Archives De Pediatrie最新文献

{"title":"Description of the use of Vitamin D in children aged 0–18 months","authors":"Margot Vrignaud ,&nbsp;Stéphanie Provôt ,&nbsp;Fabienne Aubin ,&nbsp;Bénédicte Vrignaud ,&nbsp;Josselin Bernard ,&nbsp;Sonia Prot-Labarthe","doi":"10.1016/j.arcped.2025.01.006","DOIUrl":"10.1016/j.arcped.2025.01.006","url":null,"abstract":"<div><div>Following the alerts issued by the French health authorities and the craze among parents wishing to use natural medicine, many cases of intoxication have occurred in recent years. We aimed to describe vitamin D intake by patients under 18 months of age in three hospitals in the Great West of France and via social networks.</div><div>Data were collected on the caregivers (age, place of residence, vitamin D supplementation during mother's pregnancy, opinion on vitamin D), the patient (age, place in sibling group, diet), and the drug (prescriber, origin, form prescribed versus administered, dosage, medication or dietary supplement, number of omissions, reason for non-administration if any). Five hundred six responses were collected, highlighting a disparity in vitamin D administration in drug and dietary supplement form. Vitamin D was not administered in 7 % of the responses collected because there was no initial or renewed prescription). Food supplement was given to 77, i.e., 16 % of respondents. Only 43 % of mothers received supplementation during pregnancy. One person mentioned being very careful with the dosage as there had been a case of overdosing in their family. There were many different opinions expressed on the usefulness of supplementation: from \"no interest,\" \"gives colic,\" and \"questionable composition,\" to \"I am confused,\" and also \"essential\" or \"I have complete confidence in my doctor.\"</div><div>Misinformation about vitamin D supplementation persists in the French population and leads us to consider how to educate the population about the role of vitamin D: handing out leaflets in maternity wards, increasing communication in magazines accessible to the general public, a media campaign, etc.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 5","pages":"Pages 295-300"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galactorrhoea and amenorrhea as first symptoms of acute myeloid leukaemia: a case report and literature review","authors":"Kevin Perge ,&nbsp;Anne-Laure Peugnet ,&nbsp;Sara Cabet ,&nbsp;Sandrine Girard ,&nbsp;Carine Villanueva ,&nbsp;Cecile Renard ,&nbsp;Antony Ceraulo","doi":"10.1016/j.arcped.2025.04.003","DOIUrl":"10.1016/j.arcped.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Acute leukaemia is typically identified through clinical signs of cytopenia and/or a tumour syndrome, while paraneoplastic syndromes are rare in this context. We report a unique case of a 10-year-old girl who initially presented with inflammatory joint pain, night sweats, weight loss, amenorrhea, breast swelling, and galactorrhoea.</div></div><div><h3>Observation</h3><div>At diagnosis, she had an elevated prolactin (PRL) level (260.5 μg/L, reference &lt; 25 μg/L) and biological evidence of hypogonadism. Blood counts revealed anaemia, thrombocytopenia, and 11 % circulating blasts. Bone marrow aspiration confirmed acute leukaemia, classified as FAB M5, with a KAT6A:CREBBP fusion transcript.</div></div><div><h3>Discussion</h3><div>Cerebrospinal fluid analysis was negative for blasts, and brain magnetic resonance imaging showed no leukemic infiltration of the pituitary gland or a concomitant pituitary tumour. PRL level normalized following chemotherapy.</div></div><div><h3>Conclusion</h3><div>In the absence of central nervous system involvement, ectopic PRL secretion by leukemic blasts appears to be the most plausible explanation for the elevated PRL levels in this case.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 5","pages":"Pages 355-359"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal atresia in three overseas departments compared with metropolitan France.","authors":"M Battini, R Maximilien-François, A Paygambar, C Laplace, M-E Gatibelza, C Trabanino, H Coridon, C Tolg, P Grall, P Guemaleu, A Sika, R Sfeir, F Gottrand","doi":"10.1016/j.arcped.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.03.004","url":null,"abstract":"<p><strong>Background: </strong>Esophageal atresia (EA) is a rare defect in esophageal continuity, frequently associated with tracheoesophageal fistula. Data on EA in children from French Guiana and the French West Indies are lacking.</p><p><strong>Objectives: </strong>The objective of this study was to compare characteristics and outcomes between patients with EA in three French Departments in the Americas (DFAs) and a cohort from metropolitan France.</p><p><strong>Methods and settings: </strong>This was a retrospective, multicenter descriptive study of all children born with EA in French Guiana, Martinique, or Guadeloupe between 2008 and early 2021. Data were extracted from the French register (from 38 French medical centers), which records characteristics and outcomes from the prenatal period through 1 year of age (with two questionnaires centralized by the National Reference Center for Esophageal Anomalies through an exhaustive search using several methods, with double-checking and verification). The characteristics of infants from the three DFAs were compared with those from metropolitan France.</p><p><strong>Results: </strong>Overall, 39 children from the DFAs were included, among whom 36 had surgery at a median age of 3 days postnatally (0-81 days). At 1 year of age, eight children (21 %) had died and seven were lost to follow-up. There were no differences among the DFAs regarding mortality (p = 0.318) or morbidity, apart from a greater rate of loss to follow-up in French Guiana than in Guadeloupe (p < 0.01). Compared with metropolitan France (total of 2205 children; 1960 children with an anastomosis, 97 children died at 1 year of age), children from the DFAs had higher rates of complications (36 % vs. 24 % in metropolitan France, p = 0.04), higher mortality (21 % vs. 4 % in metropolitan France, p < 0.01), and fewer rehospitalizations per child (1 vs. 2 in metropolitan France, p < 0.01).</p><p><strong>Conclusion: </strong>The three overseas groups have similar characteristics and outcomes but significantly higher morbidity and mortality rates compared with metropolitan France.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial vitamin K metabolism deficiency responsible for a congenital binder phenotype.","authors":"Konstantinos Grammatopoulos, Annie Harroche, Cristina Peduto, Nancy Vegas, Alix Mathonnet, Genevieve Baujat, Veronique Abadie, Alix Flamant","doi":"10.1016/j.arcped.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.05.003","url":null,"abstract":"<p><p>A 4-month-old male born with a Binder Phenotype was admitted for the evacuation of a large subdural hematoma. The blood analysis revealed a prolonged prothrombin time due to vitamin K-dependent coagulation factor deficiency. Vitamin K participates in the embryonic development of the nasal cartilage. The genetic analysis of our patient revealed a rare genetic cause, responsible for the congenital Binder phenotype associated with a defect in the vitamin K metabolism, a pathogenic variant in the GGCX gene that has not been previously reported in the literature. All neonates presenting a Binder Phenotype would benefit from coagulation screening, an easy-access exam, in order to prevent severe and potentially dreadful hemorrhagic events.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful ECMO rescue for organophosphate poisoning causing refractory acute respiratory distress syndrome: a first pediatric case.","authors":"Charlotte Suermondt, Charles de Marcellus, Dominique Vodovar, Charlotte Roy, Nathanael Shraer, Mehdi Oualha, Noémie de Cacqueray","doi":"10.1016/j.arcped.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.05.001","url":null,"abstract":"<p><p>A 20-month-old girl presented with organophosphate poisoning. Her clinical course was complicated by acute respiratory failure despite oxime administration, requiring mechanical ventilation within 24 h. Due to refractory acute respiratory distress syndrome (ARDS), the patient was placed on veno-venous extracorporeal membrane oxygenation (VV-ECMO) therapy on day 3. Successful rescue and complete recovery were achieved with VV-ECMO. Veno-venous ECMO may be an option for organophosphate poisoning in case of respiratory failure.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe urological involvement in junctional epidermolysis bullosa justifying bladder enlargement by sigmoidocystoplasty and Mitrofanoff appendicovesicostomy","authors":"Marielle Ehilé-Kacou ,&nbsp;Pierre Yves Mure ,&nbsp;Delphine Demede ,&nbsp;Alice Phan ,&nbsp;Justine Bacchetta ,&nbsp;Valeska Bidault ,&nbsp;Bruno Ranchin","doi":"10.1016/j.arcped.2025.01.002","DOIUrl":"10.1016/j.arcped.2025.01.002","url":null,"abstract":"<div><div>The urological complications of junctional epidermolysis bullosa (JEB) are difficult to manage because of the fragility of the skin and mucosa, and are not the subject of any recommendations. We report on 2 cases of chronic lower urinary tract dysfunction causing chronic kidney disease, treated by bladder enlargement with sigmoidocystoplasty and Mitrofanoff appendicovesicostomy after failure of medical treatment and suprapubic catheterisation several times a day. Follow-up was favourable in both children, with kidney function preservation and significant improvement of quality of life.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 4","pages":"Pages 281-284"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety disorders and major depressive disorders in 299 adolescents hospitalized for assessment of common obesity: A retrospective cohort study","authors":"Morgan Seyler ,&nbsp;Caroline Barry ,&nbsp;Alexandra Loisel ,&nbsp;Marie Rose Moro ,&nbsp;Jonathan Lachal ,&nbsp;Hervé Lefèvre","doi":"10.1016/j.arcped.2025.01.004","DOIUrl":"10.1016/j.arcped.2025.01.004","url":null,"abstract":"<div><h3>Background</h3><div>Obesity has major psychosocial impacts in adolescents. Anxiety and depression are the most common psychiatric conditions in adolescents suffering from obesity.</div></div><div><h3>Objectives</h3><div>To measure and discuss the prevalence of psychiatric disorders in adolescents hospitalized for biopsychosocial assessment of common obesity during multidisciplinary care.</div></div><div><h3>Methods</h3><div>This retrospective monocentric study describes mental disorders over a decade (2012–2021) in 299 adolescents with obesity hospitalized for a global somatic and psychiatric assessment. Patients aged 11–18 were included. Sociodemographic data, psychiatric diagnosis, self-report questionnaires (CDI, <em>Children's Depression Inventory,</em> STAIC, <em>State-Trait Anxiety Inventory for children,</em> BES, <em>Binge Eating Scale</em>) were analyzed.</div></div><div><h3>Results</h3><div>27,4 % of adolescents had an anxiety disorder (AD), 18,7 % had a major depressive disorder (MDD) and 49,2 % had no mental disorder. In multiple regression models, exposure to physical violence (<em>p</em> &lt; 0.01), and the BES score (<em>p</em> &lt; 0.05) were also associated with a risk of AD. Exposure to physical violence, year of admission and the BES score were risk factors for MDD (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Prevalence of mental disorders is high and increasing, confirming the psychological suffering in adolescent with obesity. Some present with incomplete clinical profiles. MDD and AD are associated with a personal history of violence and a high BES score, reflecting in some adolescents a phenomenon of compensatory binge eating.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 4","pages":"Pages 261-265"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events associated with intravenous immunoglobulin infusions in pediatric patients with primary immunodeficiency: A 10-year single-center study","authors":"Murat Özer,&nbsp;Seher Tekeli,&nbsp;Selçuk Doğan,&nbsp;Sema Çetin,&nbsp;Rıdvan Selen,&nbsp;Caner Aytekin","doi":"10.1016/j.arcped.2025.01.008","DOIUrl":"10.1016/j.arcped.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Intravenous immunoglobulin G (IVIg) is used as a replacement therapy in primary immunodeficiency disorders (PIDs). Although IVIg is generally accepted as a safe treatment, the incidence of adverse events (AEs), most of which are mild and transient, varies between 1 % and 81 %. The aim of this study was to determine the adverse effects and influencing factors associated with IVIg replacement therapy in pediatric patients with PID.</div></div><div><h3>Materials and Methods</h3><div>Children with PID who received IVIg replacement therapy between January 1, 2012 and December 31, 2021, at Dr. Sami Ulus Children's Hospital were included in our study.</div></div><div><h3>Results</h3><div>Overall, 69 (52 male, 17 female) patients who received a total of 2,025 IVIg infusions were evaluated. AEs were observed in 40.6 % of the patients and in 8.9 % of the infusions. All AEs encountered in the study were mild to moderate. Immediate-onset AEs were observed in 3.5 % of the infusions and delayed-onset AEs in 5.4 %. Late-onset AEs were not observed. The most commonly observed AEs were headache (<em>n</em> = 50, 2.5 %), fever (<em>n</em> = 37, 1.8 %), and malaise (<em>n</em> = 19, 0.9 %). The most common immediate AE was fever (<em>n</em> = 28, 1.4 %), while the most common delayed AE was headache (<em>n</em> = 44, 2.2 %).</div></div><div><h3>Conclusion</h3><div>AEs encountered in patients with PID receiving IVIg infusions are mild to moderate. Pediatric patients should be followed up for delayed AEs by contacting their families after the infusion is completed and should be questioned before the next infusion. IVIg replacement is a safe treatment when given with an appropriate premedication and infusion rate.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 4","pages":"Pages 231-237"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of early MRI in predicting the risk of hippocampal sclerosis in children with febrile status epilepticus","authors":"Rose Germain ,&nbsp;Mathilde Le Floch ,&nbsp;Marine Dubois ,&nbsp;Pauline Cloarec ,&nbsp;Raphaël Chouteau ,&nbsp;Bertrand Bruneau","doi":"10.1016/j.arcped.2024.12.007","DOIUrl":"10.1016/j.arcped.2024.12.007","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is the main complication of febrile status epilepticus (FSE) in children. The association between FSE and the development of hippocampal sclerosis (HS) and mesial temporal lobe epilepsy (MTLE) is controversial.</div></div><div><h3>Objectives</h3><div>This study primarily aimed to evaluate the role of magnetic resonance imaging (MRI) in diffusion-weighted imaging (DWI) sequence during the acute phase of FSE in predicting long-term development of HS and epilepsy. The secondary objective was to assess the value of arterial spin labeling (ASL) perfusion MRI in the acute phase of FSE.</div></div><div><h3>Methods and settings</h3><div>Patients with a first episode of FSE between 6 months and 5 years of age who underwent early MRI were retrospectively included. MRI analysis focused on the DWI signal and the presence of perfusion abnormalities on ASL imaging. We also examined the first electroencephalogram (EEG) during the acute phase. Long-term follow-up analysis assessed the occurrence of HS on MRI scans and the development of epilepsy.</div></div><div><h3>Results</h3><div>A total of 15 children were included. The presence of restricted diffusion areas on MRIs performed in the acute phase after FSE was significantly associated with the later development of HS. However, the association between restricted diffusion areas on early MRIs and the development of pharmaco-resistant epilepsy on follow-up, found in 3 patients, was not statistically significant. There was a trend for an association between early ASL perfusion MRI changes and EEG findings when both examinations were performed closely.</div></div><div><h3>Conclusion</h3><div>Early DWI-MRI seems to play a major role in the prognostic evaluation of FSE in children. It may help to determine hippocampal involvement and assess the risk of subsequent HS. However, the study data are insufficient to conclude on the association between diffusion abnormalities and the development of MTLE. Although ASL perfusion may provide additional insight, more data are needed.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 4","pages":"Pages 244-254"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral parenting intervention for parents of preschool-aged children born moderately and late preterm: An experimental study","authors":"Géraldine Maigret,&nbsp;Edouard Gentaz,&nbsp;Fleur Lejeune","doi":"10.1016/j.arcped.2025.03.001","DOIUrl":"10.1016/j.arcped.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Prematurity can be associated with difficulties in emotional and behavioral regulation in children, leading to short- and long-term impacts on parental dynamics. However, moderate-late preterm children and their parents rarely receive follow-up care.</div></div><div><h3>Objectives</h3><div>The aim of this current study was to evaluate a Behavioral Parenting Intervention (BPI) specifically developed for parents of preschool-aged moderate-late preterm children, to prevent their potential difficulties in emotional and behavioral regulation.</div></div><div><h3>Method</h3><div>Thirty-eight families participated in a program consisting of 7 therapy sessions. Each experimental group was matched with a control group; the control group would become the experimental group in the following session. Parents completed questionnaires one week before the start of the program (T1) and at the end of the 7th therapy session to measure immediate effects (T2). Social validity measures were also added to this study to assess the feasibility and acceptability of our program.</div></div><div><h3>Results</h3><div>We primarily observed positive effects on the Parental Stress Index total (PSI) in the population 1. For the control group, there was no significant difference between PSI Total scores at T1 <em>(M</em> <em>=</em> <em>101.1, SD = 22.2)</em> and T2 <em>(M</em> <em>=</em> <em>101.5, SD = 19.8).</em> In contrast, the experimental group showed a significant reduction in PSI total scores from T1 <em>(M</em> <em>=</em> <em>105, SD = 23.2)</em> to T2 <em>(M</em> <em>=</em> <em>93.3, SD = 21.3),</em> with <em>p</em> &lt; .001. Similar effects were observed for both the Parent Distress and the Difficult Child subscales.</div></div><div><h3>Conclusion</h3><div>While our results are modest, the measures of social validity and our high satisfaction rates indicate the importance and necessity of a parenting intervention aimed at moderately preterm children beyond the initial phase of early development. Future research should aim to facilitate access and increase family engagement to improve the effectiveness of this type of intervention.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 4","pages":"Pages 223-230"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}