Archives De Pediatrie最新文献

{"title":"Effects of vanilla odor on hypoxia-related periodic breathing in premature newborns: A pilot study","authors":"","doi":"10.1016/j.arcped.2024.03.002","DOIUrl":"10.1016/j.arcped.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Periodic breathing (PB)-related intermittent hypoxia<span> can have long-lasting deleterious consequences in preterm infants. Olfactory stimulation using vanilla odor is beneficial for apnea of prematurity<span> in the first postnatal days/weeks. We aimed to determine for the first time whether vanilla odor can also decrease PB-related intermittent hypoxia.</span></span></div></div><div><h3>Method</h3><div><span>This pilot study was a balanced crossover clinical trial including 27 premature infants born between 30 and 33</span>⁺⁶<span><span> weeks of gestation. We performed 12-h recordings on two nights separated by a 24-h period. All infants were randomly exposed to vanilla odor on the first or second study night. The primary outcome was the </span>desaturation<span> index, defined as the number per hour of pulse oximetry (SpO</span></span>₂) values &lt;90 % for at least 5 s, together with a drop of ≥5 % from the preceding value. Univariate mixed linear models were used for the statistical analysis.</div></div><div><h3>Results</h3><div><span>Overall, exposure to vanilla odor did not significantly decrease the desaturation index (52 ± 22 events/h [mean ± SD] on the intervention night vs. 57 ± 26, </span><em>p</em> = 0.2); furthermore, it did not significantly alter any secondary outcome. In a preliminary post hoc subgroup analysis, however, the effect of vanilla odor was statistically significant in infants with a desaturation index of ≥70/h (from 86 ± 12 to 65 ± 23, <em>p</em> = 0.04).</div></div><div><h3>Conclusion</h3><div>In this pilot study, vanilla odor overall did not decrease PB-related intermittent hypoxia in infants born at 30–33⁺⁶ weeks of gestation, which is when they are close to term. Preliminary results suggesting a beneficial effect in infants with the highest desaturation index, however, justify further studies in the presence of PB-related intermittent hypoxia as well as in infants born more prematurely.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 6","pages":"Pages 369-373"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of a probiotic to prevent necrotizing enterocolitis for preterm infants in a French neonatology department","authors":"Kimberley Lefèvre ,&nbsp;Estelle Leroy ,&nbsp;Alison Leichnam ,&nbsp;Dominique Navas ,&nbsp;Laure Simon ,&nbsp;Sonia Prot-Labarthe","doi":"10.1016/j.arcped.2024.03.008","DOIUrl":"10.1016/j.arcped.2024.03.008","url":null,"abstract":"<div><div>Very premature and/or low-birth-weight infants are at risk of developing necrotizing ulcerative enterocolitis (NEC). Prophylactic use of probiotics would change the composition of the gut microbiota and thus reduce the risk of NEC. In order to choose a probiotic at the local level, international recommendations were compared, and the available specialties were listed. Discrepancies between the different recommendations appeared, and the great variability of infant specialties available, as well as their status, did not allow us to select one. The local objective will therefore be to participate in the discussion of this subject at a national level.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 6","pages":"Pages 403-406"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0929693X24000903/pdfft?md5=6db236d52da227c28e930f94886aecd0&pid=1-s2.0-S0929693X24000903-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic etiology in patients diagnosed with congenital hypothyroidism with new-generation sequencing: A single-center experience","authors":"Emel Hatun Aytaç Kaplan ,&nbsp;Serdar Mermer","doi":"10.1016/j.arcped.2024.03.005","DOIUrl":"10.1016/j.arcped.2024.03.005","url":null,"abstract":"<div><h3>Aim</h3><div><span><span>Congenital hypothyroidism (CH) is the most common </span>endocrine disorder<span> of the newborn; it is seen in every 3000–4000 births. </span></span>Genetic features can guide treatment for patients with in situ glands. The present study aimed to contribute to the literature on CH variants and to show the benefit that genetic analysis can provide to patients in follow-up.</div></div><div><h3>Method</h3><div>A total of 52 patients (47 families) diagnosed with CH were included in the study. Overall, 32 target genes involved in thyroid physiology were investigated by next-generation sequencing (NGS).</div></div><div><h3>Results</h3><div>In total, 29 (55 %) of the patients were male, and the rate of dysgenesis was 19.2 %. In this study, 29 of 52 patients had at least one variant in one gene involved in CH (<em>n</em> = 29, 33 different variants) (Including likely benign variants and variants of unknown significance). There were 21 patients (40.3 %) with gland in situ. The most common variant was <span><span>DUOX2</span></span> (20 %). The second most common variants were those in the <span><span>TPO</span></span> and <span><span>TG</span></span><span> genes (15 % and 15 %, respectively); 41.1 % of these were variants of uncertain significance (VUS), 26.4 % were pathogenic, 23.5 % were likely benign, and 11.7 % were likely pathogenic. On the basis of their zygosity, we identified 73.5 % heterozygous, 17.6 % homozygous, and 8.9 % combined heterozygous variants. There were mutant variants in two genes in six patients and three in one patient.</span></div></div><div><h3>Conclusion</h3><div>This study found a variant in 55 % of the patients and shed light on the etiology of some cases of CH. The frequency of VUS was high. Although variants were identified in this study, their implication in the etiology of CH is not certain and, for most of the patients, it is also not sufficient for explaining the pathology with the current state of knowledge.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 6","pages":"Pages 374-379"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile hallux valgus: Comparison of three types of osteotomy and medium-term postoperative results","authors":"Thomas Bard ,&nbsp;Sébastien Pesenti ,&nbsp;Adrien Roy ,&nbsp;David Afonso ,&nbsp;Antoine Couvreur ,&nbsp;Yann Glard ,&nbsp;Jean-Marc Guillaume ,&nbsp;Élie Choufani ,&nbsp;Franck Launay ,&nbsp;Jean-Luc Jouve","doi":"10.1016/j.arcped.2024.04.005","DOIUrl":"10.1016/j.arcped.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><div>There is no consensus on the treatment of juvenile hallux valgus<span> (JHV). Numerous surgical techniques have been described, none of which has been proven to be superior and the mid-term results of these methods are not well known. Our objective was to compare the mid-term clinical, radiographic, and functional results of three metatarsal osteotomy techniques.</span></div></div><div><h3>Methods</h3><div>Patients under 18 years of age operated on for JHV between January 2010 and December 2019 were included in this multicenter retrospective study. Patients were excluded if they had non-idiopathic hallux valgus or if their postoperative follow-up was less than 3 years. The surgical techniques used were metatarsal osteotomies: basimetatarsal, scarf, or distal. During follow-up visits, we collected HMIS-AOFAS (Hallux Metatarsophalangeal Interphalangeal Scale–American Orthopedic<span> Foot and Ankle Society) and Visual Analogue Scale<span> (VAS) scores, acquired radiographs, and recorded complications and recurrences. Secondarily, the study population was stratified according to physis status (open vs. closed).</span></span></div></div><div><h3>Results</h3><div>During the study period, 18 patients (26 feet) met the inclusion criteria. The median postoperative follow-up was 6.5 (4.1) years. At the end of follow-up, the median HMIS score was 79.0 (20.0), the mean hallux valgus angle (HVA) improvement was 13.2° (16.8), and the complication and recurrence rates were 31 % and 23 %, respectively. There was no significant difference in the outcome measures between the three techniques or any difference according to physis status at the time of surgery.</div></div><div><h3>Discussion and conclusion</h3><div>The functional and radiographic results of metatarsal osteotomies are good in the medium term, regardless of the osteotomy site. Our results are comparable to those published in the literature. As our sample size was limited, it did not lead to the identification of statistically significant differences.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 6","pages":"Pages 393-399"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-acting growth hormone in the management of GHD in France","authors":"Agnès Linglart ,&nbsp;Régis Coutant ,&nbsp;Michel Polak ,&nbsp;Marc Nicolino","doi":"10.1016/j.arcped.2024.03.009","DOIUrl":"10.1016/j.arcped.2024.03.009","url":null,"abstract":"<div><div>Approximately 10,000 children in France with growth hormone deficiency (GHD) are being administered daily recombinant human growth hormone (rhGH). Although this treatment has long proved efficient for restoring children's growth and metabolism, daily injections of rhGH have a few limitations, such as difficulties in terms of adherence to treatment, which may compromise growth during childhood but also metabolism in adulthood. In addition to the disease burden and besides the adherence hurdles, the obligations related to daily injection have a negative impact on the quality of life of patients and their families. The hypothesis that injections administered at intervals of 1 week, or even 1 month, could improve compliance, reduce treatment discontinuations, and optimize quality of life and therapeutic effectiveness has led to the emergence of new long-acting growth hormone (LAGH). Recent access to LAGHs (somatrogon MA) on the European and French market will likely be followed by a high demand from the families concerned and may raise questions on their effectiveness, safety, and practical use. Numerous practical and practice-related points are needed to guide prescribing physicians while many concerns are still left unresolved (treatment effectiveness or ineffectiveness endpoints, long-term effectiveness, etc.). These issues can only be addressed in the future by compiling registries and conducting long-term real-world studies.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 6","pages":"Pages 357-364"},"PeriodicalIF":1.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atypical form of pediatric pityriasis rosea of the diaper area: Pityriasis marginata et circinata of Vidal","authors":"Omayma Khadiri,&nbsp;Rim Kaoua,&nbsp;Maryam Aboudourib,&nbsp;Said Amal,&nbsp;Ouafa Hocar","doi":"10.1016/j.arcped.2024.02.003","DOIUrl":"10.1016/j.arcped.2024.02.003","url":null,"abstract":"<div><p>Pityriasis rosea is a common, self-limited disease which in its typical form should not raise diagnostic doubts. Nevertheless, its atypical presentations can be a challenge for the clinician, and hence it is important to be aware of them. Recognition of these forms may enable a correct diagnosis to be made and avoid unnecessary procedures. We present two patients for whom we believe atypical PR was the most likely the diagnosis.</p></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 5","pages":"Pages 340-343"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a video training program's impact on primary teachers’ knowledge of allergies and skills in using an adrenaline autoinjector during the 2021–2022 school year","authors":"Paulina Lejtman ,&nbsp;Elise Hetroit-Vasseur ,&nbsp;Rémy Morello ,&nbsp;Sylvie Vial ,&nbsp;Jacques Brouard","doi":"10.1016/j.arcped.2024.03.003","DOIUrl":"10.1016/j.arcped.2024.03.003","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of the study was to assess the impact of a video training program (VTP) on primary school teachers’ skills in using an adrenaline auto-injector (AAI), in correlation with knowledge regarding allergies, in cases of anaphylaxis.</p></div><div><h3>Methods</h3><p>A questionnaire on teachers' knowledge of allergies and on their level of confidence in using an AAI was distributed in primary schools in the French department of Manche (2173 teachers). A VTP followed this questionnaire. A second questionnaire was then distributed. Theoretical knowledge was assessed with a score out of 20. The confidence level was rated on a scale from 1 to 4.</p></div><div><h3>Results</h3><p>We collected 218 responses to the first questionnaire (10.0 % of the population included). The response rate to the second questionnaire was 4.7 % (103 participants), and from this group, 93 of the 103 participants viewed the video (90.3 %). Overall, 76 of the 218 (34.9 %) participants who completed the first questionnaire also completed the second questionnaire and watched the VTP. The number of participants who completed the whole survey was 76 (out of 2173, 3.5 %). The VTP significantly improved teachers' knowledge of the subject of allergies (the average score increased by 2.11 points, <em>p</em> &lt; 0.001) as well as their confidence in recognizing the signs of a severe allergic reaction and in using an AAI: 85.4 % (<em>n</em> = 88) of self-confident teachers after the VTP versus 42.3 % (<em>n</em> = 92) before the VTP (<em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The VTP improved teachers’ level of knowledge and confidence in using an AAI in cases of anaphylaxis. A similar VTP could be circulated more widely in schools to offer easy access to training tools about allergies.</p></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 5","pages":"Pages 299-305"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE-Re: Parents’ participation in collegial meetings to discuss withholding or withdrawing treatment for their newborn: Working to improve information-sharing","authors":"P. Boize,&nbsp;Y. Garner,&nbsp;E. Neaud,&nbsp;S. Borrhomee","doi":"10.1016/j.arcped.2024.04.002","DOIUrl":"10.1016/j.arcped.2024.04.002","url":null,"abstract":"","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 5","pages":"Pages 346-347"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Pesticides and pediatric diseases”: France's first consultation center opens","authors":"Sylvain Chamot,&nbsp;Elodie Haraux","doi":"10.1016/j.arcped.2024.02.009","DOIUrl":"10.1016/j.arcped.2024.02.009","url":null,"abstract":"","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 5","pages":"Pages 348-349"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How the French national authority for health assesses medicines for use in pediatrics","authors":"Chloé Rebstock ,&nbsp;Bertrand Mussetta ,&nbsp;Sandrine Martinez ,&nbsp;Thierno Diatta ,&nbsp;Alice Desbiolles ,&nbsp;Corinne Alberti ,&nbsp;Patrick Niaudet ,&nbsp;Sylvie Viaux-Savelon ,&nbsp;Pierre Cochat ,&nbsp;Jean-Christophe Mercier","doi":"10.1016/j.arcped.2024.03.004","DOIUrl":"10.1016/j.arcped.2024.03.004","url":null,"abstract":"<div><p>Children deserve to be treated with appropriate medicines based on robust assessments. Despite the introduction of new regulations, the availability of medicines for children is suboptimal because of the frequent lack of relevant clinical trials due to the difficulty of conducting such trials. Thus, the Transparency Committee (TC) of the French National Authority for Health, who oversees the assessment of medicinal products in France, set up a pediatric working group with two aims: (1) The first aim was to review all opinions on medicines for pediatric use. Out of 536 opinions delivered between 2020 and 2022, 181 (34 %) concerned medicines for pediatric use. Whereas oncology largely dominated the medicines for adults, medicines for infectious diseases, endocrinology/metabolism, neurology, and hematology mostly prevailed for children. (2) The second aim was to clarify the evaluation criteria assessed by the TC, namely, the clinical benefit (CB), the clinical added value (CAV), and the public health impact (PHI) for pediatric medicinal products. An important CB was given to 113 out of 161 (71 %) opinions on medicines for pediatric use when it concerned pathologies with a severe prognosis. The quality of the demonstration (e.g., double-blind randomized trial vs. placebo or another active medicine) played a major role in the CB level. Clinical pediatric studies were also consistently associated with higher CAV levels: levels I (major) to III (moderate) in 26 out of 42 (62 %) opinions, level IV (minor) and level V (no therapeutic progress) in 43 out of 84 (51 %) and 30 out of 43 (70 %) opinions granting a sufficient CB, respectively. Conversely, 22 out of 30 (73 %) dossiers based only on literature reviews were given a level V. The main criteria leading to the qualification of a medicine for pediatric use as providing a PHI included a significant change in the morbidity and mortality of the disease and an improvement in the care pathway. Assessments were mostly aligned on the adults in the case of subsequent extensions of indications to children. Lastly, new measures were taken aimed at shortening median delays in the assessment process in order to reduce off-label use of medicines in France.</p></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"31 5","pages":"Pages 285-292"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}