Journal of Gastric Cancer最新文献

{"title":"Exploratory Analysis of Patients With Gastric/Gastroesophageal Junction Adenocarcinoma With or Without Liver Metastasis From the Phase 3 RAINBOW Study.","authors":"Takatsugu Ogata, Yukiya Narita, Zev A Wainberg, Eric Van Cutsem, Kensei Yamaguchi, Yongzhe Piao, Yumin Zhao, Patrick M Peterson, Sameera R Wijayawardana, Paolo Abada, Anindya Chatterjee, Kei Muro","doi":"10.5230/jgc.2023.23.e15","DOIUrl":"10.5230/jgc.2023.23.e15","url":null,"abstract":"<p><strong>Purpose: </strong>Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM-) LM at baseline.</p><p><strong>Materials and methods: </strong>Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM-: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM-: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan-Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM- subgroups was analyzed using the Cox regression model with reported interaction P-values.</p><p><strong>Results: </strong>The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM- (OS HR, 0.71 [LM+] vs. 0.88 [LM-]; PFS HR, 0.47 [LM+] vs. 0.76 [LM-]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05).</p><p><strong>Conclusions: </strong>RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01170663.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"289-302"},"PeriodicalIF":3.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a5/5a/jgc-23-289.PMC10154140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Four Main Gastrectomy Procedures for Proximal Gastric Cancer on Patient Quality of Life: A Nationwide Multi-Institutional Study.","authors":"Koji Nakada,&nbsp;Akitoshi Kimura,&nbsp;Kazuhiro Yoshida,&nbsp;Nobue Futawatari,&nbsp;Kazunari Misawa,&nbsp;Kuniaki Aridome,&nbsp;Yoshiyuki Fujiwara,&nbsp;Kazuaki Tanabe,&nbsp;Hirofumi Kawakubo,&nbsp;Atsushi Oshio,&nbsp;Yasuhiro Kodera","doi":"10.5230/jgc.2023.23.e14","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e14","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the effects of 4 main types of gastrectomy for proximal gastric cancer on postoperative symptoms, living status, and quality of life (QOL) using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45).</p><p><strong>Materials and methods: </strong>We surveyed 1,685 patients with upper one-third gastric cancer who underwent total gastrectomy (TG; n=1,020), proximal gastrectomy (PG; n=518), TG with jejunal pouch reconstruction (TGJP; n=93), or small remnant distal gastrectomy (SRDG; n=54). The 19 main outcome measures (MOMs) of the PGSAS-45 were compared using the analysis of means (ANOM), and the general QOL score was calculated for each gastrectomy type.</p><p><strong>Results: </strong>Patients who underwent TG experienced the lowest postoperative QOL. ANOM showed that 10 MOMs were worse in patients with TG. Four MOMs improved in patients with PG, while 1 worsened. One MOM was improved in patients with TGJP versus 8 MOMs in patients with SRDG. The general QOL scores were as follows: SRDG (+39 points), TGJP (+6 points), PG (+3 points), and TG (-1 point).</p><p><strong>Conclusions: </strong>The TG group experienced the greatest decline in postoperative QOL. SRDG and PG, which preserve part of the stomach without compromising curability, and TGJP, which is used when TG is required, enhance the postoperative QOL of patients with proximal gastric cancer. When selecting the optimal gastrectomy method, it is essential to understand the characteristics of each and actively incorporate guidance to improve postoperative QOL.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"275-288"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/68/jgc-23-275.PMC10154134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram for Predicting Extraperigastric Lymph Node Metastasis in Patients With Early Gastric Cancer.","authors":"Hyun Joo Yoo,&nbsp;Hayemin Lee,&nbsp;Han Hong Lee,&nbsp;Jun Hyun Lee,&nbsp;Kyong-Hwa Jun,&nbsp;Jin-Jo Kim,&nbsp;Kyo-Young Song,&nbsp;Dong Jin Kim","doi":"10.5230/jgc.2023.23.e18","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e18","url":null,"abstract":"<p><strong>Background: </strong>There are no clear guidelines to determine whether to perform D1 or D1+ lymph node dissection in early gastric cancer (EGC). This study aimed to develop a nomogram for estimating the risk of extraperigastric lymph node metastasis (LNM).</p><p><strong>Materials and methods: </strong>Between 2009 and 2019, a total of 4,482 patients with pathologically confirmed T1 disease at 6 affiliated hospitals were included in this study. The basic clinicopathological characteristics of the positive and negative extraperigastric LNM groups were compared. The possible risk factors were evaluated using univariate and multivariate analyses. Based on these results, a risk prediction model was developed. A nomogram predicting extraperigastric LNM was used for internal validation.</p><p><strong>Results: </strong>Multivariate analyses showed that tumor size (cut-off value 3.0 cm, odds ratio [OR]=1.886, P=0.030), tumor depth (OR=1.853 for tumors with sm2 and sm3 invasion, P=0.010), cross-sectional location (OR=0.490 for tumors located on the greater curvature, P=0.0303), differentiation (OR=0.584 for differentiated tumors, P=0.0070), and lymphovascular invasion (OR=11.125, P<0.001) are possible risk factors for extraperigastric LNM. An equation for estimating the risk of extraperigastric LNM was derived from these risk factors. The equation was internally validated by comparing the actual metastatic rate with the predicted rate, which showed good agreement.</p><p><strong>Conclusions: </strong>A nomogram for estimating the risk of extraperigastric LNM in EGC was successfully developed. Although there are some limitations to applying this model because it was developed based on pathological data, it can be optimally adapted for patients who require curative gastrectomy after endoscopic submucosal dissection.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"355-364"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/1c/jgc-23-355.PMC10154132.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9415779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach.","authors":"Tae-Han Kim,&nbsp;In-Ho Kim,&nbsp;Seung Joo Kang,&nbsp;Miyoung Choi,&nbsp;Baek-Hui Kim,&nbsp;Bang Wool Eom,&nbsp;Bum Jun Kim,&nbsp;Byung-Hoon Min,&nbsp;Chang In Choi,&nbsp;Cheol Min Shin,&nbsp;Chung Hyun Tae,&nbsp;Chung Sik Gong,&nbsp;Dong Jin Kim,&nbsp;Arthur Eung-Hyuck Cho,&nbsp;Eun Jeong Gong,&nbsp;Geum Jong Song,&nbsp;Hyeon-Su Im,&nbsp;Hye Seong Ahn,&nbsp;Hyun Lim,&nbsp;Hyung-Don Kim,&nbsp;Jae-Joon Kim,&nbsp;Jeong Il Yu,&nbsp;Jeong Won Lee,&nbsp;Ji Yeon Park,&nbsp;Jwa Hoon Kim,&nbsp;Kyoung Doo Song,&nbsp;Minkyu Jung,&nbsp;Mi Ran Jung,&nbsp;Sang-Yong Son,&nbsp;Shin-Hoo Park,&nbsp;Soo Jin Kim,&nbsp;Sung Hak Lee,&nbsp;Tae-Yong Kim,&nbsp;Woo Kyun Bae,&nbsp;Woong Sub Koom,&nbsp;Yeseob Jee,&nbsp;Yoo Min Kim,&nbsp;Yoonjin Kwak,&nbsp;Young Suk Park,&nbsp;Hye Sook Han,&nbsp;Su Youn Nam,&nbsp;Seong-Ho Kong","doi":"10.5230/jgc.2023.23.e20","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e20","url":null,"abstract":"<p><p>This corrects the article on p. 3 in vol. 23, PMID: 36750993.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"365-373"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/4a/jgc-23-365.PMC10154136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9405363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity.","authors":"Mei-Qing Qiu,&nbsp;Hui-Jun Wang,&nbsp;Ya-Fei Ju,&nbsp;Li Sun,&nbsp;Zhen Liu,&nbsp;Tao Wang,&nbsp;Shi-Feng Kan,&nbsp;Zhen Yang,&nbsp;Ya-Yun Cui,&nbsp;You-Qiang Ke,&nbsp;Hong-Min He,&nbsp;Shu Zhang","doi":"10.5230/jgc.2023.23.e19","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e19","url":null,"abstract":"<p><strong>Purpose: </strong>Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC.</p><p><strong>Materials and methods: </strong>We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq).</p><p><strong>Results: </strong>Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics.</p><p><strong>Conclusions: </strong>These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"340-354"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/13/jgc-23-340.PMC10154133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant PD-1 Inhibitor Plus Apatinib and Chemotherapy Versus Apatinib Plus Chemotherapy in Treating Patients With Locally Advanced Gastric Cancer: A Prospective, Cohort Study.","authors":"Chunjing Wang,&nbsp;Zhen Wang,&nbsp;Yue Zhao,&nbsp;Fujing Wang","doi":"10.5230/jgc.2023.23.e17","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e17","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy and safety of neoadjuvant programmed cell death-1 (PD-1) inhibitors plus apatinib and chemotherapy (PAC) in patients with locally advanced gastric cancer (LAGC).</p><p><strong>Materials and methods: </strong>Seventy-three patients with resectable LAGC were enrolled and named the PAC group (n=39) or apatinib plus chemotherapy (AC) group (n=34) based on the treatment they chose. Neoadjuvant therapy was administered in a 21-day cycle for 3 consecutive cycles, after which surgery was performed.</p><p><strong>Results: </strong>The PAC group exhibited a higher objective response rate than the AC group (74.4% vs. 58.8%, P=0.159). Moreover, the PAC group showed a numerically better response profile than the AC group (P=0.081). Strikingly, progression-free survival (PFS) (P=0.019) and overall survival (OS) (P=0.049) were prolonged, whereas disease-free survival (DFS) tended to be longer in the PAC group than in the AC group (P=0.056). Briefly, the 3-year PFS, DFS, and OS rates were 76.1%, 76.1%, and 86.7% in the PAC group and 46.9%, 49.9%, and 70.3% in the AC group, respectively. Furthermore, PAC (vs. AC) treatment (hazard ratio=0.286, P=0.034) was independently associated with prolonged PFS in multivariate Cox regression analyses. The incidence of adverse events did not differ between the two groups (all P>0.05), where leukopenia, anemia, hypertension, and other adverse events were commonly observed in the PAC group.</p><p><strong>Conclusions: </strong>Neoadjuvant PAC therapy may achieve a preferable pathological response, delayed progression, and prolonged survival compared to AC therapy with a similar safety profile in patients with LAGC; however, further validation is warranted.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 2","pages":"328-339"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/8a/jgc-23-328.PMC10154141.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9415773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Big Step Forward in the New KGCA Guidelines.","authors":"Sang-Yong Son,&nbsp;Sang-Uk Han","doi":"10.5230/jgc.2023.23.e8","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e8","url":null,"abstract":"https://jgc-online.org What is learned rapidly becomes outdated. Experiences and things learned by reading research evidence may be selective or inappropriately implemented. In addition, research evidence is everchanging and, consequently, no practitioner can keep abreast of all updates. However, quality and efficiency must be ensured to treat patients encountered in clinical practice. This may be the main reason why so much time is spent developing and reading guidelines.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 1","pages":"1-2"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/4d/jgc-23-1.PMC9911620.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Sentinel Node Navigation Surgery for Early Gastric Cancer.","authors":"Eisuke Booka,&nbsp;Hiroya Takeuchi","doi":"10.5230/jgc.2023.23.e4","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e4","url":null,"abstract":"<p><p>Maintaining the postoperative quality of life (QOL) while ensuring curability without overtreatment is important in the treatment of early gastric cancer. Postoperative QOL is anticipated to be maintained through minimally invasive function-preserving gastrectomy in early gastric cancer. The concept of the sentinel lymph node (SN) basin is essential to maintain the curability of early gastric cancer using minimally invasive function-preserving gastrectomy. However, additional resection after surgery is difficult to perform in gastric cancer. Thus, the SN basin theory is important. Recently, a multicenter randomized phase III trial in South Korea (SENORITA trial) proved that laparoscopic sentinel node navigation surgery (LSNNS) for stomach preservation results in better postoperative QOL compared with standard gastrectomy in patients with early gastric cancer. LSNNS contributes to patients' QOL based on the concept that curability is not impaired. A multicenter nonrandomized phase III trial is ongoing in Japan, and oncologic safety is expected to be demonstrated. LSNNS has been established as a treatment option for selected patients with early gastric cancer, and its application will become widespread in the future.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 1","pages":"159-170"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/96/jgc-23-159.PMC9911613.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach.","authors":"Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong","doi":"10.5230/jgc.2023.23.e11","DOIUrl":"10.5230/jgc.2023.23.e11","url":null,"abstract":"<p><p>Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology and guideline development methodology. Total of 33 key questions were updated or proposed after a collaborative review by the working group and 40 statements were developed according to the systematic review using the MEDLINE, Embase, Cochrane Library and KoreaMed database. The level of evidence and the grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. Evidence level, benefit, harm, and clinical applicability was considered as the significant factors for recommendation. The working group reviewed recommendations and discussed for consensus. In the earlier part, general consideration discusses screening, diagnosis and staging of endoscopy, pathology, radiology, and nuclear medicine. Flowchart is depicted with statements which is supported by meta-analysis and references. Since clinical trial and systematic review was not suitable for postoperative oncologic and nutritional follow-up, working group agreed to conduct a nationwide survey investigating the clinical practice of all tertiary or general hospitals in Korea. The purpose of this survey was to provide baseline information on follow up. Herein we present a multidisciplinary-evidence based gastric cancer guideline.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 1","pages":"3-106"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/df/jgc-23-3.PMC9911619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9438183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant Chemotherapy in Asian Patients With Locally Advanced Gastric Cancer.","authors":"Xie Tong,&nbsp;Peng Zhi,&nbsp;Shen Lin","doi":"10.5230/jgc.2023.23.e12","DOIUrl":"https://doi.org/10.5230/jgc.2023.23.e12","url":null,"abstract":"<p><p>Presently, surgery is the only treatment approach for gastric cancer and improving the prognosis of locally advanced gastric cancer is one of the key factors in promoting gastric cancer survival benefit. The MAGIC study was the first to demonstrate the efficacy of neoadjuvant chemotherapy (NAC) in European countries. In recent years, several clinical trials have provided evidence for the use of NAC in Asian patients with locally advanced gastric cancer. However, clinical practice guidelines vary between Asian and non-Asian populations. Optimal NAC regimens, proper target populations, and predictors of NAC outcomes in Asian patients are still under investigation. Herein, we summarized the current progress in the administration of NAC in Asian patients with gastric cancer.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"23 1","pages":"182-193"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/3b/jgc-23-182.PMC9911622.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}