For the membrane stability study, the coordination compounds and ligand L elicited \u0000more potent anti-inflammatory activity than the standard drug.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48852083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Application of TIRFM in Biomolecule Research and Clinical Medicine TIRFM在生物分子研究和临床医学中的应用

生物化学进展(英文) Pub Date : 2021-09-26 DOI: 10.4236/abc.2021.115014

Ye-Qin Zhang

引用次数: 1

Triterpenoids and Semisynthetic Derivatives with Antimicrobial Activities from the Leaves of Caloncoba glauca (Flacourtiaceae) 海苔叶中的三萜类化合物及具有抗菌活性的半合成衍生物

生物化学进展(英文) Pub Date : 2021-07-22 DOI: 10.4236/abc.2021.114011

J. Mpetga, A. R. N. Donfack, J. Tamokou, Iréne Chinda Kengne, P. Tane, Xiao-jiang Hao, Mathieu Tene

{"title":"Triterpenoids and Semisynthetic Derivatives with Antimicrobial Activities from the Leaves of Caloncoba glauca (Flacourtiaceae)","authors":"J. Mpetga, A. R. N. Donfack, J. Tamokou, Iréne Chinda Kengne, P. Tane, Xiao-jiang Hao, Mathieu Tene","doi":"10.4236/abc.2021.114011","DOIUrl":"https://doi.org/10.4236/abc.2021.114011","url":null,"abstract":"Chemical investigation of the MeOH extract from the \u0000leaves of C. glauca yielded nine known triterpenoids (1-9) \u0000belonging to the cycloartane and friedelane series. Two of these \u0000compounds namely glaucartanoic acid A (1) and 3β,21β-dihydroxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic \u0000acid (5) were subjected to chemical derivatizations and afforded five \u0000new derivatives: diacetylglaucartanoic acid A (1a), \u000024-acetylglaucartanoic acid A (1b), glaucartanoic acid A methyl ester (1c), \u000024-methoxyglaucartanoic acid A methyl ester \u0000(1d), and 3β,21β-diacetoxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (5a). Their structures were assigned based on their NMR and MS data \u0000and by comparison with literature values. \u0000The MeOH extract, isolated compounds and some new semi-synthetic \u0000derivatives were subjected to in vitro antimicrobial assays \u0000against a panel of pathogenic microorganisms, including Gram-positive \u0000and Gram-negative bacteria, and fungi using broth microdilution method. The \u0000MeOH extract displayed activity towards all the tested pathogenic bacterial and fungal strains with good \u0000activity (MIC against Staphylococcus aureus ATCC25923 and Shigella flexneri SDINT. Compounds 3 and 5 showed the most potent antimicrobial effect.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42607891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design, Synthesis and in Vitro Antibacterial Activity of 2-thiomethyl-benzimidazole Derivatives 2-硫代甲基苯并咪唑衍生物的设计、合成及体外抗菌活性

生物化学进展(英文) Pub Date : 2021-07-22 DOI: 10.4236/abc.2021.114012

Ablo Evrard, Coulibali Sioménan, Camara Tchambaga Etienne, Touré Daouda, C. Souleymane, Sissouma Drissa, A. Ané

引用次数: 2

Syntheses, Characterization, Antimicrobial Activity and Extraction Studies of Tetraaza Macrocyclic/Linear Schiff Bases Derived from Benzene-1,4-Dicarboxaldehyde and Their Coordination Compounds 苯-1,4-二甲酸四氮杂大环/线性席夫碱及其配位化合物的合成、表征、抗菌活性及提取研究

生物化学进展(英文) Pub Date : 2021-05-11 DOI: 10.4236/ABC.2021.113007

T. Aiyelabola, J. Jordaan, D. Otto, E. Akinkunmi

{"title":"Syntheses, Characterization, Antimicrobial Activity and Extraction Studies of Tetraaza Macrocyclic/Linear Schiff Bases Derived from Benzene-1,4-Dicarboxaldehyde and Their Coordination Compounds","authors":"T. Aiyelabola, J. Jordaan, D. Otto, E. Akinkunmi","doi":"10.4236/ABC.2021.113007","DOIUrl":"https://doi.org/10.4236/ABC.2021.113007","url":null,"abstract":"Non-template [2 + 2] condensation of benzene-1,4-dicarboxaldehyde \u0000with two diamines: ethane-1,2-diamine and propane-1,2-diamine was carried out to give Ligands 1 and 2. Additionally, \u0000template [1 + 2] condensation of benzene-1,4-dicarboxaldehyde \u0000with ethane-1,2-diamine and propane-1,2-diamine were also carried out to \u0000give Ligands 3 and 4. These were characterized using 1H \u0000and 13C NMR, UV-Vis and infra-red spectroscopy and mass \u0000spectrometry. Coordination compounds of each ligand were further synthesized \u0000using Ni(II) and Cu(II) ions. They were characterized by Uv-vis, infrared spectroscopy, mass spectrometry, \u0000magnetic susceptibility and energy dispersion X-ray spectroscopy EDX. The \u0000ligands and complexes were further analyzed for their antimicrobial activities and extraction \u0000efficiency. The results obtained suggested that tetraaza macrocyclic and linear \u0000compounds were obtained for [2 + 2] and [1 + 2] condensation reactions respectively. \u0000Coordination compounds of the macrocyclic ligand yielded octahedral geometry \u0000for Ni(II) and Cu(II) complexes of Ligand 1 and square planar geometry \u0000for Ni(II) and Cu(II) complexes of Ligand 2. On the other hand square \u0000planar geometry was proposed for coordination compounds of Ligand 3 and 4 exception for the Ni(II) complex of Ligand 3. All ligands coordinated to the \u0000metal ion in a tetradentate fashion. In some cases chelation enhanced the \u0000antimicrobial activity of some of the ligands. The results further showed that \u0000Ligands 1-4 effectively extracted cadmium(II). zinc(II) and \u0000lead(II) ions in solution.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":"11 1","pages":"79-105"},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42508690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Syntheses, Characterization and Biological Activity of Coordination Compounds of 3-Hydroxy-2-methyl-4 H -pyran-4-one and Its Mixed Ligand Complexes with 1,2-Diaminocyclohexane 3-羟基-2-甲基-4H-吡喃-4-酮及其与1,2-二氨基环己烷混合配体配合物的合成、表征及生物活性

生物化学进展(英文) Pub Date : 2021-05-11 DOI: 10.4236/ABC.2021.113008

T. Aiyelabola

{"title":"Syntheses, Characterization and Biological Activity of Coordination Compounds of 3-Hydroxy-2-methyl-4 H -pyran-4-one and Its Mixed Ligand Complexes with 1,2-Diaminocyclohexane","authors":"T. Aiyelabola","doi":"10.4236/ABC.2021.113008","DOIUrl":"https://doi.org/10.4236/ABC.2021.113008","url":null,"abstract":"Coordination compounds of 3-hydroxy-2-methyl-4H-pyran-4-one with iron(III), cobat(III) and chromium(III) were \u0000synthesized with M:L (1:2). Mixed ligand coordination compounds of \u00003-hydroxy-2-methyl-4H-pyran-4-one and 1,2-diaminocyclohexane using the \u0000same metal ions were also synthesized M:L1:L2 (1:1:1) where L1 is 3-hydroxy-2-methyl-4H-pyran-4-one and L2 is \u00001,2-diaminocyclohexane. The coordination compounds obtained were characterized \u0000using electronic and infrared spectral analyses, magnetic susceptibility and \u0000percentage metal analysis. They were also evaluated for their cytotoxic and antioxidant \u0000activities. The result obtained suggested that octahedral geometry was obtained \u0000for all the compounds, as a result of additional two molecules of the solvent \u0000coordinated to the metal ions. Both the primary and secondary ligands \u0000coordinated in a bidentate fashion. The synthesized compounds exhibited \u0000moderate cytotoxicity, although none was as active as the standard. The \u0000cobalt(III) mixed ligand complex elicited the highest activity. The synthesized \u0000compounds all exhibited good to moderate antioxidant activity.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":"11 1","pages":"106-125"},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42937202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae) 大叶五草种子的民族植物学、药理学和植物化学研究(含笑科)

生物化学进展(英文) Pub Date : 2021-05-11 DOI: 10.4236/ABC.2021.113009

P. Sinda, B. Ponou, B. Tsafack, J. Kühlborn, R. Tchuenguem, R. Teponno, J. Dzoyem, T. Opatz, L. Tapondjou

{"title":"Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae)","authors":"P. Sinda, B. Ponou, B. Tsafack, J. Kühlborn, R. Tchuenguem, R. Teponno, J. Dzoyem, T. Opatz, L. Tapondjou","doi":"10.4236/ABC.2021.113009","DOIUrl":"https://doi.org/10.4236/ABC.2021.113009","url":null,"abstract":"Phytochemical investigation of the seeds \u0000of Pentaclethra macrophylla led to the isolation of a mixture of two new aromatic monoterpene \u0000glycosides, pentamacrophylloside A \u0000(1a) and pentamacrophylloside B (1b), \u0000together with six known secondary \u0000metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5), 2-hydroxymethyl-5-(2-hydroxypropan-2-yl)phenol \u0000(6), and sucrose (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and \u00002D NMR), high-resolution mass \u0000spectrometry and by comparison of their \u0000spectral data with those of related compounds. The extracts and compounds 3 and 4 were screened for their antimicrobial activity. The n-BuOH \u0000fraction showed a weak effect against three microbial strains: Candida albicans (MIC: 256 μg/mL), Enterococcus faecalis (MIC: 512 μg/mL), and Proteus \u0000mirabilis (MIC: 512 μg/mL) while \u0000no significant inhibition was observed for pure compounds when compared to ketoconazole and ciprofloxacin used as references. Furthermore, the \u0000ethnobotany and pharmacology of this plant are reviewed, and the chemophenetic significance of the isolation of \u0000the above secondary metabolites is discussed. This is the first report on the isolation of aromatic \u0000monoterpenoids from a plant of the genus Pentaclethra.","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":"11 1","pages":"126-141"},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43847650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients 纯合子镰状细胞患者尿酸与代谢综合征的关系

生物化学进展(英文) Pub Date : 2021-05-11 DOI: 10.4236/ABC.2021.113010

Kandji Pape Matar, Djité Moustapha, Barry Nene Oumou Kesso, Sagne René Ngor, Thioune Marême, Mbacke Ndoumbé Mame, N. H. Malick, G. Fatou, Lopez-Sall Philomène, C. Aynina, D. Amadou, Gueye Papa Madièye

{"title":"Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients","authors":"Kandji Pape Matar, Djité Moustapha, Barry Nene Oumou Kesso, Sagne René Ngor, Thioune Marême, Mbacke Ndoumbé Mame, N. H. Malick, G. Fatou, Lopez-Sall Philomène, C. Aynina, D. Amadou, Gueye Papa Madièye","doi":"10.4236/ABC.2021.113010","DOIUrl":"https://doi.org/10.4236/ABC.2021.113010","url":null,"abstract":"The objective of this study was to assess the association between uric \u0000acid and the metabolic syndrome and its \u0000components in homozygous sickle cell patients. This is a prospective \u0000case/control study of sickle cell SS patients. Each patient \u0000was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to \u0000International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, \u0000Illinois, USA). Data were collected with Excel 2016 software and statistical \u0000analysis was done using XLSTAT 2019 software. Student’s T test was \u0000used to compare means and a p-value less \u0000than 0.05 was considered significant. The study \u0000population consisted of 100 homozygous sickle cell patients with an average age \u0000of 26 years with a sex ratio of 0.58. The prevalence of metabolic syndrome in \u0000our population according to the IDF 2009 was 2%. In our study 28% of patients \u0000presented with hyperuricemia. Uricaemia was significantly elevated in patients \u0000with components of the metabolic syndrome, in particular in 33% of patients \u0000with a large waist circumference, in 25% of hypertensive patients, in 50% of \u0000patients with hypertriglyceridemia and in 60% of patients with hypertriglyceridemia \u0000and low HDL-cholesterol levels. Significant correlations were found between \u0000uricemia and certain components of the metabolic syndrome, in particular the \u0000level of triglycerides (r = 0.31, p = 0.002), blood sugar (r = 0.16; p = 0.012), \u0000around size (r = 0.071; p ≤ 0.05), HDL-Cholesterol (r = ﹣0.01; p = 0.018), PAS (r = 0.076; p = 0.035) and PAD (r = ﹣0.18; p = \u00000.0015).","PeriodicalId":59114,"journal":{"name":"生物化学进展(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48271543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1