Minerva Pediatrics最新文献

{"title":"New boundaries in neurodevelopmental disorders.","authors":"Elisa Fazzi","doi":"10.23736/S2724-5276.24.07652-3","DOIUrl":"10.23736/S2724-5276.24.07652-3","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of melatonin vs. midazolam for oral premedication in children: a systematic review and meta-analysis.","authors":"Vrushali C Ponde, Neha Singh, Anuya Gursale, Anagha Patil, Airu Chia, Harikrishna Balasubramanian, Balakrishnan Ashokka","doi":"10.23736/S2724-5276.24.07519-0","DOIUrl":"10.23736/S2724-5276.24.07519-0","url":null,"abstract":"<p><strong>Introduction: </strong>Achieving appropriate levels of premedication and parental separation is needed for smooth induction of anesthesia and prevention of perioperative complications. Both melatonin and midazolam are used for the premedication in children, but we do not have consensus on which premedication is superior among them.</p><p><strong>Evidence acquisition: </strong>A systematic review of randomized controlled trials comparing the efficacy and safety of use of midazolam and melatonin as premedication in children aged 1-15 years was conducted. Patients who received drugs other than melatonin or midazolam as premedication were excluded. PubMed, Embase, Scopus, Google Scholar were searched and the last search was done in December 2022.</p><p><strong>Evidence synthesis: </strong>Full text of ten articles with a total of 774 participants (442 melatonin, 332 midazolam) were eligible. The data extracted were synthesized after quality assessment. The outcomes appraised included: sedation, anxiety in preoperative room and during induction. Among four studies examining sedation, there were no significant differences between melatonin and midazolam (SMD=0.03, 95% CI - 0.35 to 0.40, P=0.88, I²⁼81%). There were no significant differences between melatonin and midazolam among two studies examining anxiety in pre-operative room (SMD=-0.04, 95% CI -4.58,4.50, P=0.99, I²⁼0%) and anxiety during anesthesia induction as an outcome (SMD=-1.38, 95% CI -4.81 to 2.05, P=0.43, I²⁼0%).</p><p><strong>Conclusions: </strong>The review showed that melatonin is comparable to midazolam in achieving sedation for facilitating inhalational induction in pediatric patients. The review showed no significant difference in reduction of anxiety in the preoperative room and during induction of anesthesia when either melatonin or midazolam is used as premedicants. Heterogeneity in premedication doses, parameters assessed, outcomes measured, and scales that quantify efficacy resulted in the inconsistencies in how the medications were compared and hence resulted in difficulties in data synthesis. Future studies comparing efficacy of premedication need to consider the proposed standardizations in methodology for achieving optimal results that are a fair comparison of the two medications.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"94-104"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal alcohol spectrum disorders: where we have come from, trends, and future directions.","authors":"Alan Price, Clare Allely, Raja Mukherjee","doi":"10.23736/S2724-5276.24.07365-8","DOIUrl":"10.23736/S2724-5276.24.07365-8","url":null,"abstract":"<p><p>Fetal alcohol spectrum disorder (FASD) refers to a range of conditions caused by prenatal exposure to alcohol. First described in the 1970s as fetal alcohol syndrome, continuing progress has been made in the understanding, recognition and treatment of what is now recognized to be a range of related neurodevelopmental disorders. FASD is common, especially in countries with higher levels of alcohol consumption such as those in Europe and North America, where the prevalence is estimated to be around 3%. A number of diagnostic systems are in operation in different countries, and work is ongoing to develop an internationally agreed set of diagnostic criteria. People with FASD often have other developmental, mental and somatic conditions, and there appears to be a high rate of traumatic and other adverse experiences in this population. People with FASD are at increased risk of being involved in the criminal justice system, but they may be ill-equipped to successfully navigate it and are likely to provide false confessions, leading to wrongful convictions. Some interventions and treatments have been shown to be effective in improving functioning in children and families affected by FASD, which tend to take the form of coaching, education, advocacy and support. People with FASD have many strengths, which are often overlooked in research. They have been described as skilled musicians, artists and sportspeople with wide vocabularies who are resilient, compassionate, hard-working, and kind. Increasing attention is being paid to FASD but this is not enough. More research, diagnostic capacity, recognition, understanding, infrastructure and support are needed across the world.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"68-86"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying inborn errors of immunity to understand the pathogenic mechanisms underlying highly prevalent immune-mediated diseases.","authors":"Riccardo Castagnoli, Francesca Cenzato, Ivan Taietti, Amelia Licari, Gian L Marseglia","doi":"10.23736/S2724-5276.24.07668-7","DOIUrl":"10.23736/S2724-5276.24.07668-7","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"4-6"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing for reconstructive surgery in Hirschsprung disease.","authors":"Alessio Pini Prato, Enrico Felici","doi":"10.23736/S2724-5276.24.07508-6","DOIUrl":"10.23736/S2724-5276.24.07508-6","url":null,"abstract":"<p><strong>Introduction: </strong>Debate exists regarding the ideal timing for surgery in Hirschsprung disease (HSCR) in various groups of age. The aim of this paper was to suggest a possible strategy to determine the optimal timing for reconstructive surgery in patients affected by HSCR.</p><p><strong>Evidence acquisition: </strong>A systematic literature search of papers published on PubMed and Embase during the last decade, addressing \"Hirschsprung,\" \"preoperative enterocolitis,\" \"preoperative mortality,\" \"complications,\" and \"timing\" in all possible combinations, was performed.</p><p><strong>Evidence synthesis: </strong>A total of 10 out of 170 identified papers addressed this issue in detail and were subsequently assessed for in-depth analysis. Our review confirmed that the most important issue to guide surgical timing is represented by HSCR Associated Enterocolitis (HAEC). Most authors suggest performing pull-through at around 3 months of age after effective bowel decompression, which should not be continued indefinitely to avoid complications.</p><p><strong>Conclusions: </strong>Based on this systematic review we suggest the following: 1) healthy neonates should undergo surgical reconstruction at 3 months of age; 2) urgent surgery (levelling enterostomy) might be required in critically unwell patients, those with Total Colonic HSCR, or those in whom nursing proved to be ineffective; 3) surgery can be safely postponed only in older patients with a lower likelihood of HAEC (i.e. without previous HAEC occurrences) always avoiding long-lasting rectal irrigations.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"87-93"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of food-specific antibody IgG4 testing in pediatric allergic diseases.","authors":"Yan Ma, Yuhao He, Renpeng Jiang","doi":"10.23736/S2724-5276.24.07647-X","DOIUrl":"10.23736/S2724-5276.24.07647-X","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"107-109"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for standardization in the diagnosis and management of food protein-induced allergic proctocolitis (FPIAP): the time has come to act.","authors":"Maurizio Mennini, Enrico Felici, Giovanni DI Nardo","doi":"10.23736/S2724-5276.24.07650-X","DOIUrl":"10.23736/S2724-5276.24.07650-X","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"7-9"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and drug resistance analysis of Salmonella typhimurium infection in 30 children in Zhoushan.","authors":"Yufeng Gao, Zhi Lin, Qiong Wu","doi":"10.23736/S2724-5276.24.07498-6","DOIUrl":"10.23736/S2724-5276.24.07498-6","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"105-107"},"PeriodicalIF":1.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee kinematics during gait in patients with discoid lateral meniscus: a systematic review.","authors":"Marco Turati, Filippo M Anghilieri, Olivier Daniel, Massimiliano Piatti, Giulio Leone, Nicolas Bremond, Cristiano Alessandro, Marco Crippa, Luca Rigamonti, Giovanni Zatti, Aurelien Courvoisier, Marco Bigoni","doi":"10.23736/S2724-5276.24.07335-X","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07335-X","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the difference between symptomatic discoid lateral meniscus (DLM) and healthy knees in terms of gait analysis.</p><p><strong>Evidence acquisition: </strong>A systematic review was conducted from the electronic databases PubMed/MEDLINE, EMBASE and Scopus. The review was performed on studies that reported data on kinematics, gait analysis, biomechanics in discoid lateral meniscus, before and after surgery.</p><p><strong>Evidence synthesis: </strong>Out of 127 identified items, six full-text articles were assessed for eligibility. Three of these studies were included in the quantitative synthesis. Those studies reported a significantly slower gait speed and shorter stride length, smaller excursion during weight acceptance and mid-stance phases and during the whole gait cycle, smaller maximum flexion angle in swing phase, lower frontal excursion, smaller axial excursion in the DLM groups compared to the control groups. One study reported a significative increase in the walking speed and in the stride length, increase both in the maximum knee flexion angle during stance phase and swing phase, and in the range of flexion-extension after arthroscopic surgical treatment for symptomatic DLM.</p><p><strong>Conclusions: </strong>Literature about gait analysis on DLM patients is still very scarce and heterogeneous. The few studies on this topic show a different gait pattern between DLM knees and healthy knees and are encouraging about the surgical outcomes of DLM in terms of gait. Larger and standardized studies should be designed to assess a more suitable number of subjects with DLM.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on the attitude of Italian pediatricians concerning the use of the topical nasal therapy.","authors":"Giorgio Ciprandi, Attilio Varricchio","doi":"10.23736/S2724-5276.24.07803-0","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07803-0","url":null,"abstract":"","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}