Gene Expression Patterns最新文献

The significance of MDK growth factor in the antler development of sika deer (Cervus nippon): An in-depth analysis. MDK生长因子在梅花鹿鹿角发育中的意义：深入分析。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-27 DOI: 10.1016/j.gep.2024.119388

Haihua Xing, Qianghui Wang, Yukai Ma, Ruobing Han, Heping Li

{"title":"The significance of MDK growth factor in the antler development of sika deer (Cervus nippon): An in-depth analysis.","authors":"Haihua Xing, Qianghui Wang, Yukai Ma, Ruobing Han, Heping Li","doi":"10.1016/j.gep.2024.119388","DOIUrl":"10.1016/j.gep.2024.119388","url":null,"abstract":"<p><p>Deer antlers exhibit rapid growth during the velvet phase. As a critical endogenous growth factor in animals, midkine (MDK) is likely closely associated with the growth of antlers. However, the spatio-temporal expression pattern of MDK during the velvet phase was unclear. This study explored the physiological role of MDK by analyzing its molecular characterization and spatio-temporal expression dynamics during the growth of sika deer antlers. The study cloned the coding sequences (CDS) of MDK, which spanned 429 bp and encoded 142 amino acids. The results of bioinformatics prediction analysis showed that MDK was an extracellular hydrophilic secreted protein, which was mainly composed of random coil. MDK protein was relatively conserved in evolution and MDK protein of sika deer had the closest relatives to ruminants and the furthest relatives to Aves. The tip tissues (dermis, mesenchyme, precartilage, cartilage) of antlers were collected from three important growth and development nodes (early period, EP. middle period, MP. late period, LP), and quantitative real-time polymerase chain reaction (qRT-PCR) was chosen to detect the spatio-temporal expression of the MDK. The results showed that MDK was expressed in all tissue sites of antler tip in EP, MP, LP. MDK had a consistent expression pattern under all growth periods and was strongly expressed in dermis and cartilage. The expression of MDK was consistently up-regulated in precartilage, whereas it was first up-regulated and then down-regulated in other tissues, and it was highly significant in MP compared to EP and LP (P < 0.01). This study suggested that MDK may regulate the growth of dermis and cartilage tissues mainly by participating in the process of angiogenesis and bone formation, thus promoting the rapid growth of antlers.</p>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":" ","pages":"119388"},"PeriodicalIF":1.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sept10 and sept12 are expressed in specific proliferating cells in zebrafish brain. Sept10和sept12在斑马鱼大脑中特异性增殖细胞中表达。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-12 DOI: 10.1016/j.gep.2024.119387

Constantin Berger, Julia Katharina Charlotte Kreß, Frederik Helmprobst

引用次数: 0

Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis. 小鼠睾丸从出生后到成年发育阶段BMP信号修饰因子Smoc1和Smoc2的时空表达分析。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1016/j.gep.2024.119383

Michio Ono, Kuniko Nakajima, Shin-Ichi Tomizawa, Takayuki Shirakawa, Ippei Okada, Hirotomo Saitsu, Naomichi Matsumoto, Kazuyuki Ohbo

{"title":"Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis.","authors":"Michio Ono, Kuniko Nakajima, Shin-Ichi Tomizawa, Takayuki Shirakawa, Ippei Okada, Hirotomo Saitsu, Naomichi Matsumoto, Kazuyuki Ohbo","doi":"10.1016/j.gep.2024.119383","DOIUrl":"10.1016/j.gep.2024.119383","url":null,"abstract":"<p><p>Smoc1 and Smoc2, members of the SPARC family of genes, encode signaling molecules downstream of growth factors such as the TGF-β, FGF, and PDGF families. Smoc1 has been implicated in playing a crucial role in microphthalmia with limb anomalies in humans and mice, while Smoc2 deficiency causes dental developmental defects. Although developmental cytokines/growth factors including TGF-β superfamily have been shown to play critical roles in postnatal spermatogenesis, there are no reports analyzing the spatial and temporal expression of Smoc1 and Smoc2 in the postnatal testis. In this study, we investigated the mRNA and protein expression of Smoc1 and Smoc2 in neonatal, juvenile, and adult mouse testes by RNA in situ hybridization, immunofluorescence, and single-cell RNA-seq analysis. We show that Smoc1 and Smoc2 have distinct expression patterns in male germ cells: Smoc1 is more highly expressed than Smoc2 in the germline. In contrast, Smoc2 is highly expressed in testicular somatic cells from neonatal to juvenile stages. The Smoc2-expressing cells then switch from somatic cells to germ cells in adults. Thus, although SMOC1 and SMOC2 proteins are structurally very similar, their spatial and temporal expression patterns in the postnatal testis differ significantly, suggesting their distinct roles in reproduction.</p>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":" ","pages":"119383"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches. ABC转运蛋白在果蝇睾丸干细胞生态位中的表达：两种方法的比较。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-12-01 Epub Date: 2024-12-07 DOI: 10.1016/j.gep.2024.119386

Israel Wipf, Aidan Anastas, Trey Daulton, Lucas L Nelson, Swagata Maity, Kian Malone, Emily Nguyen, Rey Ramos, Kiana Wright, Jazmin Xiong, Judith Leatherman

{"title":"Expression of ABC transporters in the Drosophila testis stem cell niche: Comparison of two approaches.","authors":"Israel Wipf, Aidan Anastas, Trey Daulton, Lucas L Nelson, Swagata Maity, Kian Malone, Emily Nguyen, Rey Ramos, Kiana Wright, Jazmin Xiong, Judith Leatherman","doi":"10.1016/j.gep.2024.119386","DOIUrl":"10.1016/j.gep.2024.119386","url":null,"abstract":"<p><p>The ABC transporter gene family encodes proteins that form transmembrane channels and hydrolyze ATP to pump various substrates into and out of cells. Adult stem cell populations in numerous mammalian tissues express members of this gene family in order to efflux toxins or vital dyes, thereby conferring the \"side population\" trait, and cancer stem cells exhibit multidrug resistance upon expression of members of this gene family. In this study we investigated the expression of ABC transporters in a leading model organism stem cell niche, the Drosophila testis. We screened enhancer and gene trap lines with insertions near ABC transporter genes and identified six transporters with tissue-specific expression in the testis (ABCB7, MRP, rdog, CG3164, CG31121, and CG9663). Contrary to our expectation, we did not observe mostly stem cell-restricted expression patterns for these genes. We also report the expression patterns of ABC transporter genes in the testis from the published Fly Cell Atlas consortium single-cell sequencing of the testis (Li et al., 2022). Comparison of the expression levels and patterns of the six positive genes from the enhancer/gene trap screen with the FCA data showed only weak correlation between the two gene expression approaches. While there are reasons that the techniques might show different results, our work highlights the need for caution in over-reliance on single techniques to investigate gene expression.</p>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":" ","pages":"119386"},"PeriodicalIF":1.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of the Hippo pathway effector, TEAD1, within the developing murine forebrain 小鼠前脑发育过程中 Hippo 通路效应因子 TEAD1 的表达。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-11-16 DOI: 10.1016/j.gep.2024.119384

Alexandra Pelenyi , Cooper Atterton , Justin Jones , Laura Currey , Majd Al-Khalily , Lucinda Wright , Nyoman D. Kurniawan , Stefan Thor , Michael Piper

{"title":"Expression of the Hippo pathway effector, TEAD1, within the developing murine forebrain","authors":"Alexandra Pelenyi , Cooper Atterton , Justin Jones , Laura Currey , Majd Al-Khalily , Lucinda Wright , Nyoman D. Kurniawan , Stefan Thor , Michael Piper","doi":"10.1016/j.gep.2024.119384","DOIUrl":"10.1016/j.gep.2024.119384","url":null,"abstract":"<div><div>The Hippo pathway is a critical regulator of animal development. Activation of the Hippo pathway causes a cascade of phosphorylation events that culminate in the phosphorylation of the transcriptional co-factors YAP and TAZ, which limits their entry into the nucleus. When the Hippo pathway is ‘off’, however, YAP and TAZ can enter the nucleus, where they interact with the transcription factors of the TEA Domain (TEAD) family to regulate transcriptional activity. Despite the importance of the Hippo pathway for development, including within the nervous system, the expression of the TEAD family remains poorly defined in mammals. Here, we mapped the expression of TEAD1 in the developing mouse brain. We find that TEAD1 expression is confined to progenitor cells during embryonic development, namely radial glia and intermediate progenitor cells. TEAD1 expression is not evident in post-mitotic neurons of the cortical plate. We also identify expression of TEAD1 in developing and mature ependymal cells of the lateral and third ventricle, including within the subcommissural organ, as well as by cells within the choroid plexuses and the forebrain neurogenic niches. Finally, we find that adult mice conditionally heterozygous for <em>Tead1</em> in the central nervous system exhibit a significantly smaller brain. Collectively, these findings reveal a specific pattern of expression for TEAD1 during telencephalic development and implicate this factor in regulating neural progenitor cell proliferation.</div></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"54 ","pages":"Article 119384"},"PeriodicalIF":1.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A great diversity of ROBO4 expression and regulations identified by data mining and transgene mice 通过数据挖掘和转基因小鼠确定了 ROBO4 表达和调控的多样性。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-09-01 DOI: 10.1016/j.gep.2024.119375

Huiping Li , Huiyan Xiao , Xiaoting Mai , Shaofeng Huang , Jiongyu Chen , Xiaoqiang Xiao

{"title":"A great diversity of ROBO4 expression and regulations identified by data mining and transgene mice","authors":"Huiping Li , Huiyan Xiao , Xiaoting Mai , Shaofeng Huang , Jiongyu Chen , Xiaoqiang Xiao","doi":"10.1016/j.gep.2024.119375","DOIUrl":"10.1016/j.gep.2024.119375","url":null,"abstract":"<div><p>ROBO4 involves in the stabilization of blood vessel and mediates the migration of hematopoietic stem cell and newborn neuron. However, the patterns of expression and regulation are not quite clear. To resolve this, we analyzed the single cell sequence data, and confirmed that <em>Robo4</em> mainly expresses in various endothelial cells, but also in epithelial cells, pericytes, and stem or progenitor cells of bone marrow, fibroblast cells/mesenchymal stem cell of adipose tissues, muscle cells and neuron. <em>Robo4</em> expressions in endothelial cells derived from capillary vessel, tip/stalk/activated endothelial cells were higher than that in artery and large vein (matured endothelial cells). On the other hand, via mining the gene expression data deposited in the NCBI Gene Expression Omnibus database as well as National Genomics Data Center (NGDC), we uncovered that the expression of <em>Robo4</em> were regulated by different stimulus and variable in diseases’ condition.Moreover, we constructed enhanced GFP (eGFP) transgene mouse controlled by <em>Robo4</em> promoter using CRISPR/CAS9 system. We found GFP signals in many cell types from the embryonic section, confirming a widely expression of <em>Robo4</em>. Together, <em>Robo4</em> widely and dynamically express in multiple cell types, and can be regulated by diverse factors.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"53 ","pages":"Article 119375"},"PeriodicalIF":1.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression pattern of Wnt6, Wnt10A, and HOXA13 during regenerating tails of Gekko Japonicus 日本壁虎再生尾部过程中 Wnt6 和 HOXA13 的表达模式。

IF 1 4区生物学

Gene Expression Patterns Pub Date : 2024-08-10 DOI: 10.1016/j.gep.2024.119374

Zhen Li, Mingxuan Li, Shuai Huang, Jing Yu, Mei Liu, Yan Liu, Man Xu

引用次数: 0

Unveiling the dynamics of embryogenesis and immune genes expression pattern in the amur common carp (Cyprinus carpio haematopterus) 揭示阿穆尔鲤鱼（Cyprinus carpio haematopterus）胚胎发生动态和免疫基因表达模式。

IF 1.2 4区生物学

Gene Expression Patterns Pub Date : 2024-05-15 DOI: 10.1016/j.gep.2024.119367

Smruti Mahapatra , Bristy Ganguly , Saswati Pani , Manas Kumar Sinha , Ashis Saha , Mrinal Samanta

{"title":"Unveiling the dynamics of embryogenesis and immune genes expression pattern in the amur common carp (Cyprinus carpio haematopterus)","authors":"Smruti Mahapatra , Bristy Ganguly , Saswati Pani , Manas Kumar Sinha , Ashis Saha , Mrinal Samanta","doi":"10.1016/j.gep.2024.119367","DOIUrl":"10.1016/j.gep.2024.119367","url":null,"abstract":"<div><p>Amur common carp (<em>Cyprinus carpio haematopterus</em>), is a commercially important fish species that has been genetically improved over the years through selective breeding. Despite its significance in aquaculture, limited knowledge exists regarding its embryogenesis and immune genes associated with its early stages of life. This article represents a detailed study of the embryogenesis and innate immune gene expression analysis of the Amur common carp during its ontogenic developments. The entire embryonic developmental process of ∼44 h could be divided into eight periods, beginning with the formation of the zygote, followed by cleavage, morula, blastula, segmentation, pharyngula, and hatching. The segmentation period, which lasted for ∼ 6 h, exhibited the most significant changes, such as muscle contraction, rudimentary heart formation, increased somites number, and the initiation of blood circulation throughout the yolk. The expression of immune-related genes, namely toll-like receptor (TLR)4, nucleotide-binding oligomerization domain (NOD)1, NOD2 and interleukin (IL)-8 showed stage-specific patterns with varying levels of expression across the developmental stages. The TLR4 gene exhibited the highest expression during the neurella stage, while NOD1 and NOD2 peaked during hatching and IL-8 reached its maximum level during the gastrula stage. This is the first report of the innate immune gene expression during the embryogenesis of Amur common carp.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"52 ","pages":"Article 119367"},"PeriodicalIF":1.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of the expression patterns of TM9SF family members in mice 小鼠体内 TM9SF 家族成员表达模式的比较分析

IF 1.2 4区生物学

Gene Expression Patterns Pub Date : 2024-05-06 DOI: 10.1016/j.gep.2024.119366

Rui Zhao , Wenxiong Liao , Duo Tan , Haiyou Huang , Chun Hu , Meilan Chen

{"title":"Comparative analysis of the expression patterns of TM9SF family members in mice","authors":"Rui Zhao , Wenxiong Liao , Duo Tan , Haiyou Huang , Chun Hu , Meilan Chen","doi":"10.1016/j.gep.2024.119366","DOIUrl":"10.1016/j.gep.2024.119366","url":null,"abstract":"<div><p>Transmembrane 9 superfamily proteins (TM9SFs) define a highly conserved protein family, each member of which is characterized by a variable extracellular domain and presumably nine transmembrane domains. Although previous studies have delineated the potential cytological roles of TM9SFs like autophagy and secretory pathway, their functions during development are largely unknown. To establish the basis for dissecting the functions of TM9SFs <em>in vivo</em>, we employed the open-source database, structure prediction, immunofluorescence and Western blot to describe the gene and protein expression patterns of TM9SFs in human and mouse. While TM9SFs are ubiquitously and homogeneously expressed in all tissues in human with RNA sequencing and proteomics analysis, we found that all mice Tm9sf proteins are preferentially expressed in lung except Tm9sf1 which is enriched in brain although they all distributed in various tissues we examined. In addition, we further explored their expression patterns in the mice central nervous system (CNS) and its extension tissue retina. Interestingly, we could show that Tm9sf1is developmentally up-regulated in brain. In addition, we also detected all Tm9sf proteins are located in neurons and microglia instead of astrocytes. Importantly, Tm9sf3 is localized in the nuclei which is distinct from the other members that are dominantly targeted to the plasma membrane/cytoplasm as expected. Finally, we also found that Tm9sf family members are broadly expressed in the layers of INL, OPL, and GCL of retina and likely targeted to the plasma membrane of retinal cells. Thus, our data provided a comprehensive overview of TM9SFs expression patterns, illustrating their ubiquitous roles in different organs, implying the possible roles of Tm9sf2/3/4 in lung functions and Tm9sf1 in neurodevelopment, and highlighting a unique cell biological functions of TM9SF3 in neuronal and microglia.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"52 ","pages":"Article 119366"},"PeriodicalIF":1.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ontogeny and tissue specific expression profiles of recombination activating genes (RAGs) during development in Nile tilapia, Oreochromis niloticus 尼罗罗非鱼（Oreochromisniloticus）发育过程中重组激活基因（RAGs）的本体和组织特异性表达谱。

IF 1.2 4区生物学

Gene Expression Patterns Pub Date : 2024-03-07 DOI: 10.1016/j.gep.2024.119358

Ravikumar M. Chovatia , Arpit Acharya , Kiran D. Rasal , Megha Kadam Bedekar , Kezhedath Jeena , R. Bharathi Rathinam , Chandana Dinakaran , Gayatri Tripathi

{"title":"Ontogeny and tissue specific expression profiles of recombination activating genes (RAGs) during development in Nile tilapia, Oreochromis niloticus","authors":"Ravikumar M. Chovatia , Arpit Acharya , Kiran D. Rasal , Megha Kadam Bedekar , Kezhedath Jeena , R. Bharathi Rathinam , Chandana Dinakaran , Gayatri Tripathi","doi":"10.1016/j.gep.2024.119358","DOIUrl":"10.1016/j.gep.2024.119358","url":null,"abstract":"<div><p>Recombination activating genes (<em>RAGs</em>) mediates the process of rearrangement and somatic recombination (V(D)J) to generate different antibody repertoire. Studies on the expression pattern of adaptive immune genes during ontogenic development are crucial for the formulation of fish immunization strategy. In the present study, Nile tilapia was taken to explore the relative expression profile of <em>RAG</em> genes during their developmental stages. The developmental stages of Nile tilapia, i.e., unfertilized egg, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28 and 30 days post-hatch (dph) and kidney, blood, gill, liver and spleen tissues from adult fish were collected and the cDNA synthesis was carried out. Gene specific primers for <em>RAG-1</em> and <em>RAG-2</em> of Nile tilapia were designed and their annealing temperature (Tm) was optimized by gradient PCR. Consequently, PCR was performed to confirm the specific amplification of <em>RAG-1</em> and <em>RAG-2</em> genes. Quantitative real-time PCR (qRT-PCR) gene expression of <em>RAG-1</em> and <em>RAG-2</em> were noticed in all the developmental stages; however, a significant increase was observed after 12 dph and peaked at 24 dph, followed by a gradual decrease until 30 dph. Tissue-specific gene expression profiling revealed that the highest expression of <em>RAG-1</em> and <em>RAG-2</em> was observed in the kidney, followed by spleen, gill, liver and blood. The findings of the study explored the suitable timing of lymphoid maturation that could be technically used for the adoption of strategies to improve disease resistance of fish larvae for mitigating larval mortality.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"52 ","pages":"Article 119358"},"PeriodicalIF":1.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0