History and Philosophy of the Life Sciences最新文献_第4页

What teleology (if any) does the Organisational Approach naturalise? 组织方法归化了什么目的论（如果有的话）？

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-04-17 DOI: 10.1007/s40656-026-00731-8

Rebecca Riccardo Cuciniello

{"title":"What teleology (if any) does the Organisational Approach naturalise?","authors":"Rebecca Riccardo Cuciniello","doi":"10.1007/s40656-026-00731-8","DOIUrl":"10.1007/s40656-026-00731-8","url":null,"abstract":"The Organisational Approach (OA) draws from Kant's notion of natural purpose to offer a naturalistic account of teleology grounded in biological organisation, and a characterisation of biological purposiveness, i.e. what goals organisms have, and how they seek and achieve them. This paper re-examines the OA in light of two persistent issues: (1) whether organisational teleology can be causally realised in a way compatible with mechanism; and (2) how far the OA successfully extends across biological areas, development in particular. I distinguish two versions of the OA: a minimal model, focused on the self-maintenance of a stable organisation; a regulative model, which introduces regulation as a principle of teleological change. I argue that the minimal model successfully naturalises teleology, but at the price of a too narrow view of purposiveness as physiological self-maintenance. Instead, the regulative model offers a sui generis and potentially fruitful view of teleological change, blurring the boundary between physiology and development; however, it struggles to remain a naturalistic account. I introduce \"design\" and \"epigeneticity\" criteria for biological teleology to show how different ways of defining biological goals can either hinder or favour teleological naturalism, and thus the OA itself. This paper thus clarifies what kind of teleology the OA can naturalise, and where further theoretical work is required.","PeriodicalId":56308,"journal":{"name":"History and Philosophy of the Life Sciences","volume":"48 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The DSM validation method and its decision points: value judgments, metaphysical presuppositions, and validators. DSM验证方法及其决策点：价值判断、形而上的预设和验证者。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-04-15 DOI: 10.1007/s40656-026-00728-3

Antonio Rodríguez Puente

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引用次数: 0

Sorting out and navigating uncertainty in precision medicine. 精准医疗中不确定性的分类和导航。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-24 DOI: 10.1007/s40656-026-00726-5

Cornelius Borck, Simon Lohse

引用次数: 0

Overcoming medical scholasticism in New Spain: experience and indigenous knowledge in Arias de Benavides' treatment of syphilis. 克服新西班牙的医学经院哲学：阿里亚斯·德·贝纳维德斯治疗梅毒的经验和本土知识。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-23 DOI: 10.1007/s40656-025-00699-x

Manuel Méndez Alonzo, Luis Alejandro Villanueva

引用次数: 0

The Kantian background of Uexküll's notions of time and space. 论郁克烈时间与空间观念的康德背景。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-19 DOI: 10.1007/s40656-026-00722-9

Jonas Müller

引用次数: 0

Rewilding: history, intervention and the quest for immanence. 荒野回归：历史、干预和对内在的追求。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-19 DOI: 10.1007/s40656-026-00727-4

Nuria Valverde Pérez, Òscar Castro García

引用次数: 0

Sentience in the history of early plant physiology: Augustin-Pyramus de Candolle's contribution. 早期植物生理学史上的感觉：augutin - pyramus de Candolle的贡献。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-18 DOI: 10.1007/s40656-026-00723-8

Quentin Hiernaux

引用次数: 0

The experimental psychology behind coordination. 协调背后的实验心理学。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-18 DOI: 10.1007/s40656-026-00724-7

Flavia Padovani

{"title":"The experimental psychology behind coordination.","authors":"Flavia Padovani","doi":"10.1007/s40656-026-00724-7","DOIUrl":"10.1007/s40656-026-00724-7","url":null,"abstract":"In the philosophy of science, the problem of coordination concerns the difficulty of linking abstract theoretical concepts with their empirical counterparts—that is, determining how theoretical terms such as “mass” or “temperature” correspond to observable phenomena. A closely analogous issue arises in psychology in relation to the concept of construct validity, which addresses the extent to which an empirical measure accurately represents the theoretical construct it is intended to assess. From the perspective of contemporary literature on coordination and validity, Reichenbach’s interpretation of coordination stands out as uniquely engaging, not only because it offers an account involving issues of particular significance within the philosophy of measurement, but also because it originated in a less limited conceptual landscape than it is generally assumed. In this paper, I will emphasize some historical aspects underlying Reichenbach’s formulation, particularly his early engagement with experimental psychology, which underpins and strengthens the potential of the connection between the concept of coordination and that of construct validity.","PeriodicalId":56308,"journal":{"name":"History and Philosophy of the Life Sciences","volume":"48 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards functional precision medicine? Evidence standards of organoids as patient-specific models. 走向功能精准医学？类器官作为患者特异性模型的证据标准。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-03-02 DOI: 10.1007/s40656-026-00720-x

Sara Green, Henrik Vogt, Maxence Gaillard

{"title":"Towards functional precision medicine? Evidence standards of organoids as patient-specific models.","authors":"Sara Green, Henrik Vogt, Maxence Gaillard","doi":"10.1007/s40656-026-00720-x","DOIUrl":"10.1007/s40656-026-00720-x","url":null,"abstract":"Evidence-based medicine (EBM), with meta-analysis of randomized clinical trials as its gold standard, has been criticized for failing to represent the individuality and variability of disease. Precision medicine (PM) has been proposed as an alternative to EBM's \"averaging approach\", leveraging genomic and other biological information at the individual level. However, PM is still an emerging and changing concept. It is unclear what constitutes acceptable evidence, when the number of patients with a specific condition approaches one. Despite large investments, PM´s overall capacity to predict and improve treatment responses remains limited. This raises the question of whether PM has failed, or whether another strategy can improve the situation. Here, we examine the implications of functional precision medicine (FPM), a strategy aiming to bridge the gap between genomic information and phenotypic complexity through functional testing of treatments on patient-derived organoid (PDO), an advanced form of cell culture. We unpack how observed treatment effects in such personalized models are emerging as a means to predict treatment efficacy in individual patients. Drawing on exploratory interviews with scientists at the forefront of clinical implementation, we examine the philosophical implications of FPM in the contexts of cystic fibrosis and cancer. We unpack how the \"functional approach\" addresses biological complexity by black boxing many mechanistic details and focusing on phenotypic responses in PDOs. Moreover, we show that, to work as personalized models, they paradoxically must be validated by developing the same type of population-based evidence they aim to reduce reliance on.","PeriodicalId":56308,"journal":{"name":"History and Philosophy of the Life Sciences","volume":"48 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling versatility as the hallmark of model organisms. 建模多功能性作为模式生物的标志。

IF 1 3区哲学

History and Philosophy of the Life Sciences Pub Date : 2026-02-24 DOI: 10.1007/s40656-026-00718-5

Guido I Prieto, Alejandro Fábregas-Tejeda

引用次数: 0