一项单中心前瞻性观察性研究的结果：出生后第一年需要搭桥手术的先天性心脏病患儿的儿科喂养障碍（PFD）与神经发育不佳（SND）之间的关系

IF 2.2 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Archives of Cardiovascular Diseases Pub Date : 2025-09-01 DOI:10.1016/j.acvd.2025.06.031

Julia Chambon , Olivia Domanski , Sylvie Nguyen The Tich , Sylvie Joriot , Laurence Chaton , Riyad Hanafi , Alix Persyn , François Godart , Jean Benoit Baudelet , Francis Juthier , Gabriella Riccardi , Martin Dubernet , Clémence Etienne , Stephanie Delangue , Morgan Recher

{"title":"一项单中心前瞻性观察性研究的结果：出生后第一年需要搭桥手术的先天性心脏病患儿的儿科喂养障碍（PFD）与神经发育不佳（SND）之间的关系","authors":"Julia Chambon , Olivia Domanski , Sylvie Nguyen The Tich , Sylvie Joriot , Laurence Chaton , Riyad Hanafi , Alix Persyn , François Godart , Jean Benoit Baudelet , Francis Juthier , Gabriella Riccardi , Martin Dubernet , Clémence Etienne , Stephanie Delangue , Morgan Recher","doi":"10.1016/j.acvd.2025.06.031","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Suboptimal neurodevelopmental issues concern 30 to 60% of infants with congenital heart disease, cardiac surgery before 1 year being a major risk factor. We ought to demonstrate the association between pediatric feeding disorders (PFD) and suboptimal neurodevelopment (SND) in this population.</div></div><div><h3>Method</h3><div>We conducted a prospective study to assess the prevalence of PFD, as defined by Goday et al., diagnosed by a speech therapist, and their correlation with SND at twelve months in children who underwent surgery with cardiopulmonary bypass (CPB) before the age of one. A total of 45 children were included between October 2020 and February 2024 in a systematic monitoring protocol of our institution.</div></div><div><h3>Results</h3><div>Preoperatively, 38% of infants had a PFD, compared to 29% at twelve months (<span><span>Figure 1</span></span>a) Additionally, 77% showed suboptimal neurodevelopment (SND) (defined by ASQ<2SD and/or AIMS<5=0,03). Infants with preoperative PFD were more cyanotic before surgery (<em>p</em>  =0.013), and had a smaller head circumference at twelve months (<em>p</em>  =0.01), and with 12 months PFD (<em>p</em>  =0.04).</div></div><div><h3>Conclusion</h3><div>Feeding difficulties diagnosed by speech therapists (and not only the presence of a feeding tube) appearing before surgery could serve as an early warning sign to predict neurodevelopmental issues in this population and help identify prematurely children that will need dedicated support.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"118 8","pages":"Pages S263-S264"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between pediatric feeding disorders (PFD) and suboptimal neurodevelopment (SND) in children with congenital heart disease requiring bypass surgery in the first year of life: Results from a single-center prospective observational study\",\"authors\":\"Julia Chambon , Olivia Domanski , Sylvie Nguyen The Tich , Sylvie Joriot , Laurence Chaton , Riyad Hanafi , Alix Persyn , François Godart , Jean Benoit Baudelet , Francis Juthier , Gabriella Riccardi , Martin Dubernet , Clémence Etienne , Stephanie Delangue , Morgan Recher\",\"doi\":\"10.1016/j.acvd.2025.06.031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Suboptimal neurodevelopmental issues concern 30 to 60% of infants with congenital heart disease, cardiac surgery before 1 year being a major risk factor. We ought to demonstrate the association between pediatric feeding disorders (PFD) and suboptimal neurodevelopment (SND) in this population.</div></div><div><h3>Method</h3><div>We conducted a prospective study to assess the prevalence of PFD, as defined by Goday et al., diagnosed by a speech therapist, and their correlation with SND at twelve months in children who underwent surgery with cardiopulmonary bypass (CPB) before the age of one. A total of 45 children were included between October 2020 and February 2024 in a systematic monitoring protocol of our institution.</div></div><div><h3>Results</h3><div>Preoperatively, 38% of infants had a PFD, compared to 29% at twelve months (<span><span>Figure 1</span></span>a) Additionally, 77% showed suboptimal neurodevelopment (SND) (defined by ASQ<2SD and/or AIMS<5=0,03). Infants with preoperative PFD were more cyanotic before surgery (<em>p</em>  =0.013), and had a smaller head circumference at twelve months (<em>p</em>  =0.01), and with 12 months PFD (<em>p</em>  =0.04).</div></div><div><h3>Conclusion</h3><div>Feeding difficulties diagnosed by speech therapists (and not only the presence of a feeding tube) appearing before surgery could serve as an early warning sign to predict neurodevelopmental issues in this population and help identify prematurely children that will need dedicated support.</div></div>\",\"PeriodicalId\":55472,\"journal\":{\"name\":\"Archives of Cardiovascular Diseases\",\"volume\":\"118 8\",\"pages\":\"Pages S263-S264\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Cardiovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1875213625003584\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Cardiovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875213625003584","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

30 - 60%的先天性心脏病患儿存在神经发育不佳问题，一岁前进行心脏手术是主要危险因素。我们应该证明小儿喂养障碍（PFD）和亚理想神经发育（SND）之间的关联在这一人群。方法我们进行了一项前瞻性研究，以评估1岁前接受体外循环手术（CPB）的儿童在12个月时PFD的患病率（由Goday等人定义，由语言治疗师诊断）及其与SND的相关性。在2020年10月至2024年2月期间，共有45名儿童被纳入我们机构的系统监测方案。结果手术后，38%的婴儿有PFD，而12个月时为29%（图1a）。此外，77%的婴儿在12个月时表现为神经发育次优（SND）（由ASQ和/或AIMS第5百分位定义）（图1b和c）。术前PFD与12个月时的神经发育无显著相关性，但术前PFD与12个月时的SND相关（p = 0.03）。术前患有PFD的婴儿在手术前更紫（p = 0.017），手术年龄更大（p = 0.013），与没有进食障碍的婴儿相比，12个月时头围更小（p = 0.006）。鼻胃管（NGT）的存在与术前PFD相关（p = 0.01），与12个月PFD相关（p = 0.01），但阳性预测值较低（VPP分别为61%和50%）。术前或术后NGT与12个月时的神经发育结果无显著相关性。但12个月PFD与较低的ASQ沟通结果相关（p = 0.04）。结论在手术前由语言治疗师诊断出的喂养困难（不仅仅是喂食管的存在）可以作为预测这一人群神经发育问题的早期预警信号，并有助于识别需要专门支持的早产儿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Association between pediatric feeding disorders (PFD) and suboptimal neurodevelopment (SND) in children with congenital heart disease requiring bypass surgery in the first year of life: Results from a single-center prospective observational study

Introduction

Suboptimal neurodevelopmental issues concern 30 to 60% of infants with congenital heart disease, cardiac surgery before 1 year being a major risk factor. We ought to demonstrate the association between pediatric feeding disorders (PFD) and suboptimal neurodevelopment (SND) in this population.

Method

We conducted a prospective study to assess the prevalence of PFD, as defined by Goday et al., diagnosed by a speech therapist, and their correlation with SND at twelve months in children who underwent surgery with cardiopulmonary bypass (CPB) before the age of one. A total of 45 children were included between October 2020 and February 2024 in a systematic monitoring protocol of our institution.

Results

Preoperatively, 38% of infants had a PFD, compared to 29% at twelve months (Figure 1a) Additionally, 77% showed suboptimal neurodevelopment (SND) (defined by ASQ < 2SD and/or AIMS <5 ^th percentile) at 12 months (Figure 1b and c). No significant association was found between PFD and neurodevelopment at twelve months, but preoperative PFD was linked to SND at twelve months (p = 0,03). Infants with preoperative PFD were more cyanotic before surgery (p = 0.017), underwent surgery at an older age (p = 0.013), and had a smaller head circumference at twelve months (p = 0.006) compared to those without feeding disorders. The presence of a nasogastric tube (NGT) was associated with preoperative PFD (p = 0.01), and with 12 months PFD (p = 0.01) but positive predictive value was low (VPP respectively 61% and 50%). NGT pre or postoperatively was not significantly associated with neurodevelopment outcome at twelve months. But 12 months PFD was associated with lower ASQ communication result (p = 0.04).

Conclusion

Feeding difficulties diagnosed by speech therapists (and not only the presence of a feeding tube) appearing before surgery could serve as an early warning sign to predict neurodevelopmental issues in this population and help identify prematurely children that will need dedicated support.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Archives of Cardiovascular Diseases 医学-心血管系统

CiteScore

4.40

自引率

6.70%

发文量

审稿时长

34 days

期刊介绍： The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.