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Multisystem inflammatory syndrome in children: an evolving understanding of a syndrome amid the inflammatory continuum. 儿童多系统炎症综合征：对炎症连续体中一种综合征不断发展的认识。
IF 1
Minerva Pediatrics Pub Date : 2024-08-01 Epub Date: 2023-06-16 DOI: 10.23736/S2724-5276.23.07279-8
Sathya Areti, Marissa Parrillo, Lena Baker, Alexandra Meszaros, Alexandra Dram, Kenneth E Remy
{"title":"Multisystem inflammatory syndrome in children: an evolving understanding of a syndrome amid the inflammatory continuum.","authors":"Sathya Areti, Marissa Parrillo, Lena Baker, Alexandra Meszaros, Alexandra Dram, Kenneth E Remy","doi":"10.23736/S2724-5276.23.07279-8","DOIUrl":"10.23736/S2724-5276.23.07279-8","url":null,"abstract":"<p><p>Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory and immunosuppressed condition affecting children exposed to COVID-19. MIS-C has been associated with an over-exaggerated innate and adaptive immune response characterized by a 'selective' cytokine production and T cell suppression. As COVID-19 information has evolved, the knowledge and field surrounding MIS-C is ever evolving. Thus, a comprehensive clinical review that concisely presents current literature findings regarding common clinical presentations and comparisons with similar conditions, associations with the COVID-19 vaccine effects and relevant epigenetic markers and evaluates treatment and long-term outcomes to help guide future studies is needed and provided.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wet lung or wet baby? An intricate problem. 湿肺还是湿婴？错综复杂的问题
IF 1
Minerva Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-01-29 DOI: 10.23736/S2724-5276.23.07471-2
Vincenzo Zanardo, Pietro Guerrini, Lorenzo Severino, Gianluca Straface
{"title":"Wet lung or wet baby? An intricate problem.","authors":"Vincenzo Zanardo, Pietro Guerrini, Lorenzo Severino, Gianluca Straface","doi":"10.23736/S2724-5276.23.07471-2","DOIUrl":"10.23736/S2724-5276.23.07471-2","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TMT-based serum proteomics analysis of infantile hemangioma patients. 基于 TMT 的婴儿血管瘤患者血清蛋白质组学分析
IF 1
Minerva Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-05-07 DOI: 10.23736/S2724-5276.24.07585-2
Yuting Wang, Wenyi Liu, Jiayang Wang, Lixin Lin, Ran Huo
{"title":"TMT-based serum proteomics analysis of infantile hemangioma patients.","authors":"Yuting Wang, Wenyi Liu, Jiayang Wang, Lixin Lin, Ran Huo","doi":"10.23736/S2724-5276.24.07585-2","DOIUrl":"10.23736/S2724-5276.24.07585-2","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting healthy eating in childhood: results from the Children PrOmOting Nutrition throUgh Theatre (COcONUT) project. 促进儿童健康饮食：COCONUT（儿童通过剧院促进营养）项目的成果。
IF 1
Minerva Pediatrics Pub Date : 2024-08-01 Epub Date: 2021-04-16 DOI: 10.23736/S2724-5276.21.06249-2
Vincenza Gianfredi, Gaia Bertarelli, Liliana Minelli, Daniele Nucci
{"title":"Promoting healthy eating in childhood: results from the Children PrOmOting Nutrition throUgh Theatre (COcONUT) project.","authors":"Vincenza Gianfredi, Gaia Bertarelli, Liliana Minelli, Daniele Nucci","doi":"10.23736/S2724-5276.21.06249-2","DOIUrl":"10.23736/S2724-5276.21.06249-2","url":null,"abstract":"<p><strong>Background: </strong>Despite several international initiatives aimed to contrast childhood overweight and obesity, these still represent a major public health problem. Recently, the World Health Organization called for a new type of preventive action, requiring stakeholders from both governments and civil society, to play a decisive role in shaping healthy environments, especially for children.</p><p><strong>Methods: </strong>COcONUT (Children PrOmOting Nutrition throUgh Theatre) was a nutrition education project, involving children aged 5-12 years, aimed to raise awareness on healthy eating, through theatrical and practical workshops. Within this project we conducted an observational study assessing: 1) children adherence to the Mediterranean diet, using the KIDMED questionnaire; 2) parental nutritional knowledge and families' food habits using the ZOOM8 questionnaire. The non-parametric Wilcoxon and the McNemar's Test were used. Statistical significance was fixed P<0.05.</p><p><strong>Results: </strong>Our data show a statistically significant improvement in Mediterranean Diet adherence among children (P=0.0004). Moreover, we found positive trends in some families' food habits, as for instance less perceived barriers in fruits/vegetables/pulses consumption, less perceived barriers in doing sports and less consumption of unhealthy snacks.</p><p><strong>Conclusions: </strong>Our results confirm the important role played by funny and active learning in health promotion initiatives.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38799560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levodropropizine for children and adolescents with acute post-viral cough: an evidence-based choice. 左旋多巴嗪治疗儿童和青少年病毒后急性咳嗽：循证选择。
IF 1
Minerva Pediatrics Pub Date : 2024-07-30 DOI: 10.23736/S2724-5276.24.07638-9
Gian L Marseglia, Giorgio Ciprandi
{"title":"Levodropropizine for children and adolescents with acute post-viral cough: an evidence-based choice.","authors":"Gian L Marseglia, Giorgio Ciprandi","doi":"10.23736/S2724-5276.24.07638-9","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07638-9","url":null,"abstract":"<p><p>Acute post-viral cough is a common symptom, usually mild-moderate and self-resolving. However, acute cough may be particularly annoying, affecting sleep, and quality of life, also of the family. Thus, treatment is deemed necessary. Antitussive remedies may be pharmacological or non-pharmacological. Antitussive drugs are either central or peripheral. Central drugs are burdened with significant side effects and can cause abuse, especially in adolescents. Levodropropyzine, on the other hand, is an effective peripheral drug, as demonstrated by two meta-analyses, and has an optimal safety profile. Non-pharmacological remedies tend to be safe, but few substances have a documented degree of efficacy. Therefore, when managing children and adolescents with a post-viral cough, the practical approach may be based on levodropropizine use, which is preferable when the cough is particularly persistent and disturbs sleep.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on anxiety and depression in adolescent peripheral vertigo patients with sleep disorders. 关于患有睡眠障碍的青少年周围性眩晕患者的焦虑和抑郁的研究。
IF 1
Minerva Pediatrics Pub Date : 2024-07-30 DOI: 10.23736/S2724-5276.24.07687-0
Runwu Xiang, Sha Liu, Lei Zhang, Dongrong Zhao
{"title":"Study on anxiety and depression in adolescent peripheral vertigo patients with sleep disorders.","authors":"Runwu Xiang, Sha Liu, Lei Zhang, Dongrong Zhao","doi":"10.23736/S2724-5276.24.07687-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07687-0","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying inborn errors of immunity to understand the pathogenic mechanisms underlying highly prevalent immune-mediated diseases. 研究先天性免疫错误，了解高发免疫介导疾病的致病机制。
IF 1
Minerva Pediatrics Pub Date : 2024-07-08 DOI: 10.23736/S2724-5276.24.07668-7
Riccardo Castagnoli, Francesca Cenzato, Ivan Taietti, Amelia Licari, Gian L Marseglia
{"title":"Studying inborn errors of immunity to understand the pathogenic mechanisms underlying highly prevalent immune-mediated diseases.","authors":"Riccardo Castagnoli, Francesca Cenzato, Ivan Taietti, Amelia Licari, Gian L Marseglia","doi":"10.23736/S2724-5276.24.07668-7","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07668-7","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing for reconstructive surgery in Hirschsprung disease. 赫氏胃肠病整形手术的时机。
IF 1
Minerva Pediatrics Pub Date : 2024-07-08 DOI: 10.23736/S2724-5276.24.07508-6
Alessio Pini Prato, Enrico Felici
{"title":"Timing for reconstructive surgery in Hirschsprung disease.","authors":"Alessio Pini Prato, Enrico Felici","doi":"10.23736/S2724-5276.24.07508-6","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07508-6","url":null,"abstract":"<p><strong>Introduction: </strong>Debate exists regarding the ideal timing for surgery in Hirschsprung disease (HSCR) in various groups of age. The aim of this paper was to suggest a possible strategy to determine the optimal timing for reconstructive surgery in patients affected by HSCR.</p><p><strong>Evidence acquisition: </strong>A systematic literature search of papers published on PubMed and Embase during the last decade, addressing \"Hirschsprung,\" \"preoperative enterocolitis,\" \"preoperative mortality,\" \"complications,\" and \"timing\" in all possible combinations, was performed.</p><p><strong>Evidence synthesis: </strong>A total of 10 out of 170 identified papers addressed this issue in detail and were subsequently assessed for in-depth analysis. Our review confirmed that the most important issue to guide surgical timing is represented by HSCR Associated Enterocolitis (HAEC). Most authors suggest performing pull-through at around 3 months of age after effective bowel decompression, which should not be continued indefinitely to avoid complications.</p><p><strong>Conclusions: </strong>Based on this systematic review we suggest the following: 1) healthy neonates should undergo surgical reconstruction at 3 months of age; 2) urgent surgery (levelling enterostomy) might be required in critically unwell patients, those with Total Colonic HSCR, or those in whom nursing proved to be ineffective; 3) surgery can be safely postponed only in older patients with a lower likelihood of HAEC (i.e. without previous HAEC occurrences) always avoiding long-lasting rectal irrigations.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and genetic analysis of Emery-Dreifuss muscular dystrophy type 2 caused by LMNA gene mutation. 由 LMNA 基因突变引起的 Emery-Dreifuss 肌营养不良 2 型的临床和遗传分析。
IF 1
Minerva Pediatrics Pub Date : 2024-07-04 DOI: 10.23736/S2724-5276.24.07560-8
Yang Yang
{"title":"Clinical and genetic analysis of Emery-Dreifuss muscular dystrophy type 2 caused by LMNA gene mutation.","authors":"Yang Yang","doi":"10.23736/S2724-5276.24.07560-8","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07560-8","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological and clinical features of bronchiolitis after the COVID-19 outbreak: comparison of two epidemic seasons. COVID-19 爆发后支气管炎的流行病学和临床特征：两个流行季节的比较。
IF 1
Minerva Pediatrics Pub Date : 2024-06-26 DOI: 10.23736/S2724-5276.24.07510-4
Antonietta Curatola, Lorenzo DI Sarno, Marta Barbato, Antonio Gatto, Elena Cultrera DI Montesano, Antonio Chiaretti
{"title":"Epidemiological and clinical features of bronchiolitis after the COVID-19 outbreak: comparison of two epidemic seasons.","authors":"Antonietta Curatola, Lorenzo DI Sarno, Marta Barbato, Antonio Gatto, Elena Cultrera DI Montesano, Antonio Chiaretti","doi":"10.23736/S2724-5276.24.07510-4","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07510-4","url":null,"abstract":"<p><strong>Background: </strong>The first aim of this study was to compare Pediatric Emergency Department (PED) admissions for acute bronchiolitis during the 2022-2023 season to those of the season 2021-2022. The secondary aim was to assess the difference in the recurrence of bronchiolitis episodes in the same patient between the two seasons.</p><p><strong>Methods: </strong>This is a retrospective, observational, cross-sectional study conducted at the PED of IRCCS A. Gemelli University Polyclinic Foundation (Rome, Italy). We included all children aged between 0 and 2 years admitted to PED with the diagnosis of bronchiolitis. We compared features of seasons 2021-2022 and 2022-2023.</p><p><strong>Results: </strong>The median age of children enrolled during the 2022-23 season was 5 months (IQR: 2-8) compared to 7 months (IQR: 2-14) in the previous one (P=0.02). We observed in the last season a higher number of children admitted to PED with a high priority code and an increased therapeutic use of high-flow nasal cannula and inhaled adrenaline. During the 2022-23 season we found 31 (12.8%) children presenting more than one episode of bronchiolitis in the same epidemic season, compared to 16 (7.6%) children in the previous season (P=0.048).</p><p><strong>Conclusions: </strong>Our data emphasize that the epidemiological features of bronchiolitis after COVID-19 outbreak have changed and are still evolving.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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