Plants-Basel最新文献

{"title":"Tissue-Specific RNA-Seq Analysis of Cotton Roots' Response to Compound Saline-Alkali Stress and the Functional Validation of the Key Gene <i>GhERF2</i>.","authors":"Aiming Zhang, Qiankun Liu, Xue Du, Baoguang Xing, Shaoliang Zhang, Yanfang Li, Liuan Hao, Yangyang Wei, Yuling Liu, Pengtao Li, Shoulin Hu, Renhai Peng","doi":"10.3390/plants14050756","DOIUrl":"10.3390/plants14050756","url":null,"abstract":"<p><p>Saline-alkali stress is one of the major abiotic stresses threatening crop growth. Cotton, as a \"pioneer crop\" that can grow in saline and alkali lands, is of great significance for understanding the regulatory mechanisms of plant response to stresses. Upland cotton has thus become a model plant for researchers to explore plant responses to saline-alkali stresses. In this study, RNA sequencing was employed to analyze tissue-specific expression of root tissues of TM-1 seedlings 20 min after exposure to compound saline-alkali stress. The RNA-Seq results revealed significant molecular differences in the responses of different root regions to the stress treatment. A total of 3939 differentially expressed genes (DEGs) were identified from pairwise comparisons between the non-root tip and root tip samples, which were primarily enriched in pathways including plant hormone signal transduction, MAPK signaling, and cysteine and methionine metabolism. Combined with the expression pattern investigation by quantitative real-time PCR (qRT-PCR) experiments, a key gene, <i>GhERF2</i> (<i>GH_A08G1918</i>, ethylene-responsive transcription factor 2-like), was identified to be associated with saline-alkali tolerance. Through virus-induced gene silencing (VIGS), the <i>GhERF2</i>-silenced plants exhibited a more severe wilting phenotype under combined salt-alkali stress, along with a significant reduction in leaf chlorophyll content and fresh weights of plants and roots. Additionally, these plants showed greater cellular damage and a lower ability to scavenge reactive oxygen species (ROS) when exposed to the stress. These findings suggest that the <i>GhERF2</i> gene may play a positive regulatory role in cotton responses to salt-alkali stress. These findings not only enhance our understanding of the molecular mechanisms underlying cotton response to compound saline-alkali stress, but also provide a foundation for future molecular breeding efforts aimed at improving cotton saline-alkali tolerance.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Strategies for the Extraction of Antioxidants from Fruits and Their By-Products: A Systematic Review.","authors":"Kaio Vinicius Lira da Silva Bastos, Adriana Bezerra de Souza, Alessandra Cristina Tomé, Felipe de Moura Souza","doi":"10.3390/plants14050755","DOIUrl":"10.3390/plants14050755","url":null,"abstract":"<p><p>This review highlights the recent advancements in extraction techniques for bioactive compounds from natural sources, focusing on methodologies that enhance both efficiency and sustainability. Techniques such as pressurized hot water extraction (PHWE), solid-state fermentation (SSF), ionic liquids (ILs), and electrohydrodynamic (EHD) methods have shown significant potential in improving extraction yields while preserving the bioactivity of target compounds. These innovative approaches offer significant advantages over traditional methods, including reduced energy consumption, minimal environmental impact, and the ability to extract thermosensitive compounds. PHWE and EHD are particularly effective for extracting antioxidants and thermosensitive compounds, whereas SSF provides an environmentally friendly alternative by valorizing agro-industrial waste. Ionic liquids, although promising for extracting complex phytochemicals, face challenges related to scalability and economic feasibility. The adoption of these advanced techniques represents a shift toward more sustainable and cost-effective extraction processes, promoting the discovery and utilization of high-value compounds. These methods also contribute to the development of eco-friendly, cost-effective strategies that align with green chemistry principles and regulatory standards. However, further research and technological advancements are required to address existing limitations and ensure the widespread application of these methods in industrial and pharmaceutical sectors.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of a Benthic <i>Sargassum</i> Population to Increased Temperatures: Decline in Non-Photochemical Quenching of Chlorophyll a Fluorescence (NPQ) Precedes That of Maximum Quantum Yield of PSII.","authors":"Ricardo M Chaloub, Rodrigo Mariath V da Costa, João Silva, Cristina A G Nassar, Fernanda Reinert, Maria Teresa M Széchy","doi":"10.3390/plants14050759","DOIUrl":"10.3390/plants14050759","url":null,"abstract":"<p><p><i>Sargassum</i> is an important primary producer of rocky bottom communities in coastal ecosystems. Like other parts of the planet, benthic populations of <i>S. natans</i> from Ilha Grande Bay (IGB), southeastern Brazil, have been suffering from different forms of natural and anthropogenic disturbances, in particular increasing seawater temperatures. The aim of this study was to understand the effects of temperature on the photosynthetic performance of <i>S. natans</i> using the pulse amplitude modulated (PAM) fluorometry. In the field experiments, the occurrence of photoprotection resulted in a difference between the effective and maximum quantum yields [(<i>ΔF (F'_m - F_s)/F'_m</i> and <i>F_v/F_m</i>, respectively) that was maximized at noon. The stress induced by incubation at 32-35 °C caused a decrease in <i>F_v/F_m</i> by 33% on the first day and approximately 20% on subsequent days. In the laboratory, using two co-occurred species of <i>S. natans</i> and <i>Padina gymnospora</i>, we verified that the photosynthetic apparatus of <i>S. natans</i> collapses at 34 °C. The fate of the energy absorbed by photosystem II (PSII) antenna showed that, in S. natans, photochemical activity and non-photochemical quenching of chlorophyll fluorescence (NPQ) drastically decrease, and only the passive dissipation in the form of heat and fluorescence remains. Our results indicate the disappearance of the NPQ photoprotection at 34 °C before the decline of <i>F_v/F_m</i> as the reason for the collapse of photochemistry of <i>Sargassum</i>.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological Relationships Between Woody Species Diversity and Propagation Strategies of <i>Aulonemia queko</i>.","authors":"Hugo Cedillo, Luis G García-Montero, Fernando Bermúdez, Andrés Arciniegas, Mélida Rocano, Oswaldo Jadán","doi":"10.3390/plants14050744","DOIUrl":"10.3390/plants14050744","url":null,"abstract":"<p><p>This study explores how floristic composition, diversity, and woody vegetation structure vary across floristic zones in Andean montane forests under the dominance of <i>Aulonemia queko</i> Goudot (Poaceae, Bambusoideae) dominance. As a culturally and ecologically significant non-timber forest product, <i>A. queko</i> plays a key role in shaping plant communities and requires effective propagation strategies for sustainable management. Significant differences in floristic composition were observed among zones, with indicator species identified in the lower and upper zones. However, despite environmental variability, species richness and structural attributes remained stable across the elevation gradient, suggesting resilience in woody plant communities. <i>A. queko</i> density was highest in the upper zone, while its basal area peaked in the lower and middle zones, probably shaping floristic composition through competitive interactions and habitat modification. Propagation experiments revealed that shoots with rhizomes exhibited higher survival and growth, particularly in mulch substrates with 1000 ppm indole-3-butyric acid (IBA), highlighting the importance of shoot type, substrate, and hormone dose. These findings suggest that <i>A. queko</i> is a structuring species and a potential restoration target. However, its dominance may alter forest composition, requiring adaptive management strategies that balance its ecological role with conservation and sustainable use, ensuring biodiversity and ecosystem resilience.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrogen Acquisition by Invasive Plants: Species Preferential N Uptake Matching with Soil N Dynamics Contribute to Its Fitness and Domination.","authors":"Xingang Chang, Wenying Wang, Huakun Zhou","doi":"10.3390/plants14050748","DOIUrl":"10.3390/plants14050748","url":null,"abstract":"<p><p>Plant invasions play a significant role in global environmental change. Traditionally, it was believed that invasive plants absorb and utilize nitrogen (N) more efficiently than native plants by adjusting their preferred N forms in accordance with the dominant N forms present in the soil. More recently, invasive plants are now understood to optimize their N acquisition by directly mediating soil N transformations. This review highlights how exotic species optimize their nitrogen acquisition by influencing soil nitrogen dynamics based on their preferred nitrogen forms, and the various mechanisms, including biological nitrification inhibitor (BNI) release, pH alterations, and changes in nutrient stoichiometry (carbon to nitrogen ratio), that regulate the soil nitrogen dynamics of exotic plants. Generally, invasive plants accelerate soil gross nitrogen transformations to maintain a high supply of NH₄⁺ and NO₃^- in nitrogen-rich ecosystems irrespective of their preference. However, they tend to minimize nitrogen losses to enhance nitrogen availability in nitrogen-poor ecosystems, where, in such situations, plants with different nitrogen preferences usually affect different nitrogen transformation processes. Therefore, a comprehensive understanding requires more situ data on the interactions between invasive plant species' preferential N form uptake and the characteristics of soil N transformations. Understanding the combination of these processes is essential to elucidate how exotic plants optimize nitrogen use efficiency (NUE) and minimize nitrogen losses through denitrification, leaching, or runoff, which are considered critical for the success of invasive plant species. This review also highlights some of the most recent discoveries in the responses of invasive plants to the different forms and amounts of N and how plants affect soil N transformations to optimize their N acquisition, emphasizing the significance of how plant-soil interactions potentially influence soil N dynamics.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultivars and Their Developmental Phases Interact with Temperature Fluctuations to Modulate Growth, Productivity and Seed Tuber Physiology of Potatoes (<i>Solanum tuberosum</i> L.).","authors":"Morgan D Southern, Mohan G N Kumar, Jacob M Blauer","doi":"10.3390/plants14050750","DOIUrl":"10.3390/plants14050750","url":null,"abstract":"<p><p>In view of raising concerns of climate change, the impact of temperature on potato (<i>Solanum tuberosum</i> L.) growth and productivity was investigated by planting at different times to expose plants to natural variations in air and soil temperatures. Over two seasons with differing temperature patterns, emergence, stem and tuber numbers, tuber size distribution, yield, processing quality, and seed tuber behavior were analyzed. Postharvest, tubers from each planting were stored and replanted to assess temperature carryover effects. Generally, delayed plantings increased the average number of stems per plant (37%) but did not alter the tuber numbers per plant. Early (18 April) and mid-season (9 May) plantings produced higher yields, while late planting (30 May) reduced total yield (42%), US No. 1 yield (48%), and tuber numbers (34%). Moreover, the storage period influenced subsequent stems per plant more than the prior-year temperature conditions. Optimal productivity was achieved by planting during cooler establishment temperatures, followed by warmer tuberization and relatively cooler bulking temperatures. Diurnal temperature variations and growing degree days had minimal effects on stems per plant, whereas storage duration (chronological age) and temperature significantly impacted physiological aging. These findings help growers optimize planting times to enhance tuber storability and yield to improve end use.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identity Transitions of Tapetum Phases: Insights into Vesicular Dynamics and in Mortem Support During Pollen Maturation.","authors":"Gabriel Luis L S Moreira, Maria Eduarda P Ferreira, Francisco S Linhares","doi":"10.3390/plants14050749","DOIUrl":"10.3390/plants14050749","url":null,"abstract":"<p><p>Flower development progresses through twelve distinct stages, meticulously regulated to optimize plant reproductive success. At stage 5, the initiation of anther development occurs, which is further categorized into 14 stages divided into two defined phases: phase 1, known as microsporogenesis, and phase 2, termed microgametogenesis-encompassing pollen maturation and anther dehiscence. The maturation of pollen grains must be temporally synchronized with anther dehiscence, with auxin serving as a pivotal spatio-temporal link between these processes, coordinating various aspects of anther development, including stamen elongation, anther dehiscence, and tapetum development. The tapetum, a secretory tissue adjacent to the meiocytes, is essential for nurturing developing pollen grains by secreting components of the pollen wall and ultimately undergoing programmed cell death (PCD). This review primarily focuses on microgametogenesis, the identity and function of the tapetum during the different progression phases, the role of vesicular signaling in delivering external components crucial for pollen grain maturation, and the distinctive process of PCD associated with these developmental processes.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics and Expression Analysis of CHI Gene Family in Sweet Potato.","authors":"Yaqin Wu, Xiaojie Jin, Lianjun Wang, Chong Wang, Jian Lei, Shasha Chai, Wenying Zhang, Xinsun Yang, Rui Pan","doi":"10.3390/plants14050752","DOIUrl":"10.3390/plants14050752","url":null,"abstract":"<p><p>Chalcone isomerase (CHI) is not only an enzyme related to flavonoid biosynthesis, but also one of the key enzymes in the flavonoid metabolic pathway. In this study, members of the CHI gene family were identified in the whole genome of sweet potato. Bioinformatics methods were used to analyze the physical and chemical properties, systematic evolution, conserved domain, chromosome location, cis-acting elements of the promoter, and so on, of CHI gene family members. In addition, the tissue site-specific expression of CHI gene family members and their expression patterns under three kinds of abiotic stress were analyzed. The results showed that five members of IbCHI gene family were identified in sweet potato, which were unevenly distributed on four chromosomes. The protein secondary structure and tertiary structure were consistent, and there was a conservative domain related to chalcone isomerase. The prediction of subcellular localization showed that it was mainly located in cytoplasm and chloroplast. Systematic evolution showed that the members of sweet potato CHI gene family could be divided into Type I-IV, and the Type I gene <i>IbCHI1</i> showed CHI catalytic activity in transgenic callus. The collinearity gene pairs were identified between sweet potato and allied species. Its promoter contains light response elements, hormone response elements, and stress response elements. The results of real-time fluorescence quantitative PCR (qRT-PCR) analysis showed that the expression of the IbCHI gene was tissue-specific and that the catalytic genes <i>IbCHI1</i> and <i>IbCHI5</i> serve as primary responders to abiotic stress, while the non-catalytic members <i>IbCHI3</i> and <i>IbCHI4</i> may fine-tune metabolic flux or participate in low-temperature, salt, and drought stress signaling. This study can provide a theoretical basis for a follow-up functional genomics study of the chalcone isomerase gene family in sweet potato.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitin Ligase Gene <i>OsPUB57</i> Negatively Regulates Rice Blast Resistance.","authors":"Jian Zhang, Qiang Du, Yugui Wu, Mengyu Shen, Furong Gao, Zhilong Wang, Xiuwen Xiao, Wenbang Tang, Qiuhong Chen","doi":"10.3390/plants14050758","DOIUrl":"10.3390/plants14050758","url":null,"abstract":"<p><p>The ubiquitination and degradation of proteins are widely involved in plant biotic and abiotic stress responses. E3 ubiquitin ligases play an important role in the ubiquitination of specific proteins. In this study, we identified the function of a U-box E3 ubiquitin ligase gene <i>OsPUB57</i> in rice. Expression analyses revealed that <i>OsPUB57</i> was mainly expressed in the aboveground part of rice. Drought, salt, cold, JA (jasmonic acid), PAMPs (pathogen-associated molecular patterns) or <i>Magnaporthe</i><i>oryzae</i> treatment could significantly suppress the expression of <i>OsPUB57</i> in rice. Compared with wild-type plants, <i>OsPUB57</i>-overexpressing plants showed a decrease in resistance to <i>M. oryzae</i>, while the mutant plants exhibited an enhancement of <i>M. oryzae</i> resistance. The expression level detection indicated that <i>OsPUB57</i> negatively regulates rice blast resistance, probably by down-regulating the expression of the defense-related genes <i>OsPR1a</i> and <i>OsAOS2</i>. This study provides a candidate gene for the genetic improvement of rice blast resistance.</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoespintanol Isolated from <i>Oxandra</i> cf. <i>xylopioides</i> (Annonaceae) Leaves Ameliorates Pancreatic Dysfunction and Improves Insulin Sensitivity in Murine Model of Fructose-Induced Prediabetes.","authors":"Sherley Catherine Farromeque Vásquez, Luisa González Arbeláez, Benjamín Rojano, Guillermo Schinella, Bárbara Maiztegui, Flavio Francini","doi":"10.3390/plants14050745","DOIUrl":"10.3390/plants14050745","url":null,"abstract":"<p><p>In rats, a fructose-rich diet triggers endocrine-metabolic disturbances similar to those present in human prediabetes. We evaluated the protective effect of isoespintanol, a monoterpene isolated from <i>Oxandra</i> cf. <i>xylopioides</i> (Annonaceae), on pancreatic islet. Rats were kept for three weeks with a standard commercial diet and tap water (C), plus 10% fructose (F), or F plus isoespintanol (I; 10 mg/kg, <i>i.p</i>.). Glycemia, triglyceridemia, total cholesterol, HDL-cholesterol, insulin resistance index (IRX), and glucose tolerance tests were determined. Glucose-stimulated insulin secretion (GSIS) and gene expression of insulin signalling mediators (insulin receptor -<i>IR-, IRS1/2, PI3K</i>), oxidative stress (<i>SOD-2, GPx, GSR</i>, 3'-nitrotyrosine), inflammation (<i>TNF-α, IL-1β, PAI-1</i>), mitochondrial function (<i>Bcl-2, mtTFA, PGC-1α</i>), and apoptosis markers were evaluated in pancreatic islets. The F group increased triglyceridemia, non-HDL-cholesterol, and IRX, and decreased HDL-cholesterol and impaired glucose tolerance, with alterations reversed by isoespintanol administration (<i>p</i> < 0.05). Isoespintanol normalized higher GSIS recorded in the F group. F decreased mRNA levels of insulin signalling mediators and mitochondrial function markers, and increased the expression of inflammatory, apoptotic, and oxidative stress markers, alterations that were significantly reversed by isoespintanol. Current results suggest that isoespintanol improved insular oxidative stress and inflammation by affecting the IR-PI3K pathway, which plays a pivotal role in insulin resistance development, underlying its therapeutic potential for the prevention of type 2 diabetes before its onset (prediabetes).</p>","PeriodicalId":56267,"journal":{"name":"Plants-Basel","volume":"14 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}