High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection.

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Microbiology Immunology and Infection Pub Date : 2025-03-17 DOI:10.1016/j.jmii.2025.03.005

Yu-Chang Fu, Ting-Wei Lai, Yu-Hua Su, Yu-Chao Lin, Chih-Yen Tu, Chieh-Lung Chen, Po-Ren Hsueh

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引用次数: 0

Abstract

Background: Emerging evidence highlights that respiratory syncytial virus (RSV) poses a significant risk to older adults. However, detailed clinical data on elderly patients hospitalized with RSV remains limited. This study investigates the clinical characteristics and outcomes of older adults (aged ≥50 years) hospitalized with RSV infection.

Methods: This retrospective cohort study included hospitalized patients aged ≥50 years with respiratory symptoms and laboratory-confirmed RSV infection at China Medical University Hospital between January 1, 2011, and December 31, 2023. Data on demographic characteristics and clinical presentations were collected. RSV infection-related outcomes were analyzed across various subgroups.

Results: This study included 36 patients, with the most prevalent comorbidities being diabetes mellitus (47.2 %), immunocompromised status (36.1 %), and chronic lung disease (30.6 %). Pneumonia was identified in 72.2 % of patients, while 41.7 % required invasive mechanical ventilation, and the hospital mortality rate was 33.3 %. Non-survivors had higher rates of comorbidities, particularly chronic lung disease (66.7 % vs. 12.5 %, p = 0.002), higher disease severity, elevated procalcitonin levels, and were more likely to develop septic shock and acute respiratory distress syndrome. A bacterial coinfection rate of 33.3 % was observed, with patients experiencing pneumonia or bacterial coinfection showing poorer outcomes. Moreover, patients with chronic lung disease exhibited significantly worse day-28 survival (log-rank p < 0.001).

Conclusions: The disease burden of RSV in older adults is amplified by comorbidities such as chronic lung disease, with pneumonia and bacterial coinfections further worsening outcomes. Our findings highlight the need for a more comprehensive understanding and effective preventive strategies to protect this vulnerable population.

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来源期刊

Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

15.90

自引率

5.40%

发文量

159

审稿时长

67 days

期刊介绍： Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.