Journal of Microbiology Immunology and Infection最新文献

{"title":"High-risk human papillomavirus-associated extramammary paget disease in a person with well-controlled HIV infection.","authors":"Wei-Ting Lin, Kuan-Yu Chen, Hsiang-Wei Hu, Hsin-Yun Sun, Wang-Huei Sheng, Chien-Ching Hung","doi":"10.1016/j.jmii.2026.10.002","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.002","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic gap in Q fever endocarditis: a case report in Taiwan.","authors":"Tian-Yu You, Po-Ta Chen, Kuang-Hsiung Cheng, Szu-Han Wang, Chia-Wen Li, Hsin-Ling Lee, Yu-Shan Chang, Szu-Ying Chen, Nan-Yao Lee, Wen-Chien Ko","doi":"10.1016/j.jmii.2026.10.001","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.001","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary syphilis mimicking oral malignancy in a male with heavy tobacco and betel nut exposure.","authors":"Pin-Cheng Chu, Shu-Hsien Wang, Wen-Chien Ko, Po-Lin Chen","doi":"10.1016/j.jmii.2026.10.005","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.005","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streptobacillus moniliformis from a wound of a pet rabbit in northern Taiwan.","authors":"Meng-Syun Li, Chih-Chun Tseng, Winnie Wai Yee Wong, Rachel Hui Wen Chung, Ter-Hsin Chen, Wen Yi Choong, Michio Suzuki, Ying-Chen Wu","doi":"10.1016/j.jmii.2026.10.006","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.006","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the BioFire joint infection panel in Taiwan: Impact of regional non-target pathogens and joint type on its performance.","authors":"Shih-Hao Lo, Chieh Chin, Hsuan-Ti Huang, Cheng-Jung Ho, Yu-Te Tsai, Po-Liang Lu, Chao-Ju Chen, Shin-Huei Kuo, Shang-Yi Lin","doi":"10.1016/j.jmii.2026.10.004","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.004","url":null,"abstract":"<p><strong>Objectives: </strong>The BIOFIRE® Joint Infection (BJI) panel, a rapid multiplex polymerase chain reaction assay, is used to diagnose joint infections. Here we used it to evaluate the clinical performance and impact of antimicrobial resistance (AMR) detection in Taiwan's unique microbial landscape.</p><p><strong>Methods: </strong>Adult patients with suspected septic arthritis or prosthetic joint infection were prospectively enrolled from four hospitals in southern Taiwan. Synovial fluid specimens were tested using a BJI panel and routine bacterial culturing. Performance was assessed by calculating the positive percent agreement and negative percent agreement (PPA and NPA, respectively).</p><p><strong>Results: </strong>Eighty-six specimens (native joints, 56; prosthetic joints, 30) were analyzed. The overall PPA and NPA were 92.3% and 76.7%, respectively. Native joints showed higher concordance (PPA, 93.8%; NPA, 85.0%) than prosthetic joints (PPA, 90.0%; NPA, 60.0%). The BJI panel detected pathogens in 14 culture-negative cases, predominantly among patients who previously received antibiotics. Notably, the panel identified six methicillin-resistant Staphylococcus aureus cases (three culture-negative) and one bla_CTX-M-positive E. coli detection. However, three culture-positive cases involving \"off-panel\" regional pathogens (Burkholderia pseudomallei, n = 2; Mycobacterium tuberculosis complex, n = 1) were BJI-negative. Diagnostic concordance is better in native joints and correlated significantly with higher synovial leukocyte counts.</p><p><strong>Conclusions: </strong>Our evaluation revealed the BJI panel's ability to rapidly identify pathogens and profile AMR, with additional diagnostic yield particularly in culture-negative prosthetic joint infections and in patients with prior antibiotic exposure. However, its limited detection targets leave a diagnostic gap for regionally endemic pathogens such as Burkholderia pseudomallei and Mycobacterium tuberculosis complex, indicating the continued need for conventional culturing.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 changes in the epidemiology of group A Streptococcus infections in Taiwan: A retrospective study.","authors":"Wai-Ki Goh, Yun-Chung Liu, Ya-Li Hu, Shu-Yuan Ho, Yu-Tsung Huang, Chun-Yi Lu, Hung-Jen Tang, Li-Min Huang, Tu-Hsuan Chang, Luan-Yin Chang","doi":"10.1016/j.jmii.2026.10.003","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.10.003","url":null,"abstract":"<p><strong>Background: </strong>Temporal changes in group A Streptococcus (GAS) infections have been reported worldwide, but long-term data from Taiwan remain limited. This study evaluated temporal patterns, age-specific disease characteristics, antimicrobial susceptibility, and factors associated with invasive GAS infection.</p><p><strong>Methods: </strong>We conducted a retrospective study that included patients with GAS infection at a tertiary referral center in Taiwan from 2015 to 2024. Monthly hospital-identified case counts were described, and multivariable logistic regression was used to identify factors associated with invasive disease.</p><p><strong>Results: </strong>Among 454 patients, 33 (7.3%) had invasive disease. Monthly case counts declined markedly during the COVID-19 period (2020-2022), remained low in 2023, and increased to 45 cases in 2024, still below pre-pandemic annual levels. Adults aged ≥65 years accounted for 14 of 33 invasive cases (42.4%). Age ≥18 years (adjusted odds ratio [aOR], 11.6; 95% confidence interval [CI], 4.4-30.9; p < 0.001) and the presence of two or more underlying disease categories (aOR, 29.7; 95% CI, 10.4-84.5; p < 0.001) were associated with invasive disease. All isolates were susceptible to penicillin. Invasive isolates showed higher susceptibility to clindamycin and erythromycin but lower susceptibility to tetracycline than noninvasive isolates.</p><p><strong>Conclusion: </strong>Hospital-identified GAS cases showed substantial temporal variation. Older age and greater underlying disease burden were associated with invasive infection. These findings may support clinical risk assessment and institutional surveillance.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Candida auris bloodstream infection after discontinuation of contact precautions in a hemodialysis patient.","authors":"Bo-Jhih Li, Yung-Hsuen Hsu, Yea-Yuan Chang","doi":"10.1016/j.jmii.2026.09.014","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.09.014","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of discontinuation of serum antibody test reagents and COVID-19 pandemic on the diagnosis of amebiasis: A Japanese nationwide observational study.","authors":"Yoshiro Hadano, Hirotake Mori, Satoshi Ohno","doi":"10.1016/j.jmii.2026.09.013","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.09.013","url":null,"abstract":"<p><p>We evaluated the impact of serum antibody test discontinuation and the Coronavirus disease 2019 pandemic on reported amebiasis cases in Japan using National Epidemiological Surveillance of Infectious Diseases data and interrupted time-series analysis. Both factors were independently associated with reduced case notifications.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of serum inflammatory cytokines in hospitalized COVID-19 patients treated with NRICM101: A preliminary observational study.","authors":"Ying-Chuan Wang, Ya-Hsin Yao, Sunny Jui-Shan Lin, Chun-Hsiang Chiu","doi":"10.1016/j.jmii.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.09.012","url":null,"abstract":"<p><strong>Background: </strong>SARS-CoV-2 infection can induce a hyperinflammatory response through excessive cytokine release, contributing to disease severity and mortality. NRICM101, a government-endorsed multi-herbal traditional Chinese medicine formula, has shown promising immunomodulatory and antiviral effects in preclinical studies. However, clinical evidence on its effect on inflammatory biomarkers in COVID-19 patients remains limited.</p><p><strong>Methods: </strong>To evaluate the clinical effects of NRICM101, we conducted a prospective observational study with non-randomized treatment allocation based on patient consent. A total of 51 hospitalized patients infected with the Alpha variant of SARS-CoV-2 in northern Taiwan (April-June 2021) were included. Fourteen patients received NRICM101 in addition to standard supportive care, while 37 received standard care alone. Serum cytokines-IL-6, IL-16, IP-10, MCP-1, and PDGF-BB-were measured using multiplex immunoassay. Clinical data including disease progression, oxygen requirement, length of hospitalization, and mortality were collected and analyzed.</p><p><strong>Results: </strong>Patients in the NRICM101 group showed significantly lower levels of IL-6 (p = 0.033) and IL-16 (p = 0.040) compared to controls. IP-10 and MCP-1 levels exhibited downward trends without reaching statistical significance. Despite a higher baseline rate of respiratory failure in the NRICM101 group (35.7% vs. 5.4%; P = 0.005), clinical outcomes were comparable between the groups.</p><p><strong>Conclusions: </strong>NRICM101 administration was associated with reduced serum levels of key proinflammatory cytokines, indicating a potential anti-inflammatory effect. Clinical outcomes were comparable between the two groups. NRICM101 may serve as an adjunctive therapy for patients with COVID-19-related hyperinflammation and warrants further evaluation in larger randomized trials.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surge of Legionnaires' disease at a tertiary hospital in southern Taiwan, 2024: the potential diagnostic pitfall of urinary antigen testing.","authors":"Cong-Tat Cia, Pei-Fang Tsai, Szu-Ying Chen, Yi-Shan Dai, Po-Lin Chen, Wen-Chien Ko","doi":"10.1016/j.jmii.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.jmii.2026.09.011","url":null,"abstract":"<p><p>We reported a surge of Legionnaire's disease at a tertiary hospital in Taiwan in 2024, partially attributed by falsely positive Legionella urinary antigen testing (UAT) results. Of 20 patients with positive UAT results and complete investigations, only seven (35%) had legionellosis confirmed by Legionella growth, nucleic acid detection, or seroconversion.</p>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}