Journal of Microbiology Immunology and Infection最新文献

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Emergence of terbinafine-resistant Trichophyton indotineae dermatophytosis in a familial cluster in Taiwan: Successful management with prolonged oral itraconazole. 台湾一家族性聚集性特比萘芬耐药的吲哚毛癣菌皮肤癣的出现:长期口服伊曲康唑的成功管理。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-10 DOI: 10.1016/j.jmii.2025.07.003
Han-Tang Wang, Meng-Ling Li, Wan-Lin Wu, Chi-Jung Wu, Wei-Ting Liu
{"title":"Emergence of terbinafine-resistant Trichophyton indotineae dermatophytosis in a familial cluster in Taiwan: Successful management with prolonged oral itraconazole.","authors":"Han-Tang Wang, Meng-Ling Li, Wan-Lin Wu, Chi-Jung Wu, Wei-Ting Liu","doi":"10.1016/j.jmii.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.07.003","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced humoral and cellular immunogenicity of COVID-19 vaccines in people living with HIV: A real-world analysis. COVID-19疫苗在艾滋病毒感染者中的体液和细胞免疫原性增强:现实世界分析
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-09 DOI: 10.1016/j.jmii.2025.06.013
Tzu-Ping Weng, Ming-Chi Li, Po-Lin Chen, Ching-Lung Lo, Jia-Ling Wu, Wen-Chien Ko, Nan-Yao Lee
{"title":"Enhanced humoral and cellular immunogenicity of COVID-19 vaccines in people living with HIV: A real-world analysis.","authors":"Tzu-Ping Weng, Ming-Chi Li, Po-Lin Chen, Ching-Lung Lo, Jia-Ling Wu, Wen-Chien Ko, Nan-Yao Lee","doi":"10.1016/j.jmii.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.013","url":null,"abstract":"<p><strong>Background: </strong>Immunogenicity between mRNA and protein subunit coronavirus disease 2019 (COVID-19) vaccines in people living with HIV (PLWH) remained limited. We aimed to investigate the immunogenicity after different types of COVID-19 vaccines in PLWH and non-HIV individuals.</p><p><strong>Materials and methods: </strong>The prospective observational study encompassed PLWH and non-HIV adults after primary-booster vaccinations. Humoral immunogenicity was evaluated by serum anti-spike-protein antibody (S-Ab) titer and neutralizing antibody (Nu-Ab) activity by surrogate virus neutralization assay, while cellular immunogenicity of interferon-gamma (IFN-γ) reactivity by Covi-FERON ELISA assay. The linear mixed-effects model was used for controlling confounding variables.</p><p><strong>Results: </strong>Overall 188 PLWH and 192 non-HIV participants were enrolled. The S-Ab titers were significantly lower in PLWH than non-HIV participants after controlling for confounders (P = 0.01). In PLWH, booster with an mRNA vaccine elicited higher S-Ab titers (8,709 U/mL vs. 3,690 U/mL, P = 0.049) and a greater likelihood of Nu-Ab activity (57 % vs. 32 %, P = 0.03) than a protein subunit vaccine. Homologous mRNA/mRNA/mRNA strategy produced higher S-Ab titers (15,490 U/mL vs. 7,415 U/mL, P < 0.01) and positive Nu-Ab activity (71 % vs. 49 %, P = 0.02) than heterologous ChAdO × 1-ChAdO × 1-mRNA regimens. Cellular immunity was comparable between PLWH and non-HIV individuals, though PLWH with CD4 counts ≥200 cells/μL were more likely to exhibit reactive IFN-γ responses (99 % vs. 83 %, P = 0.04).</p><p><strong>Conclusion: </strong>Primary-booster mRNA vaccination elicited stronger humoral responses than heterologous regimens in PLWH. However, additional booster vaccines may be necessary for PLWH with low CD4 counts and diminished cellular immunity despite vaccination. These findings highlight the importance of tailored vaccination strategies for the immunocompromised population.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 71-year-old man with fever and small pulmonary nodules following repeated choking. 71岁男性,反复窒息后有发热和小肺结节。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-09 DOI: 10.1016/j.jmii.2025.06.012
Bo-Ming Huang, Wen-Chia Tsai, Po-Lin Chen
{"title":"A 71-year-old man with fever and small pulmonary nodules following repeated choking.","authors":"Bo-Ming Huang, Wen-Chia Tsai, Po-Lin Chen","doi":"10.1016/j.jmii.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.012","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiometabolic multimorbidity in aging adults with HIV: Real-world evidence from a care cohort in Taiwan. 老年HIV患者的心脏代谢多病:来自台湾护理队列的真实证据。
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-09 DOI: 10.1016/j.jmii.2025.06.011
Sheng-Jie Yeh, Chia-Wen Li, Ching-Lung Lo, Po-Lin Chen, Bo-Ming Huang, Po-Hsuan Tseng, Wen-Chien Ko, Ming-Chi Li, Nan-Yao Lee
{"title":"Cardiometabolic multimorbidity in aging adults with HIV: Real-world evidence from a care cohort in Taiwan.","authors":"Sheng-Jie Yeh, Chia-Wen Li, Ching-Lung Lo, Po-Lin Chen, Bo-Ming Huang, Po-Hsuan Tseng, Wen-Chien Ko, Ming-Chi Li, Nan-Yao Lee","doi":"10.1016/j.jmii.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.011","url":null,"abstract":"<p><strong>Background: </strong>As the population of people living with HIV (PLWH) ages, the burden of non-cardiometabolic diseases-including diabetes mellitus (DM), hypertension, and hyperlipidemia-has increased. However, data on age-specific cardiometabolic multimorbidity and real-world treatment gaps remain limited.</p><p><strong>Methods: </strong>We conducted a retrospective study of 227 PLWH aged ≥50 years at a tertiary HIV center in Taiwan, stratified into premature-old (50-64 years) and old (≥65 years) groups. We assessed prevalence, incidence, and risk factors of cardiometabolic conditions, and applied Taiwan National Health Insurance(TNHI) criteria to evaluate statin eligibility.</p><p><strong>Results: </strong>Among 227 PLWH, 182 were aged 50-64 (premature-old) and 45 were ≥65 (old). At follow-up, the prevalence of diabetes, hypertension, and hyperlipidemia reached 32.2 %, 48.5 %, and 76.2 %, respectively. Multimorbidity increased from 28.0 % to 46.7 % in premature-old group and 48.9 %-73.3 % in old group. Risk factors for DM included body mass index (BMI) ≥24.0 kg/m<sup>2</sup> and high-density lipoprotein cholesterol (HDL-C) <40 mg/dL. Risk factors for hypertension included HIV diagnosis >5 years, BMI ≥24.0 kg/m<sup>2</sup>, HDL-C <40 mg/dL, chronic kidney disease (CKD), and specific antiretroviral regimens. BMI ≥24.0 kg/m<sup>2</sup>, HDL-C <40 and CKD increased the risks for hyperlipidemia. Among statin non-users, 33.3 % of premature-old and 40.0 % of old patients met TNHI eligibility criteria.</p><p><strong>Conclusion: </strong>Cardiometabolic multimorbidity is common among aging PLWH in Taiwan. The premature-old group showed considerable disease burden and treatment gaps, indicating missed prevention opportunities. These findings emphasize the need for age-appropriate, integrated care approaches to address the evolving health challenges in this population.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of ten-day bismuth quadruple therapy for first-line anti-Helicobacter pylori infection in the elderly- A multicenter real-world report. 10天铋四联疗法治疗老年人一线抗幽门螺杆菌感染的疗效和安全性-一项多中心真实世界报告。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-02 DOI: 10.1016/j.jmii.2025.06.010
Kuo-Hsuan Huang, Wei-Chen Tai, Feng-Woey Tsay, Pin-I Hsu, Deng-Chyang Wu, Song-Seng Loke, Chih-Chien Yao, Seng-Kee Chuah, Chih-Ming Liang
{"title":"Efficacy and safety of ten-day bismuth quadruple therapy for first-line anti-Helicobacter pylori infection in the elderly- A multicenter real-world report.","authors":"Kuo-Hsuan Huang, Wei-Chen Tai, Feng-Woey Tsay, Pin-I Hsu, Deng-Chyang Wu, Song-Seng Loke, Chih-Chien Yao, Seng-Kee Chuah, Chih-Ming Liang","doi":"10.1016/j.jmii.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.010","url":null,"abstract":"<p><strong>Background: </strong>Aging may influence the effectiveness of Helicobacter pylori (H. pylori) eradication. The purpose of this study was to evaluate the efficacy and safety of 10-day bismuth quadruple therapy as a first-line treatment for H. pylori infection in elderly individuals.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of prospectively collected data from September 2018 to December 2021 in southern Taiwan. All patients received 10-day quadruple therapy consisting of rabeprazole 20 mg twice daily, bismuth subcitrate 120 mg four times daily, metronidazole 500 mg three times daily, and tetracycline 500 mg four times daily. Patients were categorized into two groups: an elderly group (aged ≥65) and a control group (aged <65).</p><p><strong>Results: </strong>The study included 231 naive patients receiving 10-day quadruple therapy. The eradication rates in the elderly and control groups were 80.3 % (95 % confidence interval [CI]: 68.1 %-89.4 %) and 85.3 % (95 % CI: 79.1 %-90.3 %) (P = 0.364), respectively, in the intention-to-treat analysis. In the per-protocol analysis, eradication rates were 89.1 % (95 % CI: 77.8 %-95.9 %) for the elderly group and 94.8 % (95 % CI: 90.0 %-97.7 %) for the control group (P = 0.149). Adverse event rates were 34.5 % in the elderly group and 27.5 % in the control group (P = 0.322). Compliance was slightly lower in the elderly group than the control group (89.1 % vs. 95.4 %, P = 0.096).</p><p><strong>Conclusions: </strong>The efficacy of 10-day bismuth quadruple therapy as a first-line treatment for H. pylori was comparable between elderly and non-elderly cohorts, with similar levels of adverse effects.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory Networks in Helicobacter pylori: The Roles of Two-Component Systems and CsrA in Stress Adaptation. 幽门螺杆菌的调控网络:双组分系统和CsrA在应激适应中的作用。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-01 DOI: 10.1016/j.jmii.2025.06.009
Pei-Yun Kuo, Cheng-Yen Kao
{"title":"Regulatory Networks in Helicobacter pylori: The Roles of Two-Component Systems and CsrA in Stress Adaptation.","authors":"Pei-Yun Kuo, Cheng-Yen Kao","doi":"10.1016/j.jmii.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.009","url":null,"abstract":"<p><p>Helicobacter pylori (H. pylori) is a major human pathogen, infecting nearly half of the global population. It has evolved remarkable adaptability to the harsh gastric environment, contributing to gastrointestinal diseases and gastric cancer. During infection, H. pylori encounters various environmental stresses, including acidity, reactive species, metal ion fluctuations, and osmotic changes. Two-component systems (TCSs) are key regulatory mechanisms that enable bacteria to respond to such environmental stimuli. Compared to other gram-negative bacteria, H. pylori encodes a relatively limited number of TCSs, consisting of four (ArsRS, CrdRS, FlgRS, and CheY1Y2A) along with two orphan regulators (HP1021 and HsrA). These systems regulate gene transcription, playing essential roles in bacterial adaptation and survival. Additionally, the global regulator CsrA, positioned at the center of the regulatory hierarchy, orchestrates stress response mechanisms. This review summarizes how H. pylori utilizes TCSs and CsrA to modulate cellular responses under environmental stresses. We further explore potential interactions among these regulators and discuss the feasibility of targeting TCSs and CsrA as alternative strategies for H. pylori treatment.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms and targets underlying immune evasion by human cytomegalovirus. 人巨细胞病毒免疫逃避的分子机制和靶点。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-07-01 DOI: 10.1016/j.jmii.2025.06.005
Yitian Shen, Liang Zhang, Xiangyang Xue, Shiyu Feng
{"title":"Molecular mechanisms and targets underlying immune evasion by human cytomegalovirus.","authors":"Yitian Shen, Liang Zhang, Xiangyang Xue, Shiyu Feng","doi":"10.1016/j.jmii.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.005","url":null,"abstract":"<p><p>Human cytomegalovirus (HCMV) establishes lifelong latency in humans largely through the evolution of sophisticated immune evasion strategies that allow it to escape recognition and clearance by the host immune system. While significant progress has been made in elucidating the mechanisms underlying HCMV immune evasion, the precise regulation of host immune responses that enables viral persistence remains incompletely understood. In this review, we provide a comprehensive overview of the current knowledge on HCMV immune evasion, with a particular emphasis on the functions of HCMV-encoded genes. We examine how these gene products impair immune cell responses, inhibit interferon production, reshape the immune microenvironment, and interact synergistically to promote viral latency and long-term persistence. Furthermore, we also explore the potential involvement of HCMV in the pathogenesis of cancer and autoimmune diseases, aiming to bridge molecular mechanisms with clinical implications and provide insights for the prevention and treatment of HCMV and related conditions.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Javanicin inhibits the secretion of hepatitis B virus particles thorough the proteasome-dependent degradation of core protein. 爪哇霉素通过蛋白酶体依赖的核心蛋白降解抑制乙型肝炎病毒颗粒的分泌。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-06-28 DOI: 10.1016/j.jmii.2025.06.004
Nayeon Park, Gwang-Hoon Ko, Yun Seo Park, Jung-Ah Kang, Sang Hee Shim, Sung-Gyoo Park
{"title":"Javanicin inhibits the secretion of hepatitis B virus particles thorough the proteasome-dependent degradation of core protein.","authors":"Nayeon Park, Gwang-Hoon Ko, Yun Seo Park, Jung-Ah Kang, Sang Hee Shim, Sung-Gyoo Park","doi":"10.1016/j.jmii.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.004","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) is the primary cause of liver disease. Nucleot(s)ide analogues such as Entecavir are commonly used to treat HBV infection; however, although these drugs attenuate the virus, they are not a cure. Therefore, it is important to find a novel anti-HBV compounds that enable complete remission of chronic hepatitis B (CHB) infection.</p><p><strong>Methods: </strong>We screened 190 natural product libraries using the HepG2.2.15 cell line. Additionally, anti-HBV activities were assessed across genotypes C and D. The mechanism underlying the inhibition of HBV replication by the identified compound was elucidated through cell-based assays.</p><p><strong>Results: </strong>We identified a hit compound called Javanicin, which is derived from the endophytic fungus JS169. The IC<sub>50</sub> of Javanicin is < 500 nM, and the selectivity index (SI = CC<sub>50</sub>/IC<sub>50</sub>) is > 10. Javanicin induced proteasome-mediated degradation of the HBV core protein, and reduced the amount of HBV capsid protein. Javanicin and Entecavir acted synergistically, and were more effective than either drug alone. Additionally, structural analysis showed that Javanicin carries several modifiable moieties, which may lead to development of derivatives.</p><p><strong>Conclusions: </strong>Javanicin is a novel class of HBV capsid assembly inhibitors, functioning by inducing proteasome-mediated degradation. Furthermore, when paired with Entecavir, Javanicin holds potential as a curative treatment for CHB.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of haptoglobin gene deletion and antibodies against haptoglobin in a patient with severe anaphylactic transfusion reaction. 1例严重过敏性输血反应患者接触珠蛋白基因缺失及抗接触珠蛋白抗体检测。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-06-27 DOI: 10.1016/j.jmii.2025.06.008
Kao-Yu Chang, Kuan-Hua Chu, Mei-Hwa Lin, Chun-Min Kang, Shyh-Chyi Lo
{"title":"Detection of haptoglobin gene deletion and antibodies against haptoglobin in a patient with severe anaphylactic transfusion reaction.","authors":"Kao-Yu Chang, Kuan-Hua Chu, Mei-Hwa Lin, Chun-Min Kang, Shyh-Chyi Lo","doi":"10.1016/j.jmii.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.008","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of climate change on prevalence of pollen sensitization in northern Taiwan. 气候变化对台湾北部花粉敏化流行的影响。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-06-25 DOI: 10.1016/j.jmii.2025.06.007
Yu-Jung Liang, Bor-Luen Chiang, Chun-Min Kang, Kuan-Hua Chu, Yao-Hsu Yang, Yu-Tsan Lin, Jyh-Hong Lee, Hsin-Hui Yu, Ya-Chiao Hu, Li-Chieh Wang
{"title":"Influence of climate change on prevalence of pollen sensitization in northern Taiwan.","authors":"Yu-Jung Liang, Bor-Luen Chiang, Chun-Min Kang, Kuan-Hua Chu, Yao-Hsu Yang, Yu-Tsan Lin, Jyh-Hong Lee, Hsin-Hui Yu, Ya-Chiao Hu, Li-Chieh Wang","doi":"10.1016/j.jmii.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jmii.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Pollen sensitization is not as common as mite sensitization in Taiwan. The dearth of regional aeropalynological studies and relevant clinical analyses has, therefore, led to an underestimation of the prevalence of pollen allergies. To investigate this impact, we evaluated the alteration of pollen sensitization and its association with climate change in northern Taiwan.</p><p><strong>Methods: </strong>We enrolled the patients from National Taiwan University Hospital who lived in Taipei and New Taipei City, tested positive for pollen-specific immunoglobulin E (IgE) on an OPTIGEN® allergen-specific IgE assay, and had relevant symptoms. Their data were cross-referenced with climate data from the Central Weather Bureau for the same period.</p><p><strong>Results: </strong>In total, 11,895 patients were enrolled, of whom 930 (7.8 %) tested positive for pollen-specific IgE. Black willow was the most common pollen allergen identified. According to the Cochran-Armitage test, the annual sensitization to Bermuda grass, Japanese cedar, pigweed, ragweed mix, and black willow pollen varied significantly. According to Spearman's correlation test, the annual sensitization to Bermuda grass, white mulberry, ragweed mix, timothy grass, and black willow positively correlated with the mean winter temperature, whereas that to white mulberry and timothy grass negatively correlated with mean winter rainfall.</p><p><strong>Conclusion: </strong>The pollen sensitization pattern has changed gradually in northern Taiwan over recent years. Warm mean temperatures and low mean rainfall in winter significantly correlated with annual sensitization to some pollen allergens. Climate change may have exacerbated the prevalence of pollen sensitization, and the emerging burden of pollen allergies should not be neglected in Taiwan.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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