Journal of Gastric Cancer最新文献

{"title":"Peritoneal Oligometastasis in Gastric Cancer: Diagnostic Strategies, Patient Selection, and Emerging Therapeutic Approaches.","authors":"Hyoung-Il Kim, Brian D Badgwell","doi":"10.5230/jgc.2025.25.e36","DOIUrl":"10.5230/jgc.2025.25.e36","url":null,"abstract":"<p><p>Peritoneal metastasis (PM) from gastric cancer is a critical determinant of poor prognosis and has limited therapeutic options. However, recent advances in diagnostic and therapeutic strategies have reshaped the clinical landscape, enabling curative treatment of select patients. Accurate staging based on the peritoneal cancer index (PCI) is central to disease stratification and treatment planning. A PCI threshold of ≤6 has emerged as a consensus-based cutoff to define peritoneal oligometastasis, a limited metastatic state with potential for long-term survival following aggressive multimodal therapy. Therefore, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy remains the cornerstone of curative treatment. Additionally, innovative peritoneum-directed therapies-including normothermic intraperitoneal chemotherapy, early postoperative intraperitoneal chemotherapy, and pressurized intraperitoneal aerosol chemotherapy- have expanded the therapeutic landscape for both curative and palliative indications. This review highlights the evolving strategies for the diagnosis and treatment of gastric cancer with PM, with emphasis on PCI-based patient selection and treatment optimization. We also discuss the future roles of liquid biopsy, artificial intelligence, and photodynamic therapy in enhancing precision oncology for PM. Defining and targeting peritoneal oligometastases may enable tailored interventions and improve outcomes of this historically intractable disease.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 3","pages":"409-423"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success Rate and Factors Associated With Surveillance Endoscopy After Proximal Gastrectomy With Double-Tract Reconstruction: A Retrospective Multicenter Cohort Study.","authors":"Ji Won Seo, Ki Bum Park","doi":"10.5230/jgc.2025.25.e32","DOIUrl":"10.5230/jgc.2025.25.e32","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the rate of adequate observation of the remnant stomach after proximal gastrectomy (PG) with double-tract reconstruction (DTR).</p><p><strong>Materials and methods: </strong>Data from patients who underwent PG with DTR for gastric cancer at 6 institutions in South Korea were included. The clinicopathological and serial endoscopic data were retrospectively analyzed. Successful surveillance endoscopy was defined as photographic documentation of the pyloric antrum. Factors associated with successful endoscopy were analyzed using a mixed-effects logistic regression model.</p><p><strong>Results: </strong>In total, 634 surveillance endoscopies were performed in 160 patients after they underwent PG with DTR. The median time from surgery to endoscopy was 17.5 months (range, 0-137 months). The overall success rate of endoscopy was 75.6%. The mean total procedure time for successful endoscopies was 439.4±336.0 seconds, compared with 373.7±326.0 seconds for failed examinations (P=0.033). Although 31.9% of the patients experienced failure during their first endoscopy, all but 3 patients achieved at least one successful endoscopy by the fourth session. Factors associated with successful endoscopy included longer procedure time (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.01-1.72), endoscopy performed by an endoscopist without prior PG experience (OR, 0.19; 95% CI, 0.11-0.36), and a longer duration after surgery (OR, 1.33; 95% CI, 1.02-1.72).</p><p><strong>Conclusions: </strong>Understanding the anatomical changes after PG with DTR is essential for successful surveillance endoscopy. In addition, the failure rates across all serial endoscopies are very low. Therefore, clinicians should ensure sufficient procedure time during endoscopy, regardless of the outcomes of previous examinations.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 3","pages":"466-477"},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2023.","authors":"Dong Jin Kim, Jeong Ho Song, Ji-Hyeon Park, Sojung Kim, Sin Hye Park, Cheol Min Shin, Yoonjin Kwak, Kyunghye Bang, Chung-Sik Gong, Sung Eun Oh, Yoo Min Kim, Young Suk Park, Jeesun Kim, Ji Eun Jung, Mi Ran Jung, Bang Wool Eom, Ki Bum Park, Jae Hun Chung, Sang-Il Lee, Young-Gil Son, Dae Hoon Kim, Sang Hyuk Seo, Sejin Lee, Won Jun Seo, Dong Jin Park, Yoonhong Kim, Jin-Jo Kim, Ki Bum Park, In Cho, Hye Seong Ahn, Sung Jin Oh, Ju-Hee Lee, Hayemin Lee, Seong Chan Gong, Changin Choi, Ji-Ho Park, Eun Young Kim, Chang Min Lee, Jong Hyuk Yun, Seung Jong Oh, Eunju Lee, Seong-A Jeong, Jung-Min Bae, Jae-Seok Min, Hyun-Dong Chae, Sung Gon Kim, Daegeun Park, Dong Baek Kang, Hogoon Kim, Seung Soo Lee, Sung Il Choi, Seong Ho Hwang, Su-Mi Kim, Moon Soo Lee, Sang Hyun Kim, Sang-Ho Jeong, Yusung Yang, Yonghae Baik, Sang Soo Eom, Inho Jeong, Yoon Ju Jung, Jong-Min Park, Jin Won Lee, Jungjai Park, Ki Han Kim, Kyung-Goo Lee, Jeongyeon Lee, Seongil Oh, Ji Hun Park, Jong Won Kim","doi":"10.5230/jgc.2025.25.e25","DOIUrl":"10.5230/jgc.2025.25.e25","url":null,"abstract":"<p><p>This corrects the article on p. 115 in vol. 25, PMID: 39822171.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"400-402"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Braun Jejunojejunostomy Necessary? Comparison Between Billroth-II Alone and Billroth-II With Braun Anastomosis After Distal Gastrectomy.","authors":"Jane Chungyoon Kim, Min Jung Lee, Hyuk-Joon Lee, Kyoyoung Park, Min Kyu Kang, Sa-Hong Kim, Chun Zhuang, Abdullah Almayouf, Ma Jeanesse C Bernardo, Jeesun Kim, Yo-Seok Cho, Seong-Ho Kong, Soo-Jeong Cho, Do Joong Park, Han-Kwang Yang","doi":"10.5230/jgc.2025.25.e13","DOIUrl":"10.5230/jgc.2025.25.e13","url":null,"abstract":"<p><strong>Purpose: </strong>The optimal reconstruction method following distal gastrectomy has not been elucidated. Since Billroth-II (B-II) reconstruction is commonly associated with increased bile reflux, Braun jejunojejunostomy has been proposed to reduce this complication.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 325 patients with gastric cancer who underwent distal gastrectomy with B-II reconstruction between January 2015 and December 2017, comprising 159 patients without Braun anastomosis and 166 with Braun anastomosis. Outcomes were assessed over three years using annual gastroscopy based on the residual food, gastritis, and bile reflux criteria and the Los Angeles classification for reflux esophagitis.</p><p><strong>Results: </strong>In the first postoperative year, the group with Braun anastomosis showed a significant reduction in bile reflux compared to the group without Braun anastomosis (75.9% vs. 86.2%; P=0.019). Moreover, multivariate analysis identified Braun anastomosis as the sole factor associated with this outcome. Additionally, the group with Braun anastomosis had a lower incidence of heartburn (12.0% vs. 20.1%; P=0.047) and reduced use of prokinetics (P<0.001) and acid reducers (P=0.002) compared to the group without Braun anastomosis. However, these benefits diminished in subsequent years, with no significant differences in residual food, gastritis, or reflux esophagitis between the groups. Both groups showed similar body mass index scores and nutritional outcomes over the 3-year follow-up period.</p><p><strong>Conclusions: </strong>Although Braun anastomosis offers short-term benefits in reducing bile reflux after B-II reconstruction, these effects are not sustainable. The routine use of Braun anastomosis should be reconsidered, though either approach remains a viable option depending on the patient's circumstances.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"318-329"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Lifestyle Behaviors and Body Mass Index Changes on Long-term Outcomes After Gastric Cancer Surgery: A Population-Based Cohort Study.","authors":"Ju-Hee Lee, Jiyeong Kim, Dong-Gyu Lee","doi":"10.5230/jgc.2025.25.e18","DOIUrl":"10.5230/jgc.2025.25.e18","url":null,"abstract":"<p><strong>Purpose: </strong>The present study investigated the impact of lifestyle behaviors and body mass index (BMI) on late recurrence, gastric remnant cancer (GRC), and long-term survival after curative gastrectomy.</p><p><strong>Materials and methods: </strong>This retrospective study utilized data from the Korean National Health Insurance claims database. Among 71,014 patients with gastric cancer who underwent curative gastrectomy between January 2009 and December 2012, 23,359 remained cancer-free for five years. Of these, 7,735 patients with health examination data within 2 years before surgery and 5 years after surgery were analyzed for lifestyle behaviors, including smoking, alcohol consumption, and physical activity. Multivariable analysis was used to evaluate the independent effects of these factors and changes in BMI on late recurrence, GRC, and long-term survival.</p><p><strong>Results: </strong>Late recurrence or GRC occurred among 628 patients (8.1%). Older age (≥60 years) and total gastrectomy were identified as risk factors. Although lifestyle behaviors and BMI changes did not directly affect recurrence, they significantly affected mortality. In the total gastrectomy group, current underweight status (hazard ratio [HR], 1.586) was associated with increased mortality. Among the partial gastrectomy group, continued smoking (HR, 1.366) and current underweight status (HR, 1.915) increased mortality risk. Conversely, regular physical activity (starting: HR, 0.674; continuing: HR, 0.699) and postoperative overweight or obesity (BMI >25 kg/m²) (HR, 0.713) were associated with reduced mortality. Changes in alcohol consumption showed inconsistent effects between the partial and total gastrectomy groups.</p><p><strong>Conclusions: </strong>The long-term survival of post-gastrectomy patients improved with smoking cessation, regular physical activity, and maintenance of body weight.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"356-369"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the Findings Reliable? A Critical Evaluation of \"Lifestyle Behaviors in Patients With Gastric Cancer\".","authors":"Basil Joy","doi":"10.5230/jgc.2025.25.e21","DOIUrl":"10.5230/jgc.2025.25.e21","url":null,"abstract":"","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"261-262"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Are the Findings Reliable? A Critical Evaluation of \"Lifestyle Behaviors in Patients With Gastric Cancer\".","authors":"Ji Won Seo, Ki Bum Park","doi":"10.5230/jgc.2025.25.e23","DOIUrl":"10.5230/jgc.2025.25.e23","url":null,"abstract":"","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"263-265"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratifying Risk of Lymph Node Metastasis After Non-Curative Endoscopic Submucosal Dissection of Early Gastric Cancer: Comparison of the eCura System and Elderly Criteria.","authors":"Tae-Woo Kim, Hyo-Joon Yang, Giho Lee, Soo-Kyung Park, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn","doi":"10.5230/jgc.2025.25.e22","DOIUrl":"10.5230/jgc.2025.25.e22","url":null,"abstract":"<p><strong>Purpose: </strong>The novel curability criteria for elderly (EL) patients have been proposed to stratify their risk of lymph node metastasis (LNM), following non-curative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Hence, this study aimed to evaluate the effectiveness of the EL criteria and compare them with those of the well-known eCura system.</p><p><strong>Materials and methods: </strong>A retrospective analysis was performed on 143 patients who did not meet the curative ESD criteria at a tertiary hospital in Korea between 2011 and 2022. Of these, 102 underwent additional surgery, while 41 were followed up without further treatment. The LNM rates based on the EL and eCura systems were stratified and compared.</p><p><strong>Results: </strong>In the surgery group, 29.4% (30/102) patients were classified as EL-low (EL-L) and 70.2% (72/102) as EL-high (EL-H). The LNM rates (95% confidence interval) were 0.0% (0.0-11.6) and 9.7% (4.0-19.0) for EL-L and EL-H, respectively (P=0.102). EL-L was closely aligned with the eCura low-risk category, with a similar patient proportion (32.4%) and an LNM rate of 0.0% (0.0-10.6). The eCura system classified 94.1% (48/51) of the EL-L patients as low-risk, with an 86% concordance rate (123/143). Discordant cases included patients with positive vertical margins, but without other risk factors, who were classified as EL-H without LNM.</p><p><strong>Conclusions: </strong>Patients with EL-L showed no LNM, and the EL criteria demonstrated high concordance with the eCura system. The EL criteria may be as effective as the eCura system in identifying low-risk patients after non-curative ESD for EGC.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"370-381"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Inflammatory Burden Index Predicts Primary Resistance to Combinations of ICIs With Chemotherapy in Patients With HER-2-Negative Advanced Gastric Cancer.","authors":"Tingting Wang, Huihui Zeng, Ting Hu, Junhao Zhang, Zishu Wang","doi":"10.5230/jgc.2025.25.e14","DOIUrl":"10.5230/jgc.2025.25.e14","url":null,"abstract":"<p><strong>Purpose: </strong>Combinations of immune checkpoint inhibitors (ICIs) and chemotherapy have become the standard first-line treatment for human epidermal growth factor receptor 2 (HER-2)-negative advanced gastric cancer. However, primary resistance remains a challenge, with no effective biomarkers available for its prediction. This retrospective study explores the relationship between the baseline inflammatory burden index (IBI) and primary resistance in such context.</p><p><strong>Materials and methods: </strong>We analyzed 62 patients with HER-2-negative advanced gastric cancer who received ICIs and chemotherapy as their first-line treatment. The IBI was calculated as follows: C-reactive protein (mg/L) × neutrophil count (10³/mm³)/lymphocyte count (10³/mm³). Based on disease progression within 6 months, patients were categorized into the primary resistant or the control group. We compared baseline characteristics and IBI scores between the groups and assessed the predictive value of the IBI using the receiver operating characteristic curve. Both univariate and multivariate binary logistic regression analyses were conducted to identify factors influencing primary resistance.</p><p><strong>Results: </strong>Nineteen patients were included in the primary resistance group, and forty-three patients were included in the control group. The IBI was significantly higher in the resistant group compared to the control group (P<0.01). The area under the curve for the IBI was 0.82, indicating a strong predictive value. Multivariate analysis identified the IBI as an independent predictor of primary resistance (P=0.014).</p><p><strong>Conclusions: </strong>The baseline IBI holds promise as a predictor of primary resistance to combined ICIs and chemotherapy in patients with HER-2-negative advanced gastric cancer.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"266-275"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordance in Claudin 18.2 Expression Between Primary and Metastatic Lesions in Patients With Gastric Cancer.","authors":"Seung-Myoung Son, Chang Gok Woo, Ok-Jun Lee, Sun Kyung Lee, Minkwan Cho, Yong-Pyo Lee, Hongsik Kim, Hee Kyung Kim, Yaewon Yang, Jihyun Kwon, Ki Hyeong Lee, Dae Hoon Kim, Hyo Yung Yun, Hye Sook Han","doi":"10.5230/jgc.2025.25.e2","DOIUrl":"10.5230/jgc.2025.25.e2","url":null,"abstract":"<p><strong>Purpose: </strong>Claudin 18.2 (CLDN18.2) has emerged as a promising therapeutic target for CLDN18.2-expressing gastric cancer (GC). We sought to examine the heterogeneity of CLDN18.2 expression between primary GC (PGC) and metastatic GC (MGC) using various scoring methods.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed data from 102 patients with pathologically confirmed paired primary and metastatic gastric or gastroesophageal junction adenocarcinomas. CLDN18.2 expression was evaluated through immunohistochemistry on formalin-fixed paraffin-embedded tissue samples. We assessed CLDN18.2 positivity using multiple scoring approaches, including the immunoreactivity score, H-score, and the percentage of tumor cells showing moderate-to-strong staining intensity. We analyzed the concordance rates between PGC and MGC and the association of CLDN18.2 positivity with clinicopathological features.</p><p><strong>Results: </strong>CLDN18.2 positivity varied from 25% to 65% depending on the scoring method, with PGC consistently showing higher expression levels than MGC. Intratumoral heterogeneity was noted in 25.5% of PGCs and 19.6% of MGCs. Intertumoral heterogeneity, manifesting as discordance in CLDN18.2 positivity between PGC and MGC, was observed in about 20% of cases, with moderate agreement across scoring methods (κ=0.47 to 0.60). In PGC, higher CLDN18.2 positivity correlated with synchronous metastasis, presence of peritoneal metastasis, poorly differentiated grade, and biopsy specimens. In MGC, positivity was associated with synchronous metastasis, presence of peritoneal metastasis, and metastatic peritoneal tissues.</p><p><strong>Conclusions: </strong>CLDN18.2 expression demonstrates significant heterogeneity between PGC and MGC, with a 20% discordance rate. Comprehensive tissue sampling and reassessment of CLDN18.2 status are crucial, especially before initiating CLDN18.2-targeted therapies.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"25 2","pages":"303-317"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}