[The Roles of Sirtuins in DNA Damage and Repair].

生理科学进展 Pub Date : 2016-08-01

Tian Gao, Mei-Ting Li, Tian-Yun Hou, Yang Yang

引用次数: 0

Abstract

Sirtuins, class III HDAC, has originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes. There are seven mammalian sirtuins (SIRTI07), which mainly deaceylate lysine residue on various proteins as a deacetylase. Sirtuins regulate a diverse array of biological processes, including DNA damage and repair, gene transcription regulation, apoptosis, metabolism and aging. In this research perspective we review the role and molecular mechanism of Sirtuin in DNA damage and repair.

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[Sirtuins在DNA损伤和修复中的作用]。

Sirtuins, III类HDAC，最初被定义为烟酰胺腺嘌呤二核苷酸依赖酶家族。哺乳动物有7种sirtuins (SIRTI07)，主要作为去乙酰化酶对各种蛋白质上的赖氨酸残基进行去乙酰化。Sirtuins调节多种生物过程，包括DNA损伤和修复、基因转录调控、细胞凋亡、代谢和衰老。本文就Sirtuin在DNA损伤与修复中的作用及分子机制进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理科学进展

自引率

0.00%

发文量

5953

期刊介绍： Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.