Seminars in Colon and Rectal Surgery最新文献_第4页

Global perspectives on young-onset colorectal cancer: epidemiology, challenges, and advances 年轻发病结直肠癌的全球视角：流行病学、挑战和进展

IF 0.5

Seminars in Colon and Rectal Surgery Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1016/j.scrs.2025.101118

Drew Goldberg , Erica Pettke

{"title":"Global perspectives on young-onset colorectal cancer: epidemiology, challenges, and advances","authors":"Drew Goldberg , Erica Pettke","doi":"10.1016/j.scrs.2025.101118","DOIUrl":"10.1016/j.scrs.2025.101118","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. It is thought to mainly affect older populations, typically considered those aged 50 or above. Recent trends have shown that CRC in patients younger than 50 years old, known as early onset colorectal cancer (EOCRC), is on the rise while rates of disease in older populations have leveled off or even decreased in many places. This alarming trend is described globally, with a clear relationship between highly developed nations and EOCRC disease burden. More granular disease drivers remain elusive but have been linked to diet, lifestyle, genetic predispositions, and environmental exposure. The clinical, genetic, and histological characteristics of EOCRC imply it is a separate oncologic entity from CRC within older populations. Challenges in management of global EOCRC include standardized clinical guidance, diagnostic consensus, and treatment strategies. Advancements in care have allowed for improved public awareness and disease risk prediction. The pattern of global EOCRC trends represents a significant population health concern, and as such deserves increased attention from clinicians, patients, and the public alike.</div></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"36 3","pages":"Article 101118"},"PeriodicalIF":0.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young-onset colorectal cancer quality of life and psychosocial concerns 年轻发病结直肠癌的生活质量和社会心理问题

IF 0.5

Seminars in Colon and Rectal Surgery Pub Date : 2025-09-01 Epub Date: 2025-07-03 DOI: 10.1016/j.scrs.2025.101120

Jaewon J Lee, Kristen E Dougherty, Karyn B Stitzenberg

引用次数: 0

Fertility considerations young onset CRC 生育方面的考虑，早发性结直肠癌

IF 0.5

Seminars in Colon and Rectal Surgery Pub Date : 2025-09-01 Epub Date: 2025-07-03 DOI: 10.1016/j.scrs.2025.101119

Jared Matson MD, Shanglei Liu MD MAS

{"title":"Fertility considerations young onset CRC","authors":"Jared Matson MD, Shanglei Liu MD MAS","doi":"10.1016/j.scrs.2025.101119","DOIUrl":"10.1016/j.scrs.2025.101119","url":null,"abstract":"<div><div>The incidence of young-onset colorectal cancer (YOCRC) is rising. This patient population often presents with advanced disease and is treated more aggressively, raising unique challenges—particularly regarding fertility and sexual function. This chapter explores the multifaceted impact of YOCRC treatment on fertility and the importance of early reproductive counseling. YOCRC patients frequently undergo multimodal therapy, including chemotherapy, radiation, and surgery—all of which can impair fertility. Chemotherapeutic agents like oxaliplatin and irinotecan are known to be gonadotoxic, with variable long-term effects in both men and women. Pelvic radiation carries high risks for both gonadal failure and uterine or testicular dysfunction. Surgical interventions can damage reproductive organs or alter anatomical and hormonal function, leading to infertility. Fertility preservation methods—including sperm or oocyte cryopreservation, embryo freezing, ovarian transposition, and tissue cryopreservation—offer patients the possibility of future biological parenthood but require early intervention. Additionally, sexual dysfunction is common, driven by nerve damage, radiation effects, anatomical changes, and psychological distress, all of which may further impair reproductive potential. Given that YOCRC patients are often first evaluated by surgeons, it is critical for providers to discuss fertility and sexual health early and refer patients to reproductive specialists. Improved provider awareness and proactive counseling can help preserve future family-building options and enhance quality of life for this growing patient population.</div></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"36 3","pages":"Article 101119"},"PeriodicalIF":0.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology, molecular biology, and genetics of sporadic young onset colorectal cancer 散发性青年结直肠癌的流行病学、分子生物学和遗传学

IF 0.5

Seminars in Colon and Rectal Surgery Pub Date : 2025-09-01 Epub Date: 2025-07-23 DOI: 10.1016/j.scrs.2025.101122

Yasamin Taghikhan MD, Sean Flynn MD

{"title":"Epidemiology, molecular biology, and genetics of sporadic young onset colorectal cancer","authors":"Yasamin Taghikhan MD, Sean Flynn MD","doi":"10.1016/j.scrs.2025.101122","DOIUrl":"10.1016/j.scrs.2025.101122","url":null,"abstract":"<div><div>The incidence of colorectal cancer (CRC) in individuals under 50 years of age—termed young-onset colorectal cancer (YOCRC)—has been increasing despite declining rates of CRC overall. YOCRC now comprises up to 15 % of new CRC diagnoses. Most cases of YOCRC are sporadic, occurring without identifiable hereditary syndromes or family history. It exhibits distinct epidemiological and molecular characteristics, including a predilection for rectal and left-sided tumors, aggressive histology, and more advanced stage at diagnosis. Suspected risk factors contributing to this rising incidence are multifactorial and include lifestyle and environmental exposures, such as westernized diets, obesity, sedentary behavior, increased antibiotic exposure, and chronic inflammation. These factors interact with the gut microbiome to induce dysbiosis, pro-inflammatory states, and DNA damage. At the molecular level, YOCRC is most associated with chromosomal instability (CIN), while a minority exhibit microsatellite instability (MSI) or CpG island methylator phenotype (CIMP). Compared to late-onset CRC, YOCRC displays lower rates of KRAS, BRAF, and APC mutations, but increased TP53 and PTEN alterations. Emerging research also highlights differences in the tumor microenvironment, including immune cell infiltration and complement expression, which may influence therapeutic response. Understanding the unique biology of sporadic YOCRC is essential for developing risk stratification models, refining screening strategies, and advancing targeted treatment approaches. Continued investigation into genetic susceptibility, environmental triggers, and tumor immunobiology will be crucial in addressing this evolving public health challenge.</div></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"36 3","pages":"Article 101122"},"PeriodicalIF":0.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The path to career advancement in surgical research 外科研究的职业发展之路

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101104

Erin Wolf Horrell MD, PhD , Alexander T Hawkins MD, MPH

引用次数: 0

The role of surgical societies in surgical leadership and career development 外科学会在外科领导和职业发展中的作用

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101107

Sean J. Langenfeld MD

引用次数: 0

The role of surgical leadership and career development in the social media era 外科领导和职业发展在社交媒体时代的作用

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101106

Kristyn Kraus DO , Avery Walker MD, FACS, FASCRS

引用次数: 0

From OR to boardroom: Transferring surgical skills to executive leadership roles 从手术室到会议室：将外科技能转化为行政领导角色

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101100

Walter R. Peters Jr. MD, MBA

引用次数: 0

Surgical entrepreneurship: Navigating the intersection of medicine, business and leadership 外科创业：驾驭医学、商业和领导力的交叉点

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101101

Arshad M. Bachelani MD, MMM , Mark K. Soliman MD, MBA

{"title":"Surgical entrepreneurship: Navigating the intersection of medicine, business and leadership","authors":"Arshad M. Bachelani MD, MMM , Mark K. Soliman MD, MBA","doi":"10.1016/j.scrs.2025.101101","DOIUrl":"10.1016/j.scrs.2025.101101","url":null,"abstract":"<div><div>Surgeons possess a unique constellation of skills—adaptability, leadership, and problem-solving—that translates well to entrepreneurial ventures. This chapter outlines a framework for surgeon-entrepreneurs to identify and address unmet needs within healthcare through innovation. Beginning with ideation and problem definition, the text highlights the importance of validating market demand and engaging stakeholders early. It then describes the iterative process of prototyping and developing a minimum viable product (MVP), detailing how resource-efficient strategies can confirm feasibility and guide product refinement. Building a high-functioning team is discussed in the context of complementary expertise and shared vision, which is vital when navigating complex regulatory and financial landscapes. The chapter also explores surgeon entrepreneurs' cultural challenges, emphasizing how an entrepreneurial mindset can extend rather than detract from clinical responsibilities. By demonstrating how established surgical skills can be harnessed to create impactful new solutions, this work underscores the potential for surgeon-led ventures to improve patient care and streamline healthcare delivery on a larger scale.</div></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"36 2","pages":"Article 101101"},"PeriodicalIF":0.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultivating diversity and inclusion in surgical leadership 培养外科领导的多样性和包容性

IF 0.4

Seminars in Colon and Rectal Surgery Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.scrs.2025.101102

Kristen M. Westfall MD, MPH , Karri E. Hester MD, MS , Erin King-Mullins MD , Melissa I. Chang MD, MSE

{"title":"Cultivating diversity and inclusion in surgical leadership","authors":"Kristen M. Westfall MD, MPH , Karri E. Hester MD, MS , Erin King-Mullins MD , Melissa I. Chang MD, MSE","doi":"10.1016/j.scrs.2025.101102","DOIUrl":"10.1016/j.scrs.2025.101102","url":null,"abstract":"<div><div>Diverse leadership within healthcare enhances decision-making, fosters innovation, and improves patient outcomes. This chapter advocates for a shift from traditional diversity, equity, and inclusion (DEI) frameworks to the concept of inclusive excellence, embedding diversity as a core component of organizational success. Inclusive excellence emphasizes intersectionality, recognizing the unique value of individuals’ varied identities, including race, gender, socioeconomic background, and professional experiences.</div><div>Inclusive leadership addresses the underrepresentation of marginalized groups in surgical leadership by transforming organizational culture, revamping recruitment processes, and creating pathways for aspiring leaders. Lessons from industries outside healthcare offer actionable strategies to embed intersectionality as a foundation for leadership development. While these efforts are essential to reducing health disparities and improving systems, political and legal challenges to diversity initiatives pose significant threats. Strong institutional support is critical to safeguarding progress. By fostering inclusive leadership, surgery can better reflect and serve diverse populations, ensuring compassionate, equitable, and innovative care for all patients.</div></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"36 2","pages":"Article 101102"},"PeriodicalIF":0.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0