Korean Journal of Pain最新文献_第8页

Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation. 高良姜素的镇痛和抗炎作用：抑制瞬时受体电位香草素 1 受体激活的潜在途径。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-04-01 DOI: 10.3344/kjp.23363

Kaiwen Lin, Datian Fu, Zhongtao Wang, Xueer Zhang, Canyang Zhu

{"title":"Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation.","authors":"Kaiwen Lin, Datian Fu, Zhongtao Wang, Xueer Zhang, Canyang Zhu","doi":"10.3344/kjp.23363","DOIUrl":"10.3344/kjp.23363","url":null,"abstract":"Background: Galangin, commonly employed in traditional Chinese medicine for its diverse medicinal properties, exhibits potential in treating inflammatory pain. Nevertheless, its mechanism of action remains unclear.Methods: Mice were randomly divided into 4 groups for 7 days: a normal control group, a galangin-treated (25 and 50 mg/kg), and a positive control celecoxib (20 mg/kg). Analgesic and anti-inflammatory effects were evaluated using a hot plate test, acetic acid-induced writhing test, acetic acid-induced vascular permeability test, formalininduced paw licking test, and carrageenan-induced paw swelling test. The interplay between galangin, transient receptor potential vanilloid 1 (TRPV1), NF-κB, COX-2, and TNF-α proteins was evaluated via molecular docking. COX- 2, PGE2, IL-1β, IL-6, and TNF-α levels in serum were measured using ELISA after capsaicin administration (200 nmol/L). TRPV1 expression in the dorsal root ganglion was analyzed by Western blot. The quantities of substance P (SP) and calcitonin gene-related peptide (CGRP) were assessed using qPCR.Results: Galangin reduced hot plate-induced licking latency, acetic acid-induced contortions, carrageenantriggered foot inflammation, and capillary permeability in mice. It exhibited favorable affinity towards TRPV1, NF- κB, COX-2, and TNF-α, resulting in decreased levels of COX-2, PGE2, IL-1β, IL-6, and TNF-α in serum following capsaicin stimulation. Galangin effectively suppressed the upregulation of TRPV1 protein and associated receptor neuropeptides CGRP and SP mRNA, while concurrently inhibiting the expression of NF-κB, TNF-α, COX-2, and PGE2 mRNA.Conclusions: Galangin exerts its anti-inflammatory pain effects by inhibiting TRPV1 activation and regulating COX-2, NF-κB/TNF-α expression, providing evidence for the use of galangin in the management of inflammatory pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"37 2","pages":"151-163"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee Trigona thoracica in mice. 评估无刺蜂Trigona thoracica提取的天然蜂胶对小鼠的抗镇痛活性。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-04-01 DOI: 10.3344/kjp.23318

Nurul Alina Muhamad Suhaini, Mohd Faeiz Pauzi, Siti Norazlina Juhari, Noor Azlina Abu Bakar, Jee Youn Moon

{"title":"Evaluation of the antinociceptive activities of natural propolis extract derived from stingless bee Trigona thoracica in mice.","authors":"Nurul Alina Muhamad Suhaini, Mohd Faeiz Pauzi, Siti Norazlina Juhari, Noor Azlina Abu Bakar, Jee Youn Moon","doi":"10.3344/kjp.23318","DOIUrl":"10.3344/kjp.23318","url":null,"abstract":"Background: : Stingless bee propolis is a popular traditional folk medicine and has been employed since ancient times. This study aimed to evaluate the antinociceptive activities of the chemical constituents of aqueous propolis extract (APE) collected by Trigona thoracica in a nociceptive model in mice.Methods: : The identification of chemical constituents of APE was performed using high-performance liquid chromatography (HPLC). Ninety-six male Swiss mice were administered APE (400 mg/kg, 1,000 mg/kg, and 2,000 mg/kg) before developing nociceptive pain models. Then, the antinociceptive properties of each APE dose were evaluated in acetic acid-induced abdominal constriction, hot plate test, and formalin-induced paw licking test. Administration of normal saline, acetylsalicylic acid (ASA, 100 mg/kg, orally), and morphine (5 mg/kg, intraperitoneally) were used for the experiments.Results: : HPLC revealed that the APE from Trigona thoracica contained p-coumaric acid (R2 = 0.999) and caffeic acid (R2 = 0.998). Although all APE dosages showed inhibition of acetic acid-induced abdominal constriction, only 2,000 mg/kg was comparable to the result of ASA (68.7% vs. 73.3%, respectively). In the hot plate test, only 2,000 mg/kg of APE increased the latency time significantly compared to the control. In the formalin test, the durations of paw licking were significantly reduced at early and late phases in all APE groups with a decrease from 45.1% to 53.3%.Conclusions: : APE from Trigona thoracica, containing p-coumaric acid and caffeic acid, exhibited antinociceptive effects, which supports its potential use in targeting the prevention or reversal of central and peripheral sensitization that may produce clinical pain conditions.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"37 2","pages":"141-150"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complement system: a potential target for the comorbidity of chronic pain and depression. 补体系统：慢性疼痛和抑郁症并发症的潜在靶点。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.3344/kjp.23284

Shanshan Tang, Wen Hu, Helin Zou, Qingyang Luo, Wenwen Deng, Song Cao

{"title":"The complement system: a potential target for the comorbidity of chronic pain and depression.","authors":"Shanshan Tang, Wen Hu, Helin Zou, Qingyang Luo, Wenwen Deng, Song Cao","doi":"10.3344/kjp.23284","DOIUrl":"10.3344/kjp.23284","url":null,"abstract":"The mechanisms of the chronic pain and depression comorbidity have gained significant attention in recent years. The complement system, widely involved in central nervous system diseases and mediating non-specific immune mechanisms in the body, remains incompletely understood in its involvement in the comorbidity mechanisms of chronic pain and depression. This review aims to consolidate the findings from recent studies on the complement system in chronic pain and depression, proposing that it may serve as a promising shared therapeutic target for both conditions. Complement proteins C1q, C3, C5, as well as their cleavage products C3a and C5a, along with the associated receptors C3aR, CR3, and C5aR, are believed to have significant implications in the comorbid mechanism. The primary potential mechanisms encompass the involvement of the complement cascade C1q/C3-CR3 in the activation of microglia and synaptic pruning in the amygdala and hippocampus, the role of complement cascade C3/C3a-C3aR in the interaction between astrocytes and microglia, leading to synaptic pruning, and the C3a-C3aR axis and C5a-C5aR axis to trigger inflammation within the central nervous system. We focus on studies on the role of the complement system in the comorbid mechanisms of chronic pain and depression.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"91-106"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of high-voltage, long-duration pulsed radiofrequency for the treatment of acute herpes zoster-related trigeminal neuralgia in a patient with permanent pacemaker. 高压、长效脉冲射频治疗带永久起搏器的急性带状疱疹相关三叉神经痛的疗效。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-04-01 DOI: 10.3344/kjp.23324

Li-Mei Li, Xiao-Dong Liu, Yue Liu, Ting-Ting Liu, Zhi-Li Zhang

引用次数: 0

Increasing opioid prescription in Korea: a pressing public health concern and necessitating initiatives. 韩国阿片类药物处方的增加：紧迫的公共卫生问题和必要的举措。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 DOI: 10.3344/kjp.23349

Francis Sahngun Nahm

引用次数: 0

A comprehensive overview and scope of interventional pain management. 介入疼痛治疗的全面概述和范围。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 DOI: 10.3344/kjp.24076

Daehyun Jo

引用次数: 0

Comparison of international medical costs for interventional pain treatment: a focus on Korea and Japan. 介入性疼痛治疗的国际医疗成本比较：以韩国和日本为重点。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 Epub Date: 2023-12-11 DOI: 10.3344/kjp.23254

Eun Young Lee, Hyung-Sun Won, Miyoung Yang, Hyungtae Kim, Yeon-Dong Kim

{"title":"Comparison of international medical costs for interventional pain treatment: a focus on Korea and Japan.","authors":"Eun Young Lee, Hyung-Sun Won, Miyoung Yang, Hyungtae Kim, Yeon-Dong Kim","doi":"10.3344/kjp.23254","DOIUrl":"10.3344/kjp.23254","url":null,"abstract":"Background: The rise in national health care costs has emerged as a global problem given the ever-aging population and rapid development of medical technology. The utilization of interventional pain management has, similarly, shown a continued rise worldwide. This study evaluates the differences in the medical costs in the field of interventional pain treatment (IPT) between two countries: Korea and Japan.Methods: Korean medical insurance costs for 2019 related to pain management focused on IPT were compared to those of Japan. Purchasing power parity (PPP) was used to adjust the exchange rate differences and to compare prices in consideration of the respective societies' economic power.Results: The cost of trigger point injections in Japan was 1.06 times higher than that of Korea, whereas the perineural and intraarticular injection prices were lower in Japan. The cost of epidural blocks was higher in Japan compared to Korea in both cervical/thoracic and lumbar regions. As for blocks of peripheral branches of spinal nerves, the cost of scapular nerve blocks in Japan was lower than that in Korea, given a PPP ratio 0.09. For nerve blocks in which fluoroscopy guidance is mandatory, the costs of epidurography in Japan were greater than those in Korea, given a PPP ratio 1.04.Conclusions: This is the first comparative study focusing on the medical costs related to IPT between Korea and Japan, which reveals that the costs differed along various categories. Further comparisons reflecting more diverse countries and socio-economic aspects will be required.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"51-58"},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity. 西他列汀在动物模型中的抗炎和抗痛觉作用以及抗痛觉活性的可能机制。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.3344/kjp.23262

Valiollah Hajhashemi, Hossein Sadeghi, Fatemeh Karimi Madab

{"title":"Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity.","authors":"Valiollah Hajhashemi, Hossein Sadeghi, Fatemeh Karimi Madab","doi":"10.3344/kjp.23262","DOIUrl":"10.3344/kjp.23262","url":null,"abstract":"Background: Sitagliptin is an antidiabetic drug that inhibits dipeptidyl peptidase-4 enzyme. This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin in formalin and carrageenan tests and determine the possible mechanism(s) of its antinociceptive activity.Methods: Male Swiss mice (25-30 g) and male Wistar rats (180-220 g) were used for formalin and carrageenan tests, respectively. In the formalin test, paw licking time and in the carrageenan test, paw thickness were considered as indexes of pain behavior and inflammation respectively. Three doses of sitagliptin (2.5, 5, and 10 mg/kg) were used in these tests. Also, several antagonists and enzyme inhibitors were used to evaluate the role of adrenergic, serotonergic, dopaminergic, and opioid receptors as well as the NO/cGMP/KATP pathway in the antinociceptive effect of sitagliptin (5 mg/kg).Results: Sitagliptin showed significant antinociceptive and anti-inflammatory effects in the formalin and carrageenan tests respectively. In the carrageenan test, all three doses of sitagliptin significantly (P < 0.001) reduced paw thickness. Pretreatment with yohimbine, prazosin, propranolol, naloxone, and cyproheptadine could not reverse the antinociceptive effect of sitagliptin (5 mg/Kg), which indicates that adrenergic, opioid, and serotonin receptors (5HT2) are not involved in the antinociceptive effects. L-NAME, methylene blue, glibenclamide, ondansetron, and sulpiride were able to reverse this effect.Conclusions: NO/cGMP/KATP, 5HT3 and D2 pathways play an important role in the antinociceptive effect of sitagliptin. Additionally significant anti-inflammatory effects observed in the carrageenan test might contribute in reduction of pain response in the second phase of the formalin test.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"26-33"},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative analgesic effects of the quadratus lumborum block in pediatric patients: a systematic review and meta-analysis. 小儿腰方肌阻滞术的术后镇痛效果：系统回顾和荟萃分析。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.3344/kjp.23268

Insun Park, Jae Hyon Park, Hyun-Jung Shin, Hyo-Seok Na, Bon-Wook Koo, Jung-Hee Ryu, Ah-Young Oh

{"title":"Postoperative analgesic effects of the quadratus lumborum block in pediatric patients: a systematic review and meta-analysis.","authors":"Insun Park, Jae Hyon Park, Hyun-Jung Shin, Hyo-Seok Na, Bon-Wook Koo, Jung-Hee Ryu, Ah-Young Oh","doi":"10.3344/kjp.23268","DOIUrl":"10.3344/kjp.23268","url":null,"abstract":"Background: This study assessed the postoperative analgesic efficacy and safety of the quadratus lumborum block (QLB) in pediatric patients.Methods: Electronic databases were searched for studies comparing the QLB to conventional analgesic techniques in pediatric patients. The primary outcome was the need for rescue analgesia 12 and 24 hours after surgery. Secondary outcomes covered the Face-Legs-Activity-Cry-Consolability Scale (FLACC) scores at various time points; parental satisfaction; time to the first rescue analgesia; hospitalization time; block execution time; block failure rates, and adverse events.Results: Sixteen randomized controlled trials were analyzed involving 1,061 patients. The QLB significantly reduced the need for rescue analgesia both at 12 and 24 hours after surgery (12 hours, relative risk [RR]: 0.45; 95% confidence interval [CI]: 0.01, 0.88; 24 hours, RR: 0.51; 95% CI: 0.31, 0.70). In case of 24 hours after surgery, type 1 QLB significantly reduced the need for rescue analgesia (RR: 0.56; 95% CI: 0.36, 0.76). The QLB also exhibited lower FLACC scores at 1 hour (standardized mean difference [SMD]: -0.87; 95% CI: -1.56, -0.18) and 6 hours (SMD: -1.27; 95% CI: -2.33, -0.21) following surgery when compared to non-QLB. Among QLBs, type 2 QLB significantly extended the time until the first rescue analgesia (SMD: 1.25; 95% CI: 0.84, 1.67). No significant differences were observed in terms of parental satisfaction, hospitalization time, block execution time, block failure, or adverse events between QLB and non-QLB groups.Conclusions: The QLB provides non-inferior analgesic efficacy and safety to conventional methods in pediatric patients.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"59-72"},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facet joint disorders: from diagnosis to treatment. 面关节疾病：从诊断到治疗。

IF 2.8 3区医学

Korean Journal of Pain Pub Date : 2024-01-01 Epub Date: 2023-12-11 DOI: 10.3344/kjp.23228

Yeong-Min Yoo, Kyung-Hoon Kim

{"title":"Facet joint disorders: from diagnosis to treatment.","authors":"Yeong-Min Yoo, Kyung-Hoon Kim","doi":"10.3344/kjp.23228","DOIUrl":"10.3344/kjp.23228","url":null,"abstract":"One of the most common sources of spinal pain syndromes is the facet joints. Cervical, thoracic, and lumbar facet joint pain syndromes comprise 55%, 42%, and 31% of chronic spinal pain syndromes, respectively. Common facet joint disorders are degenerative disorders, such as osteoarthritis, hypertrophied superior articular process, and facet joint cysts; septic arthritis; systemic and metabolic disorders, such as ankylosing spondylitis or gout; and traumatic dislocations. The facet pain syndrome from osteoarthritis is suspected from a patient's history (referred pain pattern) and physical examination (tenderness). Other facet joint disorders may cause radicular pain if mass effect from a facet joint cyst, hypertrophied superior articular process, or tumors compress the dorsal root ganglion. However, a high degree of morphological change does not always provoke pain. The superiority of innervating nerve block or direct joint injection for diagnosis and treatment is still a controversy. Treatment includes facet joint injection in facet joint osteoarthritis or whiplash injury provoking referred pain or decompression in mass effect in cases of hypertrophied superior articular process or facet joint cyst eliciting radicular pain. In addition, septic arthritis is treated using a proper antibiotic, based on infected tissue or blood culture. This review describes the diagnosis and treatment of common facet joint disorders.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"3-12"},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0