Disability Studies Quarterly最新文献_第9页

Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production. 线粒体丙酮酸载体阻断可通过调节线粒体能量产生，减少破骨细胞生成和骨吸收。

Disability Studies Quarterly Pub Date : 2022-03-04 DOI: 10.1016/j.jbc.2022.101775

Qian Guo, Hongjian Zhao, Haozhe Cheng, Honglei Kang, Yimin Dong, Renpeng Peng, Meipeng Zhu, Zhong Fang, Feng Li

{"title":"Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.","authors":"Qian Guo, Hongjian Zhao, Haozhe Cheng, Honglei Kang, Yimin Dong, Renpeng Peng, Meipeng Zhu, Zhong Fang, Feng Li","doi":"10.1016/j.jbc.2022.101775","DOIUrl":"10.1016/j.jbc.2022.101775","url":null,"abstract":"<p><p>It's widely accepted that increasing mitochondrial respiration plays a pivotal role during osteoclastogenesis. Mitochondrial pyruvate carrier (MPC) is the key transporter that links glycolysis to mitochondrial respiration but little is known about its role during osteoclastogenesis. Our goal was to determine the effects of its blockade on osteoclastogenesis and bone resorption in vivo and in vitro. To address this issue, we performed gene knockdown or pharmacologically inhibited MPC in primary bone marrow-derived monocytes (BMMs) or in an ovariectomized mouse model. We also studied the metabolic changes in RANKL-induced differentiating BMMs with MPC blockade and performed rescue experiments. We found that MPC blockade resulted in decreased osteoclastogenesis both in vivo and in vitro and inhibiting MPC significantly alleviated ovariectomy-induced trabecular bone loss. Further investigations showed that MPC blockade significantly reversed the metabolic profile related to RANK activation, including decreased intermediates involved in citric acid cycle and glutamine metabolism. Moreover, metabolic flux analysis verified that MPC blockade decreased pyruvate flux into TCA cycle with no significant effect on glycolysis. Besides, MPC blockade resulted in suppressed mitochondrial biogenesis in addition to oxidative phosphorylation. Rescue experiments revealed that inhibiting pyruvate dehydrogenase kinase (PDK) via sodium dichloroacetate (DCA), but not targeting glutamine metabolism, could reverse the effects of MPC blockade on osteoclastogenesis. These implied that the effects of MPC blockade were mediated by reduced pyruvate fuel into citric acid cycle in multiple aspects. Taken together, our data demonstrated the inhibitory effects of MPC blockade on osteoclastogenesis, which was mediated by decreased mitochondrial energy production.</p>","PeriodicalId":55735,"journal":{"name":"Disability Studies Quarterly","volume":"31 1","pages":"101775"},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80236284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abya Yala's Disability: Weaving With the Thread and Breath of the Ancestors 阿比亚亚拉的残疾：用祖先的丝线和呼吸编织

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8445

Alexander Yarza de los Ríos

引用次数: 0

Enduring the Storm: Dealing with Mental Disabilities in Oceania 忍受风暴:处理大洋洲的精神残疾

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8457

Juliann Anesi

引用次数: 0

Indigeneity and Disabilities in the Ecuadorian Oral History Archives 厄瓜多尔口述历史档案中的愤怒和残疾

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8454

S. Gibson, S. Newman, Antonia Carcelén-Estrada

引用次数: 0

Stories Out of Place: Archives of Disability and Settler Colonialism in and from Life of Black Hawk 不合时宜的故事：黑鹰生活中的残疾和殖民主义档案

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8482

Amanda Stuckey

引用次数: 0

Defying the odds: A self-reflection of an Indigenous woman lawyer with a disability in Ghana 不顾困难:加纳一名残疾土著女律师的自我反思

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8458

Esther Gyamfi

引用次数: 1

Thinking about mental health and spirituality from the Indigenous knowledge systems frame of reference 从土著知识体系的参考框架思考心理健康和精神

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8450

Lieketseng Ned, Lily N. A. Kpobi, C. Ohajunwa

引用次数: 1

Dangerous Representations: 'Indigenous Infanticide,' Disability, and Karitiana Relations in Brazil 危险的表现:“土著杀婴”、残疾和巴西的卡里蒂亚纳关系

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8443

Íris Morais Araújo

引用次数: 0

"The Way History Lands on a Face": Disability, Indigeneity, and Embodied Violence in Tommy Orange's There There “历史落在一张脸上的方式”:汤米·奥兰治的《那里那里》中的残疾、土著和具体化的暴力

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8483

Brandi Bushman, Pasquale S. Toscano

{"title":"\"The Way History Lands on a Face\": Disability, Indigeneity, and Embodied Violence in Tommy Orange's There There","authors":"Brandi Bushman, Pasquale S. Toscano","doi":"10.18061/dsq.v41i4.8483","DOIUrl":"https://doi.org/10.18061/dsq.v41i4.8483","url":null,"abstract":"At the start of Tommy Orange's There There, Cheyenne child Tony Loneman peers into his television screen and considers a playground taunt: \"Why's your face look like that?\" Confronted with his reflection, he discovers the \"Drome\"—the way fetal alcohol syndrome has contoured his body, \"the way history lands on a face.\" The novel ends with another question from Tony: \"Grandma, what are we?\" With these pillared concerns—the \"why\" of nonnormative embodiment and the \"what\" of cultural identity—There There invites us to consider the ways that Indigeneity and disability are constitutive of one another. We argue that Orange (Cheyenne and Arapaho) explores how the disabled Native bodymind is always under the surveillance of the present colonial eye. We do so via close-readings of three of Tony's encounters in the novel: with himself, with an able-bodied, non-Native interlocutor who interrogates his cultural and bodymind alterity, and with his grandmother. Embodying the ancestral trauma renewed in these moments, Tony must not only live within a multi-generational temporality but must also (re)assemble his reality through constant encounters with non-Native interlocuters, moments that mimic and remind the reader of the original contact zones of American coloniality. In analyzing these moments, this article considers how disability and Indigeneity are, at once, in tension while also mutually constitutive of one another through three ongoing operations of the colonial project: the branding, transformation, and invasive reading of the bodymind. As settler colonialism continues to find its \"specific, irreducible element\" of territoriality not only on the geographical space of the Americas, but also on the individual bodymind, disability and Indigeneity, the corporeal and the ideological, the national and the personal, become metonymically connected and intimately imbricated.","PeriodicalId":55735,"journal":{"name":"Disability Studies Quarterly","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47202366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indigenous Concepts of Difference: an alternative to Western disability labeling 差异的本土概念:对西方残疾标签的替代

Disability Studies Quarterly Pub Date : 2022-01-21 DOI: 10.18061/dsq.v41i4.8468

L. Lovern

引用次数: 1