Archives of Cardiovascular Diseases最新文献

{"title":"Pediatric Behçet's disease and intracardiac thrombosis","authors":"Yasmine Semar ,&nbsp;Yousra Tazerouti ,&nbsp;Nadia Ouadah ,&nbsp;Radjaa Arous ,&nbsp;Adel Djermane ,&nbsp;Lynda Kermi ,&nbsp;Hadjer Latreche ,&nbsp;Mourad Abdelbaki ,&nbsp;Mohamed Touati ,&nbsp;Samira Aggoune","doi":"10.1016/j.acvd.2025.06.040","DOIUrl":"10.1016/j.acvd.2025.06.040","url":null,"abstract":"<div><h3>Introduction</h3><div>Behçet's disease (BD) is a rare multisystemic vasculitis in children, primarily affecting the mucocutaneous tissues, joints and eyes. Although uncommon, cardiovascular involvement can be a potentially severe complication.</div></div><div><h3>Method</h3><div>To report the clinical presentation of cardiac involvement revealing pediatric BD, we present the case of a child who developed two intracardiac thrombi in the right ventricle in the context of a history of intracranial thrombosis.</div></div><div><h3>Results</h3><div>During the management of acute dyspnea in a 13-year-old boy, chest computed tomography and echocardiography revealed two intracardiac thrombi: one measuring 38<!--> <!-->×<!--> <!-->24<!--> <!-->mm at the apex of the right ventricle, and another in the right ventricle outflow tract measuring 21<!--> <!-->×<!--> <!-->13<!--> <!-->mm. Combining these findings with the patient's medical history (cerebral venous thrombosis) and physical examination (oral ulcers and ocular involvement), the diagnosis of BD was made. Treatment included a combination of anticoagulants, immunosuppressants, and corticosteroids.</div></div><div><h3>Conclusion</h3><div>Cardiac thrombosis in children is rare. The clinical context of multisystemic and progressive involvement supports its association with BD.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S268"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Antibiotic Step-Down Therapy for Pediatric Infective Endocarditis: A Single-Center retrospective Experience","authors":"Pauline Remyon ,&nbsp;Thibault Tromeur ,&nbsp;Pauline Gras ,&nbsp;François Godart ,&nbsp;Pierre Mauran ,&nbsp;Sylvie Falcon-Eicher ,&nbsp;Gallet Jean ,&nbsp;Dorothée Ardourel ,&nbsp;Gilles Bosser ,&nbsp;Anne-Sophie Leborgne-Meyer ,&nbsp;Tristan Hazelzet ,&nbsp;Elise Barre ,&nbsp;Sabine Dirani ,&nbsp;Annabel Sudaka ,&nbsp;Bertrand Stos ,&nbsp;Helene Ansquer ,&nbsp;Berangere Urbina-Hiel ,&nbsp;Emre Belli ,&nbsp;Sebastien Hascoet","doi":"10.1016/j.acvd.2025.06.022","DOIUrl":"10.1016/j.acvd.2025.06.022","url":null,"abstract":"<div><h3>Introduction</h3><div>Pediatric infective endocarditis (IE) primarily affects children with congenital heart disease, often involving prosthetic material. Standard treatment consists of 4–6 weeks of intravenous (IV) antibiotics, requiring prolonged hospitalization. While adult data (<em>e.g.</em>, POET trial) support partial oral therapy, pediatric studies remain limited, and guidelines are outdated. Practices vary widely in France.</div></div><div><h3>Method</h3><div>We conducted a retrospective observational single-center study including patients under 18 years diagnosed with definite or probable IE (Duke criteria) between January 2019 and June 2024. Patients were treated with either full IV therapy or IV followed by oral step-down antibiotics.</div></div><div><h3>Results</h3><div>Twenty-eight cases were analyzed (64% male), with a median age of 11 years (IQR: 5.9–16.1). Ninety-three percent had congenital heart disease and 67% had prosthetic material. There were 14 cases of right-sided infective endocarditis, 8 cases of left-sided infective endocarditis, 1 IE on Blalock shunt, 2 cases on a ventricular septal patch, and 1 on a atrial septal defect occluder. Seventy-nine percent of the patients underwent surgery. Oral step-down therapy was used in 15 patients (54%). Among them, 11 had favorable outcomes, 2 had relapses or a new IE, and 2 lacked outcome data. Seventeen patients completed part of their treatment at home: 9 with oral antibiotics, 4 with outpatient parenteral antibiotic therapy, and 4 with both. The mean duration of home treatment was 17 days, accounting for one-third of the average total treatment length (54 days). Three patients experienced unfavorable outcomes (relapse or new IE)—two in the oral therapy group—but no death occurred. No adverse events related to oral therapy were reported.</div></div><div><h3>Conclusion</h3><div>In selected pediatric IE cases, oral step-down antibiotic therapy appears safe and effective, enabling early discharge and improved comfort. These findings support the development of national recommendations to standardize pediatric IE management and consider oral therapy as a viable option.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S259"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter correction of superior sinus venosus defects: Early and mid-term results in a prospective, nationwide, multi-center study","authors":"Grégoire Albenque ,&nbsp;clement Batteux ,&nbsp;Clement Karsenty ,&nbsp;Bouzguenda Ivan ,&nbsp;Philippe Aldebert ,&nbsp;Jelena Radojevic ,&nbsp;Gilles Bosser ,&nbsp;Fanny Dion ,&nbsp;Bruno Lefort ,&nbsp;Pamela Moceri ,&nbsp;François Godart ,&nbsp;Raymond Haddad ,&nbsp;Fabien Labombarda ,&nbsp;Charlotte Denis ,&nbsp;Elise Barre ,&nbsp;Hélène Bouvaist ,&nbsp;Nicolas Combes ,&nbsp;Ali Houeijeh ,&nbsp;Vlad Ciobotaru ,&nbsp;Sebastien Hascoet","doi":"10.1016/j.acvd.2025.06.047","DOIUrl":"10.1016/j.acvd.2025.06.047","url":null,"abstract":"<div><h3>Introduction</h3><div>Transcatheter correction has been a new innovative treatment for superior sinus venosus defects (SVDs). A dedicated long partially covered XXL stent has been developed specifically for this procedure. Its safety and efficacy have to be investigated.</div></div><div><h3>Method</h3><div>This study aims to evaluate the efficacy and safety of transcatheter SVDs correction with the OTIMUS XXL® partially covered stent.</div></div><div><h3>Results</h3><div>Thirty adults were enrolled over one year in 5 centers (mean age 61 years; female, 73%; dyspnea, 90%; history of atrial arrhythmia, 43%; pulmonary hypertension, 40%; heart failure, 47%; mean indexed right ventricular end-telediastolic volume<!--> <!-->=<!--> <!-->140<!--> <!-->mL/m² on MRI). Simulation of transcatheter SVD closure was done virtually and on 3D printed models in all cases. All procedures were successful. Pulmonary vein pathway was protected in 57% of cases. Stents of 100<!--> <!-->mm and 80<!--> <!-->mm were implanted in 67% and 33% of cases respectively, using Gemini balloons. Additional stents were implanted at the upper part in 3 patients (10%). An ostium secundum atrial septal defect was closed during the same procedure in 2 patients (6.7%). No stent embolization, pulmonary vein compression, significant residual shunt or tamponade were observed. No peri-procedural death was reported during the follow-up. In one patient, a moderate pericardial effusion was observed 7 days after the procedure and resolved spontaneously. A flat thrombus of 4<!--> <!-->×<!--> <!-->22<!--> <!-->mm was fortuitously observed upholstering the bottom part of the covered stent on the systematic computed tomography scan control at 6 months. No other stent related adverse event.</div></div><div><h3>Conclusion</h3><div>Transcatheter SVDs correction using OPTIMUS XXL® covered stents is safe and effective with excellent early and mid-term outcomes.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Page S272"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OPTIVENOSUS-ECO Efficiency of endovascular treatment with covered stents compared with surgical treatment in patients with sinus venosus defects: A randomized trial","authors":"Sebastien Hascoet ,&nbsp;Florence Lecerf ,&nbsp;Clément Karsenty ,&nbsp;Roland Henaine ,&nbsp;Nicolas Combes ,&nbsp;Philippe Aldebert ,&nbsp;Alain Fraisse ,&nbsp;Damien Bonnet ,&nbsp;Raymond Haddad ,&nbsp;Régine Roussin ,&nbsp;Alban-Elouen Baruteau ,&nbsp;Ali Houeijeh ,&nbsp;Bouzguenda Ivan ,&nbsp;Marien Lenoir ,&nbsp;Isabelle Durand Zaleski ,&nbsp;Pascal Amédro ,&nbsp;Magalie Ladouceur ,&nbsp;Jurgen Hoerer ,&nbsp;clement Batteux ,&nbsp;Gilles Chatellier","doi":"10.1016/j.acvd.2025.06.046","DOIUrl":"10.1016/j.acvd.2025.06.046","url":null,"abstract":"<div><h3>Introduction</h3><div>Sinus venosus defect (SVD) is a rare complex congenital heart defect (1 in 1500 births) that was, until recently, corrected by open-heart surgery with cardiopulmonary bypass. A transcatheter correction of SVD was developed. This medical-economic project is a continuation of a feasibility study on a national cohort “OPTIVENOSUS”, which aimed to evaluate the effectiveness and safety of the transcatheter correction of SVD compared to the standard surgical method in patients deemed uneligible for surgery in a national multi-disciplinary meeting.</div></div><div><h3>Objective</h3><div>The primary objective of the ECO-OPTIVENOSUS study is to assess the efficiency of transcatheter correction of SVD in adolescents and adults compared to open-heart surgery. The study will focus on clinical outcomes and economic implications, aiming to demonstrate that the minimally invasive approach is more efficient in patients eligible for both procedures.</div></div><div><h3>Methods</h3><div>This multicenter, randomized (2 to 1), prospective, controlled trial will involve 13 expert centers in France (M3C network). A total of 90 patients will be recruited, with 60 undergoing endovascular procedures and 30 receiving surgical treatment. The study will evaluate clinical and economic criteria during the perioperative period and up to six months post-intervention. Key metrics include hospital stay duration, costs, quality of life, and clinical success rates. This study is under review for a PRME grant and aim to start in 2026.</div></div><div><h3>Expected results</h3><div>It is anticipated that the endovascular approach will significantly reduce hospital stays (from an average of 9 days for surgery to 3 days for endovascular treatment) and associated costs (estimated at €10,000 for endovascular devices versus €20,688 for open-heart surgery). The study aims to demonstrate comparable or improved clinical outcomes, including quality of life and functional capacity, without compromising safety.</div></div><div><h3>Perspectives</h3><div>The findings from this trial are expected to provide critical evidence for redefining treatment algorithms for SVD. The results will inform international guidelines and optimize patient management strategies, potentially leading to a paradigm shift in the treatment of this complex congenital heart defect.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages S271-S272"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and regional disparities in adult thoracic aortic aneurysm-related mortality rates in the USA: Insights from a CDC WONDER analysis (1999–2020)","authors":"Armaghan Ur Rehman ,&nbsp;Muhammad Asfandyar Nadir ,&nbsp;Ariba Fida ,&nbsp;Muhammad Sheheryar Javed ,&nbsp;Talha Abbas ,&nbsp;Mohsin Raza ,&nbsp;Muhammad Bilal Sardar ,&nbsp;Hooria Waqas Saeed ,&nbsp;Sophia Ahmed","doi":"10.1016/j.acvd.2025.02.009","DOIUrl":"10.1016/j.acvd.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Aneurysmal degenerations of the thoracic aorta, known as thoracic aortic aneurysms, significantly contribute to the global mortality burden. Despite progress in medical care, disparities in thoracic aortic aneurysm-related mortality rates continue to affect various demographic and regional groups in the USA.</div></div><div><h3>Aims</h3><div>To investigate trends and disparities in thoracic aortic aneurysm-related mortality rates among adults in the USA from 1999 to 2020, with a focused analysis across demographic (sex, ethnicity and age group), temporal and geographical (census region, urbanization and state) domains.</div></div><div><h3>Methods</h3><div>We analysed death certificate data from the Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research (CDC WONDER) database (1999–2020), with a focus on individuals aged<!--> <!-->≥<!--> <!-->25<!--> <!-->years. Age-adjusted mortality rates per 100,000 and annual percent changes, along with 95% confidence intervals, were calculated using joinpoint regression analysis.</div></div><div><h3>Results</h3><div>From 1999 to 2020, a total of 47,136 thoracic aortic aneurysm-related deaths occurred in the USA, with an overall age-adjusted mortality rate of 1.01 per 100,000 individuals. Age-adjusted mortality rate trends revealed a significant decline from 1999 to 2012 (annual percent change −5.31), followed by stabilization from 2012 to 2020 (annual percent change −0.15). Disparities were observed across sex, ethnicity and census regions, with males, non-Hispanic Blacks and individuals residing in the Midwest showing higher age-adjusted mortality rates. Rural areas exhibited slightly higher age-adjusted mortality rates than urban areas, although both showed a decline over time.</div></div><div><h3>Conclusions</h3><div>This study underscores the persistent burden of thoracic aortic aneurysm-related deaths in the USA, revealing notable disparities in mortality rates across various demographic groups and regions. The results highlight the critical need for targeted public health interventions to address these disparities, and to improve thoracic aortic aneurysm-related outcomes for all population segments.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages 436-445"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the transfusion strategy in acute type A aortic dissection: A call for precision haemostasis.","authors":"Brijesh Sathian, Javed Iqbal, Syed Muhammad Ali","doi":"10.1016/j.acvd.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.07.008","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns regarding the article entitled \"Changes in microcirculation following transcatheter aortic valve implantation in patients with stable coronary artery disease\" by Battistolo et al.","authors":"Muhammad Nouman Javed","doi":"10.1016/j.acvd.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.07.006","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter in response to the article entitled \"Transfusion and coagulation management in acute type A aortic dissection\" by Pfeiffer et al.: Insights from clinical data.","authors":"Miaomiao Yue, Jingjia Yang, Bin Liu","doi":"10.1016/j.acvd.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.08.002","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoattenuated leaflet thickening after transcatheter pulmonary valve replacement with the Venus-P valve.","authors":"Laurianne Le Gloan, Karine Warin-Fresse, Pierre-Guillaume Piriou, Patrice Guérin, Robin Le Ruz, Julien Plessis","doi":"10.1016/j.acvd.2025.08.003","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.08.003","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis-induced cardiomyopathy: Time to bring the heart back to the forefront.","authors":"Nadia Aissaoui","doi":"10.1016/j.acvd.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.acvd.2025.08.004","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}