Korean Journal of Pain最新文献

{"title":"Neuropathic pain feature in cancer-induced bone pain: does it matter? a prospective observational study.","authors":"Nantthasorn Zinboonyahgoon,&nbsp;Choopong Luansritisakul","doi":"10.3344/kjp.22392","DOIUrl":"https://doi.org/10.3344/kjp.22392","url":null,"abstract":"<p><strong>Background: </strong>Cancer-induced bone pain (CIBP) is considered to have both nociceptive and neuropathic components. However, the prevalence, risk factors, and impact of the neuropathic components are yet poorly understood.</p><p><strong>Methods: </strong>We estimate the prevalence of neuropathic pain (NP) features in patients with CIBP at a tertiary care pain clinic setting using the Douleur Neuropathique 4 questionnaire and evaluate their associated factors and their impact after 4 weeks of treatment using the Brief Pain Inventory questionnaire and the Edmonton Symptom Assessment System.</p><p><strong>Results: </strong>A total of 133 patients were recruited. The estimated prevalence of NP was 30.8% (95% confidence interval: 23.6%-39.1%). Initially, the patients with NP had significantly higher average pain scores (6.00 vs. 5.05, <i>P</i> = 0.006), higher total interference scores (5.84 vs. 4.89, <i>P</i> = 0.033), and symptom distress scores (35.88 vs. 26.52, <i>P</i> = 0.002). After 4 weeks of treatment, patients in both groups reported significantly decreased pain intensity and improved quality of life. However, the patients with NP still reported significantly higher average pain (4.61 vs. 3.58, <i>P</i> = 0.048), trending toward higher total interference scores (3.52 vs. 2.99, <i>P</i> = 0.426), and symptom distress scores (23.30 vs. 20.77, <i>P</i> = 0.524). From multivariate analysis, the independent risk factors for NP were younger age, pain in the extremities, and higher average pain scores.</p><p><strong>Conclusions: </strong>NP are common in patients with CIBP. These conditions negatively affect pain intensity and the patient's quality of life before and after treatment.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"253-267"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/0a/kjp-36-2-253.PMC10043784.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of three different exercise trainings in patients with chronic neck pain: a randomized controlled study.","authors":"Besta Hazal Gumuscu,&nbsp;Eylul Pinar Kisa,&nbsp;Begum Kara Kaya,&nbsp;Rasmi Muammer","doi":"10.3344/kjp.22371","DOIUrl":"https://doi.org/10.3344/kjp.22371","url":null,"abstract":"<p><strong>Background: </strong>Neck pain is a common problem in the general population and second only to low back pain in musculoskeletal problems. The aim of this study is to compare three different types of exercise training in patients with chronic neck pain.</p><p><strong>Methods: </strong>This study was conducted on 45 patients with neck pain. Patients were divided into 3 groups: Group 1 (conventional treatment), Group 2 (conventional treatment plus deep cervical flexor training), and Group 3 (conventional treatment plus stabilization of the neck and core region). The exercise programs were applied for four weeks, three days a week. The demographic data, pain intensity (verbal numeric pain scale), posture (Reedco's posture scale), cervical range of motion ([ROM] goniometer), and disability (Neck Disability Index [NDI]) were evaluated.</p><p><strong>Results: </strong>In all groups, a significant improvement was found in terms of pain, posture, ROM, and NDI values in all groups (<i>P</i> < 0.001). Between the groups, analyses showed that the pain and posture improved more in Group 3, while the ROM and NDI improved more in Group 2.</p><p><strong>Conclusions: </strong>In addition to conventional treatment, applying core stabilization exercises or deep cervical flexor muscle training to patients with neck pain may be more effective in reducing pain and disability and increasing ROM than conventional treatment alone.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"242-252"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/15/kjp-36-2-242.PMC10043788.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9196237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term consistency of clinical sensory testing measures for pain assessment.","authors":"Pablo Bellosta-López,&nbsp;Víctor Doménech-García,&nbsp;Thorvaldur Skuli Palsson,&nbsp;Pablo Herrero,&nbsp;Steffan Wittrup Mcphee Christensen","doi":"10.3344/kjp.23011","DOIUrl":"https://doi.org/10.3344/kjp.23011","url":null,"abstract":"<p><strong>Background: </strong>Understanding the stability of quantitative sensory tests (QSTs) over time is important to aid clinicians in selecting a battery of tests for assessing and monitoring patients. This study evaluated the short- and long-term reliability of selected QSTs.</p><p><strong>Methods: </strong>Twenty healthy women participated in three experimental sessions: Baseline, 2 weeks, and 6 months. Measurements included pressure pain thresholds (PPT) in the neck, upper back, and leg; Pressure-cuff pain tolerance around the upper-arm; conditioned pain modulation during a pressure-cuff stimulus; and referred pain following a suprathreshold pressure stimulation. Intraclass correlation coefficients (ICC) and minimum detectable change (MDC) were calculated.</p><p><strong>Results: </strong>Reliability for PPT was excellent for all sites at 2 weeks (ICC, 0.96-0.99; MDC, 22-55 kPa) and from good to excellent at 6 months (ICC, 0.88-0.95; MDC, 47-91 kPa). ICC for pressure-cuff pain tolerance indicated excellent reliability at both times (0.91-0.97). For conditioned pain modulation, reliability was moderate for all sites at 2 weeks (ICC, 0.57-0.74; MDC, 24%-35%), while it was moderate at the neck (ICC, 0.54; MDC, 27%) and poor at the upper back and leg at 6 months. ICC for referred pain areas was excellent at 2 weeks (0.90) and good at 6 months (0.86).</p><p><strong>Conclusions: </strong>PPT, pressure pain tolerance, and pressure-induced referred pain should be considered reliable procedures to assess the pain-sensory profile over time. In contrast, conditioned pain modulation was shown to be unstable. Future studies prospectively analyzing the pain-sensory profile will be able to better calculate appropriate sample sizes.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"173-183"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/70/kjp-36-2-173.PMC10043786.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analgesic effect of programmed cell death protein-1.","authors":"Jong Yeon Park","doi":"10.3344/kjp.23082","DOIUrl":"https://doi.org/10.3344/kjp.23082","url":null,"abstract":"mental research paper about the heparanase and cancer pain progression was presented [1]. Heparanase treatment aggravated mechanical allodynia, cold response, and spontaneous pain. Additionally, the contents of inflammatory cytokines (TNF-α, NF-κB, IL-1β, and IL-6) was increased, and programmed death-ligand 1 (PD-L1) level was decreased in tumor tissue. Inversely, the heparanase inhibitor (SST0001) exhibited opposite results [1]. Programmed cell death protein 1, also known as PD-1, is a type I transmembrane glycoprotein and a cell surface receptor. PD-1 is broadly presented on cytotoxic T cells, regulatory T cells, B cells, natural killer cells, microglia, macrophages, and certain types of neurons [2–4]. PD-1 has a role in suppressing the inflammatory actions of T cells. Therefore, the immune system is downregulated, self-tolerance is promoted, autoimmune diseases are attenuated, and killing actions against cancer cells by the immune system could be prevented [5]. PD-1 is an essential and negatively acting regulator related to diverse biological effects and diseases, such as cancer immunotherapy, brain tumors, Alzheimer’s disease, stroke, multiple sclerosis and cognitive dysfunctions [6,7]. PD-1 signaling modulates synaptic plasticity, synaptic transmission, and neuronal excitability in neurons [2]. The neuronal signaling of PD-1 regulates pain by modulating dephosphorylating transient receptor potential subtype V1 (TRPV1) [8], GABAergic neurotransmission [4], and sodium/potassium channels [3]. In an experiment with Pd1 knockout mice, Pd1 knockout mice were more sensitive to pain stimulation than wild type mice, and it presented that PD-1 performs a crucial role in the modulation of pain [3]. Additionally, the activation of PD-1 signaling by PD-L1 is related to the regulations of μ-opioid receptor signals in the nociceptive neurons, and it enhances the antinociceptive actions of morphine [9]. Therefore, small molecular peptides targeting PD-1 could be an alternative medicine for treating chronic pain. On the other hand, PD-1 inhibitors, a newly developed class of anticancer medicine that block PD-1, could activate the immune system to attack cancer cells and could be used to treat special types of cancers [5]. For example, Pembrolizumab is a humanized IgG4 isotype antibody, and it blocks a protective mechanism of cancer cells and allows the immune system to destroy cancer cells. It targets the PD-1 receptor of lymphocytes and acts by targeting the cellular pathway of proteins, known as PD-1/PDL1, found on the immune cells and certain cancer cells. Pembrolizumab is used as an immunotherapy medicine","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"147-148"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/5f/kjp-36-2-147.PMC10043789.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of chronic pain and contributing factors: a cross-sectional population-based study among 2,379 Iranian adolescents.","authors":"Maryam Shaygan,&nbsp;Azita Jaberi,&nbsp;Marziehsadat Razavizadegan,&nbsp;Zainab Shayegan","doi":"10.3344/kjp.22336","DOIUrl":"https://doi.org/10.3344/kjp.22336","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the prevalence of chronic pain and its contributing factors among teenagers aged 12-21 years in Shiraz, Iran.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on adolescents aged 12-21 years. Demographic variables of the adolescents and their parents as well as the pain characteristics were assessed. Descriptive statistics, multinomial logistic regression, and regression models were used to describe the characteristics of the pain and its predictive factors.</p><p><strong>Results: </strong>The prevalence of chronic pain was 23.7%. The results revealed no significant difference between the male and female participants regarding the pain characteristics, except for the home medications used for pain relief. The results of a chi-square test showed that the mother's pain, education, and occupation, and the father's education were associated significantly with chronic pain in adolescents (<i>P</i> < 0.05). Multinomial logistic regression also showed the mother's history of pain played a significant role in the incidence of adolescents' chronic pain.</p><p><strong>Conclusions: </strong>The prevalence of chronic pain was relatively high in these adolescents. The results also provided basic and essential information about the contributing factors in this area. However, consideration of factors such as anxiety, depression, school problems, sleep, and physical activity are suggested in future longitudinal studies.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"230-241"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/b2/kjp-36-2-230.PMC10043785.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and reliability of various morphologic features on magnetic resonance imaging for iliotibial band friction syndrome.","authors":"Jin Kyem Kim,&nbsp;Taeho Kim,&nbsp;Hong Seon Lee,&nbsp;Dong Kyu Kim","doi":"10.3344/kjp.22399","DOIUrl":"https://doi.org/10.3344/kjp.22399","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the feasibility, inter-reader reliability, and intra-reader reliability for various morphological features reported to be related to iliotibial band friction syndrome (ITBFS) on knee magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>A total of 145 patients with a clinical diagnosis and knee MRI findings consistent with ITBFS were included in the \"study group\" and 232 patients without knee pathology on both physical examination and MRI were included in the \"control group\". Various morphologic features on knee MRI were assessed including the patella shape, patella height, lateral epicondyle anterior-posterior (AP) width, lateral epicondyle height, ITB diameter (ITB-d), and ITB area (ITB-a).</p><p><strong>Results: </strong>Patients in the study group had significantly higher lateral epicondyle height (13.9 mm <i>vs.</i> 12.92 mm, <i>P</i> = 0.003), ITB-d (2.9 mm <i>vs.</i> 2.0 mm, <i>P</i> = 0.022), and ITB-a (38.5 mm² <i>vs.</i> 23.8 mm², <i>P</i> < 0.001) than the control group. ITB-a showed higher area under the curve index (0.849 with 74.1% sensitivity and 72.4% specificity at a 30.3 mm² cutoff) than ITB-d (0.710 with 70.8% sensitivity and 61.2% specificity at 2.4 mm cutoff) and lateral epicondyle height (0.776 with 72.4% sensitivity and 67.8% specificity at 13.4 mm cutoff). However, only the interreader agreement for ITB-a (intraclass correlation coefficient = 0.65) was moderate, while the agreements for other morphologic features were good or excellent.</p><p><strong>Conclusions: </strong>Lateral epicondyle height seems to be a reliable and feasible morphologic feature for diagnosis of ITBFS.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"208-215"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/a1/kjp-36-2-208.PMC10043787.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9201815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided PENG block <i>versus</i> intraarticular corticosteroid injection in hip osteoarthritis: a randomised controlled study.","authors":"Selin Guven Kose,&nbsp;Halil Cihan Kose,&nbsp;Feyza Celikel,&nbsp;Serkan Tulgar,&nbsp;Omer Taylan Akkaya","doi":"10.3344/kjp.22325","DOIUrl":"https://doi.org/10.3344/kjp.22325","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the effectiveness of the pericapsular nerve group (PENG) block and intra-articular injection (IAI) of steroid-bupivacaine in the treatment of hip osteoarthritis (OA).</p><p><strong>Methods: </strong>After randomization, patients received either a PENG block or IAI under ultrasound-guidance. Clinical evaluations were recorded at baseline, day 1, and weeks 1, 4, and 8 post-intervention. The numerical rating scale (NRS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), Harris Hip Scale (HHS) scores, pain medication use determined by a quantitative analgesic questionnaire, and patient satisfaction were evaluated.</p><p><strong>Results: </strong>Sixty patients were included in this study. NRS scores improved significantly for both groups during the follow-up compared to pretreatment (<i>P</i> < 0.001), with better pain scores for the PENG group (<i>P</i> < 0.001) at day 1 with larger effect size (Cohen's d = 4.62), and IAI group at 4 (Cohen's d = 5.15) and 8 (Cohen's d = 4.33) weeks (<i>P</i> < 0.001). There was no significant difference in pain medication consumption (<i>P</i> = 0.499) and patient satisfaction (<i>P</i> = 0.138) between groups. Patients in the IAI group experienced significant improvement in HHS (Cohen's d = 2.16, <i>P</i> = 0.007) and WOMAC (Cohen's d = 1.02, <i>P</i> = 0.036) scores at 8 weeks compared to the PENG group.</p><p><strong>Conclusions: </strong>The ultrasound-guided PENG block provides effective pain relief which improves functionality and quality of life in hip OA patients up to 2 months. The PENG block can be considered an easy, safe, and useful alternative treatment modality for hip OA.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"195-207"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/6c/kjp-36-2-195.PMC10043791.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical strategies for the prevention and management of chronic postsurgical pain.","authors":"Bo Rim Kim,&nbsp;Soo-Hyuk Yoon,&nbsp;Ho-Jin Lee","doi":"10.3344/kjp.23080","DOIUrl":"https://doi.org/10.3344/kjp.23080","url":null,"abstract":"<p><p>Chronic postsurgical pain (CPSP) is a multifactorial condition that affects a significant proportion of patients undergoing surgery. The prevention and management of CPSP require the identification of preoperative risk factors to screen high-risk patients and establish appropriate perioperative pain management plans to prevent its development. Active postoperative pain management should be provided to prevent CPSP in patients with severe pain following surgery. These tasks have become important for perioperative team members in the management of CPSP. This review article provides a comprehensive overview of the latest research on the role of perioperative team members in preventing and managing CPSP. Additionally, it highlights practical strategies that can be employed in clinical practice, covering the definition and risk factors for CPSP, including preoperative, intraoperative, and postoperative factors, as well as a risk prediction model. The article also explores various treatments for CPSP, as well as preventive measures, including preemptive analgesia, regional anesthesia, pharmacological interventions, psychoeducational support, and surgical technique modification. This article emphasizes the importance of a comprehensive perioperative pain management plan that includes multidisciplinary interventions, using the transitional pain service as an example. By adopting a multidisciplinary and collaborative approach, perioperative team members can improve patient outcomes, enhance patient satisfaction, and reduce healthcare costs. However, further research is necessary to establish targeted interventions to effectively prevent and manage CPSP.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"149-162"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/db/kjp-36-2-149.PMC10043790.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of analgesic efficacy and safety of clonidine and methylprednisolone as additives to 0.25% ropivacaine in stellate ganglion block for the treatment of complex regional pain syndrome: a prospective randomised single blind study.","authors":"Sreyashi Naskar,&nbsp;Debesh Bhoi,&nbsp;Heena Garg,&nbsp;Maya Dehran,&nbsp;Anjan Trikha,&nbsp;Mohammed Tahir Ansari","doi":"10.3344/kjp.22299","DOIUrl":"https://doi.org/10.3344/kjp.22299","url":null,"abstract":"<p><strong>Background: </strong>The role of the sympathetic nervous system appears to be central in causing pain in complex regional pain syndrome (CRPS). The stellate ganglion block (SGB) using additives with local anesthetics is an established treatment modality. However, literature is sparse in support of selective benefits of different additives for SGB. Hence, the authors aimed to compare the efficacy and safety of clonidine with methylprednisolone as additives to ropivacaine in the SGB for treatment of CRPS.</p><p><strong>Methods: </strong>A prospective randomized single blinded study (the investigator blinded to the study groups) was conducted among patients with CRPS-I of the upper limb, aged 18-70 years with American Society of Anaesthesiologists physical status I-III. Clonidine (15 μg) and methylprednisolone (40 mg) were compared as additives to 0.25% ropivacaine (5 mL) for SGB. After medical treatment for two weeks, patients in each of the two groups were given seven ultrasound guided SGBs on alternate days.</p><p><strong>Results: </strong>There was no significant difference between the two groups with respect to visual analogue scale score, edema, or overall patient satisfaction. After 1.5 months follow-up, however, the group that received methylprednisolone had better improvement in range of motion. No significant side effects were seen with either drug.</p><p><strong>Conclusions: </strong>The use of additives, both methylprednisolone and clonidine, is safe and effective for the SGB in CRPS. The significantly better improvement in joint mobility with methylprednisolone suggests that it should be considered promising as an additive to local anaesthetics when joint mobility is the concern.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"216-229"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/5f/kjp-36-2-216.PMC10043792.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9196234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of percutaneous epidural neuroplasty using a balloon catheter in patients with chronic spinal stenosis accompanying mild spondylolisthesis: a longitudinal cohort study.","authors":"Myong-Hwan Karm,&nbsp;Chan-Sik Kim,&nbsp;Doo-Hwan Kim,&nbsp;Dongreul Lee,&nbsp;Youngmu Kim,&nbsp;Jin-Woo Shin,&nbsp;Seong-Soo Choi","doi":"10.3344/kjp.22289","DOIUrl":"https://doi.org/10.3344/kjp.22289","url":null,"abstract":"<p><strong>Background: </strong>Degenerative lumbar spondylolisthesis (DLS) is frequently associated with lumbar spinal stenosis (LSS) and conservative treatments such as epidural steroid injection do not have long-term benefits in LSS patients with DLS. This study evaluated the effectiveness of percutaneous epidural neuroplasty using a balloon catheter in patients with LSS and DLS.</p><p><strong>Methods: </strong>Patients' sex, age, body mass index, diabetes, hypertension, stenosis grading, pain duration, location, pain intensity, and medications were retrieved from electronic medical records. At 1, 3, and 6 months following the procedure, data on pain severity, medication usage, and physical functional status were analyzed. A generalized estimating equations model was used at the six-month follow-up. Patients were divided into those with DLS (the spondylolisthesis group) and those without DLS (the no spondylolisthesis group) to evaluate whether the effects of percutaneous epidural neuroplasty using a balloon catheter were different.</p><p><strong>Results: </strong>A total of 826 patients were included (spondylolisthesis: 433 patients, 52.4%; no spondylolisthesis: 393 patients, 47.6%). Age, body mass index, hypertension, pain location, and stenosis grading were statistically different between the two groups. The generalized estimating equations analyses with unadjusted and adjusted estimation revealed a significant improvement in the estimated mean numerical rating scale of pain intensities compared to that at baseline in both groups (P < 0.001). Any adverse events that occurred were minor and temporary.</p><p><strong>Conclusions: </strong>Percutaneous epidural neuroplasty using a balloon catheter may be an alternative treatment option for patients with chronic LSS, regardless of accompanying DLS, who have had failed conservative management.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 2","pages":"184-194"},"PeriodicalIF":2.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/e0/kjp-36-2-184.PMC10043794.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9207190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}