Future Journal of Pharmaceutical Sciences最新文献

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Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver 标准化可可叶提取物通过激活肝脏中的 IRS-1/PI3K/AKT/GLUT2 通路对链脲佐菌素诱导的糖尿病大鼠具有改善活性
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-23 DOI: 10.1186/s43094-024-00707-0
Fatma Abdelhakim Mohamed, Rabab H. Sayed, Mohammed N. A. Khalil, Mohamed A. Salem, Amira S. El Senousy, Ali M. El-Halawany
{"title":"Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver","authors":"Fatma Abdelhakim Mohamed,&nbsp;Rabab H. Sayed,&nbsp;Mohammed N. A. Khalil,&nbsp;Mohamed A. Salem,&nbsp;Amira S. El Senousy,&nbsp;Ali M. El-Halawany","doi":"10.1186/s43094-024-00707-0","DOIUrl":"10.1186/s43094-024-00707-0","url":null,"abstract":"<div><h3>Background</h3><p><i>Coccoloba uvifera</i> L. (Family: Polygonaceae) known as sea grape is natively distributed in middle and south America. The aqueous leaf extract showed inhibitory activities against <i>α</i>-glucosidase and <i>α</i>-amylase in previous reports. Moreover, the hydroalcoholic leaves extract ameliorated hyperglycemia in the oral glucose tolerance test. Despite these promising results, the extracts used in these studies were not standardized, nor was their mechanism of action elucidated. The current study aims to standardize the ethanolic <i>C. uvifera</i> leaves extract (CU) using markers, and assess its ameliorative activity against diabetes and its hepatoprotective activity against diabetic complications.</p><h3>Results</h3><p>Standardized leaves’ ethanolic extract contained 0.09 ± 0.00057 and 0.23 ± 0.0011 mg/g gallic acid and rutin, respectively, as estimated by HPLC. Administration of CU (100, 200 and 400 mg/kg) for 6 weeks ameliorated DM manifestations in STZ-induced diabetic rats in a dose-dependent manner. The ethanolic extract reduced fasting blood glucose, increased serum insulin and reduced elevated liver enzymes. CU counteracted oxidative stress, promoted glucose metabolizing enzymes and reduced gluconeogenesis enzymes. The underlying mechanism involved increased expression of IR, IRS-1, IRS-2 and GLUT2 in liver tissue through activation of PI3K/AKT signaling. The histopathological study demonstrated reduced inflammation and hepatocyte degeneration.</p><h3>Conclusion</h3><p>CU could be used as a promising antidiabetic drug with hepatoprotective activity in diabetes hepatic complications. The standardized CU ethanolic extract should be further assessed clinically alone or in combination with other antidiabetic remedies.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00707-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method 采用环保分光光度法同时测定罗伐他汀钙和左氧氟沙星的交联伤口敷料的体内外评价
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-23 DOI: 10.1186/s43094-024-00698-y
Marwa A. Abd El‑Fattah, Asmaa O. El-Demerdash, Heba A. Eassa, Kamilia H. A. Mohammed, Israa A. Khalil, Asmaa H. Esmaeil, Shimaa E. Abdel Aziz, Omnia M. Amin
{"title":"In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method","authors":"Marwa A. Abd El‑Fattah,&nbsp;Asmaa O. El-Demerdash,&nbsp;Heba A. Eassa,&nbsp;Kamilia H. A. Mohammed,&nbsp;Israa A. Khalil,&nbsp;Asmaa H. Esmaeil,&nbsp;Shimaa E. Abdel Aziz,&nbsp;Omnia M. Amin","doi":"10.1186/s43094-024-00698-y","DOIUrl":"10.1186/s43094-024-00698-y","url":null,"abstract":"<div><h3>Background</h3><p>Wound healing is a natural but complex process that can be delayed by infection. Rosuvastatin calcium (RVS) is an anti-hyperlipidemic that was recently reported to have a wound healing capability. The study aimed to investigate the impact of combining RVS with Levofloxacin (LV) on wound healing. A physically crosslinked polyvinyl alcohol (PVA) film loaded with RVS and LV was formulated as wound dressing. Formulation optimization was carried out using Box–Behnken design. The effect of independent variables (PVA and propylene glycol concentrations and the number of freeze–thaw cycles) on tensile strength (TS), elongation to break (%EB) and in vitro drugs’ release was studied. For simultaneous RVS and LV quantification in the formulations and pure form, three spectrophotometric methods: derivative of ratio spectrophotometry, first derivative and mean centering, were developed. Also, their greenness was evaluated by the Analytical Eco-Scale and the Green Analytical Procedure Index. Then, the wound healing effect of the optimized wound dressing was evaluated in rat models.</p><h3>Results</h3><p>The optimized dressing had sufficient mechanical strength (9.45 ± 0.67 MPa), adequate flexibility (112.6 ± 3.8% EB) and suitable drug release (52.3 ± 1.4% for LV and 38.99 ± 1.6% for RVS after 12 h). The proposed methods were validated following ICH guidelines, and greenness assessment suggested their very low environmental effect. The wound healing evaluation showed a higher wound contraction percentage when RVS was combined to LV. A histopathological study confirmed marked improvement in animals treated with combined formula with lowest inflammatory infiltration and optimum epithelialization, compared to other groups.</p><h3>Conclusion</h3><p>Study findings suggest that combined LV-RVS dressing would be a beneficial platform with potentiated wound healing capacity.</p><h3>Graphic abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00698-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC–FID, and LC–HRMS chromatographies 利用 GC/MS、GC-FID 和 LC-HRMS 色谱探索大麻籽油中的生物活性和多种代谢物
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-20 DOI: 10.1186/s43094-024-00705-2
İlhami Gulcin, Eda Mehtap Ozden, Muzaffer Mutlu, Ziba Mirzaee, Zeynebe Bingol, Ekrem Köksal, Saleh Alwasel, Ahmet C. Goren
{"title":"Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC–FID, and LC–HRMS chromatographies","authors":"İlhami Gulcin,&nbsp;Eda Mehtap Ozden,&nbsp;Muzaffer Mutlu,&nbsp;Ziba Mirzaee,&nbsp;Zeynebe Bingol,&nbsp;Ekrem Köksal,&nbsp;Saleh Alwasel,&nbsp;Ahmet C. Goren","doi":"10.1186/s43094-024-00705-2","DOIUrl":"10.1186/s43094-024-00705-2","url":null,"abstract":"<div><h3>Background</h3><p>This study investigated the antidiabetic and antioxidant properties of hemp seed oil using various bioanalytical methods. Furthermore, this study determined the suppressive properties of hemp seed oil on α-amylase, acetylcholinesterase and carbonic anhydrase II that purified by the sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatoghraphy, all of which are related to different metabolic diseases. Moreover, the phenolic concentration in the essential oil was quantified through LC–HRMS chromatography. Thirteen distinct phenolic compounds were detected in hemp seed oil. Additionally, both the chemical components and quantity of essential oils within hemp seed oil were assessed through GC–FID and GC/MS analyses.</p><h3>Results</h3><p>The predominant essential oils in hemp seed oil included linoleoyl chloride (34.62%), linoleic acid (33.21%), and 2-4-di-tert-butylphenol (5.79%). Hemp seed oil's ability to scavenge radicals was studied through the use of 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazil bioanalytical radical scavenging methods. The results unveiled its potent radical-scavenging properties, with an 46.20 μg/mL for 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals and IC<sub>50</sub> of 9.76 μg/mL for 1,1-diphenyl-2-picrylhydrazil radicals. The investigation also extended to explore the reducing capabilities of Fe<sup>3+</sup>-2,4,6-tri(2-pyridyl)-S-triazine, copper (Cu<sup>2+</sup>), and iron (Fe<sup>3+</sup>). Hemp seed oil demonstrated notable inhibitory effect against α-amylase (IC<sub>50</sub>: 545.66 μg/mL), achethylcholinesterase (IC<sub>50</sub>: 28.00 μg/mL), and carbonic anhydrase II (IC<sub>50</sub>: 322.62 μg/mL).</p><h3>Conclusions</h3><p>This interdisciplinary research will prove valuable and set the stage for future investigations into the antioxidant characteristics and enzyme inhibition patterns of plants and plants oils that hold medical and industrial significance.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00705-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action 癌症研究中的羟基酪醇:关于发现和作用机制的最新见解和历史见解
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-19 DOI: 10.1186/s43094-024-00700-7
Ajay Kumar, Brahmjot Singh, Kapil Paul, Palak Bakshi, Payal Bajaj, Manoj Kumar, Sukhvinder Dhiman, Shivam Jasrotia, Parveen Kumar, Ranjan Dutta
{"title":"Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action","authors":"Ajay Kumar,&nbsp;Brahmjot Singh,&nbsp;Kapil Paul,&nbsp;Palak Bakshi,&nbsp;Payal Bajaj,&nbsp;Manoj Kumar,&nbsp;Sukhvinder Dhiman,&nbsp;Shivam Jasrotia,&nbsp;Parveen Kumar,&nbsp;Ranjan Dutta","doi":"10.1186/s43094-024-00700-7","DOIUrl":"10.1186/s43094-024-00700-7","url":null,"abstract":"<div><h3>Background</h3><p>Cancer is a persistent global health challenge, demanding continuous exploration of innovative therapeutic strategies. Hydroxytyrosol (HT), derived from olive oil, has garnered attention for its potent antioxidant and anti-inflammatory properties, revitalizing interest due to recent breakthroughs in comprehending its intricate anticancer mechanisms.</p><h3>Main Body</h3><p>This review conducts a detailed analysis of hydroxytyrosol’s molecular mechanisms in cancer. Delve into the complex pathways and processes underlying its anticancer properties, including its impact on critical cellular events such as inhibiting cancer cell growth, proliferation, metastasis, and apoptosis. We meticulously evaluate HT efficacy and safety through scrutiny of preclinical and clinical studies. Additionally, we explore the potential synergistic effects of combining HT with conventional cancer therapies to improve treatment outcomes while reducing side effects, offering a comprehensive approach to cancer management.</p><h3>Conclusion</h3><p>This review stands as a valuable resource for researchers, clinicians, and policymakers, providing profound insights into HT potent anticancer activity at the molecular level. It underscores the immense potential of natural compounds in the intricate realm of cancer management and highlights the urgent need for further research to translate these discoveries into effective clinical applications. Ultimately, it fosters the development of targeted and personalized therapeutic approaches, reigniting hope in the ongoing battle against cancer and enhancing the quality of life for those afflicted by this relentless disease.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00700-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of isoniazid by digital image colorimetry: an integration of green chemistry and smartphone technology 通过数字图像比色法估算异烟肼:绿色化学与智能手机技术的融合
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-19 DOI: 10.1186/s43094-024-00703-4
Suvarna Yenduri, K. Naga Prashant
{"title":"Estimation of isoniazid by digital image colorimetry: an integration of green chemistry and smartphone technology","authors":"Suvarna Yenduri,&nbsp;K. Naga Prashant","doi":"10.1186/s43094-024-00703-4","DOIUrl":"10.1186/s43094-024-00703-4","url":null,"abstract":"<div><h3>Background</h3><p>This study proposes a simple digital image colorimetric method using a smartphone for the quantitative analysis of isoniazid in pharmaceutical medications. The analytical methodology employed in this study involved the utilization of the reaction between isoniazid and FC reagent under alkaline conditions. The chemical reaction led to the creation of a complex with a blue-gray color, exhibiting a peak absorption at a wavelength of 760 nm. An Android application was employed to perform a smartphone-based determination based on separating the captured color into different color channels such as red, blue, green, etc. The experimental procedure involved the utilization of three smartphones for the determination, which was subsequently followed by a comparative analysis of the results obtained from these devices using spectrophotometric measurements.</p><h3>Results</h3><p>The B channel had the highest level of optimization in terms of analytical parameters. The limits of detection (LOD) were 0.586, 2.478, and 1.396 µg/ml for S1, S2, and S3, respectively, and for the spectrophotometer, it was found to be 0.416 µg/ml. Similarly, LOQs were determined as 1.673, 7.511, 4.232, and 1.302 µg/ml. A %RSD of 1.3 for precision and an LOD of 0.013 g dm<sup>−3</sup> were obtained for the spectroscopic method. The % recovery in the accuracy study was found to be 99.69, 101.804, 109.28, and 100.13 for S1, S2, S3, and spectrophotometer, respectively.</p><h3>Conclusion</h3><p>The colorimetric results from smartphone application are similar to those from spectrophotometric analyses.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00703-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential of small molecules of dual c-Met and VEGFR inhibitors for advances and future drug discovery in cancer therapy 探索小分子 c-Met 和血管内皮生长因子受体(VEGFR)双重抑制剂在癌症治疗的进展和未来药物发现中的潜力
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-18 DOI: 10.1186/s43094-024-00688-0
Sachin A. Dhawale, Arundhati V. Deokar, Momin Aaliya Firdous, Madhuri Pandit, Minal Y. Chaudhari, Sameer B. Salve, Madhuri Khandgaonkar, Mahesh Parwe, Rupesh Khalse, Shruti G. Dake, Siddharth H. Chatse, Ganesh G. Tapadiya
{"title":"Exploring the potential of small molecules of dual c-Met and VEGFR inhibitors for advances and future drug discovery in cancer therapy","authors":"Sachin A. Dhawale,&nbsp;Arundhati V. Deokar,&nbsp;Momin Aaliya Firdous,&nbsp;Madhuri Pandit,&nbsp;Minal Y. Chaudhari,&nbsp;Sameer B. Salve,&nbsp;Madhuri Khandgaonkar,&nbsp;Mahesh Parwe,&nbsp;Rupesh Khalse,&nbsp;Shruti G. Dake,&nbsp;Siddharth H. Chatse,&nbsp;Ganesh G. Tapadiya","doi":"10.1186/s43094-024-00688-0","DOIUrl":"10.1186/s43094-024-00688-0","url":null,"abstract":"<div><h3>Background</h3><p>Cancer is uncontrolled cell proliferation that has the potential to invade other tissues and cells. The first three most prevalent cancers are breast, lung, and colon cancer. The widest family of kinase enzymes is receptor tyrosine kinases (RTKs) which are aimed by several chemotherapy medicines. The vascular endothelial growth factor (VEGFR), a well-known type IV tyrosine kinase receptor, is an effective biological target for the development of angiogenesis-related cancer treatments. The hepatocyte growth factor (also known as mesenchymal–epithelial transition factor) triggers the activation of the c-Met tyrosine kinase receptor, which controls several biological processes including cell division, survival, and proliferation.</p><h3>Main body</h3><p>In this review, we summarized the various dual inhibitors of VEGFR and c-MET receptors which are active for therapeutic action against cancer. Combination of some VEGFR and c-Met inhibitors also shows synergistic action. The developed dual inhibitors of VEGFR and c-MET such as quinolones and quinazolines derivatives, pyridine and pyrimidine derivatives, oxindole moiety and triazine derivatives are most potent for the same. Dual inhibitors of VEGFR and c-MET hold significant promise in improving cancer therapy by enhancing treatment efficacy, reducing resistance, and potentially improving patient outcomes. Clinical trials are currently being conducted on a few of them and other compounds are being under investigation. Inhibiting VEGFR and c-Met pathway activity will be discussed as novel therapeutic strategies for advanced development in treating cancer. The research progress in this review is fetched up to the current year.</p><h3>Conclusion</h3><p>Apart from the development of cancer treatment still cancer is listed as a deadly disease, due to its toxicity and resistance to treatment. Hence, the novel approach is necessary to overcome the cancer. The VEGFR and c-MET inhibitors as dual inhibitors may be more significant in future clinical anticancer treatments.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00688-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trypsin, chymotrypsin and elastase in health and disease 健康和疾病中的胰蛋白酶、糜蛋白酶和弹性蛋白酶
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-17 DOI: 10.1186/s43094-024-00709-y
Oladoyin Grace Famutimi, Victor Gbolahan Adebiyi, Bukola Grace Akinmolu, Omoniyi Vincent Dada, Isaac Olusanjo Adewale
{"title":"Trypsin, chymotrypsin and elastase in health and disease","authors":"Oladoyin Grace Famutimi,&nbsp;Victor Gbolahan Adebiyi,&nbsp;Bukola Grace Akinmolu,&nbsp;Omoniyi Vincent Dada,&nbsp;Isaac Olusanjo Adewale","doi":"10.1186/s43094-024-00709-y","DOIUrl":"10.1186/s43094-024-00709-y","url":null,"abstract":"<div><h3>Background</h3><p>Serine proteases represent over 1% of all proteins in humans. This family of proteins is found on cell surfaces, subcellular organelles like lysosomes or mitochondria, within the nucleus and the protoplasm.</p><h3>Main body of the abstract</h3><p>Among them, trypsin, chymotrypsin and elastase have aroused great interest because of their numerous functions in pathophysiological processes. Altered expression of these enzymes in experimental animal models and humans has been related to various pathologies, like developmental defects, metabolic dysfunctions, cancer, peripheral vascular diseases and infectious diseases. Trypsin and chymotrypsin-like proteases activate, or less oftentimes inactivate, numerous substrates, together with growth factors, receptors, adhesion molecules, angiogenic factors and metalloproteases. Among these substrates, a number of them are key factors in cancer progression, metastasis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease. Elastin-degrading enzyme- elastase, slowly damages elastin over the lifetime of an organism. The physiological processes triggered by elastase leads to the progression of different conditions such as cancer, metabolic syndrome, pulmonary emphysema, atherosclerosis, and chronic obstructive pulmonary disease. These serine proteases are currently considered to be targets for the development of new potent therapeutics.</p><h3>Short conclusion</h3><p>The cumulative knowledge that outlined the physiological functions and pathological implications of these proteases and the proposed strategies to regulate a number of their activities and their targeting for therapeutic application and validation in selected disease states are highlighted. These should enhance our appreciation of their roles in aetiology of some diseases as well as the chemotherapeutic benefits of their inhibition or modulation.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00709-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative pain management following laparoscopic cholecystectomy-non-opioid approaches: a review 腹腔镜胆囊切除术后疼痛管理--非阿片类药物方法:综述
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-16 DOI: 10.1186/s43094-024-00697-z
Hoda Mohamed Bayoumi, Doaa Hamed Abdelaziz, Nouran Omar El Said, Sherif Boraii, Ehab Rasmy Bendas
{"title":"Postoperative pain management following laparoscopic cholecystectomy-non-opioid approaches: a review","authors":"Hoda Mohamed Bayoumi,&nbsp;Doaa Hamed Abdelaziz,&nbsp;Nouran Omar El Said,&nbsp;Sherif Boraii,&nbsp;Ehab Rasmy Bendas","doi":"10.1186/s43094-024-00697-z","DOIUrl":"10.1186/s43094-024-00697-z","url":null,"abstract":"<div><h3>Background</h3><p>Gallstone disease with its consequences is a common clinical issue that may necessitate surgical removal. In comparison with traditional open procedures, laparoscopic cholecystectomy (LC) remains the mainstay treatment for symptomatic gallstone disease and can lead to a shorter recovery period, and a shorter hospital stay; yet, severe abdominal and shoulder pain may be experienced.</p><h3>Main body</h3><p>Novel drugs and technology for acute and chronic pain management following LC have been studied to improve patient care. The review discusses innovative pain management strategies with non-opioid approaches for laparoscopic surgery, with an emphasis on ensuring speedy and safe recovery.</p><h3>Conclusion</h3><p>The key findings state that IV paracetamol is a necessary part of multimodal postoperative pain management. There were several pharmacological interventions found to be effective in pain control: magnesium sulfate and dexamethasone showed anti-inflammatory benefits; ondansetron provided analgesic effects; gabapentinoids and alpha-2-agonists reduced central sensitization; local anesthetics offered targeted pain relief; antidepressants addressed neuropathic pain; NSAIDs proved effective for inflammatory pain. Similarly, non-pharmacological approaches, and emerging technologies, also contributed to the management of post-LC pain underscoring the need for a comprehensive approach to its management. More rigorous research is needed to guide pain management after LC. Future studies should compare multiple treatments simultaneously and involve larger patient groups. This approach will help identify optimal pain control strategies. It will also provide clearer insights into the safety and efficacy of various pain medications under comparable clinical conditions.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00697-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multichannel 3D-printed bionanoparticles-loaded tablet (M3DPBT): designing, development, and in vitro functionality assessment 多通道三维打印仿生颗粒负载片剂(M3DPBT):设计、开发和体外功能评估
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-16 DOI: 10.1186/s43094-024-00702-5
Hardik Rana, Priyanka Pathak, Vimal Patel, Vaishali Thakkar, Mansi Dholakia, Saloni Dalwadi, Tejal Gandhi
{"title":"Multichannel 3D-printed bionanoparticles-loaded tablet (M3DPBT): designing, development, and in vitro functionality assessment","authors":"Hardik Rana,&nbsp;Priyanka Pathak,&nbsp;Vimal Patel,&nbsp;Vaishali Thakkar,&nbsp;Mansi Dholakia,&nbsp;Saloni Dalwadi,&nbsp;Tejal Gandhi","doi":"10.1186/s43094-024-00702-5","DOIUrl":"10.1186/s43094-024-00702-5","url":null,"abstract":"<div><h3>Background</h3><p>The intersubject variability which was related to the genetic makeup was the major cause of change in pharmacological and pharmacokinetic behavior of same dosage form in varied human being. 3D printing technology will help therapy evolve and eliminate the limitations of conventional technologies. Nebivolol's (NBL)-limited oral bioavailability is mainly due to its poor aqueous solubility. The research aims to combine advanced 3D printing technology and nanotechnology to design customized therapy and enhance the functionality of NBL using a statistical approach.</p><h3>Results and discussion</h3><p>The results of the phase solubility indicated that NBL was a poorly aqueous soluble drug. Its solubility was increased by employing nanoparticle drug delivery, which is a promising solubility enhancement technique. The 3<sup>2</sup> full factorial design was employed to develop and optimize bionanoparticles (BNPs) by solvent evaporation technique using poly (lactic-co-glycolic acid 50:50) (PLGA 50:50) and poloxamer-407 as a surfactant. The BNPs were characterized by % encapsulation efficiency (% EE), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimeter (DSC), transmission electron microscope (TEM), zeta potential, polydispersity index (PDI), particle size, in vitro drug release, etc. The BNPs loaded of NBL were further incorporated into the multichannel 3D-controlled release tablets made by PVA filaments employing fused deposition modeling (FDM) technology optimized by central composite design (CCD). Multichannel 3D-printed bionanoparticles-loaded tablet (M3DPBT) was optimized using CCD. All designed M3DPBTs were evaluated for post-fabrication parameters. The optimized M3DPBT could release more than 85% NBL within 10 h.</p><h3>Conclusions</h3><p>The newly fabricated M3DPBT was found stable. The amount of PLGA 50:50 and Polaxomer was significant for developing BNPs. % infill and layer height were observed as critical for the designing M3DPBT. The combined novel 3D printing and nanotechnology technology will open a new direction for patient compliance and better therapeutic effects.</p><h3>Graphical abstract</h3><p>Designing and developing of M3DPBT is substantially improve the patient compliance and therapeutic effectiveness of Nebivolol.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00702-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality characteristics and HPLC detection of phosphodiesterase inhibitors in some herbal capsules indicated for male sexual disorders in Ghana 加纳一些用于治疗男性性功能障碍的草药胶囊中磷酸二酯酶抑制剂的质量特性和高效液相色谱检测
IF 3.4
Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-11 DOI: 10.1186/s43094-024-00693-3
Anita Nana Abla Oscar Akotey, Isaac Kingsley Amponsah, Francis Ackah Armah, Bernard Kofi Turkson, John Nii Addotey, Yaa Asantewaa Osei, Joseph Adu, Rita Akosua Dickson
{"title":"Quality characteristics and HPLC detection of phosphodiesterase inhibitors in some herbal capsules indicated for male sexual disorders in Ghana","authors":"Anita Nana Abla Oscar Akotey,&nbsp;Isaac Kingsley Amponsah,&nbsp;Francis Ackah Armah,&nbsp;Bernard Kofi Turkson,&nbsp;John Nii Addotey,&nbsp;Yaa Asantewaa Osei,&nbsp;Joseph Adu,&nbsp;Rita Akosua Dickson","doi":"10.1186/s43094-024-00693-3","DOIUrl":"10.1186/s43094-024-00693-3","url":null,"abstract":"<div><h3>Background</h3><p>Herbal medicines used for male sexual disorders are widespread across the globe and have been noted as likely candidates for adulteration. To assure access to safe and quality herbal products, this study aimed at sampling some herbal capsules indicated for male vitality for quality analytical checks.</p><h3>Methods</h3><p>Herbal capsules sampled from two regions were subjected to physicochemical assessment, using pharmacopeial and regulatory standards. Microbial quality analysis was also performed on the selected products. A validated HPLC method for simultaneous analysis of sildenafil citrate and tadalafil was used to detect and quantify the possible presence of phosphodiesterase inhibitors in the selected products.</p><h3>Results</h3><p>Out of a total of 57 herbal capsules, 19 were indicated for male sexual related illnesses of which only 8 fulfilled the inclusion criteria of being used exclusively for male vitality. The majority (62.5%) of the herbal products failed the weight uniformity test but all of them disintegrated within the acceptable limit of 30 min. The moisture and heavy metal contents were within limits of acceptability. Majority (87.5%) of the herbal products failed the test for the aerobic bacteria count; however, none of the isolated bacteria was pathogenic. Sildenafil citrate was detected in the majority (87.5%) of the herbal products in concentrations of 0.98–33.95 mg/g. Two products contained both sildenafil and tadalafil. High batch-to-batch variability was recorded in some physicochemical parameters and pharmaceutical adulterants.</p><h3>Conclusion</h3><p>High incidence of quality fails and adulteration of herbal capsules for sexual disorders observed means there is a real risk of unintended dosing with phosphodiesterase inhibitors. This represents a public health issue and necessitates tighter monitoring of production standards by the regulator.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-024-00693-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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