Auris Nasus Larynx最新文献

{"title":"Prediction of the efficacy of proton-pump inhibitors in patients with contact granuloma using 24-hour combined dual channel pH/impedance monitoring","authors":"Bo Hae Kim ,&nbsp;Hanaro Park ,&nbsp;Cheol Min Shin ,&nbsp;Gene Huh ,&nbsp;Young Ho Jung ,&nbsp;Woo-Jin Jeong","doi":"10.1016/j.anl.2024.02.006","DOIUrl":"https://doi.org/10.1016/j.anl.2024.02.006","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to evaluate the treatment outcomes of proton-pump inhibitors (PPIs) in patients with contact granuloma (CG) and to investigate the parameters of 24 h combined dual channel pH/impedance (24 h pH/MII) monitoring, which are reliable for predicting the response to PPI of CG patients.</p></div><div><h3>Methods</h3><p><em>:</em> We reviewed the medical records of patients with CG who had been treated with PPIs and had completed more than 6 months of follow-up. We classified the patients into two groups (cured vs. persistent), according to their PPI treatment outcomes. Reflux events were categorized into three groups based on pharyngeal pH during reflux: 1) acid reflux (pH &lt; 4), 2) weak acid reflux (4 &lt; pH &lt; 7), and 3) weak alkaline reflux (pH &gt;7), as detected by a proximal probe. We compared the results of 24h-pH/MII between the two groups and used receiver operating characteristic curve (ROC) analysis to determine the cutoff values of significant parameters for predicting responses to PPIs.</p></div><div><h3>Results</h3><p><em>:</em> Among 22 patients who completed at least 6 months of PPI treatment and follow-up, weak acid reflux events were more frequently observed in persistent group than in the cured group (<em>p</em> = 0.046), and the proportion of weak acid reflux was also higher in the persistent group (<em>p</em> = 0.031) than in the cured group. Reliable parameters predictive of a poor response to PPIs were a number of weak acid reflux events ≥ 11 (area under the curve [AUC], 0.775; <em>p</em> = 0.03) and a proportion of weak acid reflux events ≥ 56.7 % (AUC, 0.763; <em>p</em> = 0.038) in ROC analyses.</p></div><div><h3>Conclusion</h3><p><em>:</em> Weak acid reflux was identified as a significant factor associated with the treatment outcomes of PPIs in patients with CG. A number of weak acid reflux events ≥ 11 is considered to be the most reliable predictor of a poor response to PPIs in patients with CG.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 548-552"},"PeriodicalIF":1.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications including dysphagia following transoral non-robotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study","authors":"Koji Ushiro ,&nbsp;Yoshiki Watanabe ,&nbsp;Yo Kishimoto ,&nbsp;Yoshitaka Kawai ,&nbsp;Shintaro Fujimura ,&nbsp;Ryo Asato ,&nbsp;Takashi Tsujimura ,&nbsp;Ryusuke Hori ,&nbsp;Yohei Kumabe ,&nbsp;Kaori Yasuda ,&nbsp;Hisanobu Tamaki ,&nbsp;Takehiro Iki ,&nbsp;Yoshiharu Kitani ,&nbsp;Keisuke Kurata ,&nbsp;Tsuyoshi Kojima ,&nbsp;Kuniaki Takata ,&nbsp;Shinpei Kada ,&nbsp;Shinji Takebayashi ,&nbsp;Shogo Shinohara ,&nbsp;Kiyomi Hamaguchi ,&nbsp;Koichi Omori","doi":"10.1016/j.anl.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.anl.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.</p></div><div><h3>Methods</h3><p>We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study.</p></div><div><h3>Results</h3><p>Six hundred and forty patients were included. Postoperative bleeding was observed in 20 cases (3.1%), and the risk factor was advanced T category. Postoperative laryngeal edema was observed in 13 cases (2.0%), and the risk factors were prior radiotherapy, advanced T stage, and concurrent neck dissection in patients with resected HPC. Dysphagia requiring nutritional support was observed in 29 cases (4.5%) at 1 month postoperatively and in 19 cases (3.0%) at 1 year postoperatively, respectively. The risk factors for long-term dysphagia were prior radiotherapy and advanced T category. Short-term risk factors for dysphagia were prior radiotherapy, advanced T category, and concurrent neck dissection, while long-term risk factors for dysphagia were only prior radiotherapy and advanced T category.</p></div><div><h3>Conclusion</h3><p>Prior radiotherapy, advanced T stage, and concurrent neck dissection increased the incidence of postoperative laryngeal edema and short-term dysphagia, but concurrent neck dissection did not affect long-term dysphagia. Such features should be considered when considering the indication for transoral surgery and postoperative management.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 575-582"},"PeriodicalIF":1.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The error patterns of phonemes in children with prelingual hearing loss: A comparison between hearing aid and cochlear implant users","authors":"Yuri Nishiyama ,&nbsp;Shujiro Minami ,&nbsp;Ryoko Ijuin ,&nbsp;Tomoko Kuroki ,&nbsp;Ayako Tendo ,&nbsp;Yuko Kusui ,&nbsp;Satoko Wakabayashi ,&nbsp;Kimitaka Kaga","doi":"10.1016/j.anl.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.anl.2024.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>To reveal differences in error pattern of phonemes and articulation between children using cochlear implants (CIs) and those using hearing aids (HAs) due to prelingual hearing disorder and help the education of children with prelingual hearing loss.</p></div><div><h3>Method</h3><p>Children with prelingual hearing loss who were receiving auditory-verbal preschool education at an auditory center for hearing-impaired children (Fujimidai Auditory Center, Tokyo, Japan) from 2010 to 2020 were analyzed retrospectively. All participants underwent pure tone audiometry and monosyllabic intelligibility tests. The error answers were categorized into five patterns which was characterized by the substitution, addition, omission, failure, and no response according to consonant errors. In addition, the consonant errors classified into the manner of articulation and the differences of error patterns were analyzed between the HA and the CI group descriptively.</p></div><div><h3>Results</h3><p>A total of 43 children with bilateral HAs and 46 children with bimodal CIs or bilateral CIs were enrolled. No significant between-group differences in median phoneme intelligibility were found. The most common error pattern was substitution in both HA and CI groups. The error number of addition pattern in the HA group was smaller than in the CI group. In both groups, the most common errors of articulation were flap errors, and the most common error patterns were flaps to nasals, nasals to nasals, plosives to plosives. In the HA group, plosives and nasals tended not to be recognized and in the CI group plosives were prone to be added to vowels.</p></div><div><h3>Conclusions</h3><p>There were some different error patterns of articulation and consonant substitution between groups. Clarifying differences of phoneme that are difficult to hear and tend to be misheard would help for creating an effective approach to auditory training for children with hearing loss.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 537-541"},"PeriodicalIF":1.7,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-operative semicircular canal function evaluated by video head impulse test in patients with vestibular schwannoma","authors":"Keishi Fujiwara ,&nbsp;Shinya Morita ,&nbsp;Hiroaki Motegi ,&nbsp;Shigeru Yamaguchi ,&nbsp;Yukitomo Ishi ,&nbsp;Kimiko Hoshino ,&nbsp;Atsushi Fukuda ,&nbsp;Makoto Kobayashi ,&nbsp;Yuji Nakamaru ,&nbsp;Miki Fujimura ,&nbsp;Akihiro Homma","doi":"10.1016/j.anl.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.anl.2024.03.001","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate pre- and post-operative semicircular canal function in patients with vestibular schwannoma (VS) by the video Head Impulse Test (vHIT).</p></div><div><h3>Methods</h3><p>Nineteen patients with VS who underwent surgery were enrolled in this study. The gain in vestibulo-ocular reflex (VOR) and the degree of scatter in catch-up saccades were examined pre- and post-operatively for the semicircular canals in VS patients.</p></div><div><h3>Results</h3><p>Ten of 19 cases (52.6 %) with VS were defined as demonstrating both superior vestibular nerve (SVN) and inferior vestibular nerve (IVN) impairment from the results of pre-operative vHIT. Hearing level and subjective vestibular symptoms showed significant correlations with pre-operative semicircular canal function. Compared to pre-operative vHIT results, VOR gains within 1 month after surgery were significantly reduced in all three canals; however, significant differences had disappeared in the anterior and posterior semicircular canals at 6 months after surgery. Cases of unknown origin had a significantly greater reduction in posterior semicircular canal function after surgery compared with those with disease of IVN origin.</p></div><div><h3>Conclusions</h3><p>As vHIT could evaluate pre-operative vestibular nerve impairment, post-operative VOR gain reduction and the degree of vestibular compensation, semicircular canal function evaluated by vHIT provides a good deal of useful information regarding VS patients undergoing surgery compared to caloric testing, and vHIT should be performed pre- and post-operatively for patients with VS.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 542-547"},"PeriodicalIF":1.7,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of increased listening effort on the balance performance of patients with compensated vestibular lesion","authors":"Nashwa Nada ,&nbsp;Mai Mohammed El-Gohary ,&nbsp;Wessam Mostafa Essawy","doi":"10.1016/j.anl.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.anl.2023.12.001","url":null,"abstract":"<div><h3>Objectives</h3><p>This study investigated the effects of listening effort (LE) on balance in patients with compensated vestibular deficits compared to healthy peers.</p></div><div><h3>Methods</h3><p>The subjects included two main groups: a control group of 15 healthy subjects and a study group of 19 patients with compensated vestibular pathology. The computerized dynamic posturography test (CDP) was conducted without the speech-in-noise task as a baseline, then the participant was subjected to a dual task in which the auditory task (speech-in-noise sentences) was given as the primary task, and the balance function test was the secondary task.</p></div><div><h3>Results within-group analysis</h3><p>The study group showed statistically significantly worse values of all body balance parameters under dual-task than the baseline in all conditions. These differences were much higher under the compliant platform conditions. However, these findings were not statistically significant in the control group.</p></div><div><h3>Between-group analysis</h3><p>The study group showed a statistically significant decline in body balance reactions compared to the control group under dual-task with increased listening effort and the compliant platform. Study subgroup analysis revealed statistically significant differences between patients with unilateral vestibular loss (UVL) and those with bilateral vestibular loss (BVL) in the unstable platform condition.</p></div><div><h3>Conclusion</h3><p>Our study regarding implementing a dual-tasking paradigm as a measure of LE during the evaluation of chronic vestibular patients with CDP demonstrated how dual-tasking with increased LE affects postural stability. Because of this, patients will probably be more prone to tripping and falling in multitasking situations, as found in real-world settings. This fact should be taken into consideration while testing patients with chronic vertigo and compensated states at VNG. A dual-task paradigm helps uncover the unrevealed pathology.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 492-500"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Kahramanmaras, Turkey 2023 earthquakes on balance perception, dizziness and post-traumatic stress: A relational screening model between subjective balance problems and post-traumatic stress","authors":"Deniz Uğur Cengiz ,&nbsp;Feyza İnceoğlu ,&nbsp;Ercan Karababa ,&nbsp;Anı Parabakan Polat ,&nbsp;Tuğba Yılmaz ,&nbsp;Berna Deniz Kuntman ,&nbsp;Asya Fatma Men ,&nbsp;Evren Hızal","doi":"10.1016/j.anl.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.anl.2024.02.004","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of the present study was to investigate the effects of the February 6, 2023, earthquakes in Turkey and recurrent aftershocks on balance and post-traumatic stress in surviving victims.</p></div><div><h3>Methods</h3><p>Our study included 1004 participants aged 18–65 years who were exposed to the February 6 earthquakes and aftershocks in Turkey. After obtaining online consent from all participants, the Vertigo Symptom Scale (VSS), the Dizziness Handicap Index (DHI), and the Posttraumatic Post-Traumatic Disorder Checklist Scale (PCL-5) were administered online, and the interactions between the variable sets were examined using a correlational screening model.</p></div><div><h3>Results</h3><p>As a result of the structural equation model established with the observed variables, it was found that VSS total scores had a statistically significant positive effect on PCL-5 (β1 = 0.56; <em>p</em> = 0.001 &lt; 0.05). In addition, statistically significant positive high-level correlations were found between VSS and DHI (cov_VSS-DHI = 0.71), and a positive low level correlation with the number of days with dizziness (cov_{VSS-number of days with dizziness} = 0.34), and a positive low level correlation with frequency of days with dizziness (cov_{VSS-frequency of days with dizziness} = 0.37). A statistically significant positive low-level relationship was found between DHI and the number of days with dizziness (cov_{DHI-number of days with dizziness} = 0.34) and a positive low-level correlation between DHI and the frequency of days with dizziness (cov_{DHI-frequency of days with dizziness} = 0.29).</p></div><div><h3>Conclusion</h3><p>The structural equation modeling analysis showed that post-traumatic stress disorder had a significant effect on balance and dizziness.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 531-536"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential application of electronic odor diffuser in olfaction testing","authors":"Tadashi Ishimaru,&nbsp;Hitomi Ishimaru","doi":"10.1016/j.anl.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.anl.2023.12.004","url":null,"abstract":"<div><h3>Objective</h3><p>Different olfactory tests have been performed by otorhinolaryngologists in different parts of the world. For example, the University of Pennsylvania Smell Identification Test (UPSIT) has been used in the U.S., whereas the Sniffin’ Sticks Test has been used in Europe, and similarly, T&amp;T olfactometry is used in Japan. Although audiometers with electronic oscillators have long been used in hearing tests, electronic odor generators are not typically used in olfaction tests. We attempted an olfactory test using the AROMASTIC® (SONY, Tokyo, Japan), an electronically controlled device that can diffuse five different odors.</p></div><div><h3>Methods</h3><p>Forty participants who had visited an outpatient olfactory clinic were included in this study. The participants were instructed to answer whether they could smell the five different odors during the AROMASTIC® screening test (AS-test), and the number of odors smelled was summed and scored (AS-score). The patients also underwent T&amp;T olfactometry concurrently.</p></div><div><h3>Results</h3><p>The AS-scores and T&amp;T olfactometry detection and recognition thresholds showed significant correlations, confirming that the AS-test is a valid olfactory test.</p></div><div><h3>Conclusion</h3><p>Electronic odor diffusers may be useful for olfaction tests.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 507-511"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current management of carotid body tumors","authors":"Hiroyuki Ozawa","doi":"10.1016/j.anl.2024.01.007","DOIUrl":"https://doi.org/10.1016/j.anl.2024.01.007","url":null,"abstract":"<div><p>Carotid body tumors (CBTs) are neoplasms that occur at the bifurcation of the carotid artery and are pathologically classified as paragangliomas. In the 4th edition of the WHO classification, paragangliomas are categorized as neoplasms with malignant potential. Clinically, about 5% of CBTs present with malignant features such as metastasis. Currently, it is challenging to distinguish between tumors with benign courses and those that present malignantly.</p><p>Recent advances in genetic testing have elucidated the genetic characteristics of paragangliomas, including carotid body tumors. Over 20 genes have been identified as being involved in tumor development. Particularly in head and neck paragangliomas, abnormalities in genes related to succinate dehydrogenase are frequently observed. Research is ongoing to understand the mechanisms by which these genes contribute to tumor development.</p><p>The definitive treatment for CBTs is surgical resection. These tumors are prone to bleeding and often adhere firmly to the carotid artery, making intraoperative bleeding control challenging. The risk of lower cranial nerve paralysis is relatively high, and there is a risk of stroke because of manipulation of the carotid artery. Preoperative evaluation with angiography is essential, and a multi-disciplinary surgical team approach is necessary.</p><p>In cases where the tumor is difficult to resect or has metastasized, radiation therapy or chemotherapy are employed. Clinical trials involving targeted molecular therapies and radiopharmaceuticals have recently been conducted, with some applied clinically. The development of various new treatments is anticipated, providing hope for therapeutic options in refractory cases.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 501-506"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological changes in the olfactory bulb and rostral migratory stream due to interruption of olfactory input","authors":"Yukari Nakamura ,&nbsp;Takaki Miwa ,&nbsp;Hideaki Shiga ,&nbsp;Hiromi Sakata ,&nbsp;Daichi Shigeta ,&nbsp;Toshihisa Hatta","doi":"10.1016/j.anl.2024.01.009","DOIUrl":"https://doi.org/10.1016/j.anl.2024.01.009","url":null,"abstract":"<div><h3>Objective</h3><p>Periglomerular and granule cells in the adult mammalian olfactory bulb modulate olfactory signal transmission. These cells originate from the subventricular zone, migrate to the olfactory bulb via the Rostral Migratory Stream (RMS), and differentiate into mature cells within the olfactory bulb throughout postnatal life. While the regulation of neuroblast development is known to be affected by external stimuli, there is a lack of information concerning changes that occur during the recovery process after injury caused by external stimuli. To address this gap in research, the present study conducted histological observations to investigate changes in the olfactory bulb and RMS occurring after the degeneration and regeneration of olfactory neurons.</p></div><div><h3>Methods</h3><p>To create a model of olfactory neurodegeneration, adult mice were administered methimazole intraperitoneally. Nasal tissue and whole brains were removed 3, 7, 14 and 28 days after methimazole administration, and EdU was administered 2 and 4 h before removal of these tissues to monitor dividing cells in the RMS. Methimazole-untreated mice were used as controls. Olfactory nerve fibers entering the olfactory glomerulus were observed immunohistochemically using anti-olfactory marker protein. In the brain tissue, the entire RMS was observed and the volume and total number of cells in the RMS were measured. In addition, the number of neuroblasts and dividing neuroblasts passing through the RMS were measured using anti-doublecortin and anti-EdU antibodies, respectively. Statistical analysis was performed using the Tukey test.</p></div><div><h3>Results</h3><p>Olfactory epithelium degenerated was observed after methimazole administration, and recovered after 28 days. In the olfactory glomeruli, degeneration of OMP fibers began after methimazole administration, and after day 14, OMP fibers were reduced or absent by day 28, and overall OMP positive fibers were less than 20%. Glomerular volume tended to decrease after methimazole administration and did not appear to recover, even 28 days after recovery of the olfactory epithelium. In the RMS, EdU-positive cells decreased on day 3 and began to increase on day 7. However, they did not recover to the same levels as the control methimazole-untreated mice even after 28 days.</p></div><div><h3>Conclusion</h3><p>These results suggest that the division and maturation of neuroblasts migrating from the RMS was suppressed by olfactory nerve degeneration or the disruption of olfactory input.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 517-524"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otologic disease trends in Japan post-COVID-19 outbreak: A retrospective time-series analysis","authors":"Keisuke Kondo ,&nbsp;Keiji Honda ,&nbsp;Keiichi Goshima ,&nbsp;Norihiko Inoue ,&nbsp;Daisuke Shinjo ,&nbsp;Takeshi Tsutsumi ,&nbsp;Kiyohide Fushimi","doi":"10.1016/j.anl.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.anl.2024.01.004","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the potential impact of coronavirus disease 2019 (COVID-19) and vaccinations on otologic diseases, including facial nerve paralysis (including Ramsay Hunt syndrome), vestibular neuritis, sudden sensorineural hearing loss, and Meniere's disease.</p></div><div><h3>Methods</h3><p>In this retrospective study, we conducted a time-series analysis employing a causal impact algorithm on a large-scale inpatient database in Japan. We compared the actual number of hospitalized patients with otologic diseases to two predictions: one without any covariates and another with a covariate accounting for the reduction in the number of hospitalized patients due to lockdown measures. Additionally, we performed Granger causality tests to ensure the robustness of our findings.</p></div><div><h3>Results</h3><p>No significant increase was noted in the number of hospitalized patients with otologic diseases following the onset of the COVID-19 pandemic in the causal impact analysis. Similarly, no notable surge was observed in hospitalizations for these diseases following the introduction of the COVID-19 vaccine. The Granger causality tests results aligned with the causal impact analysis findings.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that COVID-19 and vaccinations had minimal discernible effects on hospitalization of patients with otologic diseases, suggesting that otologic diseases may not be significantly impacted by COVID-19 and vaccinations, which could have implications for public health policies and the allocation of healthcare resources during a pandemic. Further research and monitoring of long-term effects are warranted to validate these findings and guide healthcare decision-making.</p></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"51 3","pages":"Pages 525-530"},"PeriodicalIF":1.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}