早期发现新生儿败血症并减少抗生素总暴露量:迈向精准医疗:早期发现新生儿败血症并减少抗生素的总体使用量。

IF 1.3 4区 医学 Q3 PEDIATRICS
Martin Stocker, Laura Fillistorf, Giorgia Carra, Eric Giannoni
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引用次数: 0

摘要

感染每年夺走 50 多万新生儿的生命,并使幸存者面临终身残疾的风险。临床医生面临的挑战是如何快速识别患有侵袭性感染的新生儿,及时启动抗菌治疗,并采取措施预防和治疗器官功能障碍。此外,过度使用抗生素也是一个全球性的公共卫生问题。尽管对新生儿败血症的临床和实验室标志物进行了大量研究,但将其有效转化为临床实践的工作仍然有限。目前还没有一种单一的临床或实验室标志物,也没有任何标志物的组合能明确确认或排除新生儿败血症。对这些标志物的解释应考虑其对特定患者的诊断价值,以及对临床决策过程的附加价值。医疗保健系统的数字化、计算能力的增强以及机器学习的进步,为开发早期检测新生儿败血症的精确预测算法提供了可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early detection of neonatal sepsis and reduction of overall antibiotic exposure: Towards precision medicine: Early detection of neonatal sepsis and reduction of overall antibiotic exposure.

Infections claim the lives of over half a million newborns annually and expose survivors to the risk of lifelong disability. The challenge to clinicians is to identify newborns with invasive infections rapidly, promptly initiate antimicrobial treatment, and take measures to prevent and treat organ dysfunction. Moreover, excessive antibiotic use is a global public health problem. Despite considerable research on clinical and laboratory markers of neonatal sepsis, the effective translation into clinical practice remains limited. There is no single clinical or laboratory marker, nor any combination of markers that definitively confirms or rules out neonatal sepsis. The interpretation of these markers should take into account their diagnostic value for a given patient, along with their added value to the clinical decision-making process. The digitalization of health care systems, combined with increased computational power and advances in machine learning, offers the possibility of developing accurate predictive algorithms for early detection of neonatal sepsis.

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来源期刊
Archives De Pediatrie
Archives De Pediatrie 医学-小儿科
CiteScore
2.80
自引率
5.60%
发文量
106
审稿时长
24.1 weeks
期刊介绍: Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.
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