Archives of Cardiovascular Diseases最新文献

{"title":"Rare Cause of Pulmonary Hypertension in Newborn: Vein of Galen Aneurysmal Malformation","authors":"Rania Gargouri ,&nbsp;Chiraz Rguaieg ,&nbsp;Amina Kammoun ,&nbsp;Ines Maaloul ,&nbsp;Nedia Hammami ,&nbsp;Mariem Jabeur ,&nbsp;Nadia Hentati ,&nbsp;Leila Abid","doi":"10.1016/j.acvd.2025.06.034","DOIUrl":"10.1016/j.acvd.2025.06.034","url":null,"abstract":"<div><h3>Introduction</h3><div>Pulmonary hypertension is a life-threatening condition in newborns. While common causes include meconium aspiration, sepsis, and congenital diaphragmatic hernia, rare etiologies such as cerebral vascular malformations must be considered, particularly when standard therapies fail. Vein of Galen malformation (VOGM) is a rare congenital vascular anomaly that can lead to high-output cardiac failure and pulmonary hypertension due to increased cerebral blood flow. This malformation is caused by a direct arteriovenous fistula between choroidal arteries and the embryonic median prosencephalic vein of Markowski (the precursor to the vein of Galen). There are two major anatomic subtypes: the choroidal type and the mural type. Mortality is especially high during the neonatal period. Without intervention, over 90% of these infants progress rapidly to multiple organ failure.</div></div><div><h3>Method</h3><div>Here, we report the case of a 2-day-old female newborn presenting with severe pulmonary hypertension refractory to medical management with high output heart failure, ultimately diagnosed with a choroidal-type VOGM.</div></div><div><h3>Results</h3><div>A full-term female newborn was delivered <em>via</em> cesarean section to a diabetic mother. She exhibited tachypnea and mild desaturation. Physical examination revealed prominent jugular venous pulsations, and hepatomegaly. Chest radiography showed significant cardiomegaly. Transthoracic echocardiography revealed a structurally normal heart with dilated right-sided cavities (<span><span>Figure 1</span></span>a), isosystematic pulmonary arterial hypertension, diastolic reversal flow in the proximal descending thoracic aorta (<span><span>Figure 1</span></span>b) and Continuous and prominent carotid flow with prominent superior vena cava flow. A cerebral vascular malformation was highly suspected. Subsequent computed tomography (CT) (<span><span>Figure 1</span></span>c) angiography and magnetic resonance imaging (MRI) confirmed a choiroidal -type vein of Galen malformation with significant arteriovenous shunting. Given the poor hemodynamic tolerance and the presence of isosystemic PH with a bicetre scale score of 12, emergent embolization was decided. A femoral arterial approach was performed, with embolization of three branches of the right and left posterolateral choroidal arteries, achieving occlusion of the shunts (<span><span>Figure 1</span></span>d).</div></div><div><h3>Conclusion</h3><div>PPHN in VOGM is a rare presentation and can be challenging to diagnose and to treat. This case underscore the importance of considering cerebral vascular anomalies in neonates with hig cardiac output heart failure and refractory pulmonary hypertension.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages S265-S266"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of transcatheter correction of sinus venosus defect using 70–100 mm-long partially covered Optimus-CVS® XXL stents compared with surgery: The OPTIVENOSUS study design","authors":"Clément Batteux ,&nbsp;Vlad Ciobotaru ,&nbsp;Raymond N. Haddad ,&nbsp;Ali Houeijeh ,&nbsp;Clément Karsenty ,&nbsp;Ivan Bouzguenda ,&nbsp;Régine Roussin ,&nbsp;Nicolas Combes ,&nbsp;Mohamed Bakloul ,&nbsp;Philippe Aldebert ,&nbsp;Fanny Dion ,&nbsp;Bruno Lefort ,&nbsp;Gilles Bosser ,&nbsp;Damien Bonnet ,&nbsp;Alain Fraisse ,&nbsp;Hélène Bouvaist ,&nbsp;Jurgen Hoerer ,&nbsp;Pamela Moceri ,&nbsp;François Godart ,&nbsp;Marien Lenoir ,&nbsp;Sébastien Hascoët","doi":"10.1016/j.acvd.2025.05.003","DOIUrl":"10.1016/j.acvd.2025.05.003","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter correction of sinus venosus defect provides a less invasive alternative to open-heart surgery.</div></div><div><h3>Aim</h3><div>To evaluate the safety and efficacy of 70–100<!--> <!-->mm-long partially covered balloon-expandable Optimus-CVS® XXL stents (AndraTec, Koblenz, Germany), specifically designed for sinus venosus defect repair, compared with surgical intervention.</div></div><div><h3>Methods</h3><div>OPTIVENOSUS is a French nationwide multicentre prospective comparative cohort study of patients with indications for sinus venosus defect correction (May 2023 to February 2031). The study comprises two parts, with a comprehensive shift in patient assignment to the catheter group. Part 1 will enrol 30 adult patients (aged<!--> <!-->&gt;<!--> <!-->18<!--> <!-->years) deemed ineligible for surgery by a multidisciplinary team, who will undergo feasibility assessment for catheter correction, including virtual simulations and three-dimensional-printed bench testing. Part 2 will add 30 adult patients with favourable anatomy, considered directly for stent therapy, whereas three-dimensional-printed bench testing will be reserved for complex cases. Surgical patients (aged ≥<!--> <!-->12<!--> <!-->years) will be enrolled continuously throughout the study, with no enrolment cap. All patients will receive standardized follow-up for up to 5<!--> <!-->years.</div></div><div><h3>Results</h3><div>The primary endpoint is a 6-month composite measure of safety and efficacy, defined by trivial or absent residual shunt and the absence of major adverse events (death or surgical conversion). If no significant difference is found, efficacy (end-diastolic right ventricular volume reduction) and safety (absence of reintervention, stroke, pacemaker implantation or severe arrhythmia) will be further evaluated using hierarchical analysis.</div></div><div><h3>Conclusion</h3><div>The OPTIVENOSUS study evaluates the safety and effectiveness of transcatheter sinus venosus defect correction with Optimus-CVS® XXL stents versus surgery (<span><span>NCT05865119</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages 497-507"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redo surgical aortic valve replacement: An outdated technique in the era of valve-in-valve procedures?","authors":"Johannes Petersen ,&nbsp;Roman Stiefel ,&nbsp;Sumi Westhofen ,&nbsp;Eik Vettorazzi ,&nbsp;Till Demal ,&nbsp;Beate Reiter ,&nbsp;Björn Sill ,&nbsp;Lenard Conradi ,&nbsp;Yousuf Al Assar ,&nbsp;Hermann Reichenspurner ,&nbsp;Christian Detter","doi":"10.1016/j.acvd.2025.05.007","DOIUrl":"10.1016/j.acvd.2025.05.007","url":null,"abstract":"<div><h3>Background</h3><div>The treatment of degenerative prosthetic aortic valves is increasingly important. However, redo surgical aortic valve replacement (Re-SAVR) carries higher perioperative risks than primary surgical aortic valve replacement.</div></div><div><h3>Aim</h3><div>This study aims to identify predictors of early morbidity and death after Re-SAVR.</div></div><div><h3>Methods</h3><div>A retrospective analysis of 220 patients scheduled for elective Re-SAVR between 2009 and 2017 was conducted. Patients were divided into isolated (<em>n</em> <!-->=<!--> <!-->87) and combined (<em>n</em> <!-->=<!--> <!-->133) redo procedures. The primary endpoint was in-hospital death, and secondary endpoints were postoperative complications, such as stroke, dialysis and pacemaker implantation. Regression analysis identified independent predictors of death.</div></div><div><h3>Results</h3><div>Among the patients undergoing Re-SAVR (mean age, 62.6<!--> <!-->±<!--> <!-->13.2<!--> <!-->years; 71% male; mean EuroSCORE II, 12.6<!--> <!-->±<!--> <!-->11.1%), 86.4% received biological prostheses and 13.6% received mechanical prostheses. The in-hospital death rate was 5.7% for isolated Re-SAVR and 18.0% for combined procedures (<em>P</em> <!-->=<!--> <!-->0.003). Excluding patients with endocarditis, the in-hospital death rate was 0% for isolated Re-SAVR and 19.7% for combined procedures (<em>P</em> <!-->=<!--> <!-->0.002). The incidence of postoperative complications after an isolated procedure was similar to that after a combined procedure. Independent predictors of 30-day death were previous coronary artery bypass grafting (odds ratio: 14.12, 95% confidence interval: 4.40–51.35; <em>P</em> <!-->&lt;<!--> <!-->0.001), a combined procedure (odds ratio: 7.01, 95% confidence interval: 2.09–31.54; <em>P</em> <!-->=<!--> <!-->0.004) and New York Heart Association functional class III/IV (odds ratio: 3.73, 95% confidence interval: 1.31–12.58; <em>P</em> <!-->=<!--> <!-->0.020).</div></div><div><h3>Conclusions</h3><div>The perioperative risk of death after isolated Re-SAVR in patients without endocarditis was 0%. Independent predictors of in-hospital death included previous coronary artery bypass grafting, combined procedures and New York Heart Association class III/IV. These findings may inform the decision-making process of the heart team regarding the optimal approach (surgical or transcatheter) for redo aortic valve replacement.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages 429-435"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiles and outcomes of patients treated with oral anticoagulants for atrial fibrillation who experience bleeding events requiring hospitalization in France.","authors":"Nicolas Danchin, Dominique Guitard-Dehoux, Mélanie Née, Manon Belhassen, Olivier Hanon, Isabelle Mahé, Philippe Gabriel Steg, Claire Marant Micallef","doi":"10.1016/j.acvd.2025.04.058","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.04.058","url":null,"abstract":"<p><strong>Background: </strong>Patients with atrial fibrillation treated with oral anticoagulants are at risk of bleeding.</p><p><strong>Aim: </strong>To describe oral anticoagulant-treated patients with atrial fibrillation who experience bleeding events requiring hospitalization, treatment patterns and outcomes following the bleeding event.</p><p><strong>Methods: </strong>This was a retrospective cohort study using the French national health system claims database, analysing patients with atrial fibrillation newly treated with an oral anticoagulant, with at least one hospitalization for bleeding between 2014 and 2016, followed up to December 2019. Sites of bleeding, sociodemographic and clinical characteristics, treatment patterns before and after the first bleeding event, the number of bleeding events over follow-up, the time from index date to first bleed and the time from first bleed to death are described.</p><p><strong>Results: </strong>Among 321,346 patients, 12,616 (3.9%) experienced at least one bleeding event (34.9% gastrointestinal). The median follow-up was 3.6 years from the index inclusion and 3.0 years from the first bleed. The mean age was 79.1 years, the mean Charlson Comorbidity Index score was 6.2 and 72% had modified HAS-BLED scores≤3. Before the first bleed, 9.2% of patients had switched from the index oral anticoagulant to another oral anticoagulant, and 6.6% had stopped oral anticoagulant treatment. After the first bleed, 43.6% remained treated with the same oral anticoagulant, 5.2% switched to another oral anticoagulant and 31.7% received no oral anticoagulant. Most patients experienced only one bleeding event; the median time from first bleed to death was 9.3 months.</p><p><strong>Conclusions: </strong>These \"real-life\" data show that patients with atrial fibrillation who experience a bleeding event have a high co-morbidity score, but often a low modified HAS-BLED score. The data document treatment patterns before and after bleeding, and show that in patients treated with oral anticoagulants, bleeding is associated with a high subsequent risk of death.</p>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinical Impact of Myocardial Crypts in FBN1 mutation: New Insights from CT Imaging in Marfan Syndrome","authors":"Ronan Mirabello ,&nbsp;Jocelyn Domagne ,&nbsp;Laurent Chaussavoine ,&nbsp;Michèle Hamon ,&nbsp;Fabien Labombarda","doi":"10.1016/j.acvd.2025.06.063","DOIUrl":"10.1016/j.acvd.2025.06.063","url":null,"abstract":"<div><h3>Introduction</h3><div>Myocardial crypts are narrow invaginations of the left ventricular myocardium, detectable by cardiac MRI or CT. While common in healthy individuals (6–7% prevalence), they are more frequent in patients with myocardial disarray, such as those with hypertrophic cardiomyopathy. Similar myocardial disarray abnormalities have been described in Marfan syndrome with FBN1 mutation. We hypothesized that myocardial crypts may be more prevalent in Marfan syndrome and could potentially serve as markers of aortic disease severity.</div></div><div><h3>Method</h3><div>We performed a single-center retrospective study at CHU de Caen, a tertiary referral center for Marfan syndrome and related disorders. We reviewed previously acquired ECG-gated thoracic CT scans (Siemens Somatom Definition AS+ 128-slice) performed as part of the diagnostic workup in individuals with clinically and/or genetically confirmed Marfan syndrome or related conditions.</div></div><div><h3>Results</h3><div>A total of 101 patients with Marfan syndrome or related disorders were included, of whom 55 had confirmed FBN1 mutations. Myocardial crypts were identified in 12 FBN1+ patients (prevalence 21.8%). This prevalence was significantly higher than in the general population (21.8% <em>vs.</em> 6.7%, <em>p</em> <!-->&lt;<!--> <!-->0.001). No significant differences were observed between FBN1+ patients with or without myocardial crypts regarding the prevalence of mitral valve prolapse, aortic dissection, aortic surgery, arrhythmia, or left ventricular dysfunction. However, age at first aortic surgery tended to be lower in FBN1+ patients with myocardial crypts (26,4 [4–42] years <em>vs.</em> 38 [13–63] years, <em>p</em> <!-->=<!--> <!-->0.05)</div></div><div><h3>Conclusion</h3><div>Myocardial crypts appear to be more prevalent in patients with FBN1+ Marfan syndrome compared to the general population. They do not appear to correlate with a more severe phenotype. However, they may represent a novel imaging marker that could contribute to the diagnostic assessment of connective tissue disorders.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S281"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Norms of Myocardial Function and Dyssynchrony using 2D Speckle-Tracking: Are Z Scores a good idea?","authors":"François Capet ,&nbsp;Pascal Amédro ,&nbsp;Robert Julien ,&nbsp;Thibault Mura ,&nbsp;Marie Vincenti","doi":"10.1016/j.acvd.2025.06.064","DOIUrl":"10.1016/j.acvd.2025.06.064","url":null,"abstract":"<div><h3>Introduction</h3><div>Speckle-tracking echocardiography (STE) provides precise assessment of myocardial function (2D strain) and ventricular dyssynchrony. In pediatrics, its clinical application is limited by the absence of reference values. This study aimes to validate and refine Z-score models for 2D strain and dyssynchrony parameters, to assess their reproducibility, and to evaluate their consistency across different ultrasound systems.</div></div><div><h3>Method</h3><div>Speckle-tracking echocardiography (STE) provides precise assessment of myocardial function (2D strain) and ventricular dyssynchrony. In pediatrics, its clinical application is limited by the absence of reference values. This study aimes to validate and refine Z-score models for 2D strain and dyssynchrony parameters, to assess their reproducibility, and to evaluate their consistency across different ultrasound systems.</div></div><div><h3>Results</h3><div>The Z-score models by Romanowicz and al. and those developed specially for this study exhibited low explanatory power for 2D strain parameters (R² <!-->&lt;<!--> <!-->10%). 2D strain parameters demonstrated high inter and intra-observer reproducibility and were independent of the ultrasound system. Dyssynchrony parameters were reproducible but significantly influenced by the imaging system. Variability related to anthropometric parameters lacked clinical significance, and the utility of Z-scores was not established. Unadjusted reference values for all STE parameters are proposed.</div></div><div><h3>Conclusion</h3><div>Z-score models are not suitable for the analysis of STE parameters in pediatric population. The use of unadjusted reference values is justified due to the absence of clinically relevant anthropometric 2D strain variations during childhood. These findings support the integration of STE into pediatric cardiology, particularly for longitudinal monitoring of cardiac function in congenital heart disease and young cardiomyopathies.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S282"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic-Fluoroscopic fusion imaging with the mini 3D transesophageal probe in pediatric patients","authors":"Ramona Ghenghea ,&nbsp;Hadeed Khaled ,&nbsp;Paul Vignaud ,&nbsp;Nicolas Combes ,&nbsp;Aitor Guitarte ,&nbsp;Yves Dulac ,&nbsp;Miarisoa Ratsimandresy ,&nbsp;Julie Gobin ,&nbsp;Philippe Acar ,&nbsp;Clement Karsenty","doi":"10.1016/j.acvd.2025.06.060","DOIUrl":"10.1016/j.acvd.2025.06.060","url":null,"abstract":"<div><h3>Introduction</h3><div>Echo-fluoroscopy fusion (EFF) imaging integrates real-time echocardiography with fluoroscopy to improve guidance during interventional procedures with established use in adult cardiology. Its pediatric application was limited by the absence of suitable probes but is now feasible in patients under 30<!--> <!-->kg due to pediatric-specific 3D probes. This study aimed to evaluate the feasibility, safety, and clinical utility of EFF imaging in pediatric catheterization for congenital heart disease (CHD).</div></div><div><h3>Method</h3><div>A prospective study was conducted between September and December 2024 using EchoNavigator (Philips Healthcare) to co-register the new echocardiography probe (X11-4T) with fluoroscopy (Allura Azurion 7). The quality, accuracy, and utility of 2D/3D EFF imaging were assessed on a 5-point Likert scale.</div></div><div><h3>Results</h3><div>Twenty-two children (median [range] age 5.4 years [1.2–17.8 years]; weight 18.5 [8–61] kg) were enrolled from the pediatric cardiology unit at the Children's Hospital of Toulouse. EFF imaging was successfully implemented in all procedures with excellent fusion stability. Two patients underwent diagnostic catheterization, while atrial septal defect (ASD) and ventricular septal defect closures were performed in 11 and 9 patients, respectively, using various devices. The quality of 2D EFF imaging was rated 5/5 (95% CI: 4–5), while the quality of 3D EFF imaging was 4/5 (95% CI: 4–5). The accuracy of EFF imaging was rated 5/5 (95% CI: 5–5), and its utility was 3/5 (95% CI: 3–4). No complications related to probe insertion or image fusion occurred. EFF imaging provided clear real-time guidance for accurate device placement, particularly in complex cases like double ASDs and enhanced anatomical visualization, facilitating procedural navigation in complex CHD like cc-TGA with dextrocardia.</div></div><div><h3>Conclusion</h3><div>EFF imaging is a feasible and safe technique for guiding pediatric interventional procedures in CHD. It significantly improves anatomical visualization, device placement, and communication between the interventionalist and echocardiographer, especially in complex cases. This technology holds promise for advancing pediatric cardiac interventions.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S280"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of complete heart block: How many times will my child's pacemaker be changed? 20 year retrospective study","authors":"Jean-Benoit Baudelet ,&nbsp;Christelle Marquié ,&nbsp;Kevin Le Duc ,&nbsp;François Godart ,&nbsp;Ali Houeijeh ,&nbsp;Olivia Domanski ,&nbsp;Veronique Houfflin Debarge ,&nbsp;Thameur Rakza","doi":"10.1016/j.acvd.2025.06.065","DOIUrl":"10.1016/j.acvd.2025.06.065","url":null,"abstract":"<div><h3>Introduction</h3><div>Congenital heart block (CHB) is a rare diagnosis in fetal medecine. Causes include immunologic disease in mother (systemic lupus erythematosus, gougerot sjogren) or in assocation with congenital heart disease. CHB is a risk factor for fetal demise or prematurity. For alive newborns, pacemaker implantation is life-saving but carries the burden of iterative replacements.</div></div><div><h3>Method</h3><div>Data from alive newborns with an prenatal diagnosis of CHB and with a pacemaker implantation at birth between 2000 and 2024 were retrospectively analyzed. All records were reviewed for maternal medical history, pregnancy and birth data, follow-up data of lead or pacemaker replacement.</div></div><div><h3>Results</h3><div>Nineteen newborns were analyzed from 19 pregnancies. CHB were SSA related in 80% of cases (N<!--> <!-->=<!--> <!-->15/18, others causes: double outlet right ventricle, heterotaxy, congenitally corrected transposition of great arteries with aortic stenosis), revealing the immunologic disease in mothers in 83%. 11 patients were premature (60%), with a mean gestionnal age at birth of 33w<!--> <!-->+<!--> <!-->5d with a mean weight of 2190<!--> <!-->±<!--> <!-->449 grams. Causes of prematurity were mainly related to fetus state (N<!--> <!-->=<!--> <!-->9/11) due to low heart rate (50<!--> <!-->±<!--> <!-->1 bpm at birth) or fetal hydrops (n<!--> <!-->=<!--> <!-->1). Full term baby weighted 3324<!--> <!-->±<!--> <!-->418 grams. Pacemakers were implanted at a median age of 1 day of life (lowest weight 1140 grams) and changed approximately every 5 years (Mean age for first renewal: 5 years 6 months [2 years 11 months–7 years 8 months], at second renewal 10 years 1 month [8 years 2 months–13 years 7 months]. Median follow-up time was 11 years.</div></div><div><h3>Conclusion</h3><div>Prenatal diagnosis of CHB is associated with a high risk of premature delivery with an acceptable gestationnal age and weight for alive newborns. Newborns will need an urgent implantation of a pacemaker at birth, requiring to be changed approximately every 5 years during childhood.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S282"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduction System Pacing in Congenital Heart Disease patients: Early experience","authors":"Nathan Marimpouy ,&nbsp;Stefano Bartoletti ,&nbsp;Miarisoa Ratsimandresy ,&nbsp;Reaksmei Ly ,&nbsp;Clement Karsenty ,&nbsp;Stéphane Combes ,&nbsp;Nicolas Combes","doi":"10.1016/j.acvd.2025.06.008","DOIUrl":"10.1016/j.acvd.2025.06.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Conduction System Pacing (CSP) with his bundle or left bundle branch stimulation is an attractive emerging pacing mode associated with better haemodynamic outcomes in general population. Preliminary datas are encouraging in congenital heart disease (CHD).</div></div><div><h3>Method</h3><div>In this study with prospectively evaluate feasibility, safety and efficacy of CSP in consecutive CHD with indication of ventricular pacing.</div></div><div><h3>Results</h3><div>Between January 2022 and December 2024, 14 CHD were referred for pacing: atrioventricular canal defect (3), atrial septal defect (2), tetralogy of Fallot (2), TGA with a trial switch (2), ccTGA (1), congenital aortic stenosis (3), Ebstein anomaly (1). Indications for ventricular stimulation were: complete AV block (6), his bundle ablation for supraventricular tachycardias (3), pacing lead dysfunction (3), ventricular resynchronization (2). Mean follow-up was 11<!--> <!-->±<!--> <!-->8 months. CSP was achieved in 100% with good pacing parameters, with 1 acute complication (local haematoma). Systemic ejection fraction after pacing was stable in 6 (42%), increased in 8 (56%).</div></div><div><h3>Conclusion</h3><div>CSP in feasible in a was majority of CHD with endocavitary ventricular access. It avoids adverse haemodynamic effect of ventricular pacing with a potential effect of ventricular resynchronization with increase haemodynamics. CSP should by offered in CHD patients with indication for ventricular pacing.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S251"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse coronary artery disease: A challenge in diagnosis and treatment","authors":"Ikram El Marzouki ,&nbsp;Gilles Barone-Rochette","doi":"10.1016/j.acvd.2025.05.004","DOIUrl":"10.1016/j.acvd.2025.05.004","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages 425-428"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}