Minerva Pediatrics最新文献_第10页

Effects of dietary sugar restriction on hepatic fat in youth with obesity. 限制糖分摄入对肥胖症青少年肝脏脂肪的影响

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2023-06-07 DOI: 10.23736/S2724-5276.23.07209-9

Johanna K Distefano, Glenn S Gerhard

{"title":"Effects of dietary sugar restriction on hepatic fat in youth with obesity.","authors":"Johanna K Distefano, Glenn S Gerhard","doi":"10.23736/S2724-5276.23.07209-9","DOIUrl":"10.23736/S2724-5276.23.07209-9","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children. Like adults, children can develop the progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), which is characterized by hepatic inflammation, often in the presence of fibrosis. Children with NAFLD are at higher risk of liver-related complications, metabolic dysfunction, and cardiovascular disease in adulthood. Many factors contribute to the escalating prevalence of NAFLD in the pediatric population, among which are an array of dietary patterns such as overnutrition, poor diet quality, and heavy consumption of fat and sugar, including fructose. Findings from an increasing number of epidemiological studies support a connection between high habitual sugar consumption and NAFLD, especially within the context of obesity, but these studies are not able to demonstrate whether sugar is a contributing factor or instead an indicator of an overall poor diet (or lifestyle) quality. To date, only four randomized controlled dietary interventions assessing the effects of sucrose/fructose restriction on hepatic fat fraction in youth with obesity have been published. The objectives of this review are to summarize the key findings from these dietary interventions to achieve a better understanding of the strength of the relationship between dietary sugar restriction and liver fat reduction, despite their inherent limitations, and to discuss the potential impact of weight loss and fat mass reduction on improvement in hepatic steatosis.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"439-448"},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study on Tianma Gouteng decoction combined with haloperidol in the treatment of tic disorder in children. 天麻钩藤煎剂联合氟哌啶醇治疗儿童抽搐症的临床研究

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-08-03 DOI: 10.23736/S2724-5276.23.07373-1

Liwei Liu, Shen Cheng, Yufang Yang, Yuyan Chen

引用次数: 0

Cytokines and refractory mycoplasma pneumoniae pneumonia in children: a systematic review. 细胞因子与儿童难治性肺炎支原体肺炎：系统综述。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-05-08 DOI: 10.23736/S2724-5276.23.07158-6

Ming Yu, Qin Zhang, Haiou Yan

{"title":"Cytokines and refractory mycoplasma pneumoniae pneumonia in children: a systematic review.","authors":"Ming Yu, Qin Zhang, Haiou Yan","doi":"10.23736/S2724-5276.23.07158-6","DOIUrl":"10.23736/S2724-5276.23.07158-6","url":null,"abstract":"Introduction: The relationship between cytokines and refractory mycoplasma pneumoniae pneumonia (RMPP) in children was conflicting. The aim of the current study was to perform a systematic review to determine the relationship between cytokines and RMPP in children.Evidence acquisition: We searched PubMed, and the search was done on 21 November 2022. This search was limited to human studies, with language restriction of English. Studies were included if they reported the relationship between cytokines and RMPP.Evidence synthesis: A total of 22 relevant full articles were included in the review. TNF-α levels in the bronchoalveolar lavage fluid (BALF) and IL-18 levels in the blood samples were likely to be associated with RMPP. IL-2 and IL-4 lost significance regardless in the BALF or blood samples. Additionally, there was no significant difference in IFN-γ levels between RMPP patients and non-refractory mycoplasma pneumoniae pneumonia (NRMPP) patients in the BALF. Patients receiving different treatments had different levels of cytokines.Conclusions: This analysis offers evidence linking abnormalities of cytokines with RMPP in children, which may be essential for identifying individuals with RMPP. Large prospective studies are needed for further clarification of roles of cytokines in RMPP.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"259-267"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional support nursing measures and nursing quality analysis of critically-ill newborns with hypoglycemia. 危重新生儿低血糖的营养支持护理措施和护理质量分析。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-09-15 DOI: 10.23736/S2724-5276.23.07412-8

Junmin Xue, Jianfang Ge

引用次数: 0

Increase in pediatric intensive care mortality after the Coronavirus pandemic. 冠状病毒大流行后儿科重症监护死亡率增加。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-09-21 DOI: 10.23736/S2724-5276.23.07288-9

Thomas E Peros, Marissa R Besseling, Eva VAN Zanten, Marc VAN Heerde, Job B VAN Woensel

引用次数: 0

An unusual peak of febrile rhabdomyolysis. 一种罕见的热性横纹肌溶解症高峰。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-09-28 DOI: 10.23736/S2724-5276.23.07346-9

Marco Denina, Emanuele Castagno, Francesca Feyles, Ilaria Bruno, Angelo G Delmonaco, Licia Peruzzi, Claudia Bondone

引用次数: 0

Multisystem inflammatory syndrome in children associated with COVID-19: from pathophysiology to clinical management and outcomes. 与 COVID-19 有关的儿童多系统炎症综合征：从病理生理学到临床管理和结果。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-06-07 DOI: 10.23736/S2724-5276.23.07205-1

Simon Lee, Guliz Erdem, Jun Yasuhara

{"title":"Multisystem inflammatory syndrome in children associated with COVID-19: from pathophysiology to clinical management and outcomes.","authors":"Simon Lee, Guliz Erdem, Jun Yasuhara","doi":"10.23736/S2724-5276.23.07205-1","DOIUrl":"10.23736/S2724-5276.23.07205-1","url":null,"abstract":"Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome (PIMS), is a new postinfectious illness associated with COVID-19, affecting children after SARS-CoV-2 exposure. The hallmarks of this disorder are hyperinflammation and multisystem involvement, with gastrointestinal, cardiac, mucocutaneous, and hematologic disturbances seen most commonly. Cardiovascular involvement includes cardiogenic shock, ventricular dysfunction, coronary artery abnormalities, and myocarditis. Now entering the fourth year of the pandemic, clinicians have gained some familiarity with the clinical presentation, initial diagnosis, cardiac evaluation, and treatment of MIS-C. This has led to an updated definition from the Centers for Disease Control and Prevention in the USA driven by increased experience and clinical expertise. Furthermore, the available evidence established expert consensus treatment recommendations supporting a combination of immunoglobulin and steroids. However, the pathophysiology of the disorder and answers to what causes this remain under investigation. Fortunately, long-term outcomes continue to look promising, although continued follow-up is still needed. Recently, COVID-19 mRNA vaccination is reported to be associated with reduced risk of MIS-C, while further studies are warranted to understand the impact of COVID-19 vaccines on MIS-C. We review the findings and current literature on MIS-C, including pathophysiology, clinical features, evaluation, management, and medium- to long-term follow-up outcomes.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"268-280"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the expression level and clinical significance of HMGB1, β1 globulin and TLR-4 in serum of children with rheumatoid arthritis. 类风湿性关节炎患儿血清中 HMGB1、β1 球蛋白和 TLR-4 的表达水平及临床意义研究

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-07-18 DOI: 10.23736/S2724-5276.23.07340-8

Wei Wang, Yuanyuan Li, Feng He

引用次数: 0

Investigation on the status of ultrasonic prenatal screening for fetal closed spina bifida. 关于胎儿闭合性脊柱裂超声产前筛查现状的调查。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-09-15 DOI: 10.23736/S2724-5276.23.07414-1

Weina Zhou, Qing Yu, Shuo Cao, Bo Zhang, Jianghua Li, Zhengge Ma, Liya Zheng, Xiangling Wu

引用次数: 0

Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis. 影响囊性纤维化患儿肺加重治疗反应的因素。

IF 2.6

Minerva Pediatrics Pub Date : 2024-04-01 Epub Date: 2023-11-28 DOI: 10.23736/S2724-5276.23.07221-X

Jagdev Singh, Paul Robinson, Chetan Pandit, Brendan Kennedy, Beth Weldon, Brooke Bailey, Merilyn John, Dominic Fitzgerald, Hiran Selvadurai

{"title":"Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis.","authors":"Jagdev Singh, Paul Robinson, Chetan Pandit, Brendan Kennedy, Beth Weldon, Brooke Bailey, Merilyn John, Dominic Fitzgerald, Hiran Selvadurai","doi":"10.23736/S2724-5276.23.07221-X","DOIUrl":"10.23736/S2724-5276.23.07221-X","url":null,"abstract":"Background: Pulmonary exacerbations in cystic fibrosis (CF) significantly impact morbidity and mortality. This study aimed to assess treatment response rates and identify contributing factors towards treatment response.Methods: In this single-center, retrospective, longitudinal study spanning four years, we analyzed all pulmonary exacerbation admissions. We compared lung function at baseline, admission, end of treatment, and 6-week follow-up. Treatment response was defined as ≥95% recovery of baseline FEV<inf>1</inf>%.Results: There were 78 children who required a total of 184 admissions. The mean duration of treatment was 14.9±2.9 days. FEV<inf>1</inf>% returned to 95% of baseline in 59% following treatment. The magnitude of the decline in lung function on admission in children who did not respond to treatment was 21.7±15.2% while the decline in children who responded to treatment was 8.3±9.4%, P<0.001. Children who experienced a decline in FEV<inf>1</inf>% greater than 40% exhibited an 80% reduced likelihood of returning to their baseline values (OR -0.8, 95% CI -0.988; -0.612). Similarly, those with FEV<inf>1</inf>% reductions in the ranges of 30-39% (OR -0.63, 95% CI -0.821; -0.439), 20-29% (OR -0.52, 95% CI -0.657; -0.383), and 10-19% (OR -0.239, 95% CI -0.33; -0.148) showed progressively lower odds of returning to baseline. Fourty-eight children required readmission within 7.7±5.4 months, children who responded to treatment had a longer time taken to readmission (8.9±6.4 months) versus children who did not respond to treatment (6.4±3.5 months), (OR: -0.20, 95% CI -0.355; -0.048).Conclusions: A greater decline in lung function on admission and readmission within 6 months of the initial admission predicts non-response to treatment. This highlights the importance of re-evaluating follow-up strategies following discharge.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"245-252"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138447216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0