Minerva Pediatrics最新文献_第6页

Vitamin D levels and lipid profile in children and adolescents: a tight correlation. 儿童和青少年的维生素 D 水平与血脂状况：密切相关。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2024-01-15 DOI: 10.23736/S2724-5276.23.07352-4

Daniele Ceruti, Carla Colombo, Martina Loiodice, Simone DE Leo, Valeria Calcaterra, Valentina Fabiano

{"title":"Vitamin D levels and lipid profile in children and adolescents: a tight correlation.","authors":"Daniele Ceruti, Carla Colombo, Martina Loiodice, Simone DE Leo, Valeria Calcaterra, Valentina Fabiano","doi":"10.23736/S2724-5276.23.07352-4","DOIUrl":"10.23736/S2724-5276.23.07352-4","url":null,"abstract":"Introduction: Vitamin D is an essential hormone for humans, playing an important role in musculoskeletal and calcium homeostasis. Its deficiency/insufficiency seems to contribute to the development of cardiometabolic diseases in adults: this correlation appears less clear for children and adolescents. The aim of this paper was to review literature data on the relationship between vitamin D and lipid profile alterations in pediatric population.Evidence acquisition: We carried out a comprehensive research in electronic databases, including MEDLINE and PubMed up to December 2022, for cross-sectional or prospective studies that investigated the correlation between serum vitamin D levels and lipid profile in children and adolescents. At the end of the process, 37 articles were included in this review.Evidence synthesis: According to our findings, vitamin D deficiency/insufficiency is strongly associated with lower high-density lipoprotein (HDL) cholesterol levels and higher levels of triglycerides and total cholesterol. Data about low-density lipoproteins (LDL) cholesterol are inconsistent. The potential role of vitamin D supplements for the prevention of cardiometabolic disease currently remains a speculation.Conclusions: An increasing number of studies shows how hypovitaminosis D in the pediatric age may play a role in the pathogenesis of metabolic disorders and lipid profile alterations. Data regarding the potential role of vitamin D supplements for the prevention of cardiometabolic disease are currently controversial. Further studies are needed to evaluate the causality of this association and to assess the underlying pathogenetic mechanisms.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"790-802"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical profiles of acute arterial ischemic neonatal stroke. 急性动脉缺血性新生儿脑卒中的临床特点。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2023-05-31 DOI: 10.23736/S2724-5276.23.07301-9

Mario Mastrangelo, Rossella Bove, Giacomina Ricciardi, Laura Giordo, Paola Papoff, Emanuela Turco, Maria Lucente, Francesco Pisani

{"title":"Clinical profiles of acute arterial ischemic neonatal stroke.","authors":"Mario Mastrangelo, Rossella Bove, Giacomina Ricciardi, Laura Giordo, Paola Papoff, Emanuela Turco, Maria Lucente, Francesco Pisani","doi":"10.23736/S2724-5276.23.07301-9","DOIUrl":"10.23736/S2724-5276.23.07301-9","url":null,"abstract":"Introduction: Perinatal stroke includes a heterogeneous group of early focal neurological injuries affecting subsequent brain development, often resulting in motor sequelae, symptomatic epilepsies, and cognitive, language and behavioral impairment. The incidence of perinatal stroke is about 1/3500 live birth.Evidence acquisition: A PubMed and SCOPUS search strategy included the entries \"neonatal ischemic stroke\" OR \"perinatal ischemic stroke\" and the age of the filter under 18 years and January 2000-August 2022.Evidence synthesis: The cumulative literature analysis highlighted 3880 published patients (from 98 articles) with stroke, mainly presenting with clinical or electro-graphical seizures (2083 patients). The mean age at presentation was 2,5±2,4 days (data available for 1182 patients). Stroke occurred in the first week of life in 1164 newborns. The mainly involved ischemic areas were within the territories of the middle cerebral artery (1403 patients). Predisposing risk factors included fetal/newborn factors (1908 patients), dystocial birth (759 patients), maternal (678 patients), and placental factors (63 patients). No thrombolysis and/or endovascular treatments were performed, while data about other pharmacological treatments were restricted to a single article. The death occurred in 29 newborns. Motor, neurocognitive and language impairment were cumulatively reported in 875 patients. Epileptic seizures during the follow-up were reported in 238 cases.Conclusions: The literature analysis highlighted that every term newborn presenting with acute neurological signs and symptoms during the first week of life should always be considered for the identification of an ischemic stroke.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"767-776"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new multicomponent nasal spray for managing children with recurrent upper respiratory infections. 用于治疗儿童反复上呼吸道感染的新型多成分鼻腔喷雾剂。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2024-09-16 DOI: 10.23736/S2724-5276.24.07615-8

Ignazio LA Mantia, Giovanna Stilo, Giuliano Messina, Attilio Varricchio, Giorgio Ciprandi

引用次数: 0

Morphine versus hydromorphone in pediatrics: a narrative review of latest indications and optimal use in neonates and children. 吗啡与氢吗啡酮在儿科：新生儿和儿童最新适应症和最佳使用的叙述性回顾。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2023-09-06 DOI: 10.23736/S2724-5276.23.07275-0

Sarah Spénard, Marie-Elaine Metras, Charles Gélinas, Vibhuti Shah, Marie-Joëlle Doré-Bergeron, Kathryn Dekoven, Marc-Antoine Marquis, Evelyne D Trottier, Céline Thibault, Niina Kleiber

{"title":"Morphine versus hydromorphone in pediatrics: a narrative review of latest indications and optimal use in neonates and children.","authors":"Sarah Spénard, Marie-Elaine Metras, Charles Gélinas, Vibhuti Shah, Marie-Joëlle Doré-Bergeron, Kathryn Dekoven, Marc-Antoine Marquis, Evelyne D Trottier, Céline Thibault, Niina Kleiber","doi":"10.23736/S2724-5276.23.07275-0","DOIUrl":"10.23736/S2724-5276.23.07275-0","url":null,"abstract":"The management of pain in pediatrics is multimodal and includes non-pharmacologic and pharmacologic approaches. Opioids, and particularly morphine and hydromorphone, are frequently used to treat moderate-to-severe pain. The goals of this review are to describe the pharmacological characteristics of both drugs, to cover the latest evidence of their respective indications, and to promote their safe use in pediatrics. Morphine is the most studied opioid in children and is known to be safe and effective. Morphine and hydromorphone can be used to manage acute pain and are usually avoided when treating chronic non-cancer pain. Current evidence suggests that both opioids have a similar efficacy and adverse effect profile. Hydromorphone has not been studied in neonates but in some centers, it has been used instead of morphine for certain patients. In palliative care, the use of opioids is often indicated and their benefits extend beyond analgesia; indications include treatment of central neuropathic pain in children with severe neurologic impairment and treatment of respiratory distress in the imminently dying patients. The longstanding belief that the use of well-titrated opioids hastens death should be abandoned as robust evidence has shown the opposite. With the current opioid crisis, a responsible use of opioids should be promoted, including limiting the opioid prescription to the patient's anticipated needs, optimizing a multimodal analgesic plan including the use of non-pharmacological measures and non-opioid medications, and providing information on safe storage and disposal to patients and families. More data is needed to better guide the use of morphine and hydromorphone in children.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"777-789"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10163357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study of pit and fissure sealant combined with light-cured flowable resin in prevention of dental caries in children. 坑和裂隙封闭剂结合光固化流动树脂预防儿童龋齿的临床研究。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.23736/S2724-5276.24.07639-0

Baican Wang, Yongyu Lou

引用次数: 0

Malnutrition and sarcopenia in children with cancer. 癌症儿童的营养不良和肌肉疏松症。

IF 1

Minerva Pediatrics Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.23736/S2724-5276.24.07608-0

Antonio Ruggiero

引用次数: 0

The pediatrician's point of view on a new "emollient plus". 儿科医生对新型 "润肤剂添加剂 "的看法。