Management of patent ductus arteriosus in preterm infants: Abundant literature, low certainty of evidence for clinicians.

IF 1.3 4区 医学 Q3 PEDIATRICS
Gilles Cambonie, Florence Masson, Renaud Mesnage, Arthur Gavotto
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引用次数: 0

Abstract

Management of patent ductus arteriosus (PDA) in preterm newborns has been debated extensively for more than six decades. Some authors affirm that PDA is only an innocent mirror of infant immaturity, without specific health consequences. They also underline the futility, even danger, of treating it. Others are concerned about the hemodynamic effects of this left-right shunt, resulting in high pulmonary blood flow and low systemic output, which can contribute to the occurrence of severe morbidities - including pulmonary hemorrhage, intraventricular hemorrhage, bronchopulmonary dysplasia and necrotizing enterocolitis -and may increase the risk of death. Many management strategies have been described, ranging from expectant management to nontargeted prophylaxis, but there is currently no consensus about who to treat, when, and how.

早产儿动脉导管未闭的处理:文献资料丰富,但临床医生证据的确定性较低。
早产新生儿动脉导管未闭(PDA)的处理问题已被广泛讨论了六十多年。一些学者认为,PDA 只是婴儿不成熟的一面无辜的镜子,不会对健康造成具体影响。他们还强调治疗 PDA 是徒劳的,甚至是危险的。另一些学者则担心这种左右分流对血液动力学的影响,因为它导致肺血流量高而全身输出量低,从而引发严重的疾病,包括肺出血、脑室内出血、支气管肺发育不良和坏死性小肠结肠炎,并可能增加死亡风险。从预期管理到非靶向预防,已有许多管理策略,但目前对治疗对象、时间和方法尚未达成共识。
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来源期刊
Archives De Pediatrie
Archives De Pediatrie 医学-小儿科
CiteScore
2.80
自引率
5.60%
发文量
106
审稿时长
24.1 weeks
期刊介绍: Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.
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