Frontiers of Materials Science最新文献_第6页

Preparation and characterization of enzyme-responsive zwitterionic nanoparticles for monoclonal antibody delivery 用于单克隆抗体递送的酶响应两性离子纳米颗粒的制备和表征

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-12-02 DOI: 10.1007/s11706-023-0667-3

Changxin Hou, Huike Xing, Xubo Yuan

{"title":"Preparation and characterization of enzyme-responsive zwitterionic nanoparticles for monoclonal antibody delivery","authors":"Changxin Hou, Huike Xing, Xubo Yuan","doi":"10.1007/s11706-023-0667-3","DOIUrl":"10.1007/s11706-023-0667-3","url":null,"abstract":"<div><p>Monoclonal antibodies have been used in many diseases, but how to improve their delivery efficiency is still a key issue. As the modification of zwitterionic polymers can maintain the stability and biological activity of monoclonal antibodies, in this study, zwitterionic monomers, sulfobetaine methacrylate (SBMA), and 3-[[2-(methacryloyloxy) ethyl] dimethylammonio] propionate (CBMA) were used to prepare monoclonal antibody-loaded zwitterionic nanoparticles with the aid of the crosslinker of MMP-2 enzyme-responsive peptide which was a rapid synthesis process under mild conditions. The results from dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) indicated that a series of zwitterionic nanoparticles had been successfully prepared by the <i>in situ</i> free radical polymerization using the MMP-2 enzyme-responsive peptide as the cross-linking agent. These nanoparticles were spherical with the sizes of (18.7±1.9) nm (SBMA nanoparticle) and (18.2±2.1) nm (CBMA nanoparticle), and the surface contained zwitterionic polymers. It was revealed that they had no cytotoxicity, could be released in tumor microenvironment by enzyme to inhibit the growth of tumor cells, and was able to effectively penetrate endothelial cells (> 2%) by transwell. Therefore, the development of this strategy has a great prospect for the delivery of monoclonal antibodies.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138473156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic construction of oriented lamellar Col/nHAP composite scaffolds and mediation of macrophages to promote angiogenesis and bone regeneration 定向板层Col/nHAP复合支架的仿生构建及巨噬细胞介导血管生成和骨再生

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-11-03 DOI: 10.1007/s11706-023-0666-4

Tingting Huang, Tao Huang, Pin Luo, Di Xiao, Yiping Huang, Shenyu Yang, Rong Zeng, Mei Tu

{"title":"Biomimetic construction of oriented lamellar Col/nHAP composite scaffolds and mediation of macrophages to promote angiogenesis and bone regeneration","authors":"Tingting Huang, Tao Huang, Pin Luo, Di Xiao, Yiping Huang, Shenyu Yang, Rong Zeng, Mei Tu","doi":"10.1007/s11706-023-0666-4","DOIUrl":"10.1007/s11706-023-0666-4","url":null,"abstract":"<div><p>Pore characteristics have been identified as key design parameters for osteoimmunomodulation. The strategy reported here is to create an appropriate immune microenvironment by regulating pore characteristics of scaffolds, thereby promoting early angiogenesis and enhancing osteogenesis. A series of collagen/nanohydroxyapatite (Col/nHAP) composite scaffolds with ordered lamellar structures and different layer spacings were prepared by mimicking the ordered lamellar topology of the bone matrix. Our research indicated that the layer spacing and ordered topology of the scaffold exerted an important influence on phenotype transformation of macrophages and the secretion of angiogenic factors. The Col/nHAP-O(135) with large layer spacing not only supported cell attachment and diffusion <i>in vitro</i>, but also promoted early angiogenesis by timely switching from M1 to M2 macrophage phenotype. <i>In vivo</i> data showed that the layer spacing and the ordered structure of the scaffold synergistically regulated the inflammatory response and triggered macrophages to secrete more angiogenesis related cytokines. Col/nHAP-O(135) considerably promoted the neovascularization and new bone formation in the defect site, indicating that Col/nHAP-O(135) could significantly enhance the osteogenic activity of stem cells with the involvement of macrophages.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134795507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nonmulberry silk fibroin-based robust mandruka for rapid hemostasis treatment 一种用于快速止血治疗的非桑蚕丝素强效曼陀罗

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0660-x

Hao Zhang, Siyuan Luo, Weili Yang, Qisheng Luo, Perumal Ramesh Kannan, Yao Li, Xiangdong Kong

{"title":"A nonmulberry silk fibroin-based robust mandruka for rapid hemostasis treatment","authors":"Hao Zhang, Siyuan Luo, Weili Yang, Qisheng Luo, Perumal Ramesh Kannan, Yao Li, Xiangdong Kong","doi":"10.1007/s11706-023-0660-x","DOIUrl":"10.1007/s11706-023-0660-x","url":null,"abstract":"<div><p>Uncontrolled hemorrhage resulting from traumas causes severe health risks. There is an urgent need for expeditious hemostatic materials to treat bleeding incidents. Here, we developed a natural protein-based hemostatic sponge extracted from nonmulberry cocoons that exhibited rapid coagulation and effective absorption. We first built a degumming and dissolution system suitable for the <i>Dictyoploca japonica</i> cocoons to obtain regenerated silk fibroin (DSF). The DSF was then combined with carboxymethyl chitosan (CMCS) by glutaraldehyde (GA) crosslinking to ensure the structural stability of sponges. The resulting DSF–CMCS–GA exhibited remarkable hemostatic properties, displaying the highest absorption rate. It also demonstrated comparable efficacy to commercial hemostatic sponges. The blood-clotting index and hemolysis test showed that the prepared sponge possessed hemostatic activity and good hemocompatibility. Compared with mulberry silk fibroin hemostatic sponges (SF–CMCS–GA), DSF–CMCS–GA showed slightly better effects, making them a potential alternative to mulberry silk. In conclusion, our study introduces the use of <i>Dictyoploca japonica</i> silk fibroin for hemostasis, highlighting the exploitation of wild silkworm resources and providing an excellent silk fibroin-based hemostatic sealant for acute accident wounds and biomedical applications involving massive hemorrhage.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134878354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SnO2 nanotubes with N-doped carbon coating for advanced Li-ion battery anodes 先进锂离子电池负极用氮掺杂碳涂层SnO2纳米管

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0663-7

Junhai Wang, Jiandong Zheng, Liping Gao, Chunyu Meng, Jiarui Huang, Sang Woo Joo

引用次数: 0

One-step synthesis of triazine-based covalent organic frameworks at room temperature for efficient photodegradation of bisphenol A under visible light irradiation 室温一步法合成三嗪基共价有机骨架，用于可见光下双酚A的高效光降解

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0661-9

Pin Chen, Siyuan Di, Weixin Xie, Zihan Li, Shukui Zhu

{"title":"One-step synthesis of triazine-based covalent organic frameworks at room temperature for efficient photodegradation of bisphenol A under visible light irradiation","authors":"Pin Chen, Siyuan Di, Weixin Xie, Zihan Li, Shukui Zhu","doi":"10.1007/s11706-023-0661-9","DOIUrl":"10.1007/s11706-023-0661-9","url":null,"abstract":"<div><p>Herein, a novel visible-light-responsive photocatalyst with high efficiency was firstly synthesized at room temperature. The mild synthetic method resulted in a uniform spherical triazine-based covalent organic framework (TrCOF2) with ultra-high specific surface area as well as chemical stability. Due to the synergistic effect between the self-assembled uniform spherical structure and the abundant triazine-based structure, photoelectron–hole pairs were efficiently separated and migrated on the catalysts. On this basis, TrCOF2 was successfully applied to efficiently degrade bisphenol A (BPA). More than 98% of BPA was deraded after 60 min of visible light treatment, where the active specie of •O<span>\u0000 <sup>−</sup><sub>2</sub>\u0000 \u0000 </span> played a vital role during the degradation of BPA. The holes of TrCOF2 could produce O<sub>2</sub> by direct reaction with water or hydroxide ions. Simultaneously, photoelectrons can be captured by O<sub>2</sub> to generate •O<span>\u0000 <sup>−</sup><sub>2</sub>\u0000 \u0000 </span>. Moreover, density functional theory (DFT) calculations proved the outstanding ability of the exciting electronic conductivity. Remarkably, a reasonable photocatalytic mechanism for TrCOF2 catalysts was proposed. This research can provide a facile strategy for the synthesis of TrCOFs catalysts at room temperature, which unfolds broad application prospects in the environmental field.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced flexible humidity sensors: structures, techniques, mechanisms and performances 先进的柔性湿度传感器:结构、技术、机理和性能

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0662-8

Yuzhe Zhang, Yuxi Liu, Lifei Lin, Man Zhou, Wang Zhang, Liwei Lin, Zhongyu Li, Yuanzhe Piao, Sun Ha Paek

引用次数: 0

Highly sensitive flexible strain sensor based on microstructured biphasic hydrogels for human motion monitoring 基于微结构双相水凝胶的高灵敏度柔性应变传感器用于人体运动监测

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0665-5

Xin Gao, Xinyu Wang, Xingce Fan

{"title":"Highly sensitive flexible strain sensor based on microstructured biphasic hydrogels for human motion monitoring","authors":"Xin Gao, Xinyu Wang, Xingce Fan","doi":"10.1007/s11706-023-0665-5","DOIUrl":"10.1007/s11706-023-0665-5","url":null,"abstract":"<div><p>Flexible strain sensors have been extensively used in human motion detection, medical aids, electronic skins, and other civilian or military fields. Conventional strain sensors made of metal or semiconductor materials suffer from insufficient stretchability and sensitivity, imposing severe constraints on their utilization in wearable devices. Herein, we design a flexible strain sensor based on biphasic hydrogel via an <i>in-situ</i> polymerization method, which possesses superior electrical response and mechanical performance. External stress could prompt the formation of conductive microchannels within the biphasic hydrogel, which originates from the interaction between the conductive water phase and the insulating oil phase. The device performance could be optimized by carefully regulating the volume ratio of the oil/water phase. Consequently, the flexible strain sensor with oil phase ratio of 80% demonstrates the best sensitivity with gauge factor of 33 upon a compressive strain range of 10%, remarkable electrical stability of 100 cycles, and rapid resistance response of 190 ms. Furthermore, the human motions could be monitored by this flexible strain sensor, thereby highlighting its potential for seamless integration into wearable devices.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Ag-Cu-Ti active metal composite filler in ceramic joining: a review Ag-Cu-Ti活性金属复合填料在陶瓷连接中的应用综述

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-10-16 DOI: 10.1007/s11706-023-0664-6

Yuhang Li, Jun Wang, Ziyan Shen, Hangli Qian, Wanliang Zhang, Kaiyu Zhang, Danqing Ying, Qihang Zhou, Chengshuang Zhou, Lin Zhang

{"title":"Application of Ag-Cu-Ti active metal composite filler in ceramic joining: a review","authors":"Yuhang Li, Jun Wang, Ziyan Shen, Hangli Qian, Wanliang Zhang, Kaiyu Zhang, Danqing Ying, Qihang Zhou, Chengshuang Zhou, Lin Zhang","doi":"10.1007/s11706-023-0664-6","DOIUrl":"10.1007/s11706-023-0664-6","url":null,"abstract":"<div><p>As a structural and functional material with excellent properties, ceramics play an extremely important role in a wide range of industries, including life and production. To expand the range of applications for ceramic materials, ceramics are often joined to metals and then used. Among the physical and chemical joining methods of ceramics to metals, the AMB method is efficient and simple, suitable for industrial applications, and has been a hot topic of research. However, due to the problems of residual stresses caused by the large difference in thermal expansion coefficients between ceramic and metal brazing, composite fillers have become a very worthwhile solution by regulating the physical properties of the brazing material and improving the weld structure. This review describes the wetting principle and application of Ag-Cu-Ti active metal filler in the field of ceramic joining, with emphasis on the current stage of composite filler, and discusses the influence on the former brazing properties and organization after the introduction of dissimilar materials.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of PVA@PEI@BAC@CNC composite nanofibrous film with high efficiency filtration for PM2.5 高效过滤PM2.5的PVA@PEI@BAC@CNC复合纳米纤维膜的制备

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-09-20 DOI: 10.1007/s11706-023-0659-3

Jingda Huang, Yi Wang, Yuxin Cai, Yipeng Liang, Shite Lin, Enfu Wang, Jinhuan Zhong, Wenbiao Zhang, Kuichuan Sheng

{"title":"Preparation of PVA@PEI@BAC@CNC composite nanofibrous film with high efficiency filtration for PM2.5","authors":"Jingda Huang, Yi Wang, Yuxin Cai, Yipeng Liang, Shite Lin, Enfu Wang, Jinhuan Zhong, Wenbiao Zhang, Kuichuan Sheng","doi":"10.1007/s11706-023-0659-3","DOIUrl":"10.1007/s11706-023-0659-3","url":null,"abstract":"<div><p>It is still a challenge to prepare a water- and polymer-based electrospun air filter film with high efficiency filtration, low pressure drop, and good mechanical properties. To address this issue, polyvinyl alcohol (PVA) was employed as the main material, mixing polyethyleneimine (PEI), bamboo-based activated carbon (BAC) and cellulose nanocrystal (CNC) to construct the air filter film by electrostatic electrospinning. In this system, the negatively charged BAC and CNC are fixed in the system through bonding with the positively charged PEI, showing a double adsorption effect. One is the mechanical filtration of the porous network structure constructed by PVA@PEI electrospun nanofibers, and the other is the electrostatic adsorption of PM2.5 on the surface of BAC and CNC. It is significant that the resulting composite air filter displays a high filtration efficiency of 95.86%, a pressure drop of only 59 Pa, and good thermal stability. Moreover, the introduced methyltrimethoxysilane (MTMS) endows it with good water-resistance. Given these excellent performances, this system can provide theoretical and technical references for the development of water- and polymer-based electrospun air filter film.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24849834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper(II) sulfide nanostructures and its nanohybrids: recent trends, future perspectives and current challenges 硫化铜纳米结构及其纳米杂化:近期趋势、未来展望和当前挑战

IF 2.7 4区材料科学

Frontiers of Materials Science Pub Date : 2023-09-09 DOI: 10.1007/s11706-023-0632-1

Narinder Singh

{"title":"Copper(II) sulfide nanostructures and its nanohybrids: recent trends, future perspectives and current challenges","authors":"Narinder Singh","doi":"10.1007/s11706-023-0632-1","DOIUrl":"10.1007/s11706-023-0632-1","url":null,"abstract":"<div><p>Among various metal chalcogenides, metal oxides and phases of copper sulfide, copper(II) sulfide (covellite, CuS) nanostructures have enjoyed special attentiveness from researchers and scientists across the world owing to their complicated structure, peculiar composition and valency, attractive and panoramic morphologies, optical and electrical conductivity, less toxicity, and biocompatibility that can be exploited in advanced and technological applications. This review paper presents a brief idea about crystal structure, composition, and various chemical methods. The mechanism and effect of reaction parameters on the evolution of versatile and attractive morphologies have been described. Physical properties of CuS and its hybrid nanostructures, such as morphology and optical, mechanical, electrical, thermal, and thermoelectrical properties, have been carefully reviewed. A concise account of CuS and its hybrid nanostructures’ diverse applications in emerging and recent applications such as energy storage devices (lithium-ion batteries, supercapacitance), sensors, field emission, photovoltaic cells, organic pollutant removal, electromagnetic wave absorption, and emerging biomedical field (drug delivery, photothermal ablation, deoxyribonucleic acid detection, anti-microbial and theranostic) has also been elucidated. Finally, the prospects, scope, and challenges of CuS nanostructures have been discussed precisely.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"17 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44195291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0