Turkish Journal of Physical Medicine and Rehabilitation最新文献

{"title":"Robot-assisted gait training in stroke.","authors":"Şebnem Koldaş Doğan","doi":"10.5606/tftrd.2024.15681","DOIUrl":"10.5606/tftrd.2024.15681","url":null,"abstract":"<p><p>Stroke is the second most common cause of mortality and disability worldwide. Most of the patients cannot regain their walking ability after a stroke. Impaired gait and mobility negatively affect the activities of daily living and quality of life of stroke survivors. Restoring gait and mobility are the most important targets of the rehabilitation approaches. Advances in computers and engineering have enabled robotics to be used in many areas of rehabilitation medicine. One of them is gait training. High-intensity, repetitive task training is crucial for neural plasticity and motor learning. Robot-assisted gait training may be a promising method leading to functional recovery in patients with stroke. In this review, the efficacy of robot-assisted gait training in stroke rehabilitation is discussed in light of current literature.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"293-299"},"PeriodicalIF":1.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low-frequency repetitive magnetic transcranial stimulation in hemichorea-hemiballismus with ipsilateral basal ganglia hemorrhage: A case report.","authors":"Kim Heejae","doi":"10.5606/tftrd.2024.13022","DOIUrl":"10.5606/tftrd.2024.13022","url":null,"abstract":"<p><p>Post-stroke hemichorea-hemiballismus (HCHB) typically manifests as hyperkinetic movements contralateral to the lesion, but rarely occurs ipsilaterally. In this article, we present a rare case who initially presented with left hemiparesis and developed right HCHB after right basal ganglia hemorrhage. To facilitate motor recovery in the left hemiparesis, we applied low-frequency repetitive transcranial magnetic stimulation (rTMS) over the left primary motor cortex. Unexpectedly, the right HCHB was significantly reduced after four weeks of therapy. Post-treatment perfusion imaging showed increased cerebral blood flow in the left middle cerebral artery territory. In conclusion, low-frequency rTMS may be considered an alternative therapy for post-stroke HCHB.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"397-401"},"PeriodicalIF":1.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intra-articular versus peri-articular dextrose prolotherapy in knee osteoarthritis: A clinical trial study.","authors":"Leila Sadat Mohamadi Jahromi, Hadi Dashtimakan, Sharareh Roshanzamir, Alireza Dabbaghmanesh, Reyhaneh Parvin","doi":"10.5606/tftrd.2024.12937","DOIUrl":"10.5606/tftrd.2024.12937","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare the effectiveness of intra-articular and peri-articular dextrose prolotherapy (DPT) in patients with knee osteoarthritis (KOA) without effusion.</p><p><strong>Patients and methods: </strong>Between August 2018 and November 2018, a total of 51 participants including 27 cases (12 males, 15 females; mean age: 55.7±5.2 years; range, 38 to 70 years) in Group A and 24 cases (9 males, 15 females; mean age: 54.7±4.6 years; range, 38 to 70 years) in Group B were recruited. Group A received intra-articular DPT, while Group B received peri-articular DPT. Treatment was administered two times with two-week intervals. The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Oxford Knee Scale (OKS) questionnaires were filled at baseline, and four and eight weeks after first injection.</p><p><strong>Results: </strong>At four and eight weeks, the VAS, OKS, and WOMAC scores improved from baseline in both groups. There was no significant difference in the WOMAC and OKS scores between two methods. The VAS scores showed superiority of intra-articular method (p<0.05).</p><p><strong>Conclusion: </strong>Both peri-articular and intra-articular DPT were effective in patients with KOA. There was no superiority in terms of functional improvement between two groups. However, intra-articular prolotherapy was more effective in decreasing pain in these patients.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"327-334"},"PeriodicalIF":1.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Rocabado exercises in patients with rheumatoid arthritis in remission with temporomandibular joint involvement: A randomized-controlled study.","authors":"Manolya Ilhanlı, Ilker Ilhanlı, Simay Aksakallı","doi":"10.5606/tftrd.2024.13517","DOIUrl":"10.5606/tftrd.2024.13517","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the effectiveness of Rocabado exercises in patients with rheumatoid arthritis (RA) in remission with temporomandibular joint (TMJ) involvement.</p><p><strong>Patients and methods: </strong>Between May 2023 and July 2023, a total of 42 patients (4 males, 38 females; mean age: 47.8±13.9 years; range, 21 to 73 years) were included in this single-center, single-blind, randomized-controlled study. Only the RA patients in remission for at least three months, with TMJ complaints and who had TMJ involvement detected by magnetic resonance imaging (MRI) were included. The patients were randomized into the Rocabado exercise group (n=21) and standard TMJ exercise group (n=21). The home-based exercise programs for both groups continued for six weeks. A Visual Analog Scale (VAS) was used to evaluate pain. The TMJ examination findings were recorded. The maximum interincisal distances were measured. To evaluate the quality of life, the patients were asked to fill the Turkish Oral Health Impact Profile-14 (OHIP-14).</p><p><strong>Results: </strong>Demographic and baseline characteristics were similar between the groups. Standard TMJ exercises group showed an improvement only for OHIP-14 after treatment. Rocabado exercises group showed a statistically significant improvement for interincisal distance, OHIP-14, VAS pain, number of patients with limited mouth opening, TMJ pain with palpation, and pterygoid pain with palpation after treatment.</p><p><strong>Conclusion: </strong>Our study results indicate that Rocabado exercises may be effective in RA patients with TMJ involvement in relieving pain and improving the quality of life due to oral health.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"319-326"},"PeriodicalIF":1.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does transforaminal epidural steroid injection added to dorsal root ganglion pulsed radiofrequency treatment increase efficacy?","authors":"Gokhan Yildiz, Hamit Goksu, Erkan Yavuz Akcaboy, Seref Celik, Mustafa Yemliha Ayhan, Samet Sancar Kaya","doi":"10.5606/tftrd.2024.13479","DOIUrl":"10.5606/tftrd.2024.13479","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the treatment outcomes between dorsal root ganglion (DRG) pulsed radiofrequency (PRF) and DRG PRF plus transforaminal epidural steroid injection (TFESI) in patients with chronic lumbosacral radicular pain.</p><p><strong>Patients and methods: </strong>Eighty-one patients (39 males, 42 females; mean age: 57.5±11.9 years; range 18 to 65 years) who underwent DRG PRF (Group 1) and 59 patients (34 males, 25 females; mean age: 58.7±12.3 years; range 18 to 65 years) who underwent DRG PRF plus TFESI (Group 2) between February 2021 and June 2022 were enrolled in the retrospective study. A Visual Analog Scale (VAS) was used to assess pain severity. Patients in both groups were evaluated before treatment and at four weeks and six months after treatment.</p><p><strong>Results: </strong>The four-week and six-month VAS scores were significantly lower than the baseline VAS scores in both groups. There was no significant difference between the groups in terms of the VAS scores at baseline, four weeks, and six months. There was no significant difference between the groups in terms of the rate of pain reduction of 50% or more at either measurement point. The presence or absence of a previous lumbar surgery had no effect on achieving a significant decrease in pain.</p><p><strong>Conclusion: </strong>Although DRG PRF and TFESI are easy to apply together, adding corticosteroids to DRG PRF treatment for patients with chronic radicular pain did not improve long-term outcomes.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"390-396"},"PeriodicalIF":1.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of whole-body vibration in horizontal position on bone, quality of life, and balance in postmenopausal osteoporosis.","authors":"Feyza Akan Begoğlu, Figen Yılmaz, Julide Öncü Alptekin, Banu Kuran, Mehmet Ünal, Mehmet Hüseyin Elik","doi":"10.5606/tftrd.2024.12726","DOIUrl":"https://doi.org/10.5606/tftrd.2024.12726","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aimed to analyze the effect of high-frequency, low-magnitude whole-body vibration (WBV) therapy in horizontal position on bone, quality of life, pain, and balance in postmenopausal women.</p><p><strong>Patients and methods: </strong>Sixty postmenopausal women were included in this prospective, randomized controlled study between May 2015 to September 2015. The patients were randomized into three groups, with 20 participants in each group: <i>(i)</i> WBV + infrared group, <i>(ii)</i> infrared group, and <i>(iii)</i> control group. Bone mineral density of the lumbar and femoral regions of all the patients was measured using dual-energy X-ray absorptiometry. In addition, osteocalcin and hydroxyproline values were measured. Quality of life was assessed using the Short Form-36, pain was assessed using the Visual Analog Scale, and balance was assessed based on the participants' performance in the Berg balance test.</p><p><strong>Results: </strong>Seven patients (two from the vibration + infrared group and five from the infrared group) could not continue the study, and the analyses were conducted with the remaining 53 patients (mean age: 56.9±5.1 years; range, 45 to 65 years). At the end of a three-month treatment period, no statistically significant difference was found in bone mineral density, bone turnover markers, pain, and quality of life of the patients in all three groups compared to the pretreatment values. Berg balance test results showed a statistically significant increase after treatment in all three groups.</p><p><strong>Conclusion: </strong>High-frequency, low-magnitude WBV performed under supervision in postmenopausal women was not found to be effective in improving bone, quality of life, pain, and balance. Future studies for determining effective vibration protocols having a longer duration and higher frequency of sessions are warranted.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 4","pages":"433-442"},"PeriodicalIF":1.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effect of acupuncture on knee osteoarthritis and its effect on p38 MAPK signaling pathway.","authors":"Ye Wei, Lanying Liu, Hengqing Ge","doi":"10.5606/tftrd.2024.13186","DOIUrl":"10.5606/tftrd.2024.13186","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the curative efficacy of acupuncture on knee osteoarthritis (KOA) and its improvement on related scores and blood indexes.</p><p><strong>Patients and methods: </strong>Between January 2019 and January 2020, a total of 108 patients (48 males, 60 females; mean age: 61.0±6.8 years; range 43 to 79 years) with KOA were randomly divided into control group (n=54) and patient group (n=54). Both groups received standard treatment, including adequate rest and exercise and oral celecoxib capsules. The patient group performed acupuncture operations on the Inner knee eye (EX-LE4), outer knee eye (EX-LE5), Yanglingquan (GB34), and Zusanli (ST36). In the control group, three non-acupuncture points were determined for sham acupuncture. The level of Michel Lequesne index of severity for osteoarthritis (ISOA) score, Visual Analog Scale (VAS), Lysholm Knee Score Scale (LKSS), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-1beta (IL-1β), IL-6, transforming growth factor-beta (TGF-β), insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2 (FGF-2) and p38 mitogen-activated protein kinase (p38 MAPK) were compared before and after treatment.</p><p><strong>Results: </strong>The reduction of inflammatory markers in the patient group was greater than that in the control group after treatment. The levels of cytokines such as TGF-β, IGF-1, and FGF-2 were significantly increased after treatment, and the levels in the patient group were higher than those in the control group during the same period. In addition, p38 MAPK messenger ribonucleic acid (mRNA) was significantly downregulated after treatment, and the level in the patient group was lower than that in the control group during the same period.</p><p><strong>Conclusion: </strong>Acupuncture combined with standard treatment can effectively promote the relief of symptoms and the improvement of knee joint function and effectively inhibit the expression of p38 MAPK signaling pathway.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"335-343"},"PeriodicalIF":1.1,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Spinal Cord Injury Secondary Conditions Scale among the Turkish population with spinal cord injury.","authors":"Pınar Akpınar, Arzu Atıcı, Zeynep Demir, Feyza Unlu Ozkan, İlknur Aktaş","doi":"10.5606/tftrd.2024.14278","DOIUrl":"https://doi.org/10.5606/tftrd.2024.14278","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to determine the reliability and cross-cultural validation of the Turkish translation of the Spinal Cord Injury Secondary Conditions Scale (SCI-SCS) in individuals with spinal cord injuries (SCIs).</p><p><strong>Patients and methods: </strong>After the translation/validation process, the SCI-SCS was administered to 93 patients (69 males, 24 females; mean age: 47.9±14.3 years; range, 18 to 78 years) with SCI, diagnosed according to the American Spinal Injury Association impairment scale (grades from A to D), with at least one year after the injury, recruited between December 2022 and July 2023. Fifty-seven patients rated the SCI-SCS two to three days apart to investigate the test-retest reliability. Correlations between the first rates of the SCI-SCS and the Spinal Cord Independence Measure III (SCIM-III), Spinal Cord Injury Spasticity Evaluation Tool, Penn Spasm Frequency Scale, 36-item Short Form Health Survey (SF-36), Beck Depression Inventory, Beck Anxiety Inventory, and the pain-DETECT questionnaire were investigated for the evaluation of convergent validity.</p><p><strong>Results: </strong>There were 65 patients with paraplegia and 28 patients with tetraplegia. The SCI-SCS showed good internal consistency (alpha=0.753). The three-factor model demonstrated a good fit to the data (relative chi-square=1.12, comparative fit index=0.981, Tucker-Lewis index (TLI)=0.977, root mean square error of approximation=0.037, standardized root mean square residual=0.120). The test-retest reliability was excellent, with an intraclass correlation coefficient of 0.79 (95% confidence interval 0.67-0.87). There were statistically significant correlations between the total SCI-SCS and all other administered questionnaires, except for the social function, emotional, physical, and general health domains of SF-36 and the self-care, total, and mobility subscales of SCIM-III.</p><p><strong>Conclusion: </strong>The study demonstrated that the 14-item SCI-SCS represents a valuable scale for the assessment of secondary conditions among the Turkish population with SCI.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 4","pages":"495-505"},"PeriodicalIF":1.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Another lesson from the earthquake: Transdermal fentanyl dependence in two child victims.","authors":"Hüseyin Oğuzhan Aslantaş, Şehim Kutlay, Haydar Gök, Birkan Sonel Tur, Beyza Özkan, Süveyda Dilara Başar","doi":"10.5606/tftrd.2024.14397","DOIUrl":"10.5606/tftrd.2024.14397","url":null,"abstract":"<p><p>Thousands died in the Kahramanmaraş-centered earthquake in February 2023, and even more were injured. Some were administered transdermal fentanyl patches (TFPs) due to severe pain. Two pediatric patients, both severely injured victims of the earthquake, developed dependence on TFPs and experienced difficulties during the cessation of fentanyl treatment. The first child was discharged while still being administered fentanyl after four months. In the second case, TFPs could be ceased after four months. This study aimed to emphasize that TFPs can lead to dependence in pediatric patients as well; hence, they should be used more carefully to avoid any potential dependency.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 3","pages":"406-409"},"PeriodicalIF":1.1,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of platelet-rich plasma injections versus placebo on pain and quality of life in patients with hip osteoarthritis: A double-blind, randomized clinical trial.","authors":"Mahir Topaloglu, Ekin İlke Şen, Deniz Sarıkaya, Demirhan Dıraçoğlu","doi":"10.5606/tftrd.2024.13855","DOIUrl":"10.5606/tftrd.2024.13855","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare the efficacy of intra-articular platelet-rich plasma (PRP) injections over a saline placebo in terms of reduction of pain and impact on quality of life among patients with hip osteoarthritis.</p><p><strong>Patients and methods: </strong>A total of 60 patients (29 males, 31 females, mean age: 57.9±7.3 years; range, 47 to 69 years) with known hip osteoarthritis of Kellgren-Lawrance (KL) Grades 2/3 were randomized into placebo (n=30) and PRP groups (n=30) between June 2014 and June 2015. Both groups received intra-articular injections into the hip joint under ultrasound guidance for three consecutive weeks. The patients were followed for six months, and pain reduction was assessed using the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire, and Short Form Health Survey-36 (SF-36).</p><p><strong>Results: </strong>Intra-articular PRP treatment showed no advantage over a saline placebo in terms of VAS scores during activity. Both groups showed a significant improvement in VAS activity scores at one and six months. The placebo group showed improvements in VAS resting scores, whereas the PRP group did not. Both groups showed no improvement in WOMAC-total scores. Both groups showed no significant improvement across most SF-36 domains with the exception of improved physical role functioning at one month and general health at one and six months in the placebo group.</p><p><strong>Conclusion: </strong>Intra-articular injections of PRP show no significant difference compared to a saline placebo over a period of six months on pain, function, and quality of life scores in patients with hip osteoarthritis.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 2","pages":"212-220"},"PeriodicalIF":1.1,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11209330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}