Future Journal of Pharmaceutical Sciences最新文献

{"title":"Neurobehavioral outcomes of Achillea fragrantissima ethanolic extract in male rats: modulation of GABAergic signaling, monoaminergic expression, neuroplasticity markers (BDNF, ARC), and oxidative stress","authors":"Naglaa Z. Eleiwa,&nbsp;Mohamed H. Khairy,&nbsp;Amal M. Ahmed,&nbsp;Mohamed M. M. Metwally,&nbsp;Asmaa I. Abd El Aty,&nbsp;Ehsan H. Abu-Zeid","doi":"10.1186/s43094-026-01007-5","DOIUrl":"10.1186/s43094-026-01007-5","url":null,"abstract":"<div><p>This research aimed to examine the impact of the ethanolic extract of <i>Achillea fragrantissima</i> aerial parts (ACF) on the rat CNS. Forty mature Sprague–Dawley male rats were assigned to four groupings (<i>n</i> = 10): 1st C: (control), 2nd DIZ: (diazepam), 3rd ACF-H: (800 mg/kg extract high-dose extract), and 4th ACF-L: (400 mg/kg low-dose extract) gavaged daily for 14 days. The HPLC-identified components are naringenin, ferulic acid, catechin, chlorogenic acid, diadzein, syringic acid, rutin, hesperetin, kaempferol, caffeic acid, vanillin, and quercetin. The effect of ACF extract on rat CNS was measured using the Open field, Hole-cross, Rotarod, Negative geotaxis, and Wrist-grip tests. ACF extract administration substantially (<i>P</i> &lt; 0.05) reduced locomotor and exploratory behaviors in the open-field and hole-cross tests. In the negative geotaxis test, rats administered ACF extract exhibited a substantial delay (<i>P</i> &lt; 0.05) in the turning 180° to a head-up position. In the rotarod and wrist-grip tests, the fall-off time and the latency to fall were considerably reduced (<i>P</i> &lt; 0.05). Administration of ACF extract significantly (<i>P</i> &lt; 0.05) elevated the brain GABA levels, while the increase in dopamine concentrations was observed but should be interpreted cautiously because these findings require confirmation using more specific analytical methods. Additionally, the extract significantly increased the total antioxidant capacity (TAC), but reduced lipid peroxidation (MDA), 8-hydroxy-2-deoxyguanosine (8OH2dG), and protein carbonyl (PCO) levels. ACF oral administration significantly (<i>P</i> &lt; 0.05) upregulated brain GABAA receptor-linked protein (<i>GABARAP</i>), activity-regulated cytoskeleton-linked protein (<i>ARC</i>), and brain-derived neurotrophic factor (<i>BDNF</i>), meanwhile, significantly downregulated the monoamine oxidase A (<i>MAOA</i>) brain levels. For the first time, the outcomes of the ongoing trial demonstrated the in vivo promising effects of <i>A. fragrantissima</i> aerial parts ethanolic extract on neurobehavioral and antioxidant status in an animal model.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01007-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solanum tuberosum peel extract attenuates acetaminophen-induced hepatotoxicity through modulation of inflammatory cytokines, apoptotic pathways, and CYP3A4 expression: evidence from molecular docking, Hep G2 cell assays, and an in ovo embryonic model","authors":"Pritam Goswami,&nbsp;Debasmita Chatterjee,&nbsp;Emmanuel Gabriel Fakola,&nbsp;Anirban Roy,&nbsp;Krishnendu Paira,&nbsp;Tanusree Ghorai,&nbsp;Sayaree Pan,&nbsp;Antara Majumder,&nbsp;Satadal Das","doi":"10.1186/s43094-026-01028-0","DOIUrl":"10.1186/s43094-026-01028-0","url":null,"abstract":"<div><h3>Background</h3><p>CYP3A4 is the primary cytochrome P450 that plays a secondary role along with CYP2E1 in the oxidation of acetaminophen (APAP) to the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). APAP overdosing activates c-Jun N-terminal kinase (JNK), which activates the mitochondrial membrane permeability transition (MPT). This cascade results in disruption of the hepatic homeostasis.</p><h3>Methods</h3><p>Initially, 70 compounds were short-listed and considered for molecular docking with CYP3A4. Solanine, having shown the highest docking score (− 11.2), was considered as a potential drug, and the ethanolic extract of the fruits of <i>Solanum tuberosum</i> was prepared from pulp and peel. Cytotoxicity of the pulp and peel extracts on Hep-G2 cells was assessed by MTT assay, colony formation assay, and DAPI staining. In the next phase, 14-day-old pathogen-free, fertilised chicken eggs were procured and inoculated with 100μL of APAP (0.01 mg/ml concentration), 10% ethanolic extract of <i>Solanum tuberosum</i> (STE), and 70% alcohol (vehicle control) in five challenge sets and three control sets. After 48 h, allantoic fluids were collected for RT-PCR analysis, and histopathological examination was performed for liver, heart, and brain by H&amp;E staining.</p><h3>Results</h3><p>The peel extract demonstrated a superior safety profile, showing no inhibitory effect on Hep G2 cell proliferation up to 96 h. in ovo administration of STE significantly down-regulated IL-6, IL-10, IL-1β, TGF-β1, CYP3A4, c-Jun-K, and Bax gene expression compared with the APAP control group. Conversely, STE peels up-regulated the anti-apoptotic Bcl-2 gene. Histopathological examination revealed the protective effect of STE peel on hepatocytes against APAP-induced toxicity.</p><h3>Conclusion</h3><p><i>Solanum tuberosum</i> peel extract confers significant protection through modulation of pro-inflammatory cytokines, apoptotic markers, and CYP3A4 expression.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01028-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149132796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometrics in paving the way to analyze levodopa and dopamine in various matrices for monitoring Parkinson’s disease and other neurological disorders","authors":"Finan T. Hindam,&nbsp;Reham M. Arafa,&nbsp;Basma M. Eltanany,&nbsp;Amal M. Abou Al Alamein","doi":"10.1186/s43094-026-01029-z","DOIUrl":"10.1186/s43094-026-01029-z","url":null,"abstract":"<div><h3>Background</h3><p>Levodopa (LD) and dopamine (DA) are essential for managing Parkinson’s disease (PD), a neurological disorder that can cause serious complications. Patients often require multiple medications and ongoing monitoring to effectively manage their symptoms. Developing chemometric-assisted analytical methodologies for determining these therapeutic drugs, along with other co-administered drugs, would certainly be beneficial in clinical practice and therapeutic drug monitoring.</p><h3>Main body</h3><p>The literature has addressed challenges in analyzing LD and DA, as well as concomitant drugs, major metabolites, and impurities of levodopa due to their similar physicochemical properties, which could result in interfering signals. Combining chemometrics with various analytical techniques has offered a fast and highly predictive approach that can simultaneously determine target analytes in complex matrices. Data preprocessing is considered a critical step before applying multivariate data analysis to enhance model prediction. This review mainly focuses on the reported chemometric analytical methods for the qualitative or quantitative determination of levodopa and dopamine in different matrices. The three main perspectives being focused on are implementing chemometric models for quantitative determination, experimental optimization, and discriminant analysis. Spectrophotometry, spectrofluorimetry and voltammetry, coupled with chemometrics, were the primary analytical techniques used for analyzing the studied drugs.</p><h3>Conclusion</h3><p>This review provides a summary of the reported chemometric-assisted analytical techniques and some relevant limitations, aiming to guide researchers in enhancing the robustness and predictive power of analytical methods coupled with chemometrics. A future recommendation is to develop chemometric-assisted methods to simultaneously determine levodopa and dopamine along with other co-administered drugs and related impurities in various biological matrices, such as cerebrospinal fluid and human serum.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01029-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149132921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential breast cancer therapeutics from non-phenolic diarylheptanoids of Curcuma xanthorrhiza using network pharmacology and in silico methods","authors":"Roney Miah,&nbsp;Md. Nazim Uddin,&nbsp;Md Mahfuz Miah,&nbsp;Arafat Hossain,&nbsp;Mohd Fadhlizil Fasihi Mohd Aluwi","doi":"10.1186/s43094-026-01025-3","DOIUrl":"10.1186/s43094-026-01025-3","url":null,"abstract":"<div><h3>Background</h3><p><i>Curcuma xanthorrhiza</i>, a widely recognized medicinal plant, contains three non-phenolic diarylheptanoids (NPDs) that exhibit diverse biological properties. Despite their known bioactivities, the precise molecular mechanisms underlying their therapeutic potential, particularly in breast cancer (BRCA) treatment, remain largely unexplored. This study aims to elucidate the potential mechanisms by which NPDs may act against BRCA, employing a combination of network pharmacology, molecular docking, molecular dynamics (MD) simulations, and molecular mechanics/generalized Born surface area (MM/GBSA) analysis.</p><h3>Method</h3><p>BRCA- and NPD-associated targets were retrieved from multiple databases to construct a protein–protein interaction (PPI) network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) platform to identify relevant biological processes and signaling pathways. Molecular docking was used to predict the binding affinities between NPDs and key protein targets, which were further validated through MD simulations and MM/GBSA calculations.</p><h3>Results</h3><p>From 436 BRCA-related and 266 NPD-associated targets, 24 core targets were identified. Thirteen hub targets, including Erythroblastic oncogene B and B 2 (ERBB2), Epidermal Growth Factor Receptor (EGFR), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), and Mouse Double Minute 2 (MDM2), were found to be enriched in the KEGG cancer pathway (hsa05200). Among these, ERBB2 emerged as a top candidate for further analysis. Furthermore, the molecular docking results revealed that the NPD exhibited a comparable binding affinity toward the ERBB2 protein, with docking scores ranging from − 8.2 to − 8.5 kcal/mol, whereas the control compound, neratinib, demonstrated a slightly stronger binding affinity of − 9.6 kcal/mol. The MD simulations further confirmed the stability of the interactions, as compounds 2 and 3 maintained stable protein–ligand complexes with consistent root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and solvent-accessible surface area (SASA) profiles throughout the simulation. Moreover, the binding free energy calculations reinforced these findings, showing strong interactions between ERBB2 and compounds 2 and 3, with values of − 29.76 and − 25.27 kcal/mol, respectively.</p><h3>Conclusion</h3><p>The integrated computational approach suggests that NPDs have the potential to act as ERBB2 inhibitors, offering promising prospects for BRCA therapy.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01025-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149132688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine as an adjunct to chemotherapy in neoplastic diseases: a systematic review and meta-analysis of clinical outcomes and toxicity profiles meta-analysis","authors":"Ahmed F. Al-Talqani,&nbsp;Inas Elnady,&nbsp;Hoda Rabea,&nbsp;Raghda Yahia Abu El-Ela,&nbsp;Mohamed E. A. Abdelrahim,&nbsp;Amira B. Kassem","doi":"10.1186/s43094-026-01019-1","DOIUrl":"10.1186/s43094-026-01019-1","url":null,"abstract":"<div><h3>Background</h3><p>Hydroxychloroquine (HCQ), an antimalarial and immunomodulatory drug, has been investigated as an adjunct to chemotherapy owing to its capability to inhibit autophagy and potentially sensitize tumor cells to cytotoxic agents.</p><h3>Objective</h3><p>To assess the influence of adding hydroxychloroquine to standard chemotherapy in cases with neoplasia, with emphasis on treatment response, performance status, and adverse events.</p><h3>Methods</h3><p>A systematic review and meta-analysis have been done in line with reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, and Cochrane Library were searched up to August 2025. Eligible investigations involved adult patients with malignancy treated with chemotherapy plus HCQ versus chemotherapy alone or placebo.</p><h3>Main findings</h3><p>Seven studies comprising 383 patients have been involved. The mean patient age was 57.4 years. HCQ addition did not significantly improve complete response (OR 0.46; 95% CI, 0.08–2.61), partial response (OR 0.75; ninety-five percent CI, 0.36–1.56), stable disease (OR 1.01; 95% CI, 0.42–2.46), progressive disease (OR 2.07; 95% CI, 0.91–4.73), or objective response (OR 0.67; 95%CI, 0.30–1.46). A significant variance has been detected in ECOG 1 status (OR 1.93; 95% CI, 1.10–3.40), while ECOG 0 and ECOG 2 showed no differences. Reported adverse events, including headache and nausea/vomiting, were comparable between groups.</p><h3>Conclusion</h3><p>Adding hydroxychloroquine to conventional chemotherapy did not improve response results in cancer cases, though an association with ECOG 1 performance status was noted. HCQ was generally well tolerated without additional toxicity. Further large-scale randomized studies are required to clarify its therapeutic role.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01019-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple sensitive ICP-MS method development and validation for quantitative evaluation and risk assessment of elemental impurities in anticoagulant drug product: study aligned with ICH Q3D guideline","authors":"Shriram Pandurang Suryawanshi,&nbsp;Gayatri Barabde","doi":"10.1186/s43094-026-01021-7","DOIUrl":"10.1186/s43094-026-01021-7","url":null,"abstract":"<div><h3>Background</h3><p>Elemental impurities in pharmaceutical products present significant risks to patient safety due to their potential toxicity. These impurities may arise from various sources, including raw materials used in the process, manufacturing operations, processing equipment, and packaging materials. In this study, a simple, sensitive, and reliable analytical method using Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) was developed and validated for the quantification of elemental impurities in anticoagulant drug products, specifically Apixaban, Edoxaban, and Rivaroxaban. The developed ICP-MS method enables accurate and precise determination of elemental impurities, ensuring effective monitoring and control of potentially toxic elements in these pharmaceutical formulations to support product quality and patient safety. The method targeted the determination of 24 elemental impurities classified according to the ICH Q3D Guideline for Elemental Impurities, including Class-1 elements (As, Pb, Hg, and Cd), Class-2A elements (Ni, V, and Co), Class-2B elements (Pd, Ir, Os, Tl, Ru, Pt, Au, Se, Ag, and Rh), and Class-3 elements (Cu, Mo, Li, Sn, Sb, Cr, and Ba). The analytical procedure was developed using ICP-MS, and the optimised method was validated in accordance with USP General Chapter &lt;233&gt; and &lt;730&gt;, confirming its suitability for accurate and reliable multi-element analysis.</p><h3>Results</h3><p>The analytical procedure was validated by assessing specificity, accuracy, sensitivity, selectivity, precision, linearity, range, and LOD–LOQ precision in accordance with ICH Q3D Guideline for Elemental Impurities and relevant pharmacopeial requirements. All 24 elements showed excellent linearity with correlation coefficients greater than 0.99. Accuracy was demonstrated across the range from LOQ (30%) to 200% of the target level, and recovery was within acceptable limits, i.e. 70%–150%, and the %RSD for precision was within acceptable limits, i.e. below 20%. The validated method proved linear, accurate, and sensitive for quantifying elemental impurities in anticoagulant drug products containing Apixaban, Edoxaban, and Rivaroxaban.</p><h3>Conclusion</h3><p>The study demonstrates that the validated ICP-MS method is simple, highly sensitive, and accurate for the determination of elemental impurities in anticoagulant drug products. All detected elements were below the permissible daily exposure limits defined by the ICH Q3D Guideline for Elemental Impurities, confirming compliance with safety requirements. These findings support the suitability of ICP-MS as a reliable technique for routine quality control of pharmaceutical formulations.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01021-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design of a dual-function, LL-37/HNP-1, chimeric antimicrobial peptide: a broad-spectrum AMP against respiratory co-infections","authors":"Ghazal Ghaznavi,&nbsp;Navid Nezafat,&nbsp;Cambyz Irajie,&nbsp;Fernando Berton Zanchi,&nbsp;Aida solhjoo,&nbsp;Amir Savardashtaki","doi":"10.1186/s43094-026-01023-5","DOIUrl":"10.1186/s43094-026-01023-5","url":null,"abstract":"<div><h3>Background</h3><p>Respiratory viral–bacterial co-infections remain difficult to treat because current therapies typically target pathogens individually. In this study, we designed and computationally evaluated a dual-function chimeric antimicrobial peptide that integrates the conserved antiviral and antibacterial domains of LL-37 and human neutrophil peptide-1 (HNP-1). The domains were fused using a rigid EAAAK linker, and sequence optimization was performed to improve physicochemical properties. Methods: Using structural modeling and molecular dynamics simulations, we assessed the peptide’s stability, solubility, conformational organization, and safety. The optimized construct showed enhanced antiviral activity against <i>respiratory syncytial virus</i> (RSV) and <i>human rhinovirus</i> (hRV), along with improved predicted antibacterial activity against <i>Streptococcus pneumoniae</i> and <i>Staphylococcus aureus</i>. Results: Structural validation demonstrated favorable α-helix and β-strand organization and improved model quality. Molecular dynamics simulations further confirmed the stability and compactness of the peptide through analyses of root-mean-square deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen bonding, radius of gyration, and solvent-accessible surface area (SASA). Conclusion: Overall, these computational findings highlight the potential of the LL-37/HNP-1 fusion peptide as a broad-spectrum therapeutic candidate for respiratory co-infections, with future applications in inhalable or nanoparticle-based delivery systems. Experimental antimicrobial assays will be required to validate its biological activity.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01023-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of repurposed drugs and herbal medicines to improve cognitive deficit in postmenopausal Alzheimer's disease: a systematic review of preclinical evidence","authors":"Marwa M. Saeed,&nbsp;Shaimaa H. El-Fayoumi,&nbsp;Gehan F. Balata","doi":"10.1186/s43094-026-01005-7","DOIUrl":"10.1186/s43094-026-01005-7","url":null,"abstract":"<p>Alzheimer's disease (AD) disproportionately affects postmenopausal women, most likely due to hormonal changes that cause early neuropathological alterations. The ovariectomized/<span>d</span>-galactose (OVX/<span>d</span>-gal) model provides a dependable platform to replicate postmenopausal AD pathophysiology in preclinical studies. Menopause-related estrogen loss is becoming more widely acknowledged as a key window for AD development. Despite the growing interest in potential treatments, it is currently unknown how effective herbal remedies and repurposed medications are in this model. This systematic review assessed preclinical data on cognitive outcomes following the administration of these medications in OVX/<span>d</span>-gal-induced AD. Following the PRISMA guidelines, the research team conducted a systematic search of four databases and extracted the relevant OVX/<span>d</span>-gal AD studies according to specified inclusion and exclusion criteria, assessed the risk of bias using SYRCLE, and rated the certainty of evidence using GRADE. Seventeen pertinent studies were found after searching Web of Science, PubMed, ScienceDirect, and Scopus. Although both herbal extracts and repurposed medications showed encouraging results in enhancing cognitive function, the overall certainty of the evidence was extremely low, mostly because of small trial numbers, unclear risk of bias, and little reporting on the quality of the methods used. The most promising repurposed medications were escitalopram, telmisartan, dimethyl fumarate, and dapagliflozin, and natural compounds such as ginsenoside Rg1 and resveratrol showed persistent effects and solid mechanistic evidence. While preliminary findings are encouraging, methodological heterogeneity and reporting limitations highlight the urgent need for more robust, well-designed preclinical studies before clinical translation can be considered.</p>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01005-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Pharmacological inhibition of BUB1 suppresses UCEC progression by modulating the PI3K-AKT pathway and reversing anoikis resistance and immune evasion: a multi-omics and experimental study","authors":"Wajahat Ali,&nbsp;Mohd Abdullah Al Mamun,&nbsp;Yicheng He,&nbsp;Niaz Muhammad,&nbsp;Saleem Ahmad,&nbsp;Muhammad Umar,&nbsp; Kulsoom","doi":"10.1186/s43094-026-01022-6","DOIUrl":"10.1186/s43094-026-01022-6","url":null,"abstract":"","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01022-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal-chemical design of stimuli-responsive hydroxyapatite nanomaterials for bone implant coatings and triggered drug delivery: from lattice engineering to release control","authors":"Olumakinde Charles Omiyale,&nbsp;Svetlana Aleksandrovna Ulasevich","doi":"10.1186/s43094-026-01020-8","DOIUrl":"10.1186/s43094-026-01020-8","url":null,"abstract":"<div><h3>Background</h3><p>Hydroxyapatite (HA, Ca₁₀(PO₄)₆(OH)₂) coatings are used to improve the fixation of metal bone implants in clinical settings. However, a static HA film cannot address issues like infection, inflammation, poor vascularization, tumor recurrence, and other complications after implant placement. Responsive HA nanoparticles offer a solution by delivering an implant that responds to the pathological environment and releases therapeutic agents as needed. Reviews categorize these materials based on their triggers but do not link their responsiveness to the underlying apatite crystal chemistry that influences drug loading and release, leaving formulators without clear design guidance.</p><h3>Main body of the abstract</h3><p>This review explores stimuli-responsive HA from a particular perspective: the idea that lattice-level variables such as substitution sites, crystallinity, and solubility product determine the dissolution behavior of HA coatings, which in turn influences release kinetics. We (i) relate apatite crystal chemistry to measured release parameters and conventional pharmacological kinetic models (zero-order, Higuchi, Korsmeyer-Peppas), grounding these connections with available dissolution and release data; (ii) categorize triggers into endogenous (pH, enzymatic, redox) and exogenous (light, magnetic field, ultrasound, thermal), evaluating their strengths, limitations, and model-dependence; (iii) introduce a practical buildable “design-rules” framework that links clinical scenarios with suitable stimuli, apatite composition, architecture, and release profiles, explicitly connecting fabrication methods to their impact on crystallinity, drug loading, coating stability, and release; and (iv) analyze the readiness of each platform type for clinical translation based on clear criteria, including regulatory status, sterilization behavior, quality standards, and clinical history. The move from single- to multi-stimulus, logic-gated systems is also examined for its potential to improve dosing specificity and the additional complexity involved.</p><h3>Conclusion</h3><p>Viewing the apatite crystal lattice as a key design parameter synthesizes the diverse literature into a unified framework and offers practical guidelines for creating responsive HA carriers and coatings. Overcoming challenges like oversimplified disease models, limited understanding of the protein corona, unknown long-term behavior of responsive elements, and the lack of standardized trigger-response testing aligned with current quality standards will be critical for progress. The framework aims to shift research from passive implants toward demand-driven drug delivery systems, with clinically already-used calcium-based local delivery approaches serving as the most immediate translational opportunity.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43094-026-01020-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}