Journal of Microbiology Immunology and Infection最新文献

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Co-infection with Giardia lamblia and Blastocystis hominis in a patient with liver abscess: A diagnostic challenge 肝脓肿患者同时感染兰氏贾第鞭毛虫和人型囊虫:一个诊断挑战。
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-04 DOI: 10.1016/j.jmii.2025.02.005
Chun-Chung Lu , Wen-Sen Lee
{"title":"Co-infection with Giardia lamblia and Blastocystis hominis in a patient with liver abscess: A diagnostic challenge","authors":"Chun-Chung Lu , Wen-Sen Lee","doi":"10.1016/j.jmii.2025.02.005","DOIUrl":"10.1016/j.jmii.2025.02.005","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 5","pages":"Pages 617-618"},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness comparison between ceftazidime-avibactam and carbapenem-based regimens in nosocomial carbapenem-resistant Klebsiella pneumoniae bloodstream infections 头孢他啶-阿维巴坦与以碳青霉烯为基础的方案治疗医院耐碳青霉烯肺炎克雷伯菌血液感染的有效性比较。
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-04 DOI: 10.1016/j.jmii.2025.03.003
Ruei-Chang Huang , Li-Ying Chen , Ying-Chuan Wang , Chun-Hsiang Chiu
{"title":"Effectiveness comparison between ceftazidime-avibactam and carbapenem-based regimens in nosocomial carbapenem-resistant Klebsiella pneumoniae bloodstream infections","authors":"Ruei-Chang Huang ,&nbsp;Li-Ying Chen ,&nbsp;Ying-Chuan Wang ,&nbsp;Chun-Hsiang Chiu","doi":"10.1016/j.jmii.2025.03.003","DOIUrl":"10.1016/j.jmii.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenem-resistant <em>Klebsiella pneumoniae</em> bloodstream infections (CRKP BSI) are associated with high mortality rates and limited treatment options. This study compared the outcomes between ceftazidime-avibactam and carbapenem-based regimens in patients with nosocomial CRKP BSI.</div></div><div><h3>Methods</h3><div>This is a single-center, retrospective, observational study that analyzed adult patients with nosocomial CRKP BSI from January 2018 to December 2023. Patients were divided into ceftazidime-avibactam (n = 47) and carbapenem-based regimen (n = 54) groups. Primary outcomes included 7-, 14-, 21-, and 28-day mortality rates, microbiological cure rates, and length of hospital stay. Multivariate analysis was performed to identify factors associated with mortality.</div></div><div><h3>Results</h3><div>The ceftazidime-avibactam group showed significantly lower 7-day mortality (8.51 % vs. 25.93 %, p = 0.043) and higher survival rates in Kaplan-Meier analysis (p = 0.021). Multivariate analysis revealed that ceftazidime-avibactam significantly reduced 7-day mortality (adjusted hazard ratio: 0.182, 95 % CI: 0.050–0.660, p = 0.010). Leukemia significantly increased both 7-day and all-cause mortality. Elevated white blood cell counts, and C-reactive protein levels were associated with increased mortality risk.</div></div><div><h3>Conclusion</h3><div>Ceftazidime-avibactam demonstrated superior short-term survival benefits compared to carbapenem-based regimens in treating nosocomial CRKP BSI. However, long-term outcomes were more influenced by underlying conditions and inflammatory status.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 5","pages":"Pages 579-584"},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal methicillin-resistant Staphylococcus aureus carriage among hospitalized patients before and after COVID-19 pandemic in a regional hospital in taiwan 台湾某地区医院新冠肺炎大流行前后住院患者鼻腔耐甲氧西林金黄色葡萄球菌携带情况。
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-04 DOI: 10.1016/j.jmii.2025.02.011
Fang-Ching Liu , Cheng-Lun Li , Yi-Ching Huang , Yhu-Chering Huang
{"title":"Nasal methicillin-resistant Staphylococcus aureus carriage among hospitalized patients before and after COVID-19 pandemic in a regional hospital in taiwan","authors":"Fang-Ching Liu ,&nbsp;Cheng-Lun Li ,&nbsp;Yi-Ching Huang ,&nbsp;Yhu-Chering Huang","doi":"10.1016/j.jmii.2025.02.011","DOIUrl":"10.1016/j.jmii.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Strict mask wearing and handwashing were implemented in hospital settings during COVID-19 pandemic in Taiwan. To explore if nasal methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) carriage rate among inpatients in the hospital changed before and after COVID-19, we conducted this study.</div></div><div><h3>Methods</h3><div>Patients who were admitted to a regional hospital in central Taiwan during one week in 2012 and 2023, respectively, were enrolled. A nasal swab from each subject was obtained for MRSA detection after a written informed consent was obtained. Risk factors of MRSA carriage, and microbiologic characteristics of MRSA were analyzed.</div></div><div><h3>Results</h3><div>Overall, nasal MRSA carriage rate was 6.2 % (31/502) in 2012 and 8.0 % (40/499) in 2023. In addition to pediatric patients, risk factors significantly associated with MRSA carriage included allergic rhinitis, chest tube insertion, chronic obstructive pulmonary disease in 2012 and recent positive MRSA culture, antimicrobial usage within previous year in 2023. In 2012, the two most common strains were ST 59/pulsotype C/staphylococcal chromosomal cassette (SCC<em>mec</em>) IV/Panton-Valentine leucocidin (PVL)-negative (35.5 %) and ST 59/pulsotype D/SCC<em>mec</em> V<sub>T</sub>/PVL positive (19.4 %) while the two most common strains shifted to ST 45 (and its single locus variant)/pulsotype AK/SCC<em>mec</em> IV/PVL-negative (30.0 %) and ST 8/pulsotype AI/SCC<em>mec</em> IV/PVL positive (22.5 %) in 2023.</div></div><div><h3>Conclusions</h3><div>Nasal MRSA carriage rate among inpatients in the hospital setting was not affected by the COVID-19 pandemic in Taiwan. Molecular characteristics of colonizing MRSA isolates shifted from two local endemic community strains of ST 59 to two emerging imported strains of ST 45 and ST 8.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 5","pages":"Pages 572-578"},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fecal microbiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome 粪便微生物群移植治疗炎症性肠病中万古霉素耐药无创性梭菌感染:一项评估安全性、临床和微生物群结果的初步研究
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-04 DOI: 10.1016/j.jmii.2025.03.004
Puo-Hsien Le , Yuan-Ming Yeh , Yi-Ching Chen , Chyi-Liang Chen , Yung-Kuan Tsou , Chien-Chang Chen , Cheng-Tang Chiu , Cheng-Hsun Chiu
{"title":"Fecal microbiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome","authors":"Puo-Hsien Le ,&nbsp;Yuan-Ming Yeh ,&nbsp;Yi-Ching Chen ,&nbsp;Chyi-Liang Chen ,&nbsp;Yung-Kuan Tsou ,&nbsp;Chien-Chang Chen ,&nbsp;Cheng-Tang Chiu ,&nbsp;Cheng-Hsun Chiu","doi":"10.1016/j.jmii.2025.03.004","DOIUrl":"10.1016/j.jmii.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div><em>Clostridium innocuum</em> is a vancomycin-resistant pathobiome associated with poor clinical outcomes in inflammatory bowel disease (IBD). In ulcerative colitis (UC), it correlates with reduced remission rates, while in Crohn's disease (CD), it is linked to creeping fat formation and intestinal strictures. Notably, some patients experience refractory or recurrent <em>C. innocuemailum</em> infections despite metronidazole treatment. This study evaluates the safety and efficacy of single-dose fecal microbiota transplantation (FMT) in IBD patients with refractory or recurrent <em>C. innocuum</em> infections.</div></div><div><h3>Methods</h3><div>We conducted a feasibility pilot study involving seven IBD patients (3 CD, 4 UC) with refractory (n = 5) or recurrent (n = 2) <em>C. innocuum</em> infections following metronidazole treatment. Patients underwent single-dose FMT and were monitored for six months.</div></div><div><h3>Results</h3><div>No adverse events were recorded. All participants demonstrated improved disease activity post-FMT, as assessed by the Crohn's Disease Activity Index and Mayo Score. However, a mild increase in symptom severity was noted at six months. Follow-up cultures showed persistent <em>C. innocuum</em> infection in one patient and asymptomatic recurrence in another at three months. Alpha diversity of the gut microbiome increased post-FMT, and Bray-Curtis dissimilarity analysis revealed a microbiota composition more similar to that of the donor.</div></div><div><h3>Conclusion</h3><div>Single-dose FMT appears to be a safe and feasible therapeutic approach for refractory or recurrent <em>C. innocuum</em> infections in IBD patients, with potential benefits in disease activity and microbiome restoration. Further studies are warranted to optimize long-term outcomes.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 5","pages":"Pages 585-592"},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological, phenotypic and genotypic characteristics difference of hypervirulent and carbapenem-resistant Klebsiella pneumoniae with different capsular serotypes 不同荚膜血清型高毒力和耐碳青霉烯肺炎克雷伯菌的流行病学、表型和基因型特征差异
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-28 DOI: 10.1016/j.jmii.2025.02.010
Cong Zhou , Wencai Ke , Hui Zhang , Maosuo Xu , Baoyu Yuan , Yong Lin , Fang Shen
{"title":"Epidemiological, phenotypic and genotypic characteristics difference of hypervirulent and carbapenem-resistant Klebsiella pneumoniae with different capsular serotypes","authors":"Cong Zhou ,&nbsp;Wencai Ke ,&nbsp;Hui Zhang ,&nbsp;Maosuo Xu ,&nbsp;Baoyu Yuan ,&nbsp;Yong Lin ,&nbsp;Fang Shen","doi":"10.1016/j.jmii.2025.02.010","DOIUrl":"10.1016/j.jmii.2025.02.010","url":null,"abstract":"<div><h3>Background</h3><div>KL1, KL2 CR-hvKP and KL64, KL47 hv-CRKP all exhibit overlapping multidrug resistance and hypervirulence phenotypes, but the differences in epidemiological, phenotypic and genotypic characteristics between them remains unclear.</div></div><div><h3>Methods</h3><div>In this study, we collected non-repeated hv-CRKP/CR-hvKP isolates in a tertiary hospital in Shanghai, China from January 2019 to December 2022. Furthermore, we selected four typical hypervirulent and carbapenem-resistant <em>Klebsiella pneumoniae</em>, including ST23-KL1/ST86-KL2 CR-hvKP (WYKP3 and WYKP194) and ST11-KL64/ST11-KL47 hv-CRKP (WYKP589 and WYKP188), and tried to clarify and compare their differences in virulence and drug resistance characteristics and plasmid distribution.</div></div><div><h3>Results</h3><div>Our study found that ST23-KL1 and ST86-KL2 CR-hvKP exhibited less plasmid diversity than that of ST11-KL64 and ST11-KL47 hv-CRKP. Compared with ST11-KL64 and ST11-KL47 hv-CRKP, ST23-KL1/ST86-KL2 CR-hvKP harbored significantly fewer antimicrobial resistance genes but more virulence genes, which contributed to the higher virulence of these strains and exhibited resistance to fewer antibiotics. ST11-KL64 hv-CRKP has emerged as the most prevalent hypervirulent and carbapenem-resistant <em>Klebsiella pneumoniae</em> probably due to its clonal transmission within hospitals as well as the transmission of virulence plasmids with the help of conjugative resistance plasmids.</div></div><div><h3>Conclusions</h3><div>Due to the different evolutionary mechanisms of hypervirulent and carbapenem-resistant <em>Klebsiella pneumoniae</em> with different capsular serotypes, the epidemiological, phenotypic and genotypic characteristics of KL1, KL2 CR-hvKP and KL64, KL47 hv-CRKP are different.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 444-454"},"PeriodicalIF":4.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel 富西地酸在载抗生素水凝胶中的意外细胞毒性。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-28 DOI: 10.1016/j.jmii.2025.02.004
Jing-Gu Jiang , Yu-Chun Chen , Ni-En Jiang , Chun-Hsing Liao , Chih-Hung Chang
{"title":"Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel","authors":"Jing-Gu Jiang ,&nbsp;Yu-Chun Chen ,&nbsp;Ni-En Jiang ,&nbsp;Chun-Hsing Liao ,&nbsp;Chih-Hung Chang","doi":"10.1016/j.jmii.2025.02.004","DOIUrl":"10.1016/j.jmii.2025.02.004","url":null,"abstract":"<div><div>This study evaluated the cytotoxicity of fusidic acid-loaded HA hydrogels on different cell types. Results show significant cytotoxicity, especially at concentrations above 0.1 %, with MC3T3 cells being the most sensitive. These findings highlight the importance of considering cell-specific responses and cytotoxic effects when designing antibiotic-loaded hydrogels for biomedical applications.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 486-489"},"PeriodicalIF":4.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendation for immune prophylaxis of respiratory syncytial virus infection in children 儿童呼吸道合胞病毒感染的免疫预防建议。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-26 DOI: 10.1016/j.jmii.2025.02.007
Ping-Ing Lee , Yhu-Chering Huang , Chih-Jung Chen , Cheng-Hsun Chiu , Po-Yen Chen , Chun-Yi Lu , Ching-Chuan Liu , Nan-Chang Chiu , Hsin Chi , Chien-Yu Lin , Chun Yi Lee , Shuenn-Nan Chiu , Mei-Jy Jeng , Kuang-Che Kuo , Ren-Bin Tang , Yung-Feng Huang , Hui-Hsien Pan , Ming-Fang Cheng , Li-Min Huang , Ya-Li Hu , Tzou-Yien Lin
{"title":"Recommendation for immune prophylaxis of respiratory syncytial virus infection in children","authors":"Ping-Ing Lee ,&nbsp;Yhu-Chering Huang ,&nbsp;Chih-Jung Chen ,&nbsp;Cheng-Hsun Chiu ,&nbsp;Po-Yen Chen ,&nbsp;Chun-Yi Lu ,&nbsp;Ching-Chuan Liu ,&nbsp;Nan-Chang Chiu ,&nbsp;Hsin Chi ,&nbsp;Chien-Yu Lin ,&nbsp;Chun Yi Lee ,&nbsp;Shuenn-Nan Chiu ,&nbsp;Mei-Jy Jeng ,&nbsp;Kuang-Che Kuo ,&nbsp;Ren-Bin Tang ,&nbsp;Yung-Feng Huang ,&nbsp;Hui-Hsien Pan ,&nbsp;Ming-Fang Cheng ,&nbsp;Li-Min Huang ,&nbsp;Ya-Li Hu ,&nbsp;Tzou-Yien Lin","doi":"10.1016/j.jmii.2025.02.007","DOIUrl":"10.1016/j.jmii.2025.02.007","url":null,"abstract":"<div><div>Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. Most infections occur below 1 year of age, and almost all children have been infected before 2 years of age.</div><div>Monoclonal antibodies targeting RSV, such as palivizumab and nirsevimab, are accessible for preventing infection. A committee, consisting of experts in infectious diseases, cardiovascular diseases, and neonatal diseases in children, was assembled by the Pediatric Infectious Diseases Society of Taiwan. Collaborating with the Child Health Research Center at the National Health Research Institutes, Taiwan Pediatric Association, and Taiwan Society of Neonatology, the committee worked to formulate recommendations for immune prophylaxis against RSV infection in children. Palivizumab is recommended for the prevention of RSV infection in high-risk infants under 1 year old with one of the following (1) premature infants with a gestational age &lt;33 weeks, (2) premature infants with a gestational age &lt;35 weeks with chronic lung disease or (3) infants with hemodynamically significant CHD. Nirsevimab is recommended for the prevention of RSV infection in all infants &lt;12 months.</div><div>The recommendation is not intended as a sole source of guidance in the prevention of RSV infection in children. The provisions listed in this recommendation are comprehensive suggestions made by pediatric experts in Taiwan based on existing medical evidence. This recommendation should be subject to modification in light of additional medical research findings in the future, and these provisions should not be cited as a basis for dispute resolution.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 3","pages":"Pages 288-293"},"PeriodicalIF":4.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of bloodstream infection and its impact on mortality in septic arthritis: A 15-year review 脓毒性关节炎血流感染的预测因素及其对死亡率的影响:15年回顾
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-26 DOI: 10.1016/j.jmii.2025.02.006
Yongseop Lee , Yong Chan Kim , Jaeeun Seong, Sangmin Ahn, Min Han, Jung Ah Lee, Jung Ho Kim, Jin Young Ahn, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Su Jin Jeong
{"title":"Predictors of bloodstream infection and its impact on mortality in septic arthritis: A 15-year review","authors":"Yongseop Lee ,&nbsp;Yong Chan Kim ,&nbsp;Jaeeun Seong,&nbsp;Sangmin Ahn,&nbsp;Min Han,&nbsp;Jung Ah Lee,&nbsp;Jung Ho Kim,&nbsp;Jin Young Ahn,&nbsp;Nam Su Ku,&nbsp;Jun Yong Choi,&nbsp;Joon-Sup Yeom,&nbsp;Su Jin Jeong","doi":"10.1016/j.jmii.2025.02.006","DOIUrl":"10.1016/j.jmii.2025.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Septic arthritis is frequently complicated by bloodstream infection (BSI), which can lead to metastatic infections and sepsis. In the current study, we aimed to identify risk factors for septic arthritis-related BSI and assess its impact on clinical outcomes.</div></div><div><h3>Methods</h3><div>A retrospective review spanning 15 years (January 2009 to May 2023) was conducted on patients diagnosed with septic arthritis. Data from patients with positive synovial fluid cultures were analyzed.</div></div><div><h3>Results</h3><div>Among 456 patients with septic arthritis, 16.8 % (n = 77) developed BSI. The 90-day mortality rate was significantly higher in patients with BSI than in those without BSI (14.3 % vs. 5.3 %, <em>p</em> = 0.004). <em>Staphylococcus aureus</em> was the most commonly identified organism in synovial fluid cultures, and the presence of <em>S</em>. <em>aureus</em> infection was associated with an increased risk of BSI (adjusted odds ratio [aOR], 2.20; 95 % confidence interval [CI], 1.15–4.34; <em>p</em> = 0.019). Independent risk factors for BSI included a higher Sequential Organ Failure Assessment (SOFA) score (aOR, 1.23; 95 % CI, 1.06–1.44; <em>p</em> = 0.009), lymphopenia (aOR, 2.84; 95 % CI, 1.38–6.15; <em>p</em> = 0.006), and elevated C-reactive protein (mg/dL) levels (aOR, 1.07; 95 % CI, 1.05–1.10; <em>p</em> &lt; 0.001). Age ≥70 years (aOR, 3.96; 95 % CI, 1.49–11.85; <em>p</em> = 0.009) and a higher SOFA score (aOR, 1.36; 95 % CI, 1.12–1.67; <em>p</em> = 0.002) were significant predictors of 90-day mortality, although BSI itself was not.</div></div><div><h3>Conclusion</h3><div>Mortality in patients with septic arthritis was primarily associated with systemic sepsis due to BSI rather than BSI itself. Understanding the relationship between septic arthritis-related BSI and clinical outcomes could aid physicians in managing systemic infections and improving patient care.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 3","pages":"Pages 318-324"},"PeriodicalIF":4.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptom-based Kikuchi disease subtypes: Clinical scenarios across specialties in Taiwan with temporal trends analysis 以症状为基础的菊池病亚型:台湾不同专科的临床情况及时间趋势分析。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-26 DOI: 10.1016/j.jmii.2025.02.009
Shan-Chi Yu , Tseng-Cheng Chen , Chun-Nan Chen , Tsung-Lin Yang
{"title":"Symptom-based Kikuchi disease subtypes: Clinical scenarios across specialties in Taiwan with temporal trends analysis","authors":"Shan-Chi Yu ,&nbsp;Tseng-Cheng Chen ,&nbsp;Chun-Nan Chen ,&nbsp;Tsung-Lin Yang","doi":"10.1016/j.jmii.2025.02.009","DOIUrl":"10.1016/j.jmii.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>We propose a subtyping system for Kikuchi disease based on chief complaints and fever status.</div></div><div><h3>Methods</h3><div>A chart review of 388 patients diagnosed with Kikuchi disease.</div></div><div><h3>Results</h3><div>The subtypes afebrile lymphadenopathy (aLAP), febrile lymphadenopathy (FebLAP), and febrile accounted for 68 %, 18 %, and 14 % of cases, respectively. aLAP patients were older (median 26 years), predominantly female, had fewer laboratory abnormalities, and a lower recurrence rate (5 %). In contrast, the febrile type included younger patients (median 17 years), predominantly male, with more laboratory abnormalities and a higher recurrence rate (20 %). FebLAP exhibited intermediate characteristics. Otolaryngology had the highest number of patients (272, 70 %), mainly with aLAP, typically diagnosed via outpatient needle biopsy, with a short follow-up duration. Infectious disease specialists (adult and pediatric) managed 67 patients (17 %), often encountering the febrile type, with patients frequently seen in the emergency room or hospitalized, diagnosed via surgical biopsy, and followed up more intensively and over longer periods. Approximately 9 % of patients were referred to rheumatology; these patients more frequently used disease-modifying antirheumatic drugs and steroids and were followed for an extended duration. From 2005 to 2022, the incidence of Kikuchi disease has doubled, driven by otolaryngologists’ aggressive use of ultrasound-guided core needle biopsy to diagnose more aLAP cases.</div></div><div><h3>Conclusions</h3><div>Patients of different subtypes exhibit distinct characteristics, including demographic and laboratory data, recurrence rates, medical-seeking behaviors, diagnostic methods, treatments, and follow-up approaches, underscoring the clinical significance of this subtyping system. Changes in biopsy methods have led to the diagnosis of more aLAP cases.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 406-413"},"PeriodicalIF":4.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytomegalovirus-related thrombocytopenia in two immunocompetent siblings following vertical transmission through Breast milk 两个免疫功能正常的兄弟姐妹经母乳垂直传播后出现巨细胞病毒相关血小板减少症。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-02-26 DOI: 10.1016/j.jmii.2025.02.008
Yuan-Ning Yang , Yung-Chieh Lin , Chao-Neng Cheng
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