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[The research progress of AMPK in exercise adaption of skeletal muscle]. [AMPK在骨骼肌运动适应中的研究进展]。
生理科学进展 Pub Date : 2016-10-01
Jie Zhang, Li Fu
{"title":"[The research progress of AMPK in exercise adaption of skeletal muscle].","authors":"Jie Zhang, Li Fu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Insulin resistance and diabetic encephalopathy]. [胰岛素抵抗与糖尿病性脑病]。
生理科学进展 Pub Date : 2016-10-01
Ze-Mei Zhu, Si-Si Yang, Di Wu, Shui-Dong Feng, Hong-Yan Ling
{"title":"[Insulin resistance and diabetic encephalopathy].","authors":"Ze-Mei Zhu, Si-Si Yang, Di Wu, Shui-Dong Feng, Hong-Yan Ling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Protein Kinase A and Lipid Metabolism]. 蛋白激酶A与脂质代谢
生理科学进展 Pub Date : 2016-10-01
Chong-Jiu Chen, Xiao-Ning Yang, Bing-Wei Wang, Chen-Yu Zhang, Zhi-Jie Su, Rui-Mao Zheng
{"title":"[Protein Kinase A and Lipid Metabolism].","authors":"Chong-Jiu Chen,&nbsp;Xiao-Ning Yang,&nbsp;Bing-Wei Wang,&nbsp;Chen-Yu Zhang,&nbsp;Zhi-Jie Su,&nbsp;Rui-Mao Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Protein kinase A(PKA),as a pivotal factor in the cellular signal transduction,plays an es-sential role in the regulation of lipid metabolism.PKA activates the key lipases including hormone sensi-tive lipase (HSL)and adipose triglyceride lipase (ATGL)to promote the fat mobilization.PKA signaling up-regulates the mitochondrial thermogenesis by enhancing the expression of uncoupling protein-1 (UCP-1),which critically contributes to the body heat production.PKA is closely involved in the regulation of lipogenesis in the liver.Notably,the dysregulation of PKA signaling is associated with the pathogenic mechanisms underlying the obesity,cardiovascular diseases and diabetes mellitus.The pharmacological studies show that PKA is linked to the pharmacological effects of the major lipid regulating agents.In this review,the studies on roles of PKA in the regulation of lipid metabolism are summarized with an emphasis on progress made during the last five years for providing insights into the mechanism by which PKA regu-lates the lipid metabolism as well as the novel therapeutic strategy for lipid-metabolic diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36214863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress in the role of microglia polarization in remyelination of central nervous system]. [小胶质细胞极化在中枢神经系统髓鞘再生中的作用研究进展]。
生理科学进展 Pub Date : 2016-10-01
Xiao-Rui Wang, Hao Sun, Qi-Yan Cai, Zuo Xiao
{"title":"[Research progress in the role of microglia polarization in remyelination of central nervous system].","authors":"Xiao-Rui Wang,&nbsp;Hao Sun,&nbsp;Qi-Yan Cai,&nbsp;Zuo Xiao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases]. [SIRT6在心血管、癌症和代谢疾病中的作用]。
生理科学进展 Pub Date : 2016-08-01
Yan-Hao He, Wei-Rong Wang, Rong Lin
{"title":"[Effects of SIRT6 in cardiovascular, cancer and metabolic diseases].","authors":"Yan-Hao He,&nbsp;Wei-Rong Wang,&nbsp;Rong Lin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Movement Control of Striatum Neural Pathway]. 纹状体神经通路的运动控制。
生理科学进展 Pub Date : 2016-08-01
Bing-Wei Wang, Xiao-Ning Yang, Chen-Yu Zhang, Chong-Jiu Chen, Shi-Gong Zhu, Rui-Mao Zheng
{"title":"[Movement Control of Striatum Neural Pathway].","authors":"Bing-Wei Wang,&nbsp;Xiao-Ning Yang,&nbsp;Chen-Yu Zhang,&nbsp;Chong-Jiu Chen,&nbsp;Shi-Gong Zhu,&nbsp;Rui-Mao Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Striatum is the central structure controlling movement. It plays a pivotal role in the regulation of voluntary movement, unconscious movement, muscle tone, posture adjustment and fine movement. Dysfunction of striatum causes a variety of movement disorders ranging from the hypokinetic disorders with increased muscle tone, such as Parkinson's disease, to the hyperkinetic disorders with decreased muscle tone, such as Huntington's disease. It is generally recognized that striatum receives the neural movement signals from the motor cortex, and then processes and modifies these signals and subsequently transfers the signals back to the motor cortex via thalamus for execution of the movement through pyramidal system. The movement control function of striatum depends on a complex neural circuit system. In this review, the studies on the movement control function of striatum as well as the striatal neural circuit system are summarized with an emphasis on the progress made during recent years for better understanding the mechanism underlying the movement control function as well as the disease association of striatum.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Roles of Sirtuins in DNA Damage and Repair]. [Sirtuins在DNA损伤和修复中的作用]。
生理科学进展 Pub Date : 2016-08-01
Tian Gao, Mei-Ting Li, Tian-Yun Hou, Yang Yang
{"title":"[The Roles of Sirtuins in DNA Damage and Repair].","authors":"Tian Gao,&nbsp;Mei-Ting Li,&nbsp;Tian-Yun Hou,&nbsp;Yang Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sirtuins, class III HDAC, has originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes. There are seven mammalian sirtuins (SIRTI07), which mainly deaceylate lysine residue on various proteins as a deacetylase. Sirtuins regulate a diverse array of biological processes, including DNA damage and repair, gene transcription regulation, apoptosis, metabolism and aging. In this research perspective we review the role and molecular mechanism of Sirtuin in DNA damage and repair.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research Progress of Immunity Mechanism in Hypertension]. 高血压病免疫机制研究进展
生理科学进展 Pub Date : 2016-08-01
Long-Zhu Liu, Xi He, Man Xu, Xiao-Jiang Yu, Wei-Jin Zang
{"title":"[Research Progress of Immunity Mechanism in Hypertension].","authors":"Long-Zhu Liu,&nbsp;Xi He,&nbsp;Man Xu,&nbsp;Xiao-Jiang Yu,&nbsp;Wei-Jin Zang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypertension, which can cause a variety of cardiovascular and cerebrovascular complications, is a serious threat to human health. Currently, it is found that hypertension is related to immunoregulatory abnormality, which could lead to chronic inflammation. Then the chronic inflammation may impair vascular endothelial function and activate renin-angiotensin system, which cause vascular remodeling, angiosclerosis, dysfunctional vasoconstriction and vasodilatation, and exacerbate hypertension. The immunoregulatory abnormality of hypertension involves macrophage infiltration of the organization, the dendritic cell of antigen presentation and natural killer cells of activation in nonspecific immunity and activation of T cells in specific immune. The key of immunity mechanism of hypertension is the Toll like receptor to activate immune system and lead to inflammation. Autonomic nervous system is also closely related to the development and progression of hypertension. Autonomic imbalance in hypertension leads to immunoregulatory abnormality, cardiovascular injury, and dysfunctional vasoconstriction and vasodilatation, which ultimately results in exacerbation of hypertension. Therefore, research on neuro-immune regulation will help to provide novel strategies for therapy of hypertension. In this review, we will provide an overview of the research progress of the immunity mechanism of hypertension and the regulation of immune system by the autonomic nervous system.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Long noncoding RNA in the progression of diseases]. [长链非编码RNA在疾病进展中的作用]。
生理科学进展 Pub Date : 2016-08-01
Xiu-He Zhao, Heng-Yan Zhou, Xue Yang, Zhao-Fu Chi, Sheng-Jun Wang
{"title":"[Long noncoding RNA in the progression of diseases].","authors":"Xiu-He Zhao,&nbsp;Heng-Yan Zhou,&nbsp;Xue Yang,&nbsp;Zhao-Fu Chi,&nbsp;Sheng-Jun Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36211942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sonic hedgehog signaling pathway and stress injury]. [Sonic hedgehog信号通路与应激损伤]。
生理科学进展 Pub Date : 2016-08-01
Hong Zhang, Sha Feng, Jue Liu
{"title":"[Sonic hedgehog signaling pathway and stress injury].","authors":"Hong Zhang,&nbsp;Sha Feng,&nbsp;Jue Liu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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