Minerva PediatricsPub Date : 2024-11-07DOI: 10.23736/S2724-5276.24.07712-7
Zedong Bian, Yong Zhi, Geng Xiong, Yi Tan, Ming Liu
{"title":"The efficacy and safety of laparoscopic pyeloplasty via abdominal approach for the treatment of ureteropelvic junction obstruction in children.","authors":"Zedong Bian, Yong Zhi, Geng Xiong, Yi Tan, Ming Liu","doi":"10.23736/S2724-5276.24.07712-7","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07712-7","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-11-05DOI: 10.23736/S2724-5276.24.07696-1
Aysan Moeinafshar, Raha Zamani, Nima Rezaei
{"title":"Association between IL-1 single nucleotide polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis.","authors":"Aysan Moeinafshar, Raha Zamani, Nima Rezaei","doi":"10.23736/S2724-5276.24.07696-1","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07696-1","url":null,"abstract":"<p><strong>Introduction: </strong>Juvenile idiopathic arthritis (JIA) is one of the most common chronic diseases of childhood and presents with various clinical phenotypes. A multifactorial and complex interaction of genetic and environmental factors are responsible for JIA, of which the proinflammatory cytokine genes are of particular research interest. This meta-analysis investigates the association between IL-1A and IL-1B gene polymorphisms and susceptibility to JIA.</p><p><strong>Evidence acquisition: </strong>A total of eight studies, involving 1633 patients and 2309 controls were included, and a meta-analysis was performed on the association between IL1A -889 C/T, IL1B -511 C/T, and IL1B +3954 C/T, and susceptibility to JIA.</p><p><strong>Evidence synthesis: </strong>There was no significant association between the presence of IL1A -889 C/T, IL1B -511 C/T, and IL1B +3954 C/T polymorphisms and JIA, under any genetic model or in any ethnicity subgroups.</p><p><strong>Conclusions: </strong>Results of this study suggest that these three IL-1 variants do not increase the susceptibility to JIA. However, the limited number of studies and the considerable level of heterogeneity must be taken into account before interpretation.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-31DOI: 10.23736/S2724-5276.24.07691-2
Gian L Marseglia, Daniele Veraldi, Giorgio Ciprandi
{"title":"Management of children with acute post-viral cough: a primary care experience with levodropropizine.","authors":"Gian L Marseglia, Daniele Veraldi, Giorgio Ciprandi","doi":"10.23736/S2724-5276.24.07691-2","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07691-2","url":null,"abstract":"<p><strong>Background: </strong>Acute post-viral cough (APVC) is a disturbing complaint that may also affect the quality of life. As a result, APVC requires an adequate managing with antitussive medications. In this regard, levodropropizine is an effective and safe peripheral antitussive drug.</p><p><strong>Methods: </strong>The present retrospective observational study collected data from children with APVC and treated with levodropropizine for up to seven days. Cough intensity and frequency, impact on children's and parents' sleep, school and games, treatment days, satisfaction, and adverse events were considered.</p><p><strong>Results: </strong>Data from 92 children (mean age 5.5 years) were analyzed globally. Levodropropizine reduced cough intensity and frequency in most children and improved school and game activities and sleep quality in children and their parents. The treatment was safe. Most parents were highly satisfied with the results.</p><p><strong>Conclusions: </strong>This experience showed that levodropropizine was an effective and safe remedy for children with acute post-viral cough.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-10DOI: 10.23736/S2724-5276.24.07639-0
Baican Wang, Yongyu Lou
{"title":"Clinical study of pit and fissure sealant combined with light-cured flowable resin in prevention of dental caries in children.","authors":"Baican Wang, Yongyu Lou","doi":"10.23736/S2724-5276.24.07639-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07639-0","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-07DOI: 10.23736/S2724-5276.24.07648-1
Chunling Zhang, Jianmei Tian
{"title":"The impact of empowerment-based fine-grained nursing model on nursing outcomes, compliance, and sleep quality of pediatric pneumonia patients.","authors":"Chunling Zhang, Jianmei Tian","doi":"10.23736/S2724-5276.24.07648-1","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07648-1","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-07DOI: 10.23736/S2724-5276.24.07593-1
Alexandra L Ribeiro, Madalena V Hafe, Joana Torgal, Inês F Azevedo, Paula M Guerra
{"title":"Perceived impact of pediatric palliative care: caregiver's perspective.","authors":"Alexandra L Ribeiro, Madalena V Hafe, Joana Torgal, Inês F Azevedo, Paula M Guerra","doi":"10.23736/S2724-5276.24.07593-1","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07593-1","url":null,"abstract":"<p><strong>Background: </strong>Caregivers of children with complex chronic diseases (CCD) or life-limiting conditions (LLC) experience heightened strain. Understanding their concerns is essential for effective support, particularly in pediatric palliative care (PPC) where compassionate support is crucial. Amid substantial growth in PPC services in Portugal, assessing the effectiveness of care in addressing these concerns and adapting to the evolving needs of parents is imperative. The aim of this study was to perceive the impact of PPC from the caregivers' perspective.</p><p><strong>Methods: </strong>Participants consisted of children with CDD or LLC and their caregivers followed by the PPC team. Institutionalized children were excluded. Our mixed-methods study involved analyzing sociodemographic characteristics and assessing caregiver and child well-being using quantitative data and explored caregiver concerns and the impact of PPC through qualitative data obtained from semi-structured interviews.</p><p><strong>Results: </strong>We included 43 children and caregivers. Caregivers (90.6% mothers; mean age 40) often experience fatigue (90.7%) although they rarely feel exhausted (67.4%). Sleep disturbances (58.1%) are the children's most frequent perceived symptom. Seven categories emerge from caregivers' concerns. Among the five categories arising from caregivers' perceived impact of PPC integration, 95.3% prioritize enhanced contact with healthcare professionals. Increased support to facilitate caregiver rest and early referral emerges as primary suggestions for improving PPC.</p><p><strong>Conclusions: </strong>The PPC appears to be effective in alleviating parents' primary concerns, highlighting the crucial importance of early referral. Implementing strategies to provide respite for caregivers and closer monitoring of these children becomes a priority to improve the quality of life for this inherently intertwined dyad, the child-family unit.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-07DOI: 10.23736/S2724-5276.24.07664-X
Xiaojuan Luo, Ke Cao, Yan Zhang, Xiaoning Mao, Xueyan Chen
{"title":"The identification of a novel hemizygous interleukin 2 receptor subunit gamma (IL2RG) mutation following vaccination in a pediatric patient with X-linked severe combined immunodeficiency.","authors":"Xiaojuan Luo, Ke Cao, Yan Zhang, Xiaoning Mao, Xueyan Chen","doi":"10.23736/S2724-5276.24.07664-X","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07664-X","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-07DOI: 10.23736/S2724-5276.24.07548-7
Marco Monticone, Barbara Rocca, Fulvio Dal Farra
{"title":"The contribution of physical exercise to leukemia and lymphoma in children: a scoping review.","authors":"Marco Monticone, Barbara Rocca, Fulvio Dal Farra","doi":"10.23736/S2724-5276.24.07548-7","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07548-7","url":null,"abstract":"<p><strong>Introduction: </strong>The overall contribution of physical exercise on the management of disabling consequences of leukemia and lymphoma in children is missing. The aim of this scoping review (ScoR) was to systematically collect, map and present the current research evidence concerning studies reporting data on physical exercise among children with leukemia and lymphoma.</p><p><strong>Evidence acquisition: </strong>This ScoR was performed by adopting recommendations of the 2020 version of the \"Joanna Briggs Institute Methodological Guidance\", along with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews. PubMed, Scopus, and the Central (Cochrane) were searched up to December 2023. Original studies were included, and results were presented numerically and thematically.</p><p><strong>Evidence synthesis: </strong>One hundred twelve articles were identified through the search; 14 studies met the inclusion criteria. Publications have increased over the years. Most of the studies were conducted in Western countries. 11 articles (79%) owned to primary research (seven RCTs, and four observational studies), and 3 studies (21%) were systematic reviews. The overall sample size was of 293 individuals. 1 study included a mixed population of leukemias and lymphomas, while the others included only children with leukemia. The features of physical exercise were well described, including details on duration of treatment, frequency of exercises sessions, and duration of sittings.</p><p><strong>Conclusions: </strong>The studies indicated physical exercise as a contributor to the improvement of motor abilities and quality of life. More studies including outcome measures that assess disability are recommended. More evidence on the impact of physical exercise in children with lymphoma is needed.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva PediatricsPub Date : 2024-10-07DOI: 10.23736/S2724-5276.24.07556-6
Federico Mecarini, Giorgio Bracaglia
{"title":"Prospective, randomized, double-blind trial to validate the efficacy of an oral herbal gel on pain in the newborn during minor diagnostic-therapeutic procedures.","authors":"Federico Mecarini, Giorgio Bracaglia","doi":"10.23736/S2724-5276.24.07556-6","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07556-6","url":null,"abstract":"<p><strong>Background: </strong>Term and preterm infants are frequently exposed to painful procedures and stimuli during hospitalization in the Neonatal Intensive Care Unit (NICU). Pain is widely recognized to cause short- and long-term effects in the newborn. In recent years there has been a growing medical interest and a strong demand from parents for phytotherapeutic drugs, but literature data are limited, and excellent methodological studies are necessary to evaluate the importance of phytotherapy in the neonatal period.</p><p><strong>Methods: </strong>We evaluated the use of an oral phytotherapeutic gel based on chamomile, angelica and oats in the management of full term and preterm infant pain caused by minor diagnostic or therapeutic procedures. We enrolled full term infants (>37 weeks gestational age [GA]) and preterm infants with higher GA than 28 weeks, weighing more than 1000 grams. Assessed painful procedures were minor diagnostic or therapeutic ones. Newborns were double-blind randomized into two groups (A and B) to orally receive the phytotherapeutic gel (solution A) and a gel of the same consistency and aroma (solution B) before the painful procedure.</p><p><strong>Results: </strong>The group of newborns to whom solution A had been administered showed significantly lower scores in the Pain Scale (P<0.01) during painful procedure. This figure indicates that the herbal medicine has been effective in reducing pain experience in the population of examined newborns.</p><p><strong>Conclusions: </strong>To the best of our literature research, our work is the first scientific study highlighting the possibility of preventive beneficial effects of phytotherapeutic drugs on pain control.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}