Gene Expression Patterns最新文献

{"title":"Expression patterns and biological function of BCL2L10 during mouse preimplantation development","authors":"Yong Liu ,&nbsp;Jing Xin ,&nbsp;Shengnan Zhang ,&nbsp;Qingmei Li ,&nbsp;Wenying Wang ,&nbsp;Ji Chen ,&nbsp;Xin Ming ,&nbsp;Xiaoqing Wu ,&nbsp;Xinyan Cao ,&nbsp;Wei Cui ,&nbsp;Hongcheng Wang ,&nbsp;Wenyong Li","doi":"10.1016/j.gep.2022.119285","DOIUrl":"10.1016/j.gep.2022.119285","url":null,"abstract":"<div><p><span>BCL2-like 10 (BCL2L10) is abundantly expressed in mammalian oocytes and plays a crucial role in the completion of oocyte meiosis. However, the expression patterns of BCL2L10 and its biological functions during preimplantation development have not been well characterized. Here, we investigated the spatiotemporal expressions of </span><em>Bcl2l10</em><span> during mouse preimplantation development using RT-qPCR and immunofluorescence and its biological function using siRNA<span> and morpholino injection into pronuclear embryos. Results from RT-qPCR showed that </span></span><em>Bcl2l10</em><span> was highly expressed in the metaphase Ⅱ-stage oocytes and pronuclear-stage embryos, but expression markedly decreased from the two-cell stage onwards and was no longer detected at the four-cell stage and beyond. Immunofluorescence staining showed that BCL2L10 was detectable throughout preimplantation development and localized in the cytoplasm and nuclei. Knocking down </span><em>Bcl2l10</em><span> resulted in a reduced blastocyst formation rate (</span><em>P</em> &lt; 0.01) and decreased expression of OCT4, NANOG, and SOX17 (<em>P</em> &lt; 0.05). We concluded that the role of BCL2L10 is strongly associated with developmental competence of preimplantation mouse embryos.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish","authors":"Jian Zhou ,&nbsp;Yan-Jing Yang ,&nbsp;Rui-Hai Gan ,&nbsp;Yang Wang ,&nbsp;Zhi Li ,&nbsp;Xiao-Juan Zhang ,&nbsp;Jian-Fang Gui ,&nbsp;Li Zhou","doi":"10.1016/j.gep.2022.119286","DOIUrl":"10.1016/j.gep.2022.119286","url":null,"abstract":"<div><p><span>Foxl2 plays conserved central function in ovarian differentiation and maintenance in several fish species. However, its expression pattern and function in fish embryogenesis are still largely unknown. In this study, we first presented a sequential expression pattern of zebrafish </span><em>foxl2a</em> and <em>foxl2b</em><span> during embryo development. They were predominantly expressed in the cranial paraxial mesoderm<span><span> (CPM) and cranial venous vasculature (CVV) during </span>somitogenesis<span> and subsequently expressed in the pharyngeal arches after 48 h post-fertilization (hpf). Then, we compared the brain structures among zebrafish wildtype (WT) and three homozygous </span></span></span><em>foxl2</em> mutants (<em>foxl2a</em>^−/−, <em>foxl2b</em>^−/− and <em>foxl2a</em>^−/−;<em>foxl2b</em>^−/−<span>) and found the reduction of the fourth ventricle in the three </span><em>foxl2</em> mutants, especially in <em>foxl2a</em>^−/−;<em>foxl2b</em>^−/−<span> mutant. Finally, we detected several key transcription factors involved in the gene regulatory network of midbrain-hindbrain boundary (MHB) patterning, such as </span><em>wnt1</em>, <em>en1b</em> and <em>pax2a</em>. Their expression levels were obviously downregulated in MHB of <em>foxl2a</em>^−/− and <em>foxl2a</em>^−/−;<em>foxl2b</em>^−/−<span> mutants. Thus, we suggest that Foxl2a and Foxl2b are involved in MHB and the fourth ventricle development in zebrafish. The current study provides insights into the molecular mechanism underlying development of brain ventricular system.</span></p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and localization of NRF2/Keap1 signalling pathway genes in mouse preimplantation embryos exposed to free fatty acids","authors":"Grace Dionne ,&nbsp;Michele Calder ,&nbsp;Dean H. Betts ,&nbsp;Basim Abu Rafea ,&nbsp;Andrew J. Watson","doi":"10.1016/j.gep.2022.119281","DOIUrl":"10.1016/j.gep.2022.119281","url":null,"abstract":"<div><p>Obese women experience greater incidence of infertility, with reproductive tracts exposing preimplantation embryos to elevated free fatty acids (FFA) such as palmitic acid (PA) and oleic acid (OA). PA treatment impairs mouse preimplantation development <em>in vitro</em>, while OA co-treatment rescues blastocyst development of PA treated embryos. In the present study, we investigated the effects of PA and OA treatment on NRF2/Keap1 localization, and relative antioxidant enzyme (Glutathione peroxidase; <em>Gpx1</em>, Catalase; <em>Cat</em>, Superoxide dismutase; <em>Sod1</em> and γ-Glutamylcysteine ligase catalytic unit; <em>Gclc</em>) mRNA levels, during <em>in vitro</em> mouse preimplantation embryo development. Female mice were superovulated, mated, and embryos cultured in the presence of bovine Serum albumin (BSA) control or PA, or OA, alone (each at 100 μM) or PA + OA combined (each at 100 μM) treatment. NRF2 displayed nuclear localization at all developmental stages, whereas Keap1 primarily displayed cytoplasmic localization throughout control mouse preimplantation development <em>in vitro</em>. Relative transcript levels of <em>Nrf2</em>, <em>Keap1</em>, and downstream antioxidants significantly increased throughout control mouse preimplantation development <em>in vitro</em>. PA treatment significantly decreased blastocyst development and the levels of nuclear NRF2, while OA and PA + OA treatments did not. PA and OA treatments did not impact relative mRNA levels of <em>Nrf2</em>, <em>Keap1</em>, <em>Gpx1</em>, <em>Cat</em>, <em>Sod1</em> or <em>Gclc</em>. Our outcomes demonstrate that cultured mouse embryos display nuclear NRF2, but that PA treatment reduces nuclear NRF2 and thus likely impacts NRF2/KEAP1 stress response mechanisms. Further studies should investigate whether free fatty acid effects on NRF2/KEAP1 contribute to the reduced fertility displayed by obese patients.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1567133X22000515/pdfft?md5=fdc61a446d182e8200f13a7032917441&pid=1-s2.0-S1567133X22000515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10842700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.","authors":"Yuda Cheng, Yang Xiao, Y. Ruan, Jiali Wang, Yanping Tian, Jia-xiang Xiong, Jiaqi Wang, Feng-Po Wang, Chen Zhang, Yixiao Xu, Lianlian Liu, Meng Yu, Jiangjun Wang, Binyu Zhao, Yue Zhang, Ran Yang, Yi Yang, Zhongxiang Yao, Rui Jian, L. Xiao, Junlei Zhang","doi":"10.2139/ssrn.4102878","DOIUrl":"https://doi.org/10.2139/ssrn.4102878","url":null,"abstract":"Transcriptional enhanced associate domain (TEAD) transcription factors play important roles in embryonic stem cell (ESC) renewal and differentiation. Four TEAD transcription factors (Tead1, Tead2, Tead3 and Tead4) and their various splice variants have been discovered in mice, but the expression pattern of them during pluripotency state transition is unclear. Here, we investigated the expression of TEADs and their splice variants in mouse ESCs at different pluripotent/differentiating states and adult mouse tissues. Our results preliminarily revealed the diversity and heterogeneity of TEAD family, which is helpful for understanding their overlapping and distinctive functions. Furthermore, a novel splice variant of Tead1 was identified and named Tead1 isoform 4.","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86764561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exponential Sailfish Optimizer-based generative adversarial network for image annotation on natural scene images","authors":"Selvin Ebenezer S,&nbsp;Raghuveera Tripuraribhatla","doi":"10.1016/j.gep.2022.119279","DOIUrl":"10.1016/j.gep.2022.119279","url":null,"abstract":"<div><p>Generally, automatic image annotation can offer semantic graphics for recognizing image contents, and it creates a base for devising various techniques, which can search images in a huge dataset. Although most existing techniques mainly focus on resolving annotation issues through sculpting tag semantic information and visual image content, it ignores additional information, like picture positions and descriptions. The established Exponential Sailfish Optimizer-based Generative Adversarial Networks are therefore used to provide an efficient approach for image annotation (ESFO-based GAN). By combining Exponentially Weighted Moving Average (EWMA) and Sailfish Optimizer (SFO), the ESFO is a newly created design that is used to train the GAN classifier. Additionally, the Grabcut is presented to successfully do image annotation by extracting the background and foreground images. Additionally, DeepJoint segmentation is used to divide apart the images based on the background image that was extracted. Finally, image annotation is successfully accomplished with the aid of GAN. As a result, image annotation uses the produced ESFO-based GAN's subsequent results. The developed approach exhibited enhanced outcomes with maximum F-Measure of 98.37%, maximum precision of 97.02%, and maximal recall of 96.64%, respectively, using the flicker dataset.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression analysis of irisin during different development stages of skeletal muscle in mice","authors":"Yi Yan ,&nbsp;Ding Yang ,&nbsp;Pei Wen ,&nbsp;Yilei Li ,&nbsp;Yufang Ge ,&nbsp;Pei Ma ,&nbsp;Jiahui Yuan ,&nbsp;Pengxiang Zhang ,&nbsp;Zhiwei Zhu ,&nbsp;Xiaomao Luo ,&nbsp;Xiuju Yu ,&nbsp;Haidong Wang","doi":"10.1016/j.gep.2022.119287","DOIUrl":"10.1016/j.gep.2022.119287","url":null,"abstract":"<div><h3>Background</h3><p>As a newly discovered muscle factor secreted by skeletal muscle cells, irisin<span><span> is a polypeptide fragment formed from </span>hydrolysis<span><span> of fibronectin type Ⅲ domain-containing protein 5 (FNDC5). Irisin can promote beigeing of </span>white adipose tissue<span><span><span> (WAT) and regulate glucose and lipid metabolisms. However, the functions of irisin in skeletal muscle development remain largely unknown. In order to characterize the expression of irisin, this study investigated the expression of irisin precursor FNDC5 in </span>myoblasts and skeletal muscles during different developmental stages of </span>SPF mice.</span></span></span></p></div><div><h3>Results</h3><p><span>The Western blot, quantitative real-time PCR (qRT-PCR), and immunofluorescence assay results showed that FNDC5 was expressed in all the developmental stages of myoblasts and gastrocnemius, but its expression differed at different stages. FNDC5 protein exhibited the highest expression in gastrocnemius of sexually mature mice, followed by elderly mice and adolescent mice, and it displayed the lowest expression in pups. Additionally, FNDC5 protein was mainly expressed in cytoplasm, and it had the highest expression in primary myoblasts, followed by the myotubes with the lowest expression in </span>C2C12 myogenic cells.</p></div><div><h3>Conclusions</h3><p>Overall, FNDC5 was mainly expressed in cytoplasm and extracellular matrix with different expression levels at different developmental stages of skeletal muscle cells and tissues in mice. This study will provide new strategies for promoting skeletal muscle development and treating muscle- and metabolism-related disease by using irisin.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10496995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional differentiation of bmp2a and bmp2b genes in zebrafish","authors":"Yaming Wu ,&nbsp;Aili Sun ,&nbsp;Chunhong Nie ,&nbsp;Ze-xia Gao ,&nbsp;Shi-Ming Wan","doi":"10.1016/j.gep.2022.119288","DOIUrl":"10.1016/j.gep.2022.119288","url":null,"abstract":"<div><p><span>Bone morphogenetic protein 2<span> plays an important role in the regulation of osteoblast proliferation and differentiation. Phylogenetic analysis showed that the </span></span><em>bmp2</em><span> ortholog evolved from the same ancestral gene family in vertebrates and was duplicated in teleost, which were named </span><em>bmp2a</em> and <em>bmp2b</em><span>. The results of whole-mount in situ hybridization showed that the expression locations of </span><em>bmp2a</em> and <em>bmp2b</em> in zebrafish were different in different periods (24 hpf, 48 hpf, 72 hpf), which revealed potential functional differentiation between <em>bmp2a</em> and <em>bmp2b</em>. Phenotypic analysis showed that <em>bmp2a</em> mutations caused partial rib and vertebral deformities in zebrafish, while <em>bmp2b</em>^{<em>−/−</em>}<span> embryos died massively after 12 hpf due to abnormal somite formation. We further explored the expression pattern changes of genes (</span><em>bmp2a</em>, <em>bmp2b</em>, <em>smad1</em>, <em>fgf4</em>, <em>runx2b</em>, <em>alp</em>) related to skeletal development at different developmental stages (20 dpf, 60 dpf, 90 dpf) in wild-type and <em>bmp2a</em>^{<em>−/−</em>} zebrafish. The results showed that the expression of <em>runx2b</em> in <em>bmp2a</em>^{<em>−/−</em>} was significantly downregulated at three stages and the expression of other genes were significantly downregulated at 90 dpf compared with wild-type zebrafish. The study revealed functional differentiation of <em>bmp2a</em> and <em>bmp2b</em> in zebrafish embryonic and skeletal development.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10842720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cloning, tissue distribution of desert hedgehog (dhh) gene and expression profiling during different developmental stages of Pseudopleuronectes yokohamae","authors":"Zheng Zhang,&nbsp;Wenjie Wang,&nbsp;Yanchao Wei,&nbsp;Yixin Gu,&nbsp;Yue Wang,&nbsp;Xuejie Li,&nbsp;Wei Wang","doi":"10.1016/j.gep.2022.119277","DOIUrl":"10.1016/j.gep.2022.119277","url":null,"abstract":"<div><p>As a crucial member of the Hedgehog (Hh) protein family, desert hedgehog (<em>dhh</em><span><span>) plays a vital role in multiple developmental processes, cell differentiation and tissue </span>homeostasis. However, it is unclear how it regulates development in fish. In this study, we cloned and characterized the </span><em>dhh</em> gene from <em>Pseudopleuronectes yokohamae</em>. The full-length cDNA of <em>Pydhh</em><span><span><span> comprises 3194 bp, with a 1386 bp open reading frame<span> (ORF) that encodes a polypeptide of 461 </span></span>amino acids with a typical HH-signal domain, Hint-N and Hint-C domains. Multiple </span>sequence alignment revealed that the putative </span><em>Py</em><span>DHH protein sequence<span> was highly conserved across species, especially in the typical domains. Phylogenetic analysis showed that the </span></span><em>Py</em>DHH clustered within the <span><em>Pleuronectiformes</em></span>. Real-time quantitative PCR showed that <em>Pydhh</em><span> was detected in fourteen different tissues in adult-female and adult-male marbled flounder, and nine different tissues in juvenile fish. During early embryonic development stages, the expression of </span><em>Pydhh</em> was revealed high levels at hatching stage of embryo development. Moreover, the relative expression of <em>Pydhh</em> was significantly higher in the juvenile liver than adults’, and higher in the female skin than the male skin. To further investigate its location, the <em>in situ</em> hybridization (ISH) assay was performed, the results showed that the hybridization signal was obviously expressed in the immune organs of <em>Pseudopleuronectes yokohamae</em>, with weak signal expression in the other tissues. Our results suggested that <em>Pydhh</em> is highly conserved among species and plays a vital role in embryonic development and formation of immune related organs.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patched1 gene homologue participates in female differentiation of Cynoglossus semilaevis","authors":"Qian Qi ,&nbsp;Zhongdian Dong ,&nbsp;Ning Zhang ,&nbsp;Changwei Shao ,&nbsp;Wenteng Xu","doi":"10.1016/j.gep.2022.119265","DOIUrl":"10.1016/j.gep.2022.119265","url":null,"abstract":"<div><p><span>Patched (Ptch) is a receptor in the hedgehog signaling pathway, essential for animal development. Our previous study showed that </span><em>ptch</em><span>1 gene participates in the maintenance of the male germline<span> and spermatogenesis in </span></span><span><em>Cynoglossus semilaevis</em></span> (<em>csptch1</em>). In this study, we identified a <span><em>patched1</em></span> gene homolog (<em>csptch1 x1</em>). The <em>csptch1 x1</em><span> gene is 5761 bp long, with a 4638 bp coding sequence that encodes 1545 amino acids. The Csptch1 x1 protein has 12 transmembrane regions and sterol-sensing domains and is highly homologous to the csptch1 (91 amino acids difference). Expression pattern analysis showed that </span><em>csptch1 x1</em> is expressed in eight different tissues of adult tongue sole, and the expression is significantly higher in tissues of female than that in male tissues. The expression pattern in developmental stages was also analyzed. <em>csptch1 x1</em><span><span><span> could be detected at the 1-cell stage and was highly expressed at the blastocyst, </span>somite, and </span>blastopore<span><span> closing stages, implying that it participates in cell differentiation. In </span>ovarian development, the expression of </span></span><em>csptch1 x1</em><span> was initiated at 20 days after hatching (dah) and was significantly high at 35–50 and 95–150 dah. In situ hybridization showed that </span><em>csptch1 x1</em><span> was predominantly expressed in primordial germ cells, oocytes, and follicular cells, but the expression of the gene was lower in the testis. These results suggest that </span><em>csptch1 x1</em> may be mainly involved in female differentiation and ovarian development, different from the role of <em>csptch1</em> in spermatogenesis.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40705538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereo super-resolution images detection based on multi-scale feature extraction and hierarchical feature fusion","authors":"Junwei Luo ,&nbsp;Lingyi Liu ,&nbsp;Wenbo Xu ,&nbsp;Qilin Yin ,&nbsp;Cong Lin ,&nbsp;Hongmei Liu ,&nbsp;Wei Lu","doi":"10.1016/j.gep.2022.119266","DOIUrl":"10.1016/j.gep.2022.119266","url":null,"abstract":"<div><p>Recently, with most mobile phones coming with dual cameras, stereo image super-resolution is becoming increasingly popular in phones and other modern acquisition devices, leading stereo super-resolution images spread widely on the Internet. However, current image forensics methods are carried out in monocular images, and high false positive rate appears when detecting stereo super-resolution images by these methods. Therefore, it is important to develop stereo super-resolution image detection method. In this paper, a convolutional neural network with multi-scale feature extraction and hierarchical feature fusion is proposed to detect the stereo super-resolution images. Multi-atrous convolutions are employed to extract multi-scale features and be adapt for varying stereo super-resolution images, and hierarchical feature fusion further improve the performance and robustness of the model. Experimental results demonstrate that the proposed network can detect stereo super-resolution images effectively and achieve strong generalization and robustness. To the best of our knowledge, it is the first attempt to investigate the performance of current forensics methods when tested under stereo super-resolution images, and represent the first study of stereo super-resolution images detection. We believe that it can raise the awareness about the security of stereo super-resolution images.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40705539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}