Gene Expression Patterns最新文献

Pre-gestational restraint stress affects reproductive outcomes in adult rats by modulating ovarian and uterine function

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2025-02-25 DOI: 10.1016/j.gep.2025.119391

Harini Raghavendhira , Divya Srinivasan , Jeyakumari Paul , Ravindran Rajan , Ravi Sankar Bhaskaran

{"title":"Pre-gestational restraint stress affects reproductive outcomes in adult rats by modulating ovarian and uterine function","authors":"Harini Raghavendhira , Divya Srinivasan , Jeyakumari Paul , Ravindran Rajan , Ravi Sankar Bhaskaran","doi":"10.1016/j.gep.2025.119391","DOIUrl":"10.1016/j.gep.2025.119391","url":null,"abstract":"<div><div>The impact of gestational stress on reproductive outcomes is well-established, but the effects of pre-gestational stress remain inconclusive. Using female Wistar rats, we demonstrated that pre-gestational stress negatively affects fertility and pregnancy outcomes. The rats were subjected to restraint stress (RS) for 15 days, with 3 h of stress each day, before mating. The RS group exhibited higher levels of corticosterone and prolactin, along with lower levels of adrenocorticotropic hormone (ACTH), indicating a successful stress model. Stressed rats showed reduced fertility and fecundity indices, longer conception times, and decreased levels of ovarian steroids, such as progesterone, testosterone, and estradiol. Additionally, the ovaries of the RS group had fewer antral follicles and more ovarian cysts. Elevated protein levels of cytochrome P450 side-chain cleavage enzyme (CYP11A1) and aromatase (CYP19A1), along with decreased levels of 17β-hydroxysteroid dehydrogenase (17β-HSD), indicating impaired ovarian steroidogenesis in stress exposed rats. In the RS group, there was a significant increase in proteins associated with folliculogenesis, specifically octamer-binding transcription factor 4 (OCT 4) and growth differentiation factor 9 (GDF 9). Additionally, proteins linked to ovulation, such as the prolactin receptor (PRLR), peroxisome proliferator-activated receptor-γ (PPAR-γ), and cyclooxygenase 2 (COX 2), were elevated. The increased levels of PRLR, progesterone receptor (PR), androgen receptor (AR), and estrogen receptor (ER) combined with heightened oxidative stress in the uteri of the RS group, suggest a potential disruption in uterine function. Overall, this research indicates that pre-gestational stress can significantly impact reproductive health by altering gonadotrophin and ovarian steroid dynamics in the female reproductive tract.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"55 ","pages":"Article 119391"},"PeriodicalIF":1.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome analysis of Berberine induced accelerated tail fin regeneration in Zebrafish larvae

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2025-02-09 DOI: 10.1016/j.gep.2025.119390

Radhika Gupta , Chitra Bhasin , Adita Joshi , Nisheeth Agarwal , Ayush Aggarwal , Padmshree Mudgal

{"title":"Transcriptome analysis of Berberine induced accelerated tail fin regeneration in Zebrafish larvae","authors":"Radhika Gupta , Chitra Bhasin , Adita Joshi , Nisheeth Agarwal , Ayush Aggarwal , Padmshree Mudgal","doi":"10.1016/j.gep.2025.119390","DOIUrl":"10.1016/j.gep.2025.119390","url":null,"abstract":"<div><div>Humans have limited capacity to regenerate lost tissues post injury. The ability to modulate regenerative repair of tissues offers possibilities for restoring loss of tissue (organ) structure and function. Zebrafish (<em>Danio rerio</em>) larvae fin fold regeneration model is a simple system to study the process of regeneration and associated cellular mechanisms. Berberine, a plant alkaloid which is known to have wound healing properties shows potential to modulate regeneration. The present study aimed to explore the modulating influence of berberine on the signaling pathways involved in zebrafish larvae transected tail fin fold regeneration. Tail fin fold transection was performed on 3 dpf (days post fertilization) zebrafish larvae treated with Berberine (0.01%) and untreated control (System water (SW)). The larvae were observed under a microscope at 0, 1, 2, 3, 4, 5, hours post transection (hpt). RNA was extracted from Berberine treated and untreated (control) tail fin transected larvae at 4 hpt to perform RNA-seq analysis. PPI (protein-protein interaction) network, Shiny GO functional enrichment and topology analysis of DEGs (differentially expressed genes) was performed. Berberine treated larvae showed an accelerated regeneration growth in their transected tail fin by 4 hpt. Berberine induced accelerated regeneration is associated with the involvement of Insulin, IGF, stress response, jak-stat, cytokine, and cellular reprogramming signaling pathways as per RNA-seq analysis and String PPI network, and Shiny GO functional enrichment analysis of DEGs. Topological analysis using Cytohubba revealed <em>tnfa, stat3, jak2b, igf1, jak1, hsp90aa1.1, stat1a, stat1b, bag3, hsp70,</em> and <em>fosl1a</em> as the key Hub genes in the PPI network. The present study identifies the pathways and the Hub proteins involved in berberine induced accelerated regeneration process in zebrafish larvae.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"55 ","pages":"Article 119390"},"PeriodicalIF":1.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The significance of MDK growth factor in the antler development of sika deer (Cervus nippon): An in-depth analysis. MDK生长因子在梅花鹿鹿角发育中的意义：深入分析。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-27 DOI: 10.1016/j.gep.2024.119388

Haihua Xing, Qianghui Wang, Yukai Ma, Ruobing Han, Heping Li

{"title":"The significance of MDK growth factor in the antler development of sika deer (Cervus nippon): An in-depth analysis.","authors":"Haihua Xing, Qianghui Wang, Yukai Ma, Ruobing Han, Heping Li","doi":"10.1016/j.gep.2024.119388","DOIUrl":"10.1016/j.gep.2024.119388","url":null,"abstract":"<p><p>Deer antlers exhibit rapid growth during the velvet phase. As a critical endogenous growth factor in animals, midkine (MDK) is likely closely associated with the growth of antlers. However, the spatio-temporal expression pattern of MDK during the velvet phase was unclear. This study explored the physiological role of MDK by analyzing its molecular characterization and spatio-temporal expression dynamics during the growth of sika deer antlers. The study cloned the coding sequences (CDS) of MDK, which spanned 429 bp and encoded 142 amino acids. The results of bioinformatics prediction analysis showed that MDK was an extracellular hydrophilic secreted protein, which was mainly composed of random coil. MDK protein was relatively conserved in evolution and MDK protein of sika deer had the closest relatives to ruminants and the furthest relatives to Aves. The tip tissues (dermis, mesenchyme, precartilage, cartilage) of antlers were collected from three important growth and development nodes (early period, EP. middle period, MP. late period, LP), and quantitative real-time polymerase chain reaction (qRT-PCR) was chosen to detect the spatio-temporal expression of the MDK. The results showed that MDK was expressed in all tissue sites of antler tip in EP, MP, LP. MDK had a consistent expression pattern under all growth periods and was strongly expressed in dermis and cartilage. The expression of MDK was consistently up-regulated in precartilage, whereas it was first up-regulated and then down-regulated in other tissues, and it was highly significant in MP compared to EP and LP (P < 0.01). This study suggested that MDK may regulate the growth of dermis and cartilage tissues mainly by participating in the process of angiogenesis and bone formation, thus promoting the rapid growth of antlers.</p>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":" ","pages":"119388"},"PeriodicalIF":1.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sept10 and sept12 are expressed in specific proliferating cells in zebrafish brain Sept10和sept12在斑马鱼大脑中特异性增殖细胞中表达。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-12 DOI: 10.1016/j.gep.2024.119387

Constantin Berger , Julia Katharina Charlotte Kreß , Frederik Helmprobst

引用次数: 0

Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis 小鼠睾丸从出生后到成年发育阶段BMP信号修饰因子Smoc1和Smoc2的时空表达分析。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-01 DOI: 10.1016/j.gep.2024.119383

Michio Ono , Kuniko Nakajima , Shin-ichi Tomizawa , Takayuki Shirakawa , Ippei Okada , Hirotomo Saitsu , Naomichi Matsumoto , Kazuyuki Ohbo

{"title":"Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis","authors":"Michio Ono , Kuniko Nakajima , Shin-ichi Tomizawa , Takayuki Shirakawa , Ippei Okada , Hirotomo Saitsu , Naomichi Matsumoto , Kazuyuki Ohbo","doi":"10.1016/j.gep.2024.119383","DOIUrl":"10.1016/j.gep.2024.119383","url":null,"abstract":"<div><div><em>Smoc1</em> and <em>Smoc2</em>, members of the SPARC family of genes, encode signaling molecules downstream of growth factors such as the TGF-β, FGF, and PDGF families. <em>Smoc1</em> has been implicated in playing a crucial role in microphthalmia with limb anomalies in humans and mice, while <em>Smoc2</em> deficiency causes dental developmental defects. Although developmental cytokines/growth factors including TGF-β superfamily have been shown to play critical roles in postnatal spermatogenesis, there are no reports analyzing the spatial and temporal expression of <em>Smoc1</em> and <em>Smoc2</em> in the postnatal testis. In this study, we investigated the mRNA and protein expression of <em>Smoc1</em> and <em>Smoc2</em> in neonatal, juvenile, and adult mouse testes by RNA <em>in situ</em> hybridization, immunofluorescence, and single-cell RNA-seq analysis. We show that <em>Smoc1</em> and <em>Smoc2</em> have distinct expression patterns in male germ cells: <em>Smoc1</em> is more highly expressed than <em>Smoc2</em> in the germline. In contrast, <em>Smoc2</em> is highly expressed in testicular somatic cells from neonatal to juvenile stages. The <em>Smoc2</em>-expressing cells then switch from somatic cells to germ cells in adults. Thus, although SMOC1 and SMOC2 proteins are structurally very similar, their spatial and temporal expression patterns in the postnatal testis differ significantly, suggesting their distinct roles in reproduction.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"54 ","pages":"Article 119383"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches ABC转运蛋白在果蝇睾丸干细胞生态位中的表达：两种方法的比较。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-01 DOI: 10.1016/j.gep.2024.119386

Israel Wipf, Aidan Anastas, Trey Daulton, Lucas L. Nelson, Swagata Maity, Kian Malone, Emily Nguyen, Rey Ramos, Kiana Wright, Jazmin Xiong, Judith Leatherman

{"title":"Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches","authors":"Israel Wipf, Aidan Anastas, Trey Daulton, Lucas L. Nelson, Swagata Maity, Kian Malone, Emily Nguyen, Rey Ramos, Kiana Wright, Jazmin Xiong, Judith Leatherman","doi":"10.1016/j.gep.2024.119386","DOIUrl":"10.1016/j.gep.2024.119386","url":null,"abstract":"<div><div>The ABC transporter gene family encodes proteins that form transmembrane channels and hydrolyze ATP to pump various substrates into and out of cells. Adult stem cell populations in numerous mammalian tissues express members of this gene family in order to efflux toxins or vital dyes, thereby conferring the “side population” trait, and cancer stem cells exhibit multidrug resistance upon expression of members of this gene family. In this study we investigated the expression of ABC transporters in a leading model organism stem cell niche, the <em>Drosophila</em> testis. We screened enhancer and gene trap lines with insertions near ABC transporter genes and identified six transporters with tissue-specific expression in the testis (<em>ABCB7, MRP, rdog, CG3164, CG31121,</em> and <em>CG9663</em>). Contrary to our expectation, we did not observe mostly stem cell-restricted expression patterns for these genes. We also report the expression patterns of ABC transporter genes in the testis from the published Fly Cell Atlas consortium single-cell sequencing of the testis (Li et al., 2022). Comparison of the expression levels and patterns of the six positive genes from the enhancer/gene trap screen with the FCA data showed only weak correlation between the two gene expression approaches. While there are reasons that the techniques might show different results, our work highlights the need for caution in over-reliance on single techniques to investigate gene expression.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"54 ","pages":"Article 119386"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of the Hippo pathway effector, TEAD1, within the developing murine forebrain 小鼠前脑发育过程中 Hippo 通路效应因子 TEAD1 的表达。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-11-16 DOI: 10.1016/j.gep.2024.119384

Alexandra Pelenyi , Cooper Atterton , Justin Jones , Laura Currey , Majd Al-Khalily , Lucinda Wright , Nyoman D. Kurniawan , Stefan Thor , Michael Piper

{"title":"Expression of the Hippo pathway effector, TEAD1, within the developing murine forebrain","authors":"Alexandra Pelenyi , Cooper Atterton , Justin Jones , Laura Currey , Majd Al-Khalily , Lucinda Wright , Nyoman D. Kurniawan , Stefan Thor , Michael Piper","doi":"10.1016/j.gep.2024.119384","DOIUrl":"10.1016/j.gep.2024.119384","url":null,"abstract":"<div><div>The Hippo pathway is a critical regulator of animal development. Activation of the Hippo pathway causes a cascade of phosphorylation events that culminate in the phosphorylation of the transcriptional co-factors YAP and TAZ, which limits their entry into the nucleus. When the Hippo pathway is ‘off’, however, YAP and TAZ can enter the nucleus, where they interact with the transcription factors of the TEA Domain (TEAD) family to regulate transcriptional activity. Despite the importance of the Hippo pathway for development, including within the nervous system, the expression of the TEAD family remains poorly defined in mammals. Here, we mapped the expression of TEAD1 in the developing mouse brain. We find that TEAD1 expression is confined to progenitor cells during embryonic development, namely radial glia and intermediate progenitor cells. TEAD1 expression is not evident in post-mitotic neurons of the cortical plate. We also identify expression of TEAD1 in developing and mature ependymal cells of the lateral and third ventricle, including within the subcommissural organ, as well as by cells within the choroid plexuses and the forebrain neurogenic niches. Finally, we find that adult mice conditionally heterozygous for <em>Tead1</em> in the central nervous system exhibit a significantly smaller brain. Collectively, these findings reveal a specific pattern of expression for TEAD1 during telencephalic development and implicate this factor in regulating neural progenitor cell proliferation.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"54 ","pages":"Article 119384"},"PeriodicalIF":1.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A great diversity of ROBO4 expression and regulations identified by data mining and transgene mice 通过数据挖掘和转基因小鼠确定了 ROBO4 表达和调控的多样性。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-09-01 DOI: 10.1016/j.gep.2024.119375

Huiping Li , Huiyan Xiao , Xiaoting Mai , Shaofeng Huang , Jiongyu Chen , Xiaoqiang Xiao

{"title":"A great diversity of ROBO4 expression and regulations identified by data mining and transgene mice","authors":"Huiping Li , Huiyan Xiao , Xiaoting Mai , Shaofeng Huang , Jiongyu Chen , Xiaoqiang Xiao","doi":"10.1016/j.gep.2024.119375","DOIUrl":"10.1016/j.gep.2024.119375","url":null,"abstract":"<div><p>ROBO4 involves in the stabilization of blood vessel and mediates the migration of hematopoietic stem cell and newborn neuron. However, the patterns of expression and regulation are not quite clear. To resolve this, we analyzed the single cell sequence data, and confirmed that <em>Robo4</em> mainly expresses in various endothelial cells, but also in epithelial cells, pericytes, and stem or progenitor cells of bone marrow, fibroblast cells/mesenchymal stem cell of adipose tissues, muscle cells and neuron. <em>Robo4</em> expressions in endothelial cells derived from capillary vessel, tip/stalk/activated endothelial cells were higher than that in artery and large vein (matured endothelial cells). On the other hand, via mining the gene expression data deposited in the NCBI Gene Expression Omnibus database as well as National Genomics Data Center (NGDC), we uncovered that the expression of <em>Robo4</em> were regulated by different stimulus and variable in diseases’ condition.Moreover, we constructed enhanced GFP (eGFP) transgene mouse controlled by <em>Robo4</em> promoter using CRISPR/CAS9 system. We found GFP signals in many cell types from the embryonic section, confirming a widely expression of <em>Robo4</em>. Together, <em>Robo4</em> widely and dynamically express in multiple cell types, and can be regulated by diverse factors.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"53 ","pages":"Article 119375"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression pattern of Wnt6, Wnt10A, and HOXA13 during regenerating tails of Gekko Japonicus 日本壁虎再生尾部过程中 Wnt6 和 HOXA13 的表达模式。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-08-10 DOI: 10.1016/j.gep.2024.119374

Zhen Li, Mingxuan Li, Shuai Huang, Jing Yu, Mei Liu, Yan Liu, Man Xu

引用次数: 0

Unveiling the dynamics of embryogenesis and immune genes expression pattern in the amur common carp (Cyprinus carpio haematopterus) 揭示阿穆尔鲤鱼（Cyprinus carpio haematopterus）胚胎发生动态和免疫基因表达模式。

IF 1.2 4区生物学

Gene Expression Patterns Pub Date : 2024-05-15 DOI: 10.1016/j.gep.2024.119367

Smruti Mahapatra , Bristy Ganguly , Saswati Pani , Manas Kumar Sinha , Ashis Saha , Mrinal Samanta

{"title":"Unveiling the dynamics of embryogenesis and immune genes expression pattern in the amur common carp (Cyprinus carpio haematopterus)","authors":"Smruti Mahapatra , Bristy Ganguly , Saswati Pani , Manas Kumar Sinha , Ashis Saha , Mrinal Samanta","doi":"10.1016/j.gep.2024.119367","DOIUrl":"10.1016/j.gep.2024.119367","url":null,"abstract":"<div><p>Amur common carp (<em>Cyprinus carpio haematopterus</em>), is a commercially important fish species that has been genetically improved over the years through selective breeding. Despite its significance in aquaculture, limited knowledge exists regarding its embryogenesis and immune genes associated with its early stages of life. This article represents a detailed study of the embryogenesis and innate immune gene expression analysis of the Amur common carp during its ontogenic developments. The entire embryonic developmental process of ∼44 h could be divided into eight periods, beginning with the formation of the zygote, followed by cleavage, morula, blastula, segmentation, pharyngula, and hatching. The segmentation period, which lasted for ∼ 6 h, exhibited the most significant changes, such as muscle contraction, rudimentary heart formation, increased somites number, and the initiation of blood circulation throughout the yolk. The expression of immune-related genes, namely toll-like receptor (TLR)4, nucleotide-binding oligomerization domain (NOD)1, NOD2 and interleukin (IL)-8 showed stage-specific patterns with varying levels of expression across the developmental stages. The TLR4 gene exhibited the highest expression during the neurella stage, while NOD1 and NOD2 peaked during hatching and IL-8 reached its maximum level during the gastrula stage. This is the first report of the innate immune gene expression during the embryogenesis of Amur common carp.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"52 ","pages":"Article 119367"},"PeriodicalIF":1.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0