Seminars in Colon and Rectal Surgery最新文献_第10页

Biologic agents and small molecules – mechanism of action 生物制剂与小分子&作用机制

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100861

Katherine Falloon MD , Ruthvik Padival MD , Satya Kurada MD , Sara El Ouali MD , Florian Rieder MD

引用次数: 0

Medical treatment of intestinal Crohn's disease 肠道克罗恩病的医学治疗

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100862

Eula Plana Tetangco MD, MPH , Adam C. Stein MD

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Perioperative management of biologic agents in ulcerative colitis 溃疡性结肠炎生物制剂的围手术期处理

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100866

Amy L. Lightner MD , Phillip R. Fleshner MD

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Perioperative management of biologic agents in Crohn's disease 克罗恩病生物制剂的围手术期治疗

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100865

Valery Vilchez MD, Amy L. Lightner MD

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Treatment of severe and fulminant inflammatory bowel disease colitis 严重和暴发性结肠炎的治疗

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100864

Dominic Vitello MD, Michael F. McGee MD

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Medical treatment of ulcerative colitis 溃疡性结肠炎的医学治疗

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100863

Sumona Bhattacharya MD , Raymond K. Cross MD, MS

{"title":"Medical treatment of ulcerative colitis","authors":"Sumona Bhattacharya MD , Raymond K. Cross MD, MS","doi":"10.1016/j.scrs.2022.100863","DOIUrl":"https://doi.org/10.1016/j.scrs.2022.100863","url":null,"abstract":"<div>Ulcerative colitis is a chronic inflammatory condition characterized by abdominal pain and diarrhea usually with hematochezia. Optimal medical management of ulcerative colitis is aimed at resolving clinical symptoms as well as achieving mucosal healing. Treatments are selected based on several variables including severity of symptoms, overall inflammatory burden, and whether risk factors for poor prognosis are present. Various medications currently approved for use in ulcerative colitis include 5-aminosalicylates, corticosteroids, thiopurines, anti-tumor necrosis factor antagonists, ustekinumab, vedolizumab, and tofacitinib. While the appropriate use of these as solitary drugs or in combination is often straightforward, therapy for particularly complex patients such as those requiring a rapid onset of action, those who are elderly or have significant medical co-morbidities, those with history of or active malignancy, those who are pregnant or breastfeeding, as well as those with extra-intestinal manifestations requires special consideration.</div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"33 1","pages":"Article 100863"},"PeriodicalIF":0.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138393422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operative indications and options in intestinal Crohn's disease 肠性克罗恩病的手术适应证和选择

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Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI: 10.1016/j.scrs.2022.100867

Linda Ferrari MD , Alessandro Fichera MD

{"title":"Operative indications and options in intestinal Crohn's disease","authors":"Linda Ferrari MD , Alessandro Fichera MD","doi":"10.1016/j.scrs.2022.100867","DOIUrl":"10.1016/j.scrs.2022.100867","url":null,"abstract":"<div>Multidisciplinary management of Crohn's disease is mandated by the complexity of the clinical scenarios and interfaces between medical treatment, nutritional support, and surgical interventions. Surgery is a critical component of the treatment algorithm intended to improve patient symptoms and quality of life, resolve disease-associated complications, and maximize efficacy of medical therapy.The most common procedure performed for intestinal Crohn's disease is resection of the affected segment of bowel with primary anastomosis when feasible and indicated. Different surgical techniques have been proposed with the goals of limiting postoperative complications and preventing surgical recurrences. Selected patients affected by intestinal Crohn's disease are at especially increased risk for repeated surgical intervention and bowel sparing techniques have been developed to reduce the risk of short bowel syndrome in this population.The clinical scenarios of intestinal Crohn's disease vary as to when surgery is indicated and what techniques should be employed. Multiple surgical options might be used in a single patient with multifocal disease with an intent to provide a longer remission time. The important role of preoperative optimization and postoperative treatment reinforces the notion that timing and coordination of medical and surgical treatments is crucial in this debilitating and complex disease.</div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"33 1","pages":"Article 100867"},"PeriodicalIF":0.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48671731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and pathophysiology of low anterior resection syndrome 前低位切除综合征的流行病学和病理生理学

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Seminars in Colon and Rectal Surgery Pub Date : 2021-12-01 DOI: 10.1016/j.scrs.2021.100844

Danielle I. Kay MD, Lauren M. Theiss MD, Daniel I. Chu MD MSPH

引用次数: 1

Seminars in colon and rectal surgery: Low anterior resection syndrome 结肠直肠外科研讨会:低位前切除术综合征

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Seminars in Colon and Rectal Surgery Pub Date : 2021-12-01 DOI: 10.1016/j.scrs.2021.100843

Amanda Hayman MD, MPH, FACS, FASCRS

引用次数: 0

Low anterior resection syndrome: Future directions in treatment and prevention 下前切除术综合征:治疗和预防的未来方向

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Seminars in Colon and Rectal Surgery Pub Date : 2021-12-01 DOI: 10.1016/j.scrs.2021.100850

Craig A. Messick MD , Marylise Boutros MD

{"title":"Low anterior resection syndrome: Future directions in treatment and prevention","authors":"Craig A. Messick MD , Marylise Boutros MD","doi":"10.1016/j.scrs.2021.100850","DOIUrl":"10.1016/j.scrs.2021.100850","url":null,"abstract":"<div>There has been a recent increase in patient reported outcomes, specifically quality of life (QoL), following recovery from a restorative proctectomy. The constellation of post-operative bowel dysfunction symptoms has been collectively termed the Low Anterior Resection Syndrome (LARS). Research efforts have resulted in an international consensus statement on its definition and now establishes a foundation of future research on LARS incidence, significance and treatment options. Amidst the myriad of prior treatment options, all efforts by surgeons to provide organ (anus) preservation surgery have unfortunately resulted in an increasing number of patients who intensely suffer from LARS. Perhaps historically considered only for failure of symptom management by both surgeons and patients alike, use of a permanent colostomy may be an appropriate surgical outcome outright when patients are fully informed of what post-operative bowel “dysfunction” is likely to be expected. Still, the future of LARS treatments is just beginning to be investigated and increased physician awareness of those new management strategies may offer hope for patients who continually struggle with their QoL following a restorative proctectomy.</div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"32 4","pages":"Article 100850"},"PeriodicalIF":0.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44758066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0