Australian Endodontic Journal最新文献

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Effect of Endodontic Sealers on the Bond Strength of Glass Fibre Posts: A Systematic Review. 根管密封剂对玻璃纤维桩粘结强度影响的系统综述。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI: 10.1111/aej.70066
Thiago Bessa Marconato Antunes, Juliana D Bronzato, Vanessa Gallego Arias Pecorari, Jennifer Santos Pereira, Talita Tartari, Adriana de Jesus Soares, Brenda P F A Gomes, Marina Angélica Marciano
{"title":"Effect of Endodontic Sealers on the Bond Strength of Glass Fibre Posts: A Systematic Review.","authors":"Thiago Bessa Marconato Antunes, Juliana D Bronzato, Vanessa Gallego Arias Pecorari, Jennifer Santos Pereira, Talita Tartari, Adriana de Jesus Soares, Brenda P F A Gomes, Marina Angélica Marciano","doi":"10.1111/aej.70066","DOIUrl":"10.1111/aej.70066","url":null,"abstract":"<p><p>This systematic review evaluated the influence of resin-based, eugenol-based and bioceramic endodontic sealers on the bond strength of glass fibre posts cemented with resin cements. Searches were conducted in PubMed, Scopus, Web of Science, Cochrane Library, Google Scholar and Embase, including in vitro studies using human or bovine teeth restored with fibre posts. Risk of bias was assessed using the QUIN Tool. Thirty three studies met the eligibility criteria. Most evidence indicates that resin-based sealers promote higher bond strength values than eugenol-based sealers, whereas findings for bioceramic sealers were inconsistent. Only a minority of studies showed a low risk of bias, while most presented moderate methodological limitations. Substantial heterogeneity was also observed, including differences in irrigation protocols, sealer types, adhesive strategies and post-cementation intervals. Within the limitations of the available evidence, resin-based sealers appear to be the most favourable choice for clinical fibre post cementation. PROSPERO Registration Number: CRD42023467018.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"554-570"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjunctive SAF Infinitum With Continuous NaOCl/HEDP Chelation Reduces Hard-Tissue Debris in Flattened Canals After Single-File Preparation: A Micro-CT Study. 连续NaOCl/HEDP螯合的辅助SAF无限可减少单锉制备后扁平管中的硬组织碎片:一项微ct研究。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-04-12 DOI: 10.1111/aej.70082
Michael Solomonov, Gustavo De-Deus, Rebecca R G Frota, Emmanuel J N L Silva, Felipe G Belladonna, Joe Ben-Itzhak, Dan Henry Levy, Marco A Versiani
{"title":"Adjunctive SAF Infinitum With Continuous NaOCl/HEDP Chelation Reduces Hard-Tissue Debris in Flattened Canals After Single-File Preparation: A Micro-CT Study.","authors":"Michael Solomonov, Gustavo De-Deus, Rebecca R G Frota, Emmanuel J N L Silva, Felipe G Belladonna, Joe Ben-Itzhak, Dan Henry Levy, Marco A Versiani","doi":"10.1111/aej.70082","DOIUrl":"10.1111/aej.70082","url":null,"abstract":"<p><p>The effectiveness of an adjunctive SAF Infinitum procedure performed under continuous chelation was evaluated for reducing hard-tissue debris (HTD) after single-file root canal preparation. Thirty mandibular incisors with flattened canals were pair-matched and prepared using Reciproc Blue R25 or XP-endo Rise Shaper under irrigation with 2.5% sodium hypochlorite combined with etidronic acid. Micro-computed tomography scans were obtained at baseline, after preparation and after supplementary SAF instrumentation for 2 min under continuous NaOCl/HEDP delivery. Canal volume, surface area, HTD volume and percentage reduction were quantified. Baseline morphology and post-preparation HTD did not differ between groups. The adjunctive SAF procedure significantly reduced HTD in both groups. Final residual HTD volumes after SAF use were comparable between preparation protocols, although the percentage reduction was greater after Reciproc Blue preparation. Adjunctive SAF Infinitum with continuous chelation enhanced debris removal in flattened canals irrespective of the initial shaping system.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"526-533"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Prevalence and Morphology of Middle Mesial Canals in Bifid-Apex Mandibular Molars Using Micro-CT. 下颌双尖磨牙中近中牙管形态及分布的显微ct评价。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-04-12 DOI: 10.1111/aej.70083
Pembe Büşra Kaygısız, Cangül Keskin, Ali Keleş
{"title":"Evaluation of the Prevalence and Morphology of Middle Mesial Canals in Bifid-Apex Mandibular Molars Using Micro-CT.","authors":"Pembe Büşra Kaygısız, Cangül Keskin, Ali Keleş","doi":"10.1111/aej.70083","DOIUrl":"10.1111/aej.70083","url":null,"abstract":"<p><p>This micro-CT study analysed 90 mandibular mesial roots with and without a bifid apex. Number of orifices and main apical foramina, main canal counts at coronal/middle/apical thirds, middle mesial canal (MMC) presence, and MB-ML inter-orifice distance in two-orifice roots were measured. The prevalence of MMCs was significantly higher in bifid roots (35.5%) compared to non-bifid roots (11.4%) (p < 0.05). Bifid roots exhibited a significantly higher mean number of apical foramina (2.24 ± 0.43) than non-bifid roots (1.33 ± 0.52) (p < 0.05). In roots with two orifices, the MB-ML inter-orifice distance was significantly wider in the bifid group (2.57 ± 0.56 mm) compared to the non-bifid group (2.28 ± 0.50 mm) (p < 0.05). Canal configurations also differed significantly; bifid roots were predominantly Vertucci Type V (31.1%) and Type IV (26.7%), while non-bifid roots frequently presented with Type I (33.3%) and Type III (26.7%).</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"534-540"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Non-Invasive Detection of Arterial Stiffness Related to Endothelial Dysfunction in Apical Periodontitis Patients: A Systematic Review and Meta-Analysis. 根尖牙周炎患者与内皮功能障碍相关的动脉僵硬的早期无创检测:系统回顾和荟萃分析。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-04-19 DOI: 10.1111/aej.70084
Nishant Chauhan, Shweta Mittal, Sanjay Tewari
{"title":"Early Non-Invasive Detection of Arterial Stiffness Related to Endothelial Dysfunction in Apical Periodontitis Patients: A Systematic Review and Meta-Analysis.","authors":"Nishant Chauhan, Shweta Mittal, Sanjay Tewari","doi":"10.1111/aej.70084","DOIUrl":"10.1111/aej.70084","url":null,"abstract":"<p><p>This systematic review and meta-analysis evaluated the association between apical periodontitis (AP) and non-invasive markers of arterial stiffness, including carotid intima-media thickness (c-IMT), endothelial flow reserve (EFR), flow mediated dilatation (FMD), carotid plaques and aortic atherosclerotic burden (AAB) in systemically healthy individuals. PubMed/MEDLINE, Cochrane, Scopus and EMBASE were searched. Quality assessment was done using the Newcastle-Ottawa Scale. Six studies were selected, with two at low and four at moderate risk of bias. Five studies (two c-IMT; three EFR) underwent meta-analysis. Pooled analysis demonstrated that AP was significantly associated with increased c-IMT (mean difference: 0.16 mm; 95% CI: 0.02-0.30; p = 0.01) and reduced EFR (mean difference: -0.30; 95% CI: -0.43 to -0.16; p < 0.0001). Heterogeneity was high for c-IMT (I<sup>2</sup> = 84%), and absent for EFR (I<sup>2</sup> = 0%). Evidence quality was 'low' for c-IMT and 'moderate' for EFR (GRADEpro). AP is associated with increased arterial stiffness. Trial Registration: PROSPERO: CRD420251047888.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"641-653"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Nonsurgical Endodontic Retreatment: Relevant Aspects for Clinical Application-A Scoping Review. 选择性非手术牙髓再治疗:临床应用的相关方面——范围综述。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-02-06 DOI: 10.1111/aej.70063
Tomás Manuel Braz Marinho, Luiz Renato Paranhos, Anne Caroline Brito Cabral Dos Santos, Djessyca Miranda-E-Paulo, Rui Barbosa de Brito Júnior, João Marcos da Costa Ribeiro, Felipe de Souza Matos
{"title":"Selective Nonsurgical Endodontic Retreatment: Relevant Aspects for Clinical Application-A Scoping Review.","authors":"Tomás Manuel Braz Marinho, Luiz Renato Paranhos, Anne Caroline Brito Cabral Dos Santos, Djessyca Miranda-E-Paulo, Rui Barbosa de Brito Júnior, João Marcos da Costa Ribeiro, Felipe de Souza Matos","doi":"10.1111/aej.70063","DOIUrl":"10.1111/aej.70063","url":null,"abstract":"<p><p>This scoping review explored the clinical applications and outcomes of selective nonsurgical endodontic retreatment in cases of persistent or secondary endodontic infection. A systematic search of six databases was conducted following PRISMA-ScR guidelines, identifying seven eligible studies. Outcomes assessed included clinical success, fracture resistance, tooth survival and cost-effectiveness. Evidence suggests that selective retreatment offers comparable clinical results to conventional retreatment, with added benefits such as greater preservation of tooth structure and improved fracture resistance. It also appears to be a more cost-effective option by reducing the need for further interventions. Cone-beam computed tomography aids in diagnosis and case selection, supporting a more conservative approach. Despite these promising findings, the overall quality of evidence ranged from low to moderate, indicating the need for high-quality clinical trials to confirm the effectiveness and broader applicability of selective nonsurgical endodontic retreatment.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"541-553"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies. 粪肠球菌与牙髓治疗失败:其作用和消除策略的定性系统综述。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-03-16 DOI: 10.1111/aej.70072
Francine Santos Fernandes de Lima, Analia Gabriella Borges Ferraz Facury
{"title":"Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies.","authors":"Francine Santos Fernandes de Lima, Analia Gabriella Borges Ferraz Facury","doi":"10.1111/aej.70072","DOIUrl":"10.1111/aej.70072","url":null,"abstract":"<p><p>The aim of this study was to synthesize evidence on the influence of Enterococcus faecalis on endodontic treatment failure and strategies for its elimination. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD420251022741). PubMed and SciELO were searched using PICO terms, and 76 studies (1997 and 2025) met the inclusion criteria. Reported E. faecalis prevalence ranged from approximately 4%-78%, depending on detection methods and sampling strategies. Canal isolates frequently expressed virulence factors, formed biofilms, and survived alkaline pH and nutrient limitation, with multidrug resistance reported. Chemo-mechanical preparation with sodium hypochlorite and EDTA, often combined with ultrasonic activation, reduced intraradicular bacterial load but achieved complete sterilization. In retreatment, two-visit protocols with intracanal medication improved microbiological outcomes, although calcium hydroxide efficacy depended on vehicle and duration. Adjunctive approaches showed mainly in vitro promise. Optimised disinfection and sealing remain essential.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"585-605"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertical Root Fracture in Endodontically Treated Teeth: Risk Factors and Future Directions. 根管治疗后牙齿纵根断裂的危险因素及未来发展方向。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-05-24 DOI: 10.1111/aej.70090
Xuhui Luo, Wenxi Zhang, Nuo Han, Bin Xue, Zitong Lin
{"title":"Vertical Root Fracture in Endodontically Treated Teeth: Risk Factors and Future Directions.","authors":"Xuhui Luo, Wenxi Zhang, Nuo Han, Bin Xue, Zitong Lin","doi":"10.1111/aej.70090","DOIUrl":"10.1111/aej.70090","url":null,"abstract":"<p><p>This article provides a narrative review of risk factors of vertical root fractures (VRFs) in endodontically treated teeth, focusing on treatment-related factors and occlusal factors. Studies on treatment-related risk factors include experimental studies on the formation of dentinal microcracks caused by different root canal preparation instruments, as well as experimental studies on the variations in dentine volume and fracture resistance resulting from different access cavity and root canal preparation instruments. Studies on occlusal risk factors encompass high-risk occlusal forces, stress distribution alterations on root due to crown morphology changes and crown restoration. Currently, occlusal analysis techniques and force measurement methods remain limited, with far fewer studies available compared to those on treatment-related risk factors. Finally, this narrative review offers a prospect on occlusal risk factors exploration based on flexible sensor technology.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"666-677"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and Future Perspectives in Additive Modifications of Calcium Silicate-Based Cements: A Scoping Review (2015-2024). 硅酸盐钙基水泥添加剂改性的趋势和未来展望:范围综述(2015-2024)。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-04-07 DOI: 10.1111/aej.70077
Kenta Tsuchiya, Salvatore Sauro, Jukka P Matinlinna, Monica Yamauti, Hidehiko Sano, Kyung-San Min, Atsushi Tomokiyo
{"title":"Trends and Future Perspectives in Additive Modifications of Calcium Silicate-Based Cements: A Scoping Review (2015-2024).","authors":"Kenta Tsuchiya, Salvatore Sauro, Jukka P Matinlinna, Monica Yamauti, Hidehiko Sano, Kyung-San Min, Atsushi Tomokiyo","doi":"10.1111/aej.70077","DOIUrl":"10.1111/aej.70077","url":null,"abstract":"<p><p>This scoping review identified commonly modified commercial calcium silicate-based cements (CSCs), evaluate additive-property trends and highlight research gaps relevant to their clinical application. Laboratory studies published between 2015 and 2024 were searched in PubMed, ScienceDirect and Web of Science following PRISMA-ScR. Fifty-one studies met the inclusion criteria, with ProRoot being the most frequently studied CSC. Additive modifications primarily targeted setting time, biocompatibility, antibacterial property and osteogenic differentiation. A recent shift from bioactivity-focused to physicochemical optimization was observed. Heat map analysis demonstrated distinct additive category-property associations, with metals and fluorides mainly linked to antibacterial enhancement, phosphate-based and bioactive compounds to biocompatibility and osteogenic outcomes, and commonly used setting modifiers, including calcium chloride, associated with accelerated setting. These findings indicate that single-category additive strategies are insufficient and that several CSC properties remain underexplored, supporting the need for more integrative CSC design.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"606-618"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence for Working Length Determination in Endodontics: A Systematic Review and Meta-Analysis. 人工智能用于牙髓学工作长度的确定:系统回顾和荟萃分析。
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-08-01 Epub Date: 2026-04-12 DOI: 10.1111/aej.70081
Rajinder Kumar Bansal, Saurabh Gupta, Saru Dhir Gupta, Sangam Mittal, Gagandeep Kaur, Manish Sharma, Seema Gupta
{"title":"Artificial Intelligence for Working Length Determination in Endodontics: A Systematic Review and Meta-Analysis.","authors":"Rajinder Kumar Bansal, Saurabh Gupta, Saru Dhir Gupta, Sangam Mittal, Gagandeep Kaur, Manish Sharma, Seema Gupta","doi":"10.1111/aej.70081","DOIUrl":"10.1111/aej.70081","url":null,"abstract":"<p><p>This systematic review and meta-analysis evaluated the comparative performance of artificial intelligence (AI) models versus comparators for working-length determination using radiographic or impedance-based inputs. A comprehensive search across seven electronic databases was conducted up to 1 October 2025, identifying five eligible in vitro and ex vivo studies encompassing over 1765 teeth or radiographic images. All the included studies directly compared AI-based approaches with manual or conventional reference standards. An exploratory random-effects meta-analysis demonstrated higher odds of correct working length determination using AI-based methods compared to expert assessment. The risk of bias was moderate to high, primarily because of internal validation and the predominance of laboratory-based study designs. The overall certainty of evidence for the primary outcome was rated low. This first quantitative synthesis suggests that AI-based methods may enhance the consistency of working-length determination under controlled conditions; however, further well-designed clinical studies are required before routine clinical implementation.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":"630-640"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of Methanogenic Archaea in Necrotic Root Canal Teeth Before and After Root Canal Instrumentation-An In Vivo Study. 根管器械治疗前后坏死根管牙中产甲烷古菌的体内研究
IF 1.7 4区 医学
Australian Endodontic Journal Pub Date : 2026-07-31 DOI: 10.1111/aej.70114
Kavuda Mallika Yadav, Swathi Aravelli, Uday Kumar Podugu, Sivaram Penigalapati, Nimeshika Ramachandruni, Kasam Swetha
{"title":"Presence of Methanogenic Archaea in Necrotic Root Canal Teeth Before and After Root Canal Instrumentation-An In Vivo Study.","authors":"Kavuda Mallika Yadav, Swathi Aravelli, Uday Kumar Podugu, Sivaram Penigalapati, Nimeshika Ramachandruni, Kasam Swetha","doi":"10.1111/aej.70114","DOIUrl":"https://doi.org/10.1111/aej.70114","url":null,"abstract":"<p><p>Methanogenic archaea facilitate metabolic activities of anaerobic bacteria, thereby amplifying infection dynamics. This study aimed to determine the prevalence of methanogenic archaea in necrotic root canals before and after irrigation, involving 81 patients with apical periodontitis. Pre-irrigation intracanal samples represented native microbial status. Positive samples were subjected to second-sample collection and allocated into Group I-control with saline and Group II-3% Sodium hypochlorite, Group III-5.25% Sodium hypochlorite, each followed by saline and ethylenediaminetetra-acetic acid. Samples underwent deoxyribonucleic acid extraction and real-time polymerase chain reaction. Among the 81 samples, 48.1% were positive for methanogenic archaea. Post-irrigation analysis showed no reduction in Group I; however, Groups II and III demonstrated samples below the detection threshold, with no statistically significant difference between the two groups (p > 0.05). The study confirmed the presence of methanogenic archaea in necrotic root canals, and conventional irrigation protocols were effective against methanogenic archaea.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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