Gynecologie Obstetrique Fertilite & Senologie最新文献

{"title":"Dépistage de variant du gène CFTR chez les candidats au don de gamètes en France : quand ? Comment ? Pourquoi ?","authors":"Julie Bacus ,&nbsp;Chloé Depuydt ,&nbsp;Nathalie Arroja ,&nbsp;Juliette Chauvel ,&nbsp;Volcy Soula ,&nbsp;Aline Papaxanthos ,&nbsp;Marie-Pierre Reboul ,&nbsp;Lucie Chansel-Debordeaux","doi":"10.1016/j.gofs.2024.09.002","DOIUrl":"10.1016/j.gofs.2024.09.002","url":null,"abstract":"<div><h3>Objectives</h3><div>According to French recommendations, only the caryotype is carried out as a first line in candidates for gamete donation. The prescription of additional genetic tests for variants responsible for serious monogenic diseases is only recommended in the case of call points. However, cystic fibrosis remains the most common genetic disease with serious consequences in childhood. The purpose is to assess the different screening strategies in the Centres d’Études et de Conservation des Œufs et du Sperme humain (CECOS) regarding abnormalities of the Cystic Fibrosis Transmembrane conductance Regulator gene (<em>CFTR</em>).</div></div><div><h3>Method</h3><div>Our study is based on the analysis of data collected using a questionnaire. Private centres authorised to donate have been excluded from this work.</div></div><div><h3>Results</h3><div>Twenty-six centres participated out of the 33 interviewees. Two centres carry out systematic screening in all their sperm donation candidates while only one centre practises it in its oocyte donation candidates. For the other 23 centres, research is carried out in case of strong clinical suspicions according to personal or family history and when one of the two members of the recipient couple has a known variant. Regarding the molecular analysis technique used, 56.5% of centres use PCR with commercial kits, whereas the other centers use next-generation sequencing.</div></div><div><h3>Conclusion</h3><div>Targeted screening therefore remains widely practiced in France unlike other countries. Moving to expanded systematic screening raises ethical, financial and organisational issues.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 1","pages":"Pages 25-29"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remerciements aux relecteurs","authors":"","doi":"10.1016/j.gofs.2024.12.004","DOIUrl":"10.1016/j.gofs.2024.12.004","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 1","pages":"Page 50"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probabilité diagnostique d’une lésion de haut grade chez les patientes ASCUS HPV positif en fonction du typage HPV","authors":"Clara Rigori ,&nbsp;Scharif Benelmir ,&nbsp;Clémence Porté ,&nbsp;Mariana Malincenco ,&nbsp;Christine Devalland ,&nbsp;Catherine Gay","doi":"10.1016/j.gofs.2024.08.001","DOIUrl":"10.1016/j.gofs.2024.08.001","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of our study was to assess the proportion of high-grade histological lesions, according to HPV type, in patients referred for colposcopy involving a positive HPV-HR test and ASC-US cytology.</div></div><div><h3>Methods</h3><div>This is a retrospective descriptive study of asymptomatic patients aged 25 to 65 with a positive HPV-HR test and ASC-US cytology. Data were collected at the Nord Franche-Comté Hospital from September 2019 to February 2022. The primary outcome was the proportion of high-grade histological lesions in patients with ASC-US cytology combined to HPV 16 or 18 (associated or not with other HPV type), compared with HPV no 16 no 18.</div></div><div><h3>Results</h3><div>Among the 298 patients included, 67% were HPV no 16 no 18, 22% HPV 16 associated or not with others and 11% HPV 18 associated or not with others. We found significantly fewer high-grade lesions in patients with ASC-US cytology and HPV no 16 no 18 than in patients with HPV 16 or 18 (8.5% versus 22.7%, <em>P</em> <!-->&lt;<!--> <!-->0.01). In patients presenting an ASC-US cytology with HPV no 16, no 18: 53% of the biopsies found no histological lesion compared with 30% for the other HPVs (<em>P</em> <!-->&lt;<!--> <!-->0.01).</div></div><div><h3>Conclusions</h3><div>We have highlighted the reality of colposcopists: a high ratio of normal coloscopy associated with normal or low-grade biopsies, in patients with a positive HPV-HR test no 16, no 18 and ASC-US cytology.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 1","pages":"Pages 16-19"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visions et répercussions de l’accès aux origines dans l’assistance médicale à la procréation avec tiers donneur : étude descriptive chez les donneurs de gamètes","authors":"Clémence Cirade ,&nbsp;Inès Braham ,&nbsp;Jérôme Delotte ,&nbsp;Samir Boukaidi ,&nbsp;Sarah Dupuis ,&nbsp;Adeline Morisot ,&nbsp;Valérie Benoit ,&nbsp;Nicolas Chevalier","doi":"10.1016/j.gofs.2024.12.005","DOIUrl":"10.1016/j.gofs.2024.12.005","url":null,"abstract":"<div><h3>Objectives</h3><div>The Bioethics Law of August 2nd, 2021 established access to origins for people conceived by gamete donation. Two years after the implementation of this disposition, what is the proportion of former gamete donors informed about access to origins, and what is their position on this matter? What could be the potential repercussions of this new law on them?</div></div><div><h3>Methods</h3><div>Retrospective single-center cohort study using questionnaires.</div></div><div><h3>Results</h3><div>When former gamete donors were asked about access to origins, only 53% of oocytes donors and 71% of sperm donors were aware of this measure. When participants were asked about the ideal method of donation, it emerged that 41% of female donors and 47% of male donors were in favour of access to their identifying data for the person resulting from the donation. More than half were in favour of access to non-identifying and medical data. If one day someone conceived from their donation requested access to their identifying data, 62% of oocytes donors and 56% of sperm donors would grant it.</div></div><div><h3>Conclusions</h3><div>A significant proportion of our participants expressed the desire to benefit from information on possible descendants resulting from their donation. Among the donors interviewed, only half are informed of the legislation introducing access to origins, now two years after its implementation. These results encourage us to strengthen communication efforts around access to origins.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 5","pages":"Pages 247-252"},"PeriodicalIF":0.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premières données françaises sur les demandes de don de spermatozoïdes faites par les couples de femmes","authors":"Lina Abdiche ,&nbsp;Diane Rivet-Danon ,&nbsp;Clémence Farabet-Demarquette ,&nbsp;Clarisse Vallée ,&nbsp;Anna Ly ,&nbsp;Ludmilla Ogouma-Aworet ,&nbsp;Marie Prades ,&nbsp;Isabelle Berthaut ,&nbsp;Kamila Kolanska ,&nbsp;Nathalie Sermondade ,&nbsp;Charlotte Dupont","doi":"10.1016/j.gofs.2024.11.004","DOIUrl":"10.1016/j.gofs.2024.11.004","url":null,"abstract":"<div><h3>Objective</h3><div>The new bioethics law, enacted on August 2, 2021, has expanded access to medically assisted reproduction (MAR) with sperm donation to unmarried women and female couples. The implementation of this law led to a significant influx of sperm donation requests at French sperm banks. This major development in the field of ART in France, and in French society as a whole, prompted us to focus specifically on the requests from female couples.</div></div><div><h3>Method</h3><div>A retrospective, single-center study was conducted at a gamete donation center in Paris. The data of women in same-sex couples who attended a first consultation with a biologist between October 1, 2021, and October 31, 2022, were analyzed and compared to those of women in heterosexual couples who also requested MAR with sperm donation during the same period. The ART attempts and their outcomes were analyzed up until May 31, 2024.</div></div><div><h3>Results</h3><div>A total of 117 women in same-sex couples and 75 women in heterosexual couples were included in the study. The profiles in terms of age, ovarian reserve, and history of gynecological conditions did not differ between the two groups. The only observed differences were related to lifestyle, particularly alcohol consumption, which was slightly higher among women in same-sex couples. Additionally, women in same-sex couples appeared to belong more frequently to the category of intermediate professions, but no differences were observed concerning other occupational categories. Regarding the outcomes of ART attempts, cumulative rates of early and ongoing pregnancies were not different between the two groups.</div></div><div><h3>Conclusion</h3><div>This study thus provides an initial insight into the profile and outcomes for women in same-sex couples who received ART with sperm donation shortly after the enactment of the bioethics law in France. The similarity in profiles and ART outcomes between women in same-sex couples and those in heterosexual couples supports the approach of offering similar medical care, regardless of the couple's configuration.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 5","pages":"Pages 241-246"},"PeriodicalIF":0.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sommaire","authors":"","doi":"10.1016/S2468-7189(24)00337-4","DOIUrl":"10.1016/S2468-7189(24)00337-4","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"52 12","pages":"Pages v-vi"},"PeriodicalIF":0.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sommaire","authors":"","doi":"10.1016/S2468-7189(24)00312-X","DOIUrl":"10.1016/S2468-7189(24)00312-X","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"52 11","pages":"Pages v-vi"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilité de la mesure échographique du segment utérin inférieur avant accouchement parmi les femmes ayant un antécédent de césarienne : revue de la littérature","authors":"","doi":"10.1016/j.gofs.2024.03.007","DOIUrl":"10.1016/j.gofs.2024.03.007","url":null,"abstract":"<div><div>Identifying women with a history of cesarean delivery and at real risk for uterine rupture is an important aim in obstetric care. It is with this objective that different authors have evaluated the interest of ultrasound for predicting the risk of a cesarean scar defect by measuring the thickness of the lower uterine segment. The literature is sparse and subject to numerous biases because they are mainly prospective cohort studies with small numbers. However, the results are concordant: Ultrasound measurements of lower uterine segment thickness are strongly correlated with the operative findings observed during cesarean delivery. Moreover, the thinner the lower uterine segment on ultrasound, the higher the likelihood of a uterine defect. Two randomized trials have recently been published. The PRISMA cluster randomized controlled trial evaluated a multifaceted intervention including an ultrasound estimation of the risk of uterine rupture by ultrasound measurement of the lower uterine segment thickness and aimed at helping women in their choice of mode of delivery after a previous cesarean delivery. This multifaceted intervention resulted in a significant reduction in the rates of major perinatal and maternal morbidity, without any increase in the rate of cesarean delivery or uterine rupture. However, due to its design, it is impossible to specifically specify the benefit of lower uterine segment measurement in reducing major maternal and perinatal morbidity since the trial combined several interventions. The LUSTrial randomized controlled trial evaluated the impact on maternal-fetal morbidity and mortality of proposing a mode of delivery based on ultrasound measurement of the lower uterine segment thickness compared to usual care among women with a history of cesarean delivery. Ultrasound measurement of lower uterine segment thickness was not associated with a statistically significant reduction in maternal-fetal morbidity and mortality compared to usual care. In this literature review, we will mainly detail and analyze the results of this trial.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"52 11","pages":"Pages 639-645"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enquête nationale sur la stratégie de prise en charge du placenta accreta en France","authors":"","doi":"10.1016/j.gofs.2024.03.008","DOIUrl":"10.1016/j.gofs.2024.03.008","url":null,"abstract":"<div><h3>Objective</h3><div>Placenta accreta belongs to placenta accreta spectrum and is defined by an adhesion or even invasion of the placental villi in the myometrium. The main risk factor is a history of cesarean section. Its incidence is increasing following an increase in the cesarean section rate in recent years and the cause of severe maternal morbidity (hemorrhage, transfusions, hysterectomy). Treatment can be radical by cesarean section-hysterectomy or conservative with an attempt at uterine preservation. American, English, Canadian and international recommendations have been established but there are no French recommendations to date. The objective of this study was to investigate management strategy for placenta accreta in type III maternity hospitals in France.</div></div><div><h3>Materials and methods</h3><div>An anonymous questionnaire was sent by email to the obstetrics referents of the university hospital centers in France with type III maternity.</div></div><div><h3>Results</h3><div>Forty-eight centers were approached, with a participation rate of 77%.</div></div><div><h3>Conclusion</h3><div>The management of placenta accreta spectrum in France is relatively heterogeneous on several points such as multidisciplinary management, evaluation by placental MRI, preoperative urological evaluation, treatment adopted as first-line, cesarean section-hysterectomy or conservative treatment, therapeutic strategy according to the placental invasion. However, the literature is currently poor, which may explain divergent treatment.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"52 11","pages":"Pages 620-626"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer du sein : peut-on l’envisager comme une maladie professionnelle ?","authors":"","doi":"10.1016/j.gofs.2024.07.001","DOIUrl":"10.1016/j.gofs.2024.07.001","url":null,"abstract":"<div><h3>Objective</h3><div>Breast cancer is the leading cancer in women in terms of incidence and mortality. The literature currently identifies several risk factors, some modifiable and others not. Because of its multifactorial nature, the combination of factors either increases or reduces the risk of cancer. Since 2004, the first commission's rapport of the French National Environmental Health Plan has recognized the significant impact of occupational exposure on the development of breast cancer. However, neither primary nor secondary preventive measures have yet been implemented in work environment.</div></div><div><h3>Method</h3><div>Based on available literature, we reviewed current knowledge of breast cancer risk factors associated with occupational exposure.</div></div><div><h3>Results</h3><div>The risk factors identified were ionizing radiation, magnetic fields, certain endocrine disruptors, ethylene oxide and night shift work.</div></div><div><h3>Conclusion</h3><div>Recognition of breast cancer as an occupational disease is complicated. In some cases, however, it may be possible, particularly in cases of multifactorial exposure. This work should help to raise awareness among employers and reinforce preventive measures in the workplace.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"52 11","pages":"Pages 627-632"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}