Minerva Pediatrics最新文献_第3页

An intranasal multicomponent medical device (Saflovir®) may represent a valuable option in managing upper airways diseases. 鼻内多组分医疗器械（Saflovir®）可能是治疗上呼吸道疾病的一个重要选择。

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Minerva Pediatrics Pub Date : 2025-06-01 Epub Date: 2025-02-18 DOI: 10.23736/S2724-5276.25.07788-2

Giorgio Ciprandi, Lorenzo Drago, Ignazio LA Mantia, Maria A Tosca

引用次数: 0

Metabolomics and pediatric cardiology. 代谢组学和儿科心脏病学。

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Minerva Pediatrics Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.23736/S2724-5276.25.07751-1

Roberta Pintus, Angelica Dessì, Alice Bosco, Michele Mussap, Pier P Bassareo, Vassilios Fanos

引用次数: 0

Biomarkers to predict kidney outcomes in children with IgA vasculitis. 预测IgA血管炎患儿肾脏预后的生物标志物

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Minerva Pediatrics Pub Date : 2025-06-01 Epub Date: 2025-03-25 DOI: 10.23736/S2724-5276.24.07715-2

Chloe E C Williams, Hannah Ging, Nikolaos Skoutelis, Julien Marro, Lydia Roberts, Andrew J Chetwynd, Louise Oni

{"title":"Biomarkers to predict kidney outcomes in children with IgA vasculitis.","authors":"Chloe E C Williams, Hannah Ging, Nikolaos Skoutelis, Julien Marro, Lydia Roberts, Andrew J Chetwynd, Louise Oni","doi":"10.23736/S2724-5276.24.07715-2","DOIUrl":"10.23736/S2724-5276.24.07715-2","url":null,"abstract":"Immunoglobulin A (IgA) vasculitis (IgAV, also known as Henoch-Schoenlein purpura, HSP) is a small vessel vasculitis, most commonly presenting in childhood. In most, it has a straightforward, self-limiting disease course, however some children may develop kidney involvement (IgAV-N) which occurs 4-12 weeks following disease onset and remains the biggest contributor to long-term morbidity. Therefore, children undergo a six-month period of kidney monitoring to identify nephritis via surrogate markers including urinalysis and blood pressure measurements. On-going efforts aim at earlier identification and prevention of nephritis during the window of opportunity between disease onset and established nephritis. By identifying those at highest risk of developing poorer kidney outcomes, the number of children developing chronic kidney disease stage 5 (CKD5) as a result of IgAV-N may be reduced. This review summarizes the latest scientific evidence that support the use of novel biomarkers which may allow nephritis to be identified earlier compared to traditional markers, as well as the risk stratification of children with established IgAV-N. These biomarkers may also enhance the evolving understanding of underlying inflammatory pathways. Promising novel urinary markers of early nephritis include angiotensinogen, Gd-IgA1, various complement proteins, and MCP-1, and serum markers such as α-SMA, C-Met, PTX-3, MMP-9, MRP 8/14, and adiponectin may help identify those at risk of developing CKD5. Prospective, longitudinal, international validation studies are required to investigate these markers further, including exploration of implementation into clinical practice.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"256-271"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatrics and artificial intelligence: shaping the future of child healthcare. 儿科学与人工智能：塑造儿童医疗保健的未来。

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Minerva Pediatrics Pub Date : 2025-05-08 DOI: 10.23736/S2724-5276.25.07871-1

Valentina Pucinischi, Giovanni DI Nardo, Enrico Felici, Maurizio Mennini

引用次数: 0

High risk of malignancy in neonates with cystic pulmonary abnormalities and no antenatal findings. 新生儿囊性肺异常和没有产前检查的恶性肿瘤的高风险。

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Minerva Pediatrics Pub Date : 2025-04-15 DOI: 10.23736/S2724-5276.24.07552-9

Alessia Bertolino, Riccardo Guanà, Elisa Zambaiti, Alessia Cerrina, Alessandro Pane, Salvatore Garofalo, Fabrizio Gennari, Federico Scottoni

{"title":"High risk of malignancy in neonates with cystic pulmonary abnormalities and no antenatal findings.","authors":"Alessia Bertolino, Riccardo Guanà, Elisa Zambaiti, Alessia Cerrina, Alessandro Pane, Salvatore Garofalo, Fabrizio Gennari, Federico Scottoni","doi":"10.23736/S2724-5276.24.07552-9","DOIUrl":"https://doi.org/10.23736/S2724-5276.24.07552-9","url":null,"abstract":"Background: The postnatal management of pulmonary malformations is still controversial, especially in terms of indication and timing for surgery. Despite being rare, neonatal lung tumors should be included in the differential diagnosis in case of neonatal pulmonary abnormalities. The aim of this study is to evaluate if the absence of antenatal findings should be considered a risk factor for malignancy in patients with lung abnormalities at postnatal imaging.Methods: The medical records of neonatal patients undergone surgery for pulmonary abnormalities in our hospital, over a period of 5 years (2017-2021), were retrospectively reviewed. Histological diagnosis and presence of findings at prenatal scans were recorded. A literature review on this topic was also conducted.Results: Histological diagnosis was pulmonary primary malignancy in 3 cases (2 pulmonary blastomas, 1 fetal lung interstitial tumor), the remaining 20 were diagnosed as pulmonary malformations. We recorded that 100% of our patients affected by lung tumor had no abnormalities at prenatal scans. Three papers reporting similar results were found in literature.Conclusions: Differential diagnosis among neonatal cystic abnormalities is challenging. When a cystic lung lesion is present in infants who had no abnormalities at standard antenatal scans, a malignancy should be considered.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of empowerment-based fine-grained nursing model on nursing outcomes, compliance, and sleep quality of pediatric pneumonia patients. 基于赋权的精细化护理模式对儿科肺炎患者护理效果、依从性和睡眠质量的影响。

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Minerva Pediatrics Pub Date : 2025-04-01 Epub Date: 2024-10-07 DOI: 10.23736/S2724-5276.24.07648-1

Chunling Zhang, Jianmei Tian

引用次数: 0

Survey on the attitude of Italian pediatricians concerning the use of the topical nasal therapy. 意大利儿科医生对使用局部鼻腔治疗的态度调查。

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Minerva Pediatrics Pub Date : 2025-04-01 Epub Date: 2025-01-16 DOI: 10.23736/S2724-5276.24.07803-0

Giorgio Ciprandi, Attilio Varricchio

引用次数: 0

Higher mean platelet volume is associated with pulmonary hemorrhage in very low birth weight infants. 在极低出生体重儿中，较高的平均血小板体积与肺出血有关。

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Minerva Pediatrics Pub Date : 2025-04-01 DOI: 10.23736/S2724-5276.21.06320-5

Aslihan Köse Çetinkaya, Mehmet Büyüktiryaki, Fatma N Sari, Erbu Yarci, Evrim Alyamaç Dizdar, Cüneyt Tayman, Şerife S Oğuz

{"title":"Higher mean platelet volume is associated with pulmonary hemorrhage in very low birth weight infants.","authors":"Aslihan Köse Çetinkaya, Mehmet Büyüktiryaki, Fatma N Sari, Erbu Yarci, Evrim Alyamaç Dizdar, Cüneyt Tayman, Şerife S Oğuz","doi":"10.23736/S2724-5276.21.06320-5","DOIUrl":"https://doi.org/10.23736/S2724-5276.21.06320-5","url":null,"abstract":"Background: The aim of this study was to determine whether there was an association between platelet parameters and the presence of pulmonary hemorrhage (PH) in very low birth weight infants.Methods: Fifty preterm infants who developed PH with gestational age ≤30 weeks and birth weight ≤1500 g were analyzed retrospectively. The infants with PH were matched for gestational age and birthweight with infants without PH, who served as control group. Groups were compared in terms of demographic, clinical characteristics and for the platelet parameters. Red cell distribution width to platelet ratio (RPR) and platelet mass were also calculated.Results: A total of 150 premature infants were analyzed in the study, including 50 infants with PH and 100 controls. In terms of platelet parameters, the PH group had significantly lower platelet count, mean platelet volume (MPV) and RPR (P=0.025, P<0.001, P=0.003; respectively). Multiple logistic regression analysis showed that respiratory distress syndrome (OR: 8.69; 95%[CI]: 2.71- 27.7; P<0.001) and MPV>8.1fL (OR: 2.60; 95% CI: 1.11-6.06; P=0.019) were independent risk factors for PH.Conclusions: Our data indicated that PH was associated with the presence of RDS and higher MPV in preterm infants.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":"77 2","pages":"143-147"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal ethanol exposure from sanitizers in isolettes: a bench study. 新生儿从等离子体消毒剂中摄入乙醇：一项工作台研究。

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Minerva Pediatrics Pub Date : 2025-04-01 Epub Date: 2023-02-14 DOI: 10.23736/S2724-5276.23.07089-1

Renaud Vialet, Jean-Luc Dettori, Johanna Pirello, Marjolaine Oger, Alexandre Lacoste

{"title":"Neonatal ethanol exposure from sanitizers in isolettes: a bench study.","authors":"Renaud Vialet, Jean-Luc Dettori, Johanna Pirello, Marjolaine Oger, Alexandre Lacoste","doi":"10.23736/S2724-5276.23.07089-1","DOIUrl":"10.23736/S2724-5276.23.07089-1","url":null,"abstract":"Background: Ethanol-based hand sanitizer (EBHS) is used repeatedly in neonatology. Inadequately dried hands can increase ambient ethanol concentrations in air, especially in a small, enclosed space as isolette. We sought to better document the potential exposure to alcohol vapors on a newborn placed in an isolette, by mimicking common neonatal situations.Methods: EBHS were rubbed on hands for 10 or 30 seconds, before inserting hands in the isolette of 1 or 2 experimenters for 6 minutes. Ethanol concentrations were measured every 30 seconds with photoionization detector.Results: Twenty-six trials were made, with 286 measurements. With four hands, the concentration peak was in mean about 700 (±900) ppm and with two hands about 300 ppm. With 10-second rubbing time, the concentrations peak was in mean about 850 ppm, and with 30-second rubbing time, mean concentrations were about 100 pm. When respecting normal use (rubbing time 30 seconds), observed ethanol concentrations were low, always below 200 ppm with 2 or 4 hands.Conclusions: Concentrations of ethanol are very high when drying of EHBS is incomplete. The exposure is of short duration, but ethanol inhalation may be negatively experienced by the child during procedures, especially since they may be frequent and repeated. To minimize the child's exposure to ethanol, we suggest the hands should be completely dried before being inserted into the isolette.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"117-120"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10709971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Educational therapy for caregivers of children with obstetric brachial plexus palsy: a scoping review. 产科臂丛神经麻痹患儿看护者的教育疗法：范围界定综述。

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Minerva Pediatrics Pub Date : 2025-04-01 Epub Date: 2024-10-07 DOI: 10.23736/S2724-5276.24.07611-0

Giorgia Gaiba, Patrizia Lugari, Roberto Tedeschi

{"title":"Educational therapy for caregivers of children with obstetric brachial plexus palsy: a scoping review.","authors":"Giorgia Gaiba, Patrizia Lugari, Roberto Tedeschi","doi":"10.23736/S2724-5276.24.07611-0","DOIUrl":"10.23736/S2724-5276.24.07611-0","url":null,"abstract":"Introduction: Obstetric brachial plexus palsy (OBPP), a condition resulting from the stretching of nerve structures in an infant's upper limb during childbirth, necessitates early physiotherapy intervention. Continuation of rehabilitative activities at home is critical for optimal recovery, highlighting the need for effective caregiver education in managing this condition. This scoping review seeks to consolidate and examine existing research on physiotherapy treatments for OBPP, with a specific focus on the educational support provided to caregivers. The ultimate objective is to develop an informative booklet for caregivers, offering essential guidance for home management of affected children.Evidence acquisition: A comprehensive search was conducted across PubMed, Cochrane Library, Scopus and PEDro from May to October 2023, with no restrictions on study design, evidence level, publication date, geography, or language. Articles were selected based on preset eligibility criteria.Evidence synthesis: The search yielded 13 relevant studies, encompassing a diverse range of research designs including reviews, systematic reviews, case reports, controlled trials, and a retrospective study.Conclusions: This review underscores the necessity of a personalized rehabilitation approach in treating OBPP, with parental involvement being crucial. It also identifies a gap in research regarding the long-term effectiveness of these interventions, suggesting the need for further studies to ascertain optimal treatment modalities.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":" ","pages":"178-183"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0