Photoacoustics最新文献_第9页

Improved T-shaped quartz tuning fork with isosceles-trapezoidal grooves optimized for quartz-enhanced photoacoustic spectroscopy 改进的t形石英音叉与等腰梯形凹槽优化石英增强光声光谱。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100672

Feihu Fang , Runqiu Wang , Dongfang Shao , Yi Wang , Yilü Tao , Shengshou Lin , Yufei Ma , Jinxing Liang

{"title":"Improved T-shaped quartz tuning fork with isosceles-trapezoidal grooves optimized for quartz-enhanced photoacoustic spectroscopy","authors":"Feihu Fang , Runqiu Wang , Dongfang Shao , Yi Wang , Yilü Tao , Shengshou Lin , Yufei Ma , Jinxing Liang","doi":"10.1016/j.pacs.2024.100672","DOIUrl":"10.1016/j.pacs.2024.100672","url":null,"abstract":"<div><div>The quartz tuning fork (QTF) being the acoustic-electrical conversion element for quartz-enhanced photoacoustic spectroscopy (QEPAS) system directly affects the detection sensitivity. However, the low electromechanical conversion efficiency characteristic of standard QTF limits the further enhancement of the system. Therefore, the optimized design for QTF is becoming an important approach to improve the performance of QEPAS. In this work, 9 kHz T-shaped QTFs with isosceles-trapezoidal grooves are firstly applied to gas sensing experiments. Four types of 9 kHz QTFs are fabricated and applied to gas detection experiments. Simulation results reveal QTFs with isosceles-trapezoidal grooves are conducive to optimizing the stress distribution and enhancing electromechanical conversion efficiency. The results of the gas sensing experiment (acetylene C<sub>2</sub>H<sub>2</sub>) indicate that the signal peak and signal-to-noise ratio values of T-shaped QTF with positive isosceles-trapezoidal grooves can reach 1.44 and 1.85 times greater than the normal QTF with rectangular cross-section prongs.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100672"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compact and full-range carbon dioxide sensor using photoacoustic and resonance dependent modes 紧凑和全范围二氧化碳传感器使用光声和共振依赖模式。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100669

Yifan Li , Lixian Liu , Liang Zhao , Xueshi Zhang , Le Zhang , Jialiang Sun , Huiting Huan , Yize Liang , Jiyong Zhang , Xiaopeng Shao , Andreas Mandelis , Roberto Li Voti

{"title":"Compact and full-range carbon dioxide sensor using photoacoustic and resonance dependent modes","authors":"Yifan Li , Lixian Liu , Liang Zhao , Xueshi Zhang , Le Zhang , Jialiang Sun , Huiting Huan , Yize Liang , Jiyong Zhang , Xiaopeng Shao , Andreas Mandelis , Roberto Li Voti","doi":"10.1016/j.pacs.2024.100669","DOIUrl":"10.1016/j.pacs.2024.100669","url":null,"abstract":"<div><div>A compact and robust optical excitation photoacoustic sensor with a self-integrated laser module excitation and an optimized differential resonator was developed to achieve high sensitivity and full linear range detection of carbon dioxide (CO<sub>2</sub>) based on dual modes of wavelength modulated photoacoustic spectroscopy (WMPAS) and resonant frequency tracking (RFT). The integrated laser module equipped with three lasers (a quantum cascade laser (QCL), a distributed feedback laser (DFB) and a He-Ne laser) working in a time-division multiplexing mode was used as an integrated set of spectroscopic sources for detection of the designated concentration levels of CO<sub>2</sub>. With the absorption photoacoustic mode, the WMPAS detection with the QCL and DFB sources was capable of CO<sub>2</sub> detection at concentrations below 20 %, yielding a noise equivalent concentration (NEC) as low as 240 ppt and a normalized noise equivalent absorption coefficient (NNEA) of 4.755 × 10<sup>−10</sup> W cm<sup>−1</sup>/√Hz, and dynamic range as great as 11 orders of magnitude. Higher concentration detection ranges (20 %-100 %) of CO<sub>2</sub> were investigated using the RFT mode with an amplitude-stabilized He-Ne laser and a mechanical chopper. With the dual modes of WMPAS and RFT, the optical excitation sensor achieved full-range CO<sub>2</sub> detection, with an R² ≥ 0.9993 and a response time of 5 seconds. The compact and full-range CO<sub>2</sub> sensor combines the advantages of WMPAS and RFT and offers a solution for high sensitivity, linearity and full-range CO<sub>2</sub> detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100669"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal fluorescence-optoacoustic in vivo imaging of the near-infrared calcium ion indicator NIR-GECO2G 近红外钙离子指示剂NIR-GECO2G的多模态荧光光声体内成像。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100671

Sarah F. Shaykevich , Justin P. Little , Yong Qian , Marie-Eve Paquet , Robert E. Campbell , Daniel Razansky , Shy Shoham

{"title":"Multimodal fluorescence-optoacoustic in vivo imaging of the near-infrared calcium ion indicator NIR-GECO2G","authors":"Sarah F. Shaykevich , Justin P. Little , Yong Qian , Marie-Eve Paquet , Robert E. Campbell , Daniel Razansky , Shy Shoham","doi":"10.1016/j.pacs.2024.100671","DOIUrl":"10.1016/j.pacs.2024.100671","url":null,"abstract":"<div><div>Measuring whole-brain distributed functional activity is an important unmet need in neuroscience, requiring high temporal resolution and cellular specificity across large volumes. Functional optoacoustic neuro-tomography (FONT) with genetically encoded calcium ion indicators is a promising approach towards this goal. However, it has not yet been applied in the near-infrared (NIR) range that provides deep penetration and low vascular background optimal for <em>in vivo</em> neuroimaging. Here, we study the noninvasive multimodal fluorescence and optoacoustic imaging performance of state-of-the-art NIR calcium ion indicator NIR-GECO2G in the mouse brain. We observe robust <em>in vivo</em> signals with widefield fluorescence, and for the first time, with FONT. We also show that in both modalities, the NIR-GECO2G signal improves more than twofold in the biliverdin-enriched <em>Blvra</em><sup><em>-/-</em></sup> mouse line compared to wild type. Our findings demonstrate the potential of multimodal fluorescence and optoacoustic NIR imaging, opening new possibilities for whole-brain real-time functional imaging in rodents.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100671"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative photoacoustic imaging using known chromophores as fluence marker 定量光声成像使用已知的发色团作为通量标记。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100673

Anjali Thomas , Max Rietberg , Mervenur Akkus , Gijs van Soest , Kalloor Joseph Francis

{"title":"Quantitative photoacoustic imaging using known chromophores as fluence marker","authors":"Anjali Thomas , Max Rietberg , Mervenur Akkus , Gijs van Soest , Kalloor Joseph Francis","doi":"10.1016/j.pacs.2024.100673","DOIUrl":"10.1016/j.pacs.2024.100673","url":null,"abstract":"<div><div>Photoacoustic imaging offers optical contrast images of human tissue at acoustic resolution, making it valuable for diverse clinical applications. However, quantifying tissue composition via optical contrast remains challenging due to the unknown light fluence within the tissue. Here, we propose a method that leverages known chromophores (<em>e.g.</em>, arterial blood) to improve the accuracy of quantitative photoacoustic imaging. By using the optical properties of a known chromophore as a fluence marker and integrating it into the optical inversion process, we can estimate the unknown fluence within the tissue. Experimentally, we demonstrate that this approach successfully recovers both the spectral shape and magnitude of the optical absorption coefficient of an unknown chromophore. Additionally, we show that the fluence marker method enhances conventional optical inversion techniques, specifically (i) a straightforward iterative approach and (ii) a gradient-based method. Our results indicate an improvement in accuracy of up to 24.4% when comparing optical absorption recovery with and without the fluence marker. Finally, we present the method’s performance and illustrate its applications in carotid plaque quantification.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100673"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing 基于球囊型光声电池的多光程长度反射增强用于痕量气体传感。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100681

Ruiming Wu , Wenjun Ni , Chunyong Yang , Bingze He , Ping Lu , Sixiang Ran , Zhongke Zhao , Perry Ping Shum

{"title":"Multiple optical path length reflections enhancement based on balloon-type photoacoustic cell for trace gas sensing","authors":"Ruiming Wu , Wenjun Ni , Chunyong Yang , Bingze He , Ping Lu , Sixiang Ran , Zhongke Zhao , Perry Ping Shum","doi":"10.1016/j.pacs.2024.100681","DOIUrl":"10.1016/j.pacs.2024.100681","url":null,"abstract":"<div><div>A novel balloon-type photoacoustic cell (BTPAC) is proposed to facilitate the detection limitations of acetylene (C<sub>2</sub>H<sub>2</sub>) gas achieving ppb level. Here, an ellipsoidal photoacoustic cavity is employed as the platform for gas-light interaction. By strategically directing the excitation source towards the focal point of the ellipsoidal cavity, ensuring its trajectory traverses the focal point upon each reflection from the interior walls. This path increases the gas absorption path length and improves the efficiency of the laser-gas interaction process. Experimental results show that the quality factor of the BTPAC is 224.24 under normal temperature and pressure conditions. Notably, the system maintains a high signal-to-noise ratio even at a C<sub>2</sub>H<sub>2</sub> concentration of 0.1 ppm. Moreover, the minimum detection limit (MDL) and normalized noise equivalent absorption can be calculated to be 3.86 ppb, 6.94·10<sup>−10</sup> cm<sup>−1</sup>·W·Hz<sup>−1/2</sup>, respectively. Finally, the MDL of the sensor reaches to 0.71 ppb when the integration time reaches 100 s.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100681"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue 用于纤维组织中光轴深度估计的二色敏感光声成像。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100676

Camilo Cano , Amir Gholampour , Marc van Sambeek , Richard Lopata , Min Wu

{"title":"Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue","authors":"Camilo Cano , Amir Gholampour , Marc van Sambeek , Richard Lopata , Min Wu","doi":"10.1016/j.pacs.2024.100676","DOIUrl":"10.1016/j.pacs.2024.100676","url":null,"abstract":"<div><div>Photoacoustic imaging (PAI) is a developing image modality that benefits from light–matter interaction and low acoustic attenuation to provide functional information on tissue composition at relatively large depths. Several studies have reported the potential of dichroism-sensitive photoacoustic (DS-PA) imaging to expand PAI capabilities by obtaining morphological information of tissue regarding anisotropy and predominant orientation. However, most of these studies have limited their analysis to superficial scanning of samples, where fluence effects are negligible. Herein, we present a mathematical model for the in-depth analysis of the DS-PA signal of biological samples, focusing on estimating tissue orientation. Our model is validated with a B-scan setup for DS-PA imaging in ex-vivo porcine tendon samples, for which collagen displays optical anisotropy. Results show that for in-depth DS-PA imaging, the accumulative fluence modulation due to dichroism overcomes the effect of absorption dichroism affecting the measured signals; however, this effect can be corrected based on the presented model for determining fiber orientation.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100676"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature dependence of femtosecond photoacoustic process in high-precision characterization for metal nanofilms 飞秒光声过程在金属纳米膜高精度表征中的温度依赖性。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100678

Zhongyu Wang , Jing Min , Yong Sun , Xuesong Wang , Xiuguo Chen , Zirong Tang , Shiyuan Liu

{"title":"Temperature dependence of femtosecond photoacoustic process in high-precision characterization for metal nanofilms","authors":"Zhongyu Wang , Jing Min , Yong Sun , Xuesong Wang , Xiuguo Chen , Zirong Tang , Shiyuan Liu","doi":"10.1016/j.pacs.2024.100678","DOIUrl":"10.1016/j.pacs.2024.100678","url":null,"abstract":"<div><div>Femtosecond photoacoustic detection is a powerful all-optical technique for characterizing metal nanofilms. However, the lack of accurate descriptions of the temperature-dependent optical properties of metal nanofilms during ultrafast thermal processes hinders the deep understanding of this dynamic behavior, leading to compromised measurement accuracy. To address this, we developed Critical Point Models (CPMs) for copper and AlCu nanofilms to describe their dynamic optical properties during photoacoustic testing. By integrating dynamic behavior into ultrafast laser-matter interaction and acousto-optic processes, we explored the temperature effects throughout testing. Numerical simulations were performed to analyze the temperature, stress, and surface reflectivity distributions of the nanofilms. Compared to experimental results, our dynamic models significantly improved prediction accuracy for both copper and AlCu nanofilms. This highlights the importance of temperature dependence in femtosecond photoacoustic testing and validates our model's capability to capture the behavior of metal nanofilms under ultrafast laser irradiation.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100678"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing 用于快速灵敏气体传感的光机械能量增强型 BF-QEPAS。

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-02-01 DOI: 10.1016/j.pacs.2024.100677

Weilin Ye , Linfeng He , Weihao Liu , Zhile Yuan , Kaiyuan Zheng , Guolin Li

{"title":"Optomechanical energy enhanced BF-QEPAS for fast and sensitive gas sensing","authors":"Weilin Ye , Linfeng He , Weihao Liu , Zhile Yuan , Kaiyuan Zheng , Guolin Li","doi":"10.1016/j.pacs.2024.100677","DOIUrl":"10.1016/j.pacs.2024.100677","url":null,"abstract":"<div><div>Traditional beat frequency quartz-enhanced photoacoustic spectroscopy (BF-QEPAS) are limited by short energy accumulation times and the necessity of a decay period, leading to weaker signals and longer measurement cycles. Herein, we present a novel optomechanical energy-enhanced (OEE-) BF-QEPAS technique for fast and sensitive gas sensing. Our approach employs periodic pulse-width modulation (PWM) of the laser signal with an optimized duty cycle, maintaining the quartz tuning fork's (QTF) output at a stable steady-state level by applying stimulus signals at each half-period and allowing free vibration in alternate half-periods to minimize energy dissipation. This method enhances optomechanical energy accumulation in the QTF, resulting in an approximate 33-fold increase in response speed and a threefold increase in signal intensity compared to conventional BF-QEPAS. We introduce an energy efficiency coefficient <em>K</em> to quantify the relationship between transient signal amplitude and measurement duration, exploring its dependence on the modulation signal's period and duty cycle. Theoretical analyses and numerical simulations demonstrate that the maximum <em>K</em> occurs at a duty cycle of 50 % and an optimized beat frequency Δ<em>f</em> of 30 Hz. Experimental results using methane reveal a detection limit of 2.17 ppm with a rapid response time of 33 ms. The OEE-BF-QEPAS technique exhibits a wide dynamic range with exceptional linearity over five orders of magnitude and a record noise-equivalent normalized absorption (NNEA) coefficient of 9.46 × 10<sup>−10</sup> W cm<sup>−1</sup> Hz<sup>−1/2</sup>. Additionally, a self-calibration method is proposed for correcting resonant frequency shifts. The proposed method holds immense potential for applications requiring fast and precise gas detection.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"41 ","pages":"Article 100677"},"PeriodicalIF":7.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate-coupled-enhanced photoacoustic spectroscopy with Chebyshev rational fractional-order filtering algorithm for trace CH4 detection 基于切比雪夫有理分数阶滤波算法的多变量耦合增强光声光谱检测痕量甲烷

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-31 DOI: 10.1016/j.pacs.2025.100692

Shenlong Zha , Hang Chen , Chen Liu , Yuxiang Guo , Hongliang Ma , Qilei Zhang , Lingli Li , Shengbao Zhan , Gang Cheng , Yanan Cao , Pan Pan

{"title":"Multivariate-coupled-enhanced photoacoustic spectroscopy with Chebyshev rational fractional-order filtering algorithm for trace CH4 detection","authors":"Shenlong Zha , Hang Chen , Chen Liu , Yuxiang Guo , Hongliang Ma , Qilei Zhang , Lingli Li , Shengbao Zhan , Gang Cheng , Yanan Cao , Pan Pan","doi":"10.1016/j.pacs.2025.100692","DOIUrl":"10.1016/j.pacs.2025.100692","url":null,"abstract":"<div><div>An innovative and miniature photoacoustic spectroscopy (PAS) gas sensor based on a multivariate-coupled amplification photoacoustic cell (MVCA-PAC) with a total length of 100 mm was developed to achieve ultra-sensitive trace CH<sub>4</sub> detection. Acoustic pressure distribution simulations reveal that at the first-order resonance frequency, the MVCA-PAC achieves a maximum acoustic pressure approximately 3.9 times higher than that of a conventional photoacoustic cell. The absorption optical path of the MVCA-PAC reached 2068 mm through 22 reflections, resulting in a 2-fold increase in the amplitude of photoacoustic signals compared to the traditional photoacoustic cell with an equivalent absorption optical path. Furthermore, compared to a single-pass photoacoustic cell, the <em>2-f</em> signal intensity of the MVCA-PAC increased by a factor of 4.5. Allan variance analysis indicated a detection limit of 0.572 ppm for CH<sub>4</sub> detection with an averaging time of approximately 300 s. To further improve the measurement precision of the designed sensor, the Chebyshev rational fractional-order filtering (CRFOF) algorithm was introduced for PAS signal processing for the first time. Post-processing results demonstrated a 15.4-fold improvement in measurement precision, achieving a precision of 0.578 ppm. Finally, continuous monitoring of atmospheric CH<sub>4</sub> over a 48-hour period validated the reliability and feasibility of the sensor.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100692"},"PeriodicalIF":7.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging 通过体内光声成像对正常皮肤和黑色素瘤皮肤进行可视化、量化和比较

IF 7.1 1区医学

Photoacoustics Pub Date : 2025-01-29 DOI: 10.1016/j.pacs.2025.100693

Terese von Knorring , Tobias Buhl Ihlemann , Paul Blanche , Charlene Reichl , Niels Møller Israelsen , Caroline Meyer Olesen , Yasemin Topal Yüksel , Mette Mogensen

{"title":"Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging","authors":"Terese von Knorring , Tobias Buhl Ihlemann , Paul Blanche , Charlene Reichl , Niels Møller Israelsen , Caroline Meyer Olesen , Yasemin Topal Yüksel , Mette Mogensen","doi":"10.1016/j.pacs.2025.100693","DOIUrl":"10.1016/j.pacs.2025.100693","url":null,"abstract":"<div><div>Photoacoustic imaging (PAI) shows promise for skin cancer diagnosis by detecting chromophores like melanin, hemoglobin, lipids, and collagen. While most studies focus on malignant lesions, understanding normal skin variability across anatomical regions is crucial for validating PAI's clinical application and its use in melanoma diagnosis. We assessed normal skin in 20 healthy volunteers from three different body locations using a clinical PAI system and compared suspicious looking pigmented skin lesions, including melanomas, to adjacent normal skin (n = 74). Higher deoxyhemoglobin levels were observed in the ankle compared to the cheek and volar forearm, while melanin, lipids, and collagen showed minimal variation. Patients with malignant lesions had significantly higher deoxyhemoglobin levels (p = 0.001) than adjacent normal skin, a difference not seen in benign lesions. These findings suggest that PAI may help diagnose malignancies by identifying increased vascularity in skin cancers, while anatomical differences should be considered during diagnostic work-up.</div></div>","PeriodicalId":56025,"journal":{"name":"Photoacoustics","volume":"42 ","pages":"Article 100693"},"PeriodicalIF":7.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0