Journal of Microbiology Immunology and Infection最新文献

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The therapeutic impact of maximum chemotherapy possession days during three consecutive months in non-tuberculous mycobacterial lung disease: A real-world experience 非结核性分枝杆菌肺病连续三个月最大化疗天数的治疗效果:真实世界的经验。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-27 DOI: 10.1016/j.jmii.2025.03.016
Ping-Huai Wang , Yu-Feng Wei , Chia-Jung Liu , Chung-Yu Chen , Shu-Wen Lin , Sheng-Wei Pan , Su-Mei Wang , Chin-Chung Shu , Chin-Hao Chang , Chong-Jen Yu
{"title":"The therapeutic impact of maximum chemotherapy possession days during three consecutive months in non-tuberculous mycobacterial lung disease: A real-world experience","authors":"Ping-Huai Wang ,&nbsp;Yu-Feng Wei ,&nbsp;Chia-Jung Liu ,&nbsp;Chung-Yu Chen ,&nbsp;Shu-Wen Lin ,&nbsp;Sheng-Wei Pan ,&nbsp;Su-Mei Wang ,&nbsp;Chin-Chung Shu ,&nbsp;Chin-Hao Chang ,&nbsp;Chong-Jen Yu","doi":"10.1016/j.jmii.2025.03.016","DOIUrl":"10.1016/j.jmii.2025.03.016","url":null,"abstract":"<div><h3>Purpose</h3><div>Adherence to guideline recommendations in the treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is often difficult. Thus, this study aimed to investigate the impact of the integrity of NTM-LD treatment on treatment outcomes.</div></div><div><h3>Materials and methods</h3><div>The participants were screened from the National Taiwan University Hospital-Integrative Medical Database (NTUH-iMD) and the Taiwan National Health Insurance Research Database (NHIRD). The longest treatment duration during 3 consecutive months was defined as maximum chemotherapy possession days (MCPDs) and was categorized as low (28–55 days), medium (56–90 days), and maximum (≥91 days). We analyzed microbiological cure and 3-year mortality using MCPDs.</div></div><div><h3>Results</h3><div>Low, medium, and maximum MCPD groups had 83 (19.2 %), 94 (21.8 %), and 255 (59.0 %) participants in the NTUH-iMD cohort (N = 432) and 1203 (26.5 %), 1251 (27.6 %), and 2084 (45.9 %) participants in the NHIRD cohort (N = 4538), respectively. In the NTUH-iMD cohort, multivariable analysis showed that adjusted hazard ratios (aHRs) of 3-year mortality were 0.51 (95 % CI: 0.29–0.90) and 0.29 (0.18–0.49) in medium and maximum MCPD groups compared with the low MCPD group. The trends of survival benefit by maximum MCPDs were also found in the NHIRD cohort. The maximum MCPD group had 45.9 % participants with microbiologic cure, which was significantly higher than in medium and low MCPD groups (27.7 % and 4.0 %, respectively; p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Maximum MCPD for NTM-LD increased microbiological cure and reduced 3-year mortality by 71 % compared with low MCPD group. Maintaining NTM-LD treatment integrity as possible might positively impact disease outcomes.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 470-478"},"PeriodicalIF":4.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical and molecular characteristics of invasive Streptococcus agalactiae diseases in nonpregnant adults in Taiwan 台湾非怀孕成人侵袭性无乳链球菌病的临床及分子特征。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-25 DOI: 10.1016/j.jmii.2025.03.011
Jen-Fu Hsu , Wei-Ju Lee , Shih-Ming Chu , Yao-Sheng Wang , Hsuan-Rong Huang , Peng-Hong Yang , Jang-Jih Lu , Ming-Horng Tsai
{"title":"The clinical and molecular characteristics of invasive Streptococcus agalactiae diseases in nonpregnant adults in Taiwan","authors":"Jen-Fu Hsu ,&nbsp;Wei-Ju Lee ,&nbsp;Shih-Ming Chu ,&nbsp;Yao-Sheng Wang ,&nbsp;Hsuan-Rong Huang ,&nbsp;Peng-Hong Yang ,&nbsp;Jang-Jih Lu ,&nbsp;Ming-Horng Tsai","doi":"10.1016/j.jmii.2025.03.011","DOIUrl":"10.1016/j.jmii.2025.03.011","url":null,"abstract":"<div><h3>Background</h3><div><em>Streptococcus agalactiae</em> (Group B <em>Streptococcus</em>, GBS) is a growing threat to nonpregnant adults. We aimed to describe the clinical and molecular characteristics of invasive GBS infections in adults.</div></div><div><h3>Methods</h3><div>All adults with invasive GBS infections at a tertiary-level medical center in Taiwan between 2014 and 2020 were analyzed. Capsule serotyping, multilocus sequence typing and antibiotic susceptibility testing were performed.</div></div><div><h3>Results</h3><div>A total of 666 adults with GBS infections were analyzed. The median age at onset was 65 years (range 19–102). The most common manifestation was bacteremia without focus (80.4 %). The younger patients (19–39 years old) had a significantly higher rate of non-bloodstream infections (24.6 %, P &lt; 0.001) and were overweight in most cases (77.2 %). Most patients had underlying chronic comorbidities (82.3 %). Capsular types VI (33.0 %), Ia (19.4 %), III (15.0 %), and V (10.2 %) were predominant. Clonal complexes (CCs) 1, 12, 17, 19, 23 and 452 accounted for 96.3 % (464/482) of the cases. All GBS isolates were susceptible to β-lactam antibiotics. The rates of resistance to erythromycin and clindamycin were 42.6 % and 39.2 %, respectively, but were especially high in type III, Ib and V GBS isolates. The mortality rates at one month and one year were 5.0 % and 12.3 %, respectively, but were significantly higher in elderly patients.</div></div><div><h3>Conclusion</h3><div>The clinical manifestations of invasive GBS infections in adults are diverse. Elderly patients are susceptible to invasive GBS infections and have a relatively high mortality rate. Continuous surveillance of GBS epidemiology should be enforced given the increasing growing importance of antibiotic-resistant GBS isolates.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 437-443"},"PeriodicalIF":4.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbial signatures associated with uremic pruritus in hemodialysis patients 血液透析患者尿毒症瘙痒相关的肠道微生物特征。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-21 DOI: 10.1016/j.jmii.2025.03.010
Mei-Ju Ko , Chun-Hsing Liao , Yen-Ling Chiu , Wan-Chuan Tsai , Ju-Yeh Yang , Mei-Fen Pai , Ping-Hsiu Tsai , Shih-Ping Hsu , Yu-Sen Peng , Hon-Yen Wu
{"title":"Gut microbial signatures associated with uremic pruritus in hemodialysis patients","authors":"Mei-Ju Ko ,&nbsp;Chun-Hsing Liao ,&nbsp;Yen-Ling Chiu ,&nbsp;Wan-Chuan Tsai ,&nbsp;Ju-Yeh Yang ,&nbsp;Mei-Fen Pai ,&nbsp;Ping-Hsiu Tsai ,&nbsp;Shih-Ping Hsu ,&nbsp;Yu-Sen Peng ,&nbsp;Hon-Yen Wu","doi":"10.1016/j.jmii.2025.03.010","DOIUrl":"10.1016/j.jmii.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>The gut microbiota influences the gut–skin–kidney axis, but its role in uremic pruritus remains poorly understood. This study aimed to explore differences in gut microbial profiles between hemodialysis (HD) patients with and without uremic pruritus and identify potential microbial signatures associated with uremic pruritus.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of HD patients with and without uremic pruritus. Stool samples were collected from all participants, and the gut microbiota composition was analyzed using 16S rRNA gene sequencing. Alpha and beta diversity metrics were calculated to assess microbial diversity. LEfSe analysis was performed to identify differentially abundant taxa associated with uremic pruritus.</div></div><div><h3>Results</h3><div>Among 93 HD patients (mean age: 61.9 years, 31.2 % female), uremic pruritus occurred in 61.3 % of patients, with a median visual analog scale (VAS) score of 4.0. While alpha diversity did not differ significantly between groups, beta diversity analysis revealed significant compositional differences (unweighted UniFrac metric, <em>P</em> = 0.004; weighted UniFrac metric, <em>P</em> &lt; 0.001). LEfSe analysis revealed significant enrichment of the order <em>Pasteurellales</em>, family <em>Pasteurellaceae</em> and genus <em>Dialister</em> in patients with uremic pruritus, whereas the order <em>Corynebacteriales</em> was more abundant in patients without pruritus (<em>P</em> &lt; 0.05, LDA score &gt; 3).</div></div><div><h3>Conclusion</h3><div>In this study, we found significant differences in gut microbiota composition between HD patients with and without uremic pruritus and identified potential microbial biomarkers for uremic pruritus. Further studies are needed to elucidate the underlying mechanisms and explore microbiota-targeted therapeutic interventions.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 479-485"},"PeriodicalIF":4.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-carriage of blaNDM-1 and blaVIM-2 in different plasmids of Acinetobacter junii isolate and the transfer of blaNDM-1-carrying plasmids to Gram-negative bacteria 琼尼不动杆菌不同质粒中blaNDM-1和blaVIM-2的共载及blaNDM-1质粒向革兰氏阴性菌的转移。
IF 3.7 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-19 DOI: 10.1016/j.jmii.2025.03.008
Md Shohel Rana , Shukho Kim , Seo Yeon Ko , Nayeong Kim , Seong Yeob Kim , Da Eun Lee , Ki Tae Kwon , Yu Kyung Kim , Je Chul Lee
{"title":"Co-carriage of blaNDM-1 and blaVIM-2 in different plasmids of Acinetobacter junii isolate and the transfer of blaNDM-1-carrying plasmids to Gram-negative bacteria","authors":"Md Shohel Rana ,&nbsp;Shukho Kim ,&nbsp;Seo Yeon Ko ,&nbsp;Nayeong Kim ,&nbsp;Seong Yeob Kim ,&nbsp;Da Eun Lee ,&nbsp;Ki Tae Kwon ,&nbsp;Yu Kyung Kim ,&nbsp;Je Chul Lee","doi":"10.1016/j.jmii.2025.03.008","DOIUrl":"10.1016/j.jmii.2025.03.008","url":null,"abstract":"<div><div>Carbapenem-resistant <em>Acinetobacter junii</em> isolate co-carried <em>bla</em><sub>VIM-2</sub> and <em>bla</em><sub>NDM-1</sub> in different plasmids. <em>bla</em><sub>NDM-1</sub>- and <em>bla</em><sub>VIM-2</sub>-carrying plasmids were characterized using the whole genome sequencing. The expression of <em>bla</em><sub>NDM-1</sub> was higher than that of <em>bla</em><sub>VIM-2</sub>. <em>bla</em><sub>NDM-1</sub>-carrying plasmid was conjugally transferred to various Gram-negative bacterial species. The transferability of <em>bla</em><sub>NDM-1</sub>-carrying plasmid raises concerns about the potential spread of carbapenem resistance across diverse bacterial populations.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 5","pages":"Pages 613-616"},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world evidence of dalbavancin effectiveness as consolidation therapy in infective endocarditis due to Enterococcus spp. 达巴文星作为巩固治疗肠球菌所致感染性心内膜炎有效性的真实证据。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-17 DOI: 10.1016/j.jmii.2025.03.001
Carmen Hidalgo-Tenorio , Svetlana Sadyrbaeva-Dolgova , Eduardo Aparicio-Minguijón , Arístides Alarcón , Antonio Plata , Francisco Javier Martínez Marcos , Beatriz Álvarez-Álvarez , Belén Loeches , Benedetta Varisco , Agustín Estévez , Carmen Herrero , Francesc Escrihuela-Vidal , Lucia Boix-Palop , Yvon Ruch , Florent Valour , Nahéma Issa , Pauline Thill , Sophie Nguyen , Samantha Poloni , Romain Millot , David Luque-Paz
{"title":"Real-world evidence of dalbavancin effectiveness as consolidation therapy in infective endocarditis due to Enterococcus spp.","authors":"Carmen Hidalgo-Tenorio ,&nbsp;Svetlana Sadyrbaeva-Dolgova ,&nbsp;Eduardo Aparicio-Minguijón ,&nbsp;Arístides Alarcón ,&nbsp;Antonio Plata ,&nbsp;Francisco Javier Martínez Marcos ,&nbsp;Beatriz Álvarez-Álvarez ,&nbsp;Belén Loeches ,&nbsp;Benedetta Varisco ,&nbsp;Agustín Estévez ,&nbsp;Carmen Herrero ,&nbsp;Francesc Escrihuela-Vidal ,&nbsp;Lucia Boix-Palop ,&nbsp;Yvon Ruch ,&nbsp;Florent Valour ,&nbsp;Nahéma Issa ,&nbsp;Pauline Thill ,&nbsp;Sophie Nguyen ,&nbsp;Samantha Poloni ,&nbsp;Romain Millot ,&nbsp;David Luque-Paz","doi":"10.1016/j.jmii.2025.03.001","DOIUrl":"10.1016/j.jmii.2025.03.001","url":null,"abstract":"<div><div>Enterococcal endocarditis (EIE) affects elderly patients, with high rates of complications and mortality, and dalbavancin (DBV) exhibits significant antimicrobial activity against most enterococci. However, data are lacking on the use of DBV in EIE. The main objective was to evaluate the outcomes of treatment with DBV in the consolidation therapy of IE by <em>Enterococcus</em> spp.</div></div><div><h3>Methods</h3><div>Spanish-French retrospective observational study of patients with EIE enrolled between November 2016 and June 30, 2022 receiving DBV in consolidation phase and followed for ≥12 months.</div></div><div><h3>Results</h3><div>Ninety-eight patients were enrolled, 69.4 % male, with mean age of 71.2 (±12.51) years and median Charlson index of 5 (IQR 3–7). Criteria for definite IE were met by 84.7%; 60.2 % had IE on native valve, 26.5 % late prosthetic IE, 8.2 % early prosthetic IE, 2 % cardiovascular implantable electronic-IE (CIE-IE), and 3.1 % CIE-IE and valve. Aortic valve involvement was observed in 66.3 %. <em>E. faecalis</em> was isolated in 86.7 %, <em>E. faecium</em> in 11.2 %; 32.6 % underwent surgery, and these had a higher cure rate (100 % vs 75.8 %; p = 0.005) and lower mortality (0 vs 13.6 %; p = 0.029). DBV was administered to facilitate discharge in 88.8 %. Total dose was 2500 mg (1500–3000) over 3.5 weeks (2–4). Loss to follow-up was 0 %, relapse rate 8.2 %, 1-year IE-related mortality 3.1 %, and clinical cure rate 81.2 %. Severe adverse events affected 1 % (acute tubular necrosis). Hospital stay was reduced by 21 days (14–28).</div></div><div><h3>Conclusions</h3><div>DBV appears to be highly effective, safe, and cost-effective as consolidation therapy in patients with IE caused by <em>Enterococcus</em> spp., with minimal adverse events.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 429-436"},"PeriodicalIF":4.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culture-negative orthopedic implant-associated infection due to Mycoplasma hominis: A case report 人支原体引起的培养阴性骨科植入物相关感染1例报告。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-17 DOI: 10.1016/j.jmii.2025.03.007
Tian-Yu You , Nan-Yao Lee , Tai-Hua Yang , Po-Lin Chen , Ming-Chi Li , Shu-Li Su , Yu-Wei Hsu , Wen-Chien Ko
{"title":"Culture-negative orthopedic implant-associated infection due to Mycoplasma hominis: A case report","authors":"Tian-Yu You ,&nbsp;Nan-Yao Lee ,&nbsp;Tai-Hua Yang ,&nbsp;Po-Lin Chen ,&nbsp;Ming-Chi Li ,&nbsp;Shu-Li Su ,&nbsp;Yu-Wei Hsu ,&nbsp;Wen-Chien Ko","doi":"10.1016/j.jmii.2025.03.007","DOIUrl":"10.1016/j.jmii.2025.03.007","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 493-495"},"PeriodicalIF":4.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oseltamivir-resistant influenza in a fatal immunocompromised adult 致死性免疫功能低下成人的奥司他韦耐药流感
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-17 DOI: 10.1016/j.jmii.2025.03.006
Hao-En Jan , Yi-Ting Huang , Cong-Tat Cia , Huey-Pin Tsai , Wen-Chien Ko
{"title":"Oseltamivir-resistant influenza in a fatal immunocompromised adult","authors":"Hao-En Jan ,&nbsp;Yi-Ting Huang ,&nbsp;Cong-Tat Cia ,&nbsp;Huey-Pin Tsai ,&nbsp;Wen-Chien Ko","doi":"10.1016/j.jmii.2025.03.006","DOIUrl":"10.1016/j.jmii.2025.03.006","url":null,"abstract":"","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 490-492"},"PeriodicalIF":4.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection 在实验室确诊呼吸道合胞病毒感染的住院老年人中,高细菌合并感染率和相关死亡率。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-17 DOI: 10.1016/j.jmii.2025.03.005
Yu-Chang Fu , Ting-wei Lai , Yu-Hua Su , Yu-Chao Lin , Chih-Yen Tu , Chieh-Lung Chen , Po-Ren Hsueh
{"title":"High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection","authors":"Yu-Chang Fu ,&nbsp;Ting-wei Lai ,&nbsp;Yu-Hua Su ,&nbsp;Yu-Chao Lin ,&nbsp;Chih-Yen Tu ,&nbsp;Chieh-Lung Chen ,&nbsp;Po-Ren Hsueh","doi":"10.1016/j.jmii.2025.03.005","DOIUrl":"10.1016/j.jmii.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence highlights that respiratory syncytial virus (RSV) poses a significant risk to older adults. However, detailed clinical data on elderly patients hospitalized with RSV remains limited. This study investigates the clinical characteristics and outcomes of older adults (aged ≥50 years) hospitalized with RSV infection.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included hospitalized patients aged ≥50 years with respiratory symptoms and laboratory-confirmed RSV infection at China Medical University Hospital between January 1, 2011, and December 31, 2023. Data on demographic characteristics and clinical presentations were collected. RSV infection-related outcomes were analyzed across various subgroups.</div></div><div><h3>Results</h3><div>This study included 36 patients, with the most prevalent comorbidities being diabetes mellitus (47.2 %), immunocompromised status (36.1 %), and chronic lung disease (30.6 %). Pneumonia was identified in 72.2 % of patients, while 41.7 % required invasive mechanical ventilation, and the hospital mortality rate was 33.3 %. Non-survivors had higher rates of comorbidities, particularly chronic lung disease (66.7 % vs. 12.5 %, <em>p</em> = 0.002), higher disease severity, elevated procalcitonin levels, and were more likely to develop septic shock and acute respiratory distress syndrome. A bacterial coinfection rate of 33.3 % was observed, with patients experiencing pneumonia or bacterial coinfection showing poorer outcomes. Moreover, patients with chronic lung disease exhibited significantly worse day-28 survival (log-rank <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The disease burden of RSV in older adults is amplified by comorbidities such as chronic lung disease, with pneumonia and bacterial coinfections further worsening outcomes. Our findings highlight the need for a more comprehensive understanding and effective preventive strategies to protect this vulnerable population.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 422-428"},"PeriodicalIF":4.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine 接受富马酸替诺福韦二氧吡酯和恩曲他滨暴露前预防HIV的人的干血点中二磷酸替诺福韦和三磷酸恩曲他滨浓度的测定
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-08 DOI: 10.1016/j.jmii.2025.03.002
Ya-Ting Lin , Wang-Da Liu , Chih-Ning Cheng , Wen-Chi Chang , Chia-Chi Chuang , Hsin-Yun Sun , Kuan-Yin Lin , Yu-Shan Huang , Pei-Ying Wu , Ling-Ya Chen , Hsi-Yen Chang , Yu-Zhen Luo , Yi-Ting Chen , Wen-Chun Liu , Yi-Ching Su , Guei-Chi Li , Chien-Ching Hung , Ching-Hua Kuo
{"title":"Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine","authors":"Ya-Ting Lin ,&nbsp;Wang-Da Liu ,&nbsp;Chih-Ning Cheng ,&nbsp;Wen-Chi Chang ,&nbsp;Chia-Chi Chuang ,&nbsp;Hsin-Yun Sun ,&nbsp;Kuan-Yin Lin ,&nbsp;Yu-Shan Huang ,&nbsp;Pei-Ying Wu ,&nbsp;Ling-Ya Chen ,&nbsp;Hsi-Yen Chang ,&nbsp;Yu-Zhen Luo ,&nbsp;Yi-Ting Chen ,&nbsp;Wen-Chun Liu ,&nbsp;Yi-Ching Su ,&nbsp;Guei-Chi Li ,&nbsp;Chien-Ching Hung ,&nbsp;Ching-Hua Kuo","doi":"10.1016/j.jmii.2025.03.002","DOIUrl":"10.1016/j.jmii.2025.03.002","url":null,"abstract":"<div><h3>Background/purpose(s)</h3><div>Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.</div></div><div><h3>Methods</h3><div>Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.</div></div><div><h3>Results</h3><div>Thirty-six (62.2 %) daily PrEP users and 38 (33.6 %) on-demand PrEP users achieved TFV-DP concentrations ≥700 fmol/punch. Higher proportions of undetectable FTC-TP were observed in participants whose TFV-DP concentrations were ≤350 fmol/punch, regardless of the frequency of TDF/FTC administration. In participants who used on-demand PrEP, the TFV-DP and FTC-TP concentrations were moderately correlated with the TDF/FTC tablets taken when sampling was performed within 12–24 h after the last dose of TDF/FTC (R = 0.63, p = 0.006 and R = 0.75, p = 0.0005). In addition, on-demand PrEP users who had received 8 tablets within the last 28 days had a median TFV-DP concentration similar to that of those participants who had received 16 tablets (544.6 vs. 556.9 fmol/punch, p &gt; 0.99).</div></div><div><h3>Conclusions</h3><div>These results underscore the importance of well-controlled sampling times for obtaining reliable TFV-DP and FTC-TP concentrations to estimate the adherence and effectiveness of on-demand PrEP.</div></div>","PeriodicalId":56117,"journal":{"name":"Journal of Microbiology Immunology and Infection","volume":"58 4","pages":"Pages 414-421"},"PeriodicalIF":4.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Helicobacter pylori bacteremia in an immunocompetent elderly presenting as right ankle cellulitis 不寻常的幽门螺杆菌菌血症在免疫功能正常的老年人表现为右踝关节蜂窝织炎。
IF 4.5 2区 医学
Journal of Microbiology Immunology and Infection Pub Date : 2025-03-08 DOI: 10.1016/j.jmii.2025.02.012
Shu-Fang Kuo, Tsung Yu Huang, Chen-Hsiang Lee
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引用次数: 0
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