Minerva Pediatrics最新文献

{"title":"Pediatric tracheal surgery: indications, complications and results.","authors":"Martina Monti, Vittorio Guerriero, Roberto D'Agostino, Oliviero Sacco, Andrea Moscatelli, Mirta Della Rocca, Nicola Stagnaro, Francesca Rizzo, Girolamo Mattioli, Michele Torre","doi":"10.23736/S2724-5276.25.07753-5","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07753-5","url":null,"abstract":"<p><strong>Background: </strong>Pediatric tracheal surgery includes several complex and rare procedures. We report the surgical experience at our center.</p><p><strong>Methods: </strong>Our center has multidisciplinary team manages laryngotracheal malformations. We retrospectively analyzed all tracheal surgeries from January 2009 to September 2023, excluding endoscopic cases and tracheostomy insertion, revision, or closure not related to reconstructive tracheal surgery. We evaluated diagnosis, comorbidities, type of surgery, need for tracheostomy, complications, death, outcome in terms of decannulation and adequate caliber airway.</p><p><strong>Results: </strong>A total of 122 patients with a median age of 2.61 years (0-25.4 years) were operated for congenital (59.8%) or acquired (40.2%) tracheal pathology. The procedures performed were: cricothyroid resection (N.=18; 14.8%), laryngotracheal reconstruction with rib cartilage graft (N.=33; 27%), tracheal resection-anastomosis (N.=20; 16.4%), laryngotracheal cleft closure (N.=5; 4.1%), \"slide tracheoplasty\" (N.=15; 12.3%), posterior tracheopexy (N.=14; 11.5%); isolated tracheoesophageal fistula closure (N.=17; 13.9%). Depending on the type of operation, cardiac surgeons and otolaryngologists were involved. Preoperative tracheotomy was required in 54 patients and postoperative in 51 patients. We reported a mortality of 6.1%, or seven patients, four of whom died in the immediate postoperative period, but only one death was due to surgical causes. Other intraoperative complications were reported in two patients (1.6%) and postoperative complications in 34 patients (27.9%). Ninety-two patients (75.4%) were alive with adequate airway caliber and no need for tracheostomy.</p><p><strong>Conclusions: </strong>There are many indications for tracheal surgery and a multidisciplinary approach has been essential. Tracheal surgery is complex and potentially associated with major complications, but outcomes are generally satisfactory.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attachment and ARFID in developmental age: a clinical observational study on children and caregivers.","authors":"Federica Pagani, Camilla Rossetti, Jessica Galli","doi":"10.23736/S2724-5276.25.07905-4","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07905-4","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicomponent food supplement in managing children with allergic rhinitis: a primary care experience.","authors":"Caterina Cuppari, Carmelo Salpietro, Gian L Marseglia, Annamaria Salpietro, Federico Schettini, Domenico Minasi, Michele Miraglia Del Giudice, Maria A Tosca, Giorgio Ciprandi","doi":"10.23736/S2724-5276.25.07787-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07787-0","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicomponent food supplement in managing children with recurrent respiratory infections: a primary care experience.","authors":"Caterina Cuppari, Carmelo Salpietro, Gian L Marseglia, Annamaria Salpietro, Federico Schettini, Domenico Minasi, Michele Miraglia Del Giudice, Maria A Tosca, Giorgio Ciprandi","doi":"10.23736/S2724-5276.25.07786-9","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07786-9","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibuprofen lysine salt complexed with β-cyclodextrin oral suspension: an innovative pediatric formulation with clinical advantages.","authors":"Giorgio Ciprandi, Raffaele Badolato, Susanna Esposito, Michele Miraglia Del Giudice, Angelo Ravelli, Gianluigi Marseglia","doi":"10.23736/S2724-5276.25.07862-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07862-0","url":null,"abstract":"<p><strong>Background: </strong>Fever and acute pain are frequent symptoms in pediatric age requiring prompt relief when necessary. International guidelines recommend a standard treatment including ibuprofen and acetaminophen. Ibuprofen is an analgesic and antipyretic agent with anti-inflammatory activity. Since the ibuprofen standard formulation is acid and lipophilic, the solubility in an aqueous environment (typically the gastrointestinal mucosa) is poor. As a result, the absorption and action onset are consequently negatively affected. To solve this drawback, salifying with lysine hastens gastrointestinal absorption and increases gastrointestinal tolerability. In addition, complexation with β-cyclodextrin (β-CD) improves hydro-solubility, increasing and prolonging plasmatic concentrations.</p><p><strong>Methods: </strong>This compound is presently available as oral suspension indicated in children and adolescents. Thus, the present article reviews and discusses the pharmacological profile of this product.</p><p><strong>Results: </strong>Although ibuprofen lysine salt complexed with β-cyclodextrin (ILS-β-CD) has a similar safety profile to other NSAIDs, its quick absorption and high and prolonged plasmatic concentrations make it ideal for managing acute conditions. Two clinical studies investigated this product.</p><p><strong>Conclusions: </strong>Based on this evidence, ILS-β-CD may represent a beneficial option for managing fever and pain in children and adolescents. This formulation may provide a rapid onset of action and prolonged concentrations, assuring adequate therapeutic concentrations, optimal tolerability, and a valuable safety profile.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Italian multidisciplinary Delphi Consensus on managing children and adolescents with mild-moderate acute pain.","authors":"Michele Miraglia Del Giudice, Gianluigi Marseglia, Francesco Scaglione, Amelia Licari, Giorgio Ciprandi","doi":"10.23736/S2724-5276.25.07831-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07831-0","url":null,"abstract":"<p><p>Acute pain is a common symptom in children and adolescents. Guidelines recommend measuring pain severity in all subjects using adequate scales. In addition, guidelines recommend always to treat pain. Acetaminophen as pain-reliever and Ibuprofen as NSAID with analgesic effect are extensively considered a first-choice medications for relieving mild-moderate acute pain in children. However, among NSAIDs also ketoprofen lysine salt is indicated in young patients 6 years of age and older and proved to exert analgesic, anti-inflammatory, and antipyretic effects. The present multidisciplinary Delphi Consensus, promoted by the Italian Society of Allergy and Clinical Immunology (SIAIP), aimed at proposing practical statements about pain management and the possible use of ketoprofen lysine salt (KLS) to relieve mild-moderate acute pediatric pain. A multidisciplinary panel of 33 qualified experts discussed and anonymously voted on the statements drafted by a steering committee. The results confirmed a large agreement about the importance of adequately assessing pain severity and treating pain in all children and adolescents. The current multidisciplinary Delphi Consensus advocated constantly measuring pain through algometric scales and treating all children in all situations. The Delphi Consensus also agreed that KLS is effective, rapid, and safe in managing children from the age of six and adolescents with mild-moderate acute pain. As a result, KLS may be a valuable option in this clinical setting. The Delphi Consensus also agreed that KLS may display an efficacy and safety overlapping with ibuprofen and acetaminophen. As a result, KLS may be considered a valuable option in managing children older than six years and adolescents with mild-moderate acute pain.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural antitussive products for children and adolescents: darkness and shadow.","authors":"Giorgio Ciprandi","doi":"10.23736/S2724-5276.25.07848-6","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07848-6","url":null,"abstract":"<p><p>Acute viral respiratory infections, usually the common cold, precede the acute post-viral cough (APVC): a common complaint in childhood and adolescence. The use of cough relievers is, therefore, relevant, as documented by the market data. Several medical devices for treating APVC contain natural components. The present article reviewed the most commonly sold products in Italy. The natural agents may include polyphenols, flavonoids, saponins, glucosides, and alkaloids, contained in different botanical varieties, including Althea officinalis, Grindelia robusta, Helichrysum italicum, Plantago lanceolata, and Thymus vulgaris, and honey. Also, the European Medicine Agency (EMA) has recognized the value of some plant extracts and other natural substances to relieve APVC. These natural components are present in some products available in Italy. The Task Force on nutraceuticals and medical devices of the Italian Society of Pediatric Allergy and Immunology (SIAIP) analyzed and discussed the data concerning these products, also including honey. A few clinical studies investigated the role of non-pharmacologic remedies for APVC. Also, the evidence generally is scarce and of poor quality. Doctors should prescribe APVC natural relievers knowing their precise composition, available literature, posology, and safety. On the other hand, peripheral antitussive agents are effective and safe.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer pain in children: the before and after are important.","authors":"Alessandro Vittori, Ilaria Mascilini, Giuliano Marchetti, Riccardo Tarquini, Cecilia M Pizzo, Elisa Francia, Corrado Cecchetti","doi":"10.23736/S2724-5276.25.07883-8","DOIUrl":"https://doi.org/10.23736/S2724-5276.25.07883-8","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicomponent food supplement with quercetin Phytosome®, zinc and vitamin C may be favorable in managing children with seasonal allergic rhinitis: a pilot study.","authors":"Maria A Tosca, Chiara Ferrecchi, Vincenzo Meleca, Matteo Naso, Giorgio Ciprandi","doi":"10.23736/S2724-5276.25.07806-1","DOIUrl":"10.23736/S2724-5276.25.07806-1","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"279-280"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intranasal multicomponent medical device (Saflovir®) may represent a valuable option in managing upper airways diseases.","authors":"Giorgio Ciprandi, Lorenzo Drago, Ignazio LA Mantia, Maria A Tosca","doi":"10.23736/S2724-5276.25.07788-2","DOIUrl":"10.23736/S2724-5276.25.07788-2","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"193-196"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}