Journal of Microbiology Immunology and Infection最新文献

{"title":"Combination of trimethoprim-sulfamethoxazole and clindamycin in the treatment of relapsing toxoplasmic encephalitis","authors":"Shih-Wen Ting, Jien-Wei Liu","doi":"10.1016/j.jmii.2024.02.008","DOIUrl":"10.1016/j.jmii.2024.02.008","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 518-519"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000458/pdfft?md5=75af8bbc49ac367feb65c2f6de89046b&pid=1-s2.0-S1684118224000458-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the association between vitamin D deficiency and active tuberculosis: A prospective case-control study in Taiwan","authors":"Meng-Shiuan Hsu ,&nbsp;Tzu-Chien Chung ,&nbsp;Ping-Huai Wang ,&nbsp;Shih-Lung Cheng ,&nbsp;Yen-Wen Wu ,&nbsp;Jung-Cheng Hsu ,&nbsp;Bing-Hsiean Tzeng ,&nbsp;Heng-Hsu Lin ,&nbsp;Chung-Ming Tu ,&nbsp;Fang-Yeh Chu ,&nbsp;Chi-Tai Fang","doi":"10.1016/j.jmii.2024.03.005","DOIUrl":"10.1016/j.jmii.2024.03.005","url":null,"abstract":"<div><h3>Background</h3><p>To revisit the association between vitamin D deficiency (VDD, defined as serum 25(OH)D &lt; 20 ng/ml) and incident active tuberculosis (TB), after two potentially underpowered randomized trials showed statistically non-significant 13%–22% decrease in TB incidence in vitamin D supplementation groups.</p></div><div><h3>Methods</h3><p>We prospectively conducted an age/sex-matched case–control study that accounting for body-mass index (BMI), smoking, and other confounding factors to examine the association between VDD and active TB among non-HIV people in Taiwan (latitude 24°N), a high-income society which continues to have moderate TB burden.</p></div><div><h3>Results</h3><p>We enrolled 62 people with incident active TB and 248 people in control group. The TB case patients had a significantly higher proportion of VDD compared to the control group (51.6% vs 29.8%, <em>p</em> = 0.001). The 25(OH)D level was also significantly lower in TB patients compared to control group (21.25 ± 8.93 ng/ml vs 24.45 ± 8.36 ng/ml, <em>p</em> = 0.008). In multivariable analysis, VDD (adjusted odds ratio [aOR]: 3.03, <em>p</em> = 0.002), lower BMI (aOR: 0.81, <em>p</em> &lt; 0.001), liver cirrhosis (aOR: 8.99, <em>p</em> = 0.042), and smoking (aOR: 4.52, <em>p</em> = 0.001) were independent risk factors for incident active TB.</p></div><div><h3>Conclusions</h3><p>VDD is an independent risk factor for incident active TB. Future randomized trials examining the effect of vitamin D supplementation on TB incidence should focus on people with a low BMI or other risk factors to maximize the statistical power.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 490-497"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000689/pdfft?md5=ed5b48cc6f1590009f8468b243daf469&pid=1-s2.0-S1684118224000689-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015–2020)","authors":"Jaehee Lee ,&nbsp;Hyewon Seo ,&nbsp;Dohyang Kim ,&nbsp;Jinseub Hwang ,&nbsp;Jin-Won Kwon","doi":"10.1016/j.jmii.2024.04.003","DOIUrl":"10.1016/j.jmii.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><p>Influenza's potential impact on active tuberculosis (TB) development has been debated, with limited clinical evidence. To address this, we explored the association between influenza episodes and TB incidence in a national cohort of individuals with latent TB infection (LTBI).</p></div><div><h3>Methods</h3><p>We examined adults (≥20 years) diagnosed with LTBI between 2015 and 2020, using the Health Insurance Review and Assessment Service's national database in South Korea. We collected demographic data, comorbidities, and influenza episodes within 6 months before and after the initial LTBI diagnosis (prior vs. subsequent episode). We stratified the analysis into groups with and without TB preventive therapy (TPT).</p></div><div><h3>Results</h3><p>Among 220,483 LTBI subjects, 49% received TPT, while 51% did not. The average age was 48.4 years, with 52% having comorbidities. A prior and subsequent influenza episode was identified in 3221 and 4580 individuals, respectively. Of these, 1159 (0.53%) developed incident TB over an average follow-up of 1.86 years. The incidence rates of TB were comparable between individuals with and without prior and/or subsequent influenza episodes in the TPT group, but 1.4 times higher in the non-TPT group for those with such episodes. Cox proportional-hazards regression analysis indicated that influenza was not a risk factor for incident TB in the TPT group. However, a subsequent influenza episode significantly increased TB risk in the non-TPT group (hazard ratio: 1.648 [95% CI, 1.053–2.580]).</p></div><div><h3>Conclusions</h3><p>In individuals with LTBI not receiving TPT, experiencing an influenza episode may elevate the risk of developing active TB.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 437-445"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000719/pdfft?md5=fc1877d020ae9a07b41ecbfe251fe6e2&pid=1-s2.0-S1684118224000719-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ProFun: A web server for functional enrichment analysis of parasitic protozoan genes","authors":"Po-Jung Huang ,&nbsp;Yi-Chen Weng ,&nbsp;Kuo-Yang Huang ,&nbsp;Chi-Ching Lee ,&nbsp;Yuan-Ming Yeh ,&nbsp;Yu-Tong Chen ,&nbsp;Cheng-Hsun Chiu ,&nbsp;Petrus Tang","doi":"10.1016/j.jmii.2024.01.007","DOIUrl":"10.1016/j.jmii.2024.01.007","url":null,"abstract":"<div><h3>Background</h3><p>The initial step to interpreting putative biological functions from comparative multi-omics studies usually starts from a differential expressed gene list followed by functional enrichment analysis (FEA). However, most FEA packages are designed exclusively for humans and model organisms. Although parasitic protozoan is the most important pathogen in the tropics, no FEA package is available for protozoan functional (ProFun) enrichment analysis. To speed up comparative multi-omics research on parasitic protozoans, we constructed ProFun, a web-based, user-friendly platform for the research community.</p></div><div><h3>Methods</h3><p>ProFun utilizes the Docker container, ShinyProxy, and R Shiny to construct a scalable web service with load-balancing infrastructure. We have integrated a series of visual analytic functions, in-house scripts, and custom-made annotation packages to create three analytical modules for 40 protozoan species: (1) Gene Overlaps; (2) Over-representation Analysis (ORA); (3) Gene Set Enrichment Analysis (GSEA).</p></div><div><h3>Results</h3><p>We have established ProFun, a web server for functional enrichment analysis of differentially expressed genes. FEA becomes as simple as pasting a list of gene IDs into the textbox of our website. Users can customize enrichment parameters and results with just one click. The intuitive web interface and publication-ready charts enable users to reveal meaningful biological events and pinpoint potential targets for further studies.</p></div><div><h3>Conclusion</h3><p>ProFun is the first web application that enables gene functional enrichment analysis of parasitic protozoans. In addition to supporting FEA analysis, ProFun also allows the comparison of FEA results across complicated experimental designs. ProFun is freely available at <span>http://dalek.cgu.edu.tw:8080/app/profun</span><svg><path></path></svg>.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 509-517"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000082/pdfft?md5=da2b1e7df910725f9a188a4ac4ea5200&pid=1-s2.0-S1684118224000082-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139679427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human infection caused by avian influenza A (H10N5) virus","authors":"Chih-Cheng Lai ,&nbsp;Po-Ren Hsueh","doi":"10.1016/j.jmii.2024.04.006","DOIUrl":"10.1016/j.jmii.2024.04.006","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 343-345"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000744/pdfft?md5=2f67f94f9fa19e0c2b63c138b7f124e2&pid=1-s2.0-S1684118224000744-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of early dexamethasone on outcomes of COVID-19: A quasi-experimental study using propensity score matching","authors":"Wang-Da Liu ,&nbsp;Jann-Tay Wang ,&nbsp;Ming-Chieh Shih ,&nbsp;Kai-Hsiang Chen ,&nbsp;Szu-Ting Huang ,&nbsp;Chun-Fu Huang ,&nbsp;Tien-Hao Chang ,&nbsp;Ming-Jui Tsai ,&nbsp;Po-Hsien Kuo ,&nbsp;Yi-Chen Yeh ,&nbsp;Wan-Chen Tsai ,&nbsp;Mei-Yan Pan ,&nbsp;Guei-Chi Li ,&nbsp;Yi-Jie Chen ,&nbsp;Kuan-Yin Lin ,&nbsp;Yu-Shan Huang ,&nbsp;Aristine Cheng ,&nbsp;Pao- Yu Chen ,&nbsp;Sung-Ching Pan ,&nbsp;Hsin-Yun Sun ,&nbsp;Shan-Chwen Chang","doi":"10.1016/j.jmii.2024.02.002","DOIUrl":"10.1016/j.jmii.2024.02.002","url":null,"abstract":"<div><h3>Background</h3><p>The RECOVERY trial demonstrated that the use of dexamethasone is associated with a 36% lower 28-day mortality in hospitalized patients with COVID-19 on invasive mechanical ventilation. Nevertheless, the optimal timing to start dexamethasone remains uncertain.</p></div><div><h3>Methods</h3><p>We conducted a quasi-experimental study at National Taiwan University Hospital (Taipei, Taiwan) using propensity score matching to simulate a randomized controlled trial to receive or not to receive early dexamethasone (6 mg/day) during the first 7 days following the onset of symptoms. Treatment was standard protocol-based, except for the timing to start dexamethasone, which was left to physicians’ decision. The primary outcome is 28-day mortality. Secondary outcomes include secondary infection within 60 days and fulfilling the criteria of de-isolation within 20 days.</p></div><div><h3>Results</h3><p>A total of 377 patients with COVID-19 were enrolled. Early dexamethasone did not decrease 28-day mortality in all patients (adjusted odds ratio [aOR], 1.03; 95% confidence interval [CI], 0.97–1.10) or in patients who required O2 for severe/critical disease at admission (aOR, 1.05; 95%CI, 0.94–1.18); but is associated with a 24% increase in superinfection in all patients (aOR, 1.24; 95% CI, 1.12–1.37) and a 23% increase in superinfection in patients of O2 for several/critical disease at admission (aOR, 1.23; 95% CI, 1.02–1.47). Moreover, early dexamethasone is associated with a 42% increase in likelihood of delayed clearance of SARS-CoV-2 virus (adjusted hazard ratio, 1.42; 95% CI, 1.01–1.98).</p></div><div><h3>Conclusion</h3><p>An early start of dexamethasone (within 7 days after the onset of symptoms) could be harmful to hospitalized patients with COVID-19.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 414-425"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000392/pdfft?md5=0bc39d21d2cd775b003373e82b6aea58&pid=1-s2.0-S1684118224000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139919360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of statins on the risk of anti-tuberculosis drug-induced liver injury among patients with active tuberculosis: A cohort study","authors":"Chun-Kai Huang ,&nbsp;Jei-Yie Huang ,&nbsp;Chin-Hao Chang ,&nbsp;Shang-Jie Tsai ,&nbsp;Chin-Chung Shu ,&nbsp;Hao-Chien Wang ,&nbsp;Kuo-Liong Chien","doi":"10.1016/j.jmii.2024.04.002","DOIUrl":"10.1016/j.jmii.2024.04.002","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB) remains prevalent worldwide, and anti-TB drugs are associated with drug-induced liver injury (DILI). Statins have pleiotropic effects which may decrease inflammation and achieve immunomodulation. However, few studies have investigated the pleiotropic effects of statins on the risk of DILI. The purpose of this study was to investigate whether statins prevent anti-tuberculosis DILI among active TB patients on standard anti-TB drug therapy.</p></div><div><h3>Methods</h3><p>We conducted a hospital-based retrospective cohort study using claims data from the Integrated Medical Database of National Taiwan University Hospital (NTUH-iMD). Patients with a positive TB culture were included. The use of statins was defined as a daily equivalent dose &gt;0.5 mg of pitavastatin. Deterioration in liver function was evaluated according to elevated liver enzyme levels. The primary and secondary endpoints were the DILI and the severe DILI. The prognostic value of statins was evaluated by Kaplan–Meier analysis, and Cox proportional hazards models.</p></div><div><h3>Results</h3><p>A total of 1312 patients with a diagnosis of TB and receiving anti-TB treatment were included. During the study period, 193 patients had the DILI and 140 patients had the severe DILI. Kaplan–Meier analysis showed a significant difference between the usual statin users and controls in the DILI. In multivariable Cox proportional hazards analysis, statins showed a protective effect against the primary and secondary endpoints. In addition, the protective effect of statins showed a dose–response relationship against the DILI.</p></div><div><h3>Conclusion</h3><p>Statin treatment had a protective effect against the risk of anti-TB DILI with a positive dose–response relationship.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 498-508"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000690/pdfft?md5=65ba8eee4a37c1368e9443e571837c9f&pid=1-s2.0-S1684118224000690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year epidemiology and risk factors of cytomegalovirus infection in hematopoietic stem cell transplantation patients in Taiwan","authors":"Yi-Che Huang ,&nbsp;Fei-Yuan Hsiao ,&nbsp;Shang-Ting Guan ,&nbsp;Ming Yao ,&nbsp;Chia-Jen Liu ,&nbsp;Tzu-Ting Chen ,&nbsp;Tung-Liang Lin ,&nbsp;Yi-Chang Liu ,&nbsp;Tsai-Yun Chen ,&nbsp;Ying-Chung Hong ,&nbsp;Ming-Chun Ma ,&nbsp;Tran-Der Tan ,&nbsp;Chuan-Cheng Wang ,&nbsp;Yi-Ying Wu ,&nbsp;Po-Wei Liao ,&nbsp;Yi-Feng Wu ,&nbsp;Yi-Yang Chen ,&nbsp;Yuan-Bin Yu ,&nbsp;Yao-Yu Hsieh ,&nbsp;Ming-Yang Lee ,&nbsp;Bor-Sheng Ko","doi":"10.1016/j.jmii.2024.02.005","DOIUrl":"10.1016/j.jmii.2024.02.005","url":null,"abstract":"<div><h3>Background</h3><p>Cytomegalovirus (CMV) can cause infection and critical diseases in hematopoietic stem cell transplantation (HSCT) recipients. This study aimed to explore the cumulative incidence and risk factors for CMV infection and disease among HSCT recipients in Taiwan.</p></div><div><h3>Methods</h3><p>This retrospective cohort study using the Taiwan Blood and Marrow Transplantation Registry (TBMTR) included HSCT recipients between 2009 and 2018 in Taiwan. The primary outcome was cumulative incidence of CMV infection or disease at day 100 after HSCT. Secondary outcomes included day 180 cumulative incidence of CMV infection or disease, infection sites, risk factors for CMV infection or disease, survival analysis, and overall survival after CMV infection and disease.</p></div><div><h3>Results</h3><p>There were 4394 HSCT recipients included in the study (2044 auto-HSCT and 2350 allo-HSCT). The cumulative incidence of CMV infection and disease was significantly higher in allo-HSCT than in auto-HSCT patients at day 100 (53.7% vs. 6.0%, P &lt; 0.0001 and 6.1% vs. 0.9%, P &lt; 0.0001). Use of ATG (HR 1.819, p &lt; 0.0001), recipient CMV serostatus positive (HR 2.631, p &lt; 0.0001) and acute GVHD grades ≥ II (HR 1.563, p &lt; 0.0001) were risk factors for CMV infection, while matched donor (HR 0.856, p = 0.0180) and myeloablative conditioning (MAC) (HR 0.674, p &lt; 0.0001) were protective factors.</p></div><div><h3>Conclusion</h3><p>The study revealed a significant disparity in terms of the incidence, risk factors, and clinical outcomes of CMV infection and disease between auto and allo-HSCT patients. These findings underscore the importance of considering these factors in the management of HSCT recipients to improve outcomes related to CMV infections.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 365-374"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000434/pdfft?md5=5082e6cd549c5d226b2a326b83bedb79&pid=1-s2.0-S1684118224000434-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper affects virulence and diverse phenotypes of uropathogenic Proteus mirabilis","authors":"Wei-Syuan Huang ,&nbsp;Yuan-Ju Lee ,&nbsp;Lu Wang ,&nbsp;Hsuan- Hsuan Chen ,&nbsp;Yueh-Jung Chao ,&nbsp;Vivien Cheng ,&nbsp;Shwu-Jen Liaw","doi":"10.1016/j.jmii.2024.02.007","DOIUrl":"10.1016/j.jmii.2024.02.007","url":null,"abstract":"<div><h3>Background</h3><p>Copper plays a role in urinary tract infection (UTI) and urinary copper content is increased during <em>Proteus mirabilis</em> UTI. We therefore investigated the effect of copper on uropathogenic <em>P. mirabilis</em> and the underlying mechanisms, focusing on the virulence associated aspects.</p></div><div><h3>Methods</h3><p>Mouse colonization, swarming/swimming assays, measurement of cell length, flagellin level and urease activity, adhesion/invasion assay, biofilm formation, killing by macrophages, oxidative stress susceptibility, OMPs analysis, determination of MICs and persister cell formation, RT-PCR and transcriptional reporter assay were performed.</p></div><div><h3>Results</h3><p>We found that copper-supplemented mice were more resistant to be colonized in the urinary tract, together with decreased swarming/swimming, ureases activity, expression of type VI secretion system and adhesion/invasion to urothelial cells and increased killing by macrophages of <em>P. mirabilis</em> at a sublethal copper level. However, bacterial biofilm formation and resistance to oxidative stress were enhanced under the same copper level. Of note, the presence of copper led to increased ciprofloxacin MIC and more persister cell formation against ampicillin. In addition, the presence of copper altered the outer membrane protein profile and triggered expression of RcsB response regulator. For the first time, we unveiled the pleiotropic effects of copper on uropathogenic <em>P. mirabilis</em>, especially for induction of bacterial two-component signaling system regulating fitness and virulence.</p></div><div><h3>Conclusion</h3><p>The finding of copper-mediated virulence and fitness reinforced the importance of copper for prevention and therapeutic interventions against <em>P. mirabilis</em> infections. As such, this study could facilitate the copper-based strategies against UTI by <em>P. mirabilis</em>.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 385-395"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000446/pdfft?md5=7d573369a1469418bea28650fd3e3091&pid=1-s2.0-S1684118224000446-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140034369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestations and risk factors for COVID-19 and its severity in patients with hematological malignancies","authors":"Tzong-Yow Wu ,&nbsp;Wan-Ting Tsai ,&nbsp;Kai-Hsiang Chen ,&nbsp;Szu-Ting Huang ,&nbsp;Chun-Fu Huang ,&nbsp;Po-Hsien Kuo ,&nbsp;Ming-Jui Tsai ,&nbsp;Wang-Da Liu ,&nbsp;Kuan-Yin Lin ,&nbsp;Yu-Shan Huang ,&nbsp;Aristine Cheng ,&nbsp;Pao-Yu Chen ,&nbsp;Hsin-Yun Sun ,&nbsp;Huai-Hsuan Huang ,&nbsp;Tai-Chung Huang ,&nbsp;Shang-Ju Wu ,&nbsp;Ming Yao ,&nbsp;Jann-Tay Wang ,&nbsp;Wang-Huei Sheng ,&nbsp;Chien-Ching Hung ,&nbsp;Shan-Chwen Chang","doi":"10.1016/j.jmii.2024.03.001","DOIUrl":"10.1016/j.jmii.2024.03.001","url":null,"abstract":"<div><h3>Background</h3><p>Patients with hematological malignancies (HM) were at a high risk of developing severe disease from coronavirus disease 2019 (COVID-19). We aimed to assess the clinical outcome of COVID-19 in hospitalized patients with HM.</p></div><div><h3>Methods</h3><p>Adult patients with HM who were hospitalized with a laboratory-confirmed COVID-19 between May, 2021 and November, 2022 were retrospectively identified. Primary outcome was respiratory failure requiring mechanical ventilation or mortality within 60 days after hospitalization. We also analyzed associated factors for de-isolation (defined as defervescence with a consecutive serial cycle threshold value &gt; 30) within 28 days.</p></div><div><h3>Results</h3><p>Of 152 eligible patients, 22 (14.5%) developed respiratory failure or mortality in 60 days. Factors associated with developing respiratory failure that required mechanical ventilation or mortality included receipt of allogeneic hematopoietic stem-cell transplantation (allo-HSCT) (adjusted hazards ratio [aHR], 5.10; 95% confidence interval [CI], 1.64–15.85), type 2 diabetes mellitus (aHR, 2.47; 95% CI, 1.04–5.90), lymphopenia at admission (aHR, 6.85; 95% CI, 2.45–19.15), and receiving &lt;2 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines (aHR, 3.00; 95% CI, 1.19–7.60). Ninety-nine (65.1%) patients were de-isolated in 28 days, against which two hazardous factors were identified: receipt of B-cell depletion therapies within one year prior to COVID-19 (aHR, 0.55, 95% CI, 0.35–0.87) and lymphopenia upon admission (aHR, 0.65; 95% CI, 0.43–1.00).</p></div><div><h3>Conclusion</h3><p>We found a high rate of respiratory failure and mortality among patients with HM who contracted the SARS-CoV-2. Factors associated with developing respiratory failure or mortality in 60 days included receipt of allo-HSCT, type 2 diabetes mellitus and lymphopenia upon admission. Having received ≥2 doses of vaccination conferred protection against clinical progression.</p></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"57 3","pages":"Pages 403-413"},"PeriodicalIF":7.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1684118224000471/pdfft?md5=22b7056e92e75f4229ff425753c9d663&pid=1-s2.0-S1684118224000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140099839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}