Archives De Pediatrie最新文献

{"title":"Esophageal atresia in three overseas departments compared with metropolitan France","authors":"M. Battini ,&nbsp;R. Maximilien-François ,&nbsp;A. Paygambar ,&nbsp;C. Laplace ,&nbsp;M-E. Gatibelza ,&nbsp;C. Trabanino ,&nbsp;H. Coridon ,&nbsp;C. Tolg ,&nbsp;P. Grall ,&nbsp;P. Guemaleu ,&nbsp;A. Sika ,&nbsp;R. Sfeir ,&nbsp;F. Gottrand","doi":"10.1016/j.arcped.2025.03.004","DOIUrl":"10.1016/j.arcped.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div><span>Esophageal atresia<span> (EA) is a rare defect in esophageal continuity, frequently associated with tracheoesophageal fistula. Data on EA in children from French Guiana and the French West Indies are lacking. </span></span><em>Objectives:</em> The objective of this study was to compare characteristics and outcomes between patients with EA in three French Departments in the Americas (DFAs) and a cohort from metropolitan France.</div></div><div><h3>Methods and settings</h3><div>This was a retrospective, multicenter descriptive study of all children born with EA in French Guiana, Martinique, or Guadeloupe between 2008 and early 2021. Data were extracted from the French register (from 38 French medical centers), which records characteristics and outcomes from the prenatal period through 1 year of age (with two questionnaires centralized by the National Reference Center for Esophageal Anomalies through an exhaustive search using several methods, with double-checking and verification). The characteristics of infants from the three DFAs were compared with those from metropolitan France.</div></div><div><h3>Results</h3><div>Overall, 39 children from the DFAs were included, among whom 36 had surgery at a median age of 3 days postnatally (0–81 days). At 1 year of age, eight children (21 %) had died and seven were lost to follow-up. There were no differences among the DFAs regarding mortality (<em>p</em> = 0.318) or morbidity, apart from a greater rate of loss to follow-up in French Guiana than in Guadeloupe (<em>p</em><span> &lt; 0.01). Compared with metropolitan France (total of 2205 children; 1960 children with an anastomosis, 97 children died at 1 year of age), children from the DFAs had higher rates of complications (36 % vs. 24 % in metropolitan France, </span><em>p</em> = 0.04), higher mortality (21 % vs. 4 % in metropolitan France, <em>p</em> &lt; 0.01), and fewer rehospitalizations per child (1 vs. 2 in metropolitan France, <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>The three overseas groups have similar characteristics and outcomes but significantly higher morbidity and mortality rates compared with metropolitan France.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 374-382"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traveling children: Current situation and compliance with hepatitis A vaccination recommendations","authors":"Cassandra Varoqui ,&nbsp;Franck Thollot","doi":"10.1016/j.arcped.2025.05.002","DOIUrl":"10.1016/j.arcped.2025.05.002","url":null,"abstract":"<div><h3>Context</h3><div>Vaccination of traveling children does not seem to be the primary concern for families when preparing for a trip abroad. Few data concerning the hepatitis A vaccine are available in minors traveling outside France.</div></div><div><h3>Objectives</h3><div>The present study aimed to assess whether the vaccination recommendation against hepatitis A was followed in the population of children traveling outside of France. The secondary objectives were to explore the reasons for non-compliance with vaccination recommendations and assess the frequency of minors travelling abroad in the study settings.</div></div><div><h3>Population and methods</h3><div>This was a monocentric observational study conducted within a pediatric practice located in the Nancy metropolitan area through the distribution of a questionnaire upon arrival in the waiting room. Inclusion criteria were: age between 1 and 18 years, regular pediatric follow-up within the practice, and absence of language barriers.</div></div><div><h3>Results</h3><div>477 questionnaires were included, evaluating the proportion of traveling children (outside of France) at 59 % of our population (<em>n</em> = 282). The leading destination remained Western Europe (36 %), but 64 % of children have already traveled to an area where vaccination against hepatitis A before departure is recommended. However, only 10.5 % of patients had received one dose of vaccination before traveling, and only 2.2 % had completed vaccination. The reasons for non-vaccination were a lack of information or a lack of anticipation before departure. After distributing the questionnaire, 101 prescriptions were issued at the parents' request.</div></div><div><h3>Conclusion</h3><div>The vaccination recommendations against hepatitis A are not followed in our population of travelling children, with only 10 % of them vaccinated, while 50 % have been travelling to a high-risk country. The reasons for non-vaccination may be multifactorial, but this study also highlights the importance of a preventive period to improve the population's knowledge and help them anticipate their travel plans. Although time-consuming, this prevention was profitable since 101 vaccine doses were prescribed out of 477 questionnaires collected. A display could be put up in the waiting room to draw families' attention to the need to anticipate travel.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 363-367"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating risk factors for hypospadias: insights from a study in Eastern Algeria","authors":"Laouar Rania ,&nbsp;Chellat-Rezgoune Djalila ,&nbsp;Atrih Zoubir ,&nbsp;Benhizia Yacine ,&nbsp;Sifi Karima","doi":"10.1016/j.arcped.2025.06.001","DOIUrl":"10.1016/j.arcped.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Hypospadias is among the most common congenital anomalies of the male genitalia, with a multifactorial cause involving genetic, environmental, and maternal factors. In Algeria, the condition remains under-studied, with limited data on its epidemiology and risk factors.</div></div><div><h3>Objective</h3><div>To analyze the clinical characteristics, associated anomalies and key risk factors for hypospadias in Eastern Algeria over a 16-year period.</div></div><div><h3>Methods</h3><div>This retrospective case-control study included 483 hypospadias cases and 503 healthy controls. Cases were identified through medical records from the Pediatric Surgery Department, while controls were recruited via online questionnaires. Statistical analyses, including logistic regression, were performed to identify independent risk factors.</div></div><div><h3>Results</h3><div>Significant risk factors for hypospadias included low birth weight (&lt;2500 g; OR = 11.86, <em>p</em> &lt; 0.001), intrauterine growth restriction (IUGR) (OR = 2.36, <em>p</em> = 0.027), maternal gestational hypertension (OR = 2.65, <em>p</em> = 0.008), and rural residence (OR = 3.78, <em>p</em> &lt; 0.001). Severe forms of hypospadias were associated with a higher prevalence of anomalies, particularly genitourinary anomalies (81.82 %).</div></div><div><h3>Conclusion</h3><div>Hypospadias in Eastern Algeria is strongly influenced by perinatal, maternal, and environmental factors. Enhancing prenatal care, enforcing stricter environmental regulations, and improving healthcare access in rural areas are crucial steps in reducing the burden of this condition and its complications.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 389-394"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful ECMO rescue for organophosphate poisoning causing refractory acute respiratory distress syndrome: a first pediatric case","authors":"Charlotte Suermondt ,&nbsp;Charles de Marcellus ,&nbsp;Dominique Vodovar ,&nbsp;Charlotte Roy ,&nbsp;Nathanael Shraer ,&nbsp;Mehdi Oualha ,&nbsp;Noémie de Cacqueray","doi":"10.1016/j.arcped.2025.05.001","DOIUrl":"10.1016/j.arcped.2025.05.001","url":null,"abstract":"<div><div><span>A 20-month-old girl presented with organophosphate poisoning<span><span>. Her clinical course was complicated by </span>acute respiratory failure despite </span></span>oxime<span> administration, requiring mechanical ventilation<span><span> within 24 h. Due to refractory acute respiratory distress syndrome<span> (ARDS), the patient was placed on veno-venous extracorporeal membrane oxygenation<span> (VV-ECMO) therapy on day 3. Successful rescue and complete recovery were achieved with VV-ECMO. Veno-venous ECMO may be an option for </span></span></span>organophosphate poisoning in case of respiratory failure.</span></span></div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 423-426"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial vitamin K metabolism deficiency responsible for a congenital binder phenotype","authors":"Konstantinos Grammatopoulos ,&nbsp;Annie Harroche ,&nbsp;Cristina Peduto ,&nbsp;Nancy Vegas ,&nbsp;Alix Mathonnet ,&nbsp;Genevieve Baujat ,&nbsp;Veronique Abadie ,&nbsp;Alix Flamant","doi":"10.1016/j.arcped.2025.05.003","DOIUrl":"10.1016/j.arcped.2025.05.003","url":null,"abstract":"<div><div>A 4-month-old male born with a Binder Phenotype was admitted for the evacuation of a large subdural hematoma. The blood analysis revealed a prolonged prothrombin time due to vitamin K-dependent coagulation factor deficiency. Vitamin K participates in the embryonic development of the nasal cartilage. The genetic analysis of our patient revealed a rare genetic cause, responsible for the congenital Binder phenotype associated with a defect in the vitamin K metabolism, a pathogenic variant in the GGCX gene that has not been previously reported in the literature. All neonates presenting a Binder Phenotype would benefit from coagulation screening, an easy-access exam, in order to prevent severe and potentially dreadful hemorrhagic events.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 420-422"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent and important updates to the French meningococcal vaccination strategy","authors":"Bruno Hoen","doi":"10.1016/j.arcped.2025.06.004","DOIUrl":"10.1016/j.arcped.2025.06.004","url":null,"abstract":"","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 361-362"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Ovarian Hyperstimulation Syndrome and Hyperprolactinemia due to Primary Hypothyroidism: An Adolescent Case Report","authors":"Emel Hatun Aytaç Kaplan ,&nbsp;Nazlı Gülsüm Akyel ,&nbsp;Zümrüt Kocabey Sütçü","doi":"10.1016/j.arcped.2025.03.007","DOIUrl":"10.1016/j.arcped.2025.03.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Ovarian hyperstimulation syndrome is characterized by enlarged ovaries, multiple follicular cysts, and fluid leakage into the extravascular space caused by increased vascular permeability. Although controlled ovarian stimulation is often the main cause, spontaneous ovarian hyperstimulation syndrome is rare.</div></div><div><h3>Observation and discussion</h3><div>We present a seventeen-year-old patient with ovarian hyperstimulation syndrome and primary hypothyroidism due to autoimmune thyroiditis, who presented with galactorrhea and severe abdominal pain. The thyroid-stimulating hormone level was 713 uIU/ml. Ultrasonography and magnetic resonance imaging showed ovarian enlargement and multiple cysts. Our patient, who also had galactorrhea and hyperprolactinemia, was treated with levothyroxine and cabergoline. The ovaries, which were very large and multicystic before treatment, showed significant improvement after treatment.</div></div><div><h3>Conclusion</h3><div>Spontaneous ovarian hyperstimulation syndrome, although rare in childhood, should be considered in patients with primary hypothyroidism. Abdominal pain is an important symptom for diagnosis.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 427-431"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain death diagnostic process in children after thiopental sedation: a comparative retrospective cohort study","authors":"Victor Sartorius ,&nbsp;Ann-Marie Crowe ,&nbsp;Alina Marilena Lazarescu ,&nbsp;Laurence Labat ,&nbsp;Anna Kaminska ,&nbsp;Charles Joris Roux ,&nbsp;Gilles A Orliaguet ,&nbsp;Stéphane Blanot","doi":"10.1016/j.arcped.2025.05.004","DOIUrl":"10.1016/j.arcped.2025.05.004","url":null,"abstract":"<div><h3>Background</h3><div>The determination of brain death (BD) is the primary pathway to organ donation in children. Thiopental is a sedative drug prescribed in critical situations potentially leading to BD and has been identified as a confounder during BD diagnosis. The implications of prior thiopental sedation on the diagnostic process of BD are poorly defined.</div></div><div><h3>Objective</h3><div>To compare the timeline and process involved in BD diagnosis between patients who received thiopental sedation versus those who did not.</div></div><div><h3>Methods and Setting</h3><div>Retrospective analysis was carried out on the healthcare records of all children who underwent the process of BD evaluation and diagnosis in our institution, between January 2012 and April 2020.</div></div><div><h3>Results</h3><div>74 patients were included; 29 had been treated with thiopental and 45 had received other sedatives or none. Median [IQR] time from reporting of suspected BD patients to apnea test (19.5 [11.5–30.2] vs 11.5 [5.4–21.1] hours, <em>p</em> = 0.015) and to BD confirmatory test (24.2 [7.2–32.6] vs 13.2 [6.2–23.5] hours, <em>p</em> = 0.019) was significantly longer in the thiopental group. Organ allocation was also delayed in the thiopental group. Thiopental plasma level was measured before BD examination in 24 patients, and the median concentration of the last assay was 4.6 [0.8–8.8] mg.L^-1. The BD diagnostic process included persistent signs of cerebral blood flow interruption on transcranial Doppler in 89.7 % of patients in the thiopental group vs 68.9 % in the other group (<em>p</em> = 0.049).</div></div><div><h3>Conclusion</h3><div>Prior administration of thiopental delays the process involved in the evaluation and diagnosis of BD in children in our intensive care unit. The diagnosis of BD after thiopental sedation requires a multimodal evaluation, which should include the monitoring of thiopental plasma levels and could be guided by transcranial Doppler.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 383-388"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulty of caring for children in danger or at risk of danger in Var (a French department) by general practitioners and private pediatricians","authors":"Clemence Desmarets ,&nbsp;Julie Berbis ,&nbsp;Paul Casha ,&nbsp;Violaine Bresson ,&nbsp;Emmanuelle Bosdure ,&nbsp;Kareen Thibault ,&nbsp;Michel Delage ,&nbsp;Aurelie Morand ,&nbsp;Brigitte Chabrol ,&nbsp;Elisabeth Martin-Lebrun ,&nbsp;Lindsay Osei","doi":"10.1016/j.arcped.2025.04.006","DOIUrl":"10.1016/j.arcped.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div>The exposure of children to situations of danger or risk of danger is a major public health problem. General practitioners (GPs) and pediatricians play an essential role in identification and management of these situations thanks to two procedures: the administrative procedure consists of sending an information of concern (“Information préoccupante” -IP- in French) to the departmental unit of collection, evaluation and processing of information of concern (CRIP in French) for a child at risk of danger; the judicial procedure consists of sending an alert (“signalement” in French) to the public prosecutor for serious and immediate danger. However, hospital and private doctors only perform 5 % of child abuse alerts.</div></div><div><h3>Objective</h3><div>The main objective was to describe doctors’ practices regarding the care of children in danger or at risk of danger. The secondary objective was to identify areas for improving the efficiency of management.</div></div><div><h3>Methods</h3><div>We present a descriptive, quantitative, and cross-sectional study using questionnaires to the GPs and pediatricians in private practice in Var (French department) in 2021.</div></div><div><h3>Results</h3><div>Our sample consisted of 134 GPs and 28 pediatricians. 75.3 % had already faced children in danger. Only 17.1 % provided efficient management (according to the recommendations of the Haute Autorité de Santé) when faced with a suspicion of a child at risk, 53.4 % for suspicion of child abuse, and 44.5 % for child sexual abuse. Pediatricians were more likely to know the contact details of child protection actors, and 84.6 % of doctors expressed a desire for more exchanges with them. 85.8 % expressed a feeling of being insufficiently trained.</div></div><div><h3>Conclusion</h3><div>It is essential to enhance the training of doctors and foster more effective collaboration with child protection actors. We propose distributing a document to private doctors in the Var to help them identify and manage cases.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 404-412"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerance of neostigmine to improve digestive motility in neonates after gastroschisis surgery","authors":"Lucy Carriat ,&nbsp;Huu Kim An N’Guyen ,&nbsp;Marion Honnorat ,&nbsp;Franck Plaisant ,&nbsp;Marine Butin","doi":"10.1016/j.arcped.2025.05.013","DOIUrl":"10.1016/j.arcped.2025.05.013","url":null,"abstract":"<div><h3>Background</h3><div>The management of gastroschisis involves immediate surgery and post-surgery nutritional management. Ileus is a frequent complication, leading to difficulties in establishing enteral feeding. Parasympathomimetic agents, including neostigmine, are safely used in case of ileus in adults. Neostigmine was used in a single neonatal intensive care unit (NICU) for the management of ileus after gastroschisis repair.</div></div><div><h3>Objective</h3><div>The aim of this study was to report this experience of neostigmine use to improve digestive motility and its tolerance.</div></div><div><h3>Methods and settings</h3><div>This is an observational study from electronic health records (EHRs) that included all infants born with gastroschisis and treated with neostigmine in a NICU in Lyon, France, between June 2009 and December 2023. The primary outcome was the time to achieve effective enteral nutrition after the introduction of neostigmine. Secondary outcomes of tolerance and efficacy were also collected from the medical records. This study received approval from an ethics committee.</div></div><div><h3>Results</h3><div>Among 86 patients with gastroschisis, 16 patients received neostigmine due to either large volumes of gastric residue or absence of transit. They received neostigmine at a median (IQR) of 13.5 (12;17.25) days of life. Effective enteral feeding was achieved after a median of 11 (5.75;13) days of neostigmine treatment. Neostigmine was well tolerated, apart from one case of a serious but quickly resolved adverse event after intravenous administration.</div></div><div><h3>Conclusions</h3><div>The use of oral neostigmine in neonates with gastroschisis appears to be effective and safe. Larger prospective studies are required to determine its possible place in the management of these newborns.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 6","pages":"Pages 368-373"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}