Archives De Pediatrie最新文献

{"title":"Intracranial hypertension in a patient with Hutchinson-Gilford progeria syndrome","authors":"Léa Bonneau ,&nbsp;Maïlys Rupin-Mas ,&nbsp;Magali Descamps ,&nbsp;Marie Vincent ,&nbsp;Bénédicte Romefort ,&nbsp;Patrick Van Bogaert","doi":"10.1016/j.arcped.2024.12.006","DOIUrl":"10.1016/j.arcped.2024.12.006","url":null,"abstract":"<div><div>Hutchinson-Gilford syndrome, also known as progeria, is a rare genetic disorder that causes premature and accelerated ageing from the neonatal period. The disease is caused by de novo mutations in the LMNA gene. Patients present with a range of symptoms, including skin, bone, joint and cardiac disorders, as well as characteristic facial dysmorphia. Intracranial hypertension is not a known symptom of this disease. To the best of our knowledge, no case of a patient with Hutchinson-Gilford syndrome presenting with intracranial hypertension without a traumatic context has been reported in the literature to date. This report presents the case of a child diagnosed with Hutchinson-Gilford syndrome who presented with intracranial hypertension at the age of three years, with no secondary cause identified. Long-term treatment with acetazolamide was required to control the intracranial hypertension. We hypothesise that the intracranial hypertension may be related to vascular abnormalities observed in Hutchinson-Gilford syndrome, which may cause a venous drainage dysfunction. To support the hypothesis of a non-random association between intracranial hypertension and Hutchinson-Gilford syndrome, further reports of similar cases in children with the syndrome are required.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 210-212"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child victims of intrafamilial sexual abuse: A retrospective study at the Forensic Unit","authors":"Amandine Tchouprikoff ,&nbsp;Lucile Tuchtan ,&nbsp;Emmanuelle Bosdure ,&nbsp;Violaine Bresson ,&nbsp;Claude Borrione ,&nbsp;Marie-Dominique Piercecchi-Marti ,&nbsp;Clémence Delteil","doi":"10.1016/j.arcped.2025.01.005","DOIUrl":"10.1016/j.arcped.2025.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Reports of sexual abuse of minors are increasing, highlighting the important public health problem of child maltreatment with its long-lasting medical, forensic, emotional and social repercussions. The aim of this work was to document epidemiological data on children who were victims or suspected victims of intrafamilial sexual abuse and who were referred to a forensic unit, in order to help prevent abuse and to improve our practice in detection, diagnosis and medical, forensic, psychological and social management.</div></div><div><h3>Method</h3><div>This was a historical observational descriptive and analytical study carried out in the Forensic Unit of La Timone, part of the Assistance Publique des Hôpitaux de Marseille, France, over a 2-year period.</div></div><div><h3>Results</h3><div>One hundred and ninety perineal examinations were performed on young children (average age 9 years), 67 % of whom were more than a month old. Lesions were described in only 30 children (all girls), all of them old. Twenty-one children received psychological or psychiatric follow-up.</div></div><div><h3>Conclusion</h3><div>This study leads us to call into question our practice for overall management of child victims of sexual abuse and for forensic expert reports, with disappearance of lesions and low information yield from samples taken for genetic identification. There is a need for multidisciplinary management of these children and for specific training in obtaining their testimony. The paediatric units for children in danger (UAPED) can provide unity of time and place with multidisciplinary management.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 197-202"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring parents’ awareness, identification, and communication practices about acquaintance abuse against children in Pakistan","authors":"Sana Ali ,&nbsp;Shazia Hashmat ,&nbsp;Saadia Anwar Pasha","doi":"10.1016/j.arcped.2024.11.006","DOIUrl":"10.1016/j.arcped.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Child Sexual Abuse (CSA) is a growing healthcare issue worldwide. However, the acquittance rape is one of the underrepresented phenomena due to certain social and cultural concerns. Consequently, the role of parents is of greater significance to ensure the safety of their children outside and insider of their homes.</div></div><div><h3>Aims</h3><div>This research investigated the parents’ awareness, identification, and communication practices about acquaintance rapes against Pakistani children.</div></div><div><h3>Methods</h3><div>Data was gathered from 314 respondents having one or more children below sixteen years of age and further analyzed using Statistical Package for Social Sciences (SPSS).</div></div><div><h3>Findings</h3><div>Results showed that a majority of parents (70 %) were aware of child sexual abuse (CSA), especially acquaintance rape, as a prevalent phenomenon. However, they stayed neutral (50 %) about the possibility of female acquaintances as the possible cause of CSA and male children as victims of sexual abuse. They further reported physical and psychological signs to help identify acquaintance rape among children, with consensus ranging from 50 % to 60 %. Further, they showed different communication approaches, including telling children about CSA (50 %), their private body parts (around 45 %), abstaining from accepting gifts (50 %) and cautioning against going anywhere, even with someone they know (50 %), implying actively educating children about CSA as an effective strategy.</div></div><div><h3>Conclusions</h3><div>Effective communication between parents and children about sexual abuse is critical for deterrence. Continued efforts to challenge stereotypes, promote inclusive attitudes, and encourage comprehensive prevention approaches are important to creating safer environments for children in Pakistani society.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 191-196"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central venous catheter-related deep vein thrombosis in severe inaugural diabetic ketoacidosis: A four case-report and literature review","authors":"Mariane Mompontet ,&nbsp;Sophie Breinig ,&nbsp;Carole Morin","doi":"10.1016/j.arcped.2025.01.003","DOIUrl":"10.1016/j.arcped.2025.01.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Type 1 diabetes (T1D), particularly diabetic ketoacidosis (DKA), is believed to induce a prothrombotic state, mainly due to activation of the coagulation system, platelets, and relative hypofibrinolysis.</div></div><div><h3>Observations and discussion</h3><div>A central venous catheter (CVC) can be necessary in cases of severe inaugural DKA in the pediatric intensive care unit (PICU). Children with a CVC are at increased risk of thrombosis, particularly before the age of three.</div><div>Following a literature review and our experience in Toulouse (4 cases) of CVC-related thrombosis, we propose that CVC placement should be avoided as much as possible and alternative venous access should be preferred to minimize the risk of thrombosis.</div></div><div><h3>Conclusion</h3><div>If CVC placement cannot be avoided, preventive anticoagulation should be considered, but further studies are needed to establish a proper protocol.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 213-215"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of pittsburgh infant brain injury score in a French pediatric study","authors":"Cécile Oger ,&nbsp;Audrey Grain ,&nbsp;Elise Launay ,&nbsp;Christèle Gras-Leguen ,&nbsp;Fleur Lorton ,&nbsp;Pauline Scherdel","doi":"10.1016/j.arcped.2024.11.007","DOIUrl":"10.1016/j.arcped.2024.11.007","url":null,"abstract":"<div><h3>Background</h3><div>Abusive Head Trauma (AHT) is a leading cause of morbidity and mortality in infants requiring rapid neuroimaging performance and prognostic rapid diagnosis. The Pittsburgh Infant Brain Injury Score (PIBIS) clinical prediction rule (CPR) was derived to identify infants most likely to present brain injury, whose diagnosis would benefit from head CT. Our study aimed to externally validate the PIBIS CPR in a pediatric French population.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted in a French pediatric emergency department between 2015 and 2017. We included all consecutive infants who underwent a neurological imaging. Medical data were collected, and PIBIS score was determined, both retrospectively.</div></div><div><h3>Results</h3><div>We included 129 infants among which 33 cases (including 20 with a diagnosis of AHT). The sensitivity and specificity of the PIBIS CPR were 75.8 % (95 % CI 57.7-88.9) and 61.4 % (51.0-71.2) and negative and positive predictive values 88.1 % (77.8-94.7) and 40.3 % (33.0-48.2). Among the 20 infants with a diagnosis of AHT, 19 (95.0 %) were correctly identified by the PIBIS CPR.</div></div><div><h3>Conclusion</h3><div>Our external validation study found a lower diagnostic value of the PIBIS CPR than in the original study. This argues for adding biomarkers to improve its performance, notably in the context of suspected AHT.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 157-162"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute sclerosing panencephalitis: Disease profile in early childhood","authors":"Hanane Chettouh ,&nbsp;Karima Haddad ,&nbsp;Nafissa Mahieddine ,&nbsp;Azzedine Mekki ,&nbsp;Zoulikha Zeroual ,&nbsp;Zouhir Berrou ,&nbsp;Souhaila Rezzoug","doi":"10.1016/j.arcped.2024.11.010","DOIUrl":"10.1016/j.arcped.2024.11.010","url":null,"abstract":"<div><div>Subacute sclerosing panencephalitis (SSPE), a progressive inflammatory neurodegenerative disease of the central nervous system caused by the measles virus, is experiencing a significant resurgence following recent measles epidemics. This study aimed to investigate the pathology of SSPE in early childhood and determine its clinical, electrophysiological, and radiological characteristics.</div></div><div><h3>Materials and methods</h3><div>This retrospective, descriptive study was conducted at the Pediatric Department of Nafissa Hamoud University Hospital in Algiers. The study included children aged 2–6 years who were hospitalized for subacute neurological disorders. Data collection spanned a 3-year period from January 1, 2020, to December 31, 2022.</div></div><div><h3>Results and discussion</h3><div>A total of 47 patients were examined, comprising 37 boys and 10 girls. The average age was 45.9 months (range: 24–72 months). Notably, 41 (87 %) of the patients had not received measles vaccination, and 37 (80 %) had contracted the measles virus, with 31 cases (83.8 %) occurring in children under 1 year of age. SSPE manifested approximately 3 years after infection (range: 1–5 years). Clinical events primarily included myoclonic seizures (26 cases), tonic–clonic seizures (6 cases), atonic seizures (6 cases), and focal seizures (3 cases); movement disorders were observed in 25 patients, and cognitive decline in 28 patients. Encephalitis manifestations, such as alterations in consciousness or behavior and psychiatric symptoms, were frequently observed. Electroencephalograms (EEG) revealed characteristic periodic complexes in only 22 patients. Magnetic resonance imaging (MRI) scans were normal in 24 patients but showed characteristic anomalies in 21 patients, primarily consisting of white matter hyperintensity and cortico-subcortical atrophy.</div></div><div><h3>Conclusion</h3><div>SSPE is not rare in early childhood. The latency period between virus infection and disease onset can be very short. Clinical, electroencephalographic, and radiological signs of the disease in young children may be atypical. Genetic studies are necessary to establish a genetic predisposition to the disease. Measles vaccination remains the most effective preventive measure against SSPE.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 3","pages":"Pages 175-183"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety disorders and major depressive disorders in 299 adolescents hospitalized for assessment of common obesity: A retrospective cohort study.","authors":"Morgan Seyler, Caroline Barry, Alexandra Loisel, Marie Rose Moro, Jonathan Lachal, Hervé Lefèvre","doi":"10.1016/j.arcped.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.01.004","url":null,"abstract":"<p><strong>Background: </strong>Obesity has major psychosocial impacts in adolescents. Anxiety and depression are the most common psychiatric conditions in adolescents suffering from obesity.</p><p><strong>Objectives: </strong>To measure and discuss the prevalence of psychiatric disorders in adolescents hospitalized for biopsychosocial assessment of common obesity during multidisciplinary care.</p><p><strong>Methods: </strong>This retrospective monocentric study describes mental disorders over a decade (2012-2021) in 299 adolescents with obesity hospitalized for a global somatic and psychiatric assessment. Patients aged 11-18 were included. Sociodemographic data, psychiatric diagnosis, self-report questionnaires (CDI, Children's Depression Inventory, STAIC, State-Trait Anxiety Inventory for children, BES, Binge Eating Scale) were analyzed.</p><p><strong>Results: </strong>27,4 % of adolescents had an anxiety disorder (AD), 18,7 % had a major depressive disorder (MDD) and 49,2 % had no mental disorder. In multiple regression models, exposure to physical violence (p < 0.01), and the BES score (p < 0.05) were also associated with a risk of AD. Exposure to physical violence, year of admission and the BES score were risk factors for MDD (p < 0.05).</p><p><strong>Conclusions: </strong>Prevalence of mental disorders is high and increasing, confirming the psychological suffering in adolescent with obesity. Some present with incomplete clinical profiles. MDD and AD are associated with a personal history of violence and a high BES score, reflecting in some adolescents a phenomenon of compensatory binge eating.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe urological involvement in junctional epidermolysis bullosa justifying bladder enlargement by sigmoidocystoplasty and Mitrofanoff appendicovesicostomy.","authors":"Marielle Ehilé-Kacou, Pierre Yves Mure, Delphine Demede, Alice Phan, Justine Bacchetta, Valeska Bidault, Bruno Ranchin","doi":"10.1016/j.arcped.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.01.002","url":null,"abstract":"<p><p>The urological complications of junctional epidermolysis bullosa (JEB) are difficult to manage because of the fragility of the skin and mucosa, and are not the subject of any recommendations. We report on 2 cases of chronic lower urinary tract dysfunction causing chronic kidney disease, treated by bladder enlargement with sigmoidocystoplasty and Mitrofanoff appendicovesicostomy after failure of medical treatment and suprapubic catheterisation several times a day. Follow-up was favourable in both children, with kidney function preservation and significant improvement of quality of life.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of early MRI in predicting the risk of hippocampal sclerosis in children with febrile status epilepticus.","authors":"Rose Germain, Mathilde Le Floch, Marine Dubois, Pauline Cloarec, Raphaël Chouteau, Bertrand Bruneau","doi":"10.1016/j.arcped.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.arcped.2024.12.007","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is the main complication of febrile status epilepticus (FSE) in children. The association between FSE and the development of hippocampal sclerosis (HS) and mesial temporal lobe epilepsy (MTLE) is controversial.</p><p><strong>Objectives: </strong>This study primarily aimed to evaluate the role of magnetic resonance imaging (MRI) in diffusion-weighted imaging (DWI) sequence during the acute phase of FSE in predicting long-term development of HS and epilepsy. The secondary objective was to assess the value of arterial spin labeling (ASL) perfusion MRI in the acute phase of FSE.</p><p><strong>Methods and settings: </strong>Patients with a first episode of FSE between 6 months and 5 years of age who underwent early MRI were retrospectively included. MRI analysis focused on the DWI signal and the presence of perfusion abnormalities on ASL imaging. We also examined the first electroencephalogram (EEG) during the acute phase. Long-term follow-up analysis assessed the occurrence of HS on MRI scans and the development of epilepsy.</p><p><strong>Results: </strong>A total of 15 children were included. The presence of restricted diffusion areas on MRIs performed in the acute phase after FSE was significantly associated with the later development of HS. However, the association between restricted diffusion areas on early MRIs and the development of pharmaco-resistant epilepsy on follow-up, found in 3 patients, was not statistically significant. There was a trend for an association between early ASL perfusion MRI changes and EEG findings when both examinations were performed closely.</p><p><strong>Conclusion: </strong>Early DWI-MRI seems to play a major role in the prognostic evaluation of FSE in children. It may help to determine hippocampal involvement and assess the risk of subsequent HS. However, the study data are insufficient to conclude on the association between diffusion abnormalities and the development of MTLE. Although ASL perfusion may provide additional insight, more data are needed.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scurvy in an 18-month-old child mimicking a clinical presentation of rickets","authors":"Ai Tien Nguyen ,&nbsp;Sibylle Jalon ,&nbsp;Albane Simon ,&nbsp;Maurine Jouret ,&nbsp;Justin Le Lorier ,&nbsp;Véronique Hentgen ,&nbsp;Marie-Aliette Dommergues","doi":"10.1016/j.arcped.2024.10.006","DOIUrl":"10.1016/j.arcped.2024.10.006","url":null,"abstract":"<div><div>Scurvy is now considered to be a rare disease in European countries, even among children, but it still exists. We report the case of an 18-month-old boy who was initially hospitalized for a walking disorder and ultimately diagnosed with scurvy. Radiographs were compatible with rickets, but biological analysis ruled out this diagnosis. The vitamin C deficiency was due to an inadequate diet of a young child without any underlying conditions. This child was exclusively breastfed until the age of 17 months and his mother was also likely vitamin C deficient, as she had a diet lacking in fruits and vegetables. Practitioners should become familiar with symptoms of scurvy to prevent the ordering of unnecessary tests and delays in diagnoses.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 2","pages":"Pages 138-142"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}