Archives of Cardiovascular Diseases最新文献

{"title":"Éditorial","authors":"Le Comité d’organisation local, Philippe Acar, Nicolas Combes, Clément Karsenty, toute l’équipe médico-chirurgicale toulousaine","doi":"10.1016/j.acvd.2024.09.001","DOIUrl":"10.1016/j.acvd.2024.09.001","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between cardiopulmonary exercise test variables and health-related quality of life among children with idiopathic or heritable pulmonary hypertension","authors":"V. Dubois ,&nbsp;C. Soulatges ,&nbsp;F. El Louali ,&nbsp;C. Ovaert","doi":"10.1016/j.acvd.2024.07.034","DOIUrl":"10.1016/j.acvd.2024.07.034","url":null,"abstract":"<div><h3>Introduction</h3><p>Pulmonary hypertension (PH) is a progressive disease characterized by elevation of pulmonary vascular resistance, ultimately leading to right ventricular failure and premature death. Traditionally, physical activity has been restricted for these patients, but there's a current trend to customize exercise programs based on CPET results.</p><p>Quality of life (QoL) now stands as a determinant “patient-related outcome” and is frequently used as a secondary endpoint in cardiovascular clinical trials. Little is known about the relation between CPET data and QoL in patients with idiopathic or heritable pulmonary hypertension in children.</p></div><div><h3>Objective</h3><p>The primary objective was to correlate self and parent-reported QoL with CPET variables, while the secondary objective was to correlate QoL and CPET variables with other clinical, biological, echocardiographic or hemodynamic parameters.</p></div><div><h3>Methods</h3><p>The study was conducted retrospectively at Marseille University Hospital, involving nine children (7 heritable PH, 2 idiopathic PH) who underwent CPET and completed QoL questionnaires.</p><p>Following data were extracted from clinical files for analysis: peak of VO2, ventilatory anaerobic threshold (AT), VE/VCO2 slope and ST-wave changes on CPET; pediatric quality of life (PedsQL 4.0TM) on QoL questionnaires; age and years since diagnosis, last available RV to LV pressure ratio, mPA pressure and indexed pulmonary resistance, RV ejection fraction, NT-proBNP level.</p></div><div><h3>Expected results</h3><p>Characteristics at time of diagnosis are summarized in <span><span>Table 1</span></span>. Results are summarized in <span><span>Table 2</span></span>.</p><p>CPET parameters are very abnormal in this population and might correlate with QoL, but also with other clinical and hemodynamic severity indexes.</p><p>It is important to mention that all CPET were performed in stable conditions (once optimal treatment was achieved) and were all uneventful.</p></div><div><h3>Perspectives</h3><p>To our opinion, CPET is an important and useful tool to assess QoL but also to guide clinical management, and elaborate appropriate rehabilitation programs. This small study might serve as a pilot study before a large multicentric study.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values of cardiopulmonary exercise test parameters in the contemporary paediatric population","authors":"A. Gavotto ,&nbsp;P. Amedro ,&nbsp;S. Guillaumont ,&nbsp;G. De La Villeon ,&nbsp;M. Vincenti ,&nbsp;H. Huguet ,&nbsp;M.C. Picot ,&nbsp;T. Mura","doi":"10.1016/j.acvd.2024.07.030","DOIUrl":"10.1016/j.acvd.2024.07.030","url":null,"abstract":"<div><h3>Introduction</h3><p>The evaluation of health status by cardiopulmonary exercise test (CPET) has shown increasing interest in the paediatric population. Our group recently established reference Z-score values for paediatric cycle ergometer VO₂max, applicable to normal and extreme weights, from a cohort of 1141 healthy children. There are currently no validated reference values for the other CPET parameters in the paediatric population.</p></div><div><h3>Objective</h3><p>This study aimed to establish, from the same cohort, reference Z-score values for the main paediatric cycle ergometer CPET parameters, apart from VO₂max.</p></div><div><h3>Methods</h3><p>Cross-sectional study.</p></div><div><h3>Results</h3><p>In total, 909 healthy children aged 5 to 18 years old underwent a CPET. Linear, quadratic, and polynomial mathematical regression equations were applied to identify the best CPET parameters Z-scores, according to anthropometric parameters (sex, age, height, weight, and BMI). This study provided Z-scores for maximal CPET parameters (heart rate, respiratory exchange ratio, workload, and oxygen pulse), submaximal CPET parameters (ventilatory anaerobic threshold, VE/VCO₂slope, and oxygen uptake efficiency slope), and maximum ventilatory CPET parameters (tidal volume, respiratory rate, breathing reserve, and ventilatory equivalent for CO₂ and O₂) (<span><span>Fig. 1</span></span>).</p></div><div><h3>Conclusion</h3><p>This study defined paediatric reference Z-score values for the main cycle ergometer CPET parameters, in addition to the existing reference values for VO₂max, applicable to children of normal and extreme weights. Providing Z-scores for CPET parameters in the paediatric population should be useful in the follow-up of children with various chronic diseases. Thus, new paediatric research fields are opening up, such as prognostic studies and clinical trials using cardiopulmonary fitness outcomes.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal movements following heart surgery: A series of pediatric post-pump chorea","authors":"S. Bernheim,&nbsp;E. Saarda,&nbsp;M. Hully,&nbsp;C.J. Roux,&nbsp;M. Kossorotof,&nbsp;F. Bajolle,&nbsp;D. Bonnet,&nbsp;O. Raisky","doi":"10.1016/j.acvd.2024.07.033","DOIUrl":"10.1016/j.acvd.2024.07.033","url":null,"abstract":"<div><h3>Introduction</h3><p>Neurological disorders following heart surgery are mainly attributable to strokes. However there is a rare cause of abnormal movement following heart surgery: post-pump chorea. This complication is rare and poorly described particularly with regard to its therapeutic management and evolution.</p></div><div><h3>Methods</h3><p>Descriptive monocentric retrospective study including all children with post-pump chorea over a 10-year period (2014–2023). Clinical presentation, radiological findings, and outcomes were analyzed based on clinical, biological, and cerebral imaging data.</p></div><div><h3>Results</h3><p>Over 10<!--> <!-->years, 7059 pediatric cardiac surgeries with cardiopulmonary bypass (CBP) were performed at Necker hospital, and 11 patients experienced post-pump chorea (0.15%), including 5 boys (45%). Median age at the diagnosis of post-pump chorea was 5.7<!--> <!-->years [0.45–9.9]. One patient was premature, and none had genetic syndromes. Median BMI was low (14.8 [11.9–17.4]). Six patients had cyanotic heart disease. Six patients (55%) had previously undergone surgery with CBP. Median CBP duration and length of stay in the intensive care unit were typical, at 132<!--> <!-->minutes [64–362] and 6<!--> <!-->days [1–186], respectively. The interval between surgery and symptom onset was 20<!--> <!-->days [4–64], with a median duration of 44<!--> <!-->days [3–181]. Abnormal movements primarily affected the face (100%) and were often bilateral (82%), involving the upper limbs (91%) and lower limbs (82%). Initial cerebral MRI did not show recent ischemic lesions. Six patients (55%) received medical treatment: tetrabenazine (<em>n</em> <!-->=<!--> <!-->2), intravenous immunoglobulins (<em>n</em> <!-->=<!--> <!-->1), corticosteroids (<em>n</em> <!-->=<!--> <!-->1), L-Dopa (<em>n</em> <!-->=<!--> <!-->1), cyamemazine (<em>n</em> <!-->=<!--> <!-->1). Chorea persisted beyond 6 months in only 1 out of 11 patients.</p></div><div><h3>Conclusion</h3><p>Post-pump chorea is extremely rare and can occur several months after cardiac surgery. It does not appear to be directly related to perioperative severity criteria. The prognosis is generally favorable within 6<!--> <!-->months following diagnosis.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant congenital cardiac mortality and univentricular hearts in Latin America and Caribbean: A population-based study in French Guiana","authors":"H. Lucron ,&nbsp;M. Brard ,&nbsp;J. D’orazio ,&nbsp;L. Long ,&nbsp;A. Le Harrivel De Gonneville ,&nbsp;S. Tuttle ,&nbsp;N. Elenga ,&nbsp;J. Inamo ,&nbsp;D. Bonnet ,&nbsp;R. Banydeen","doi":"10.1016/j.acvd.2024.07.047","DOIUrl":"10.1016/j.acvd.2024.07.047","url":null,"abstract":"<div><h3>Introduction</h3><p>Except for projections from the Global Burden of Disease (GBD) study, congenital heart disease (CHD) burden remains undetermined in Latin America and Caribbean (LAC), especially for complex types such as functionally univentricular hearts (FUH) responsible for higher disease morbidity and mortality.</p></div><div><h3>Objective</h3><p>To describe CHD prevalence, characteristics and related infant mortality in French Guiana, a LAC territory.</p></div><div><h3>Methods</h3><p>Population-based registry analysis of all fetal and live birth (LB) CHD cases from January 2012 to December 2016.</p></div><div><h3>Results</h3><p>Overall, 231 CHD were diagnosed, among which 56 fetal diagnoses and 215 resulting LB. Among all CHD (<em>n</em> <!-->=<!--> <!-->231), there were 18.6% of chromosomal or genetic anomalies, and 6.5% of termination of pregnancy for fetal anomaly. Total and LB CHD prevalence were respectively 68.4 [95% CI: 67.9–68.8] and 65.2 [95% CI: 64.7–65.7] per 10,000, similar to GBD projections for TLA. The total infant mortality in the study sample was 9.4/10,000 LB [95% CI: 9.1–9.7]. Children with FUH presented the highest mortality rates. When compared to mainland France, total FUH prevalence for French Guiana was significantly higher (<em>P</em> <!-->=<!--> <!-->0.03), as were LB FUH prevalence and related infant mortality respectively two to three-fold higher (<em>P</em> <!-->&lt;<!--> <!-->0.01). However, no significant difference was observed for FUH prevalence when compared to GBD projections for TLA. FUH infant mortality could not be contrasted due to the lack of GBD data.</p></div><div><h3>Conclusion</h3><p>This first population-based study ever performed in this part of the world suggests a distinct profile for CHD in the LAC region, with elevated prevalence and mortality rates linked to FUH. Another potential determinant of the excess mortality risk might be the frequent presence of chromosomal or genetic anomalies. This constitutes a stepping-stone towards better understanding CHD burden and underlying specificities while providing future keys towards reducing infant mortality in French Guiana and others surrounding countries.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: An international multicentre study","authors":"J. Grynblat ,&nbsp;H.J. Bogaard ,&nbsp;M. Eyries ,&nbsp;O. Meyrignac ,&nbsp;L. Savale ,&nbsp;M.R. Ghigna ,&nbsp;L. Celant ,&nbsp;A. Houweling ,&nbsp;M. Levy ,&nbsp;F. Antigny ,&nbsp;A. Chaouat ,&nbsp;V. Cottin ,&nbsp;D. Bonnet ,&nbsp;M. Humbert ,&nbsp;D. Montani","doi":"10.1016/j.acvd.2024.07.032","DOIUrl":"10.1016/j.acvd.2024.07.032","url":null,"abstract":"<div><h3>Introduction</h3><p>Bone morphogenetic proteins 9 and 10 (BMP9 and BMP10), encoded by GDF2 and BMP10, respectively, play a pivotal role in pulmonary vascular regulation. GDF2 variants have been reported in pulmonary arterial hypertension (PAH) and hereditary haemorrhagic telangiectasia (HHT). However, the phenotype of GDF2 and BMP10 carriers remains largely unexplored.</p></div><div><h3>Objective</h3><p>Describe the features of <em>GDF2</em> and <em>BMP10</em> carriers with PAH.</p></div><div><h3>Methods</h3><p>We report the characteristics and outcomes of PAH patients in GDF2 and BMP10 carriers from the French and Dutch pulmonary hypertension registries. A literature review explored the phenotypic spectrum of these patients.</p></div><div><h3>Results</h3><p>Twenty-six PAH patients were identified: 20 harbouring heterozygous GDF2 variants, one homozygous GDF2 variant, four heterozygous BMP10 variants, and one with both GDF2 and BMP10 variants. The prevalence of GDF2 and BMP10 variants was 1.3% and 0.4%, respectively. Median age at PAH diagnosis was 30 years, with a female/male ratio of 1.9. Congenital heart disease (CHD) was present in 15.4% of the patients. At diagnosis, most of the patients (61.5%) were in New York Heart Association Functional Class III or IV with severe haemodynamic compromise [median (range) pulmonary vascular resistance 9.0 (3.3–40.6) WU]. Haemoptysis was reported in four patients; none met the HHT criteria. Two patients carrying BMP10 variants underwent lung transplantation, revealing typical PAH histopathology. The literature analysis showed that 7.6% of GDF2 carriers developed isolated HHT, and identified cardiomyopathy and developmental disorders in BMP10 carriers (<span><span>Fig. 1</span></span>).</p></div><div><h3>Conclusion</h3><p>GDF2 and BMP10 pathogenic variants are rare among PAH patients, and occasionally associated with CHD. HHT cases among GDF2 carriers are limited according to the literature. BMP10 full phenotypic ramifications warrant further investigation.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restrictive LV-PA conduit in ccTGA with VSD and LVOTO","authors":"A. Moiroux-Sahraoui,&nbsp;N. Derridj,&nbsp;R. Gaudin,&nbsp;M. Pontailler,&nbsp;P. Vouhe,&nbsp;D. Bonnet,&nbsp;O. Raisky","doi":"10.1016/j.acvd.2024.07.015","DOIUrl":"10.1016/j.acvd.2024.07.015","url":null,"abstract":"<div><h3>Introduction</h3><p>Congenitally corrected transposition of the great arteries (ccTGA) is a rare, complex and challenging structural heart disease. Therapeutic management remains controversial, particularly in patients with left ventricle outflow tract obstruction (LVOTO). As the natural history of ccTGA with LVOTO is overall very satisfactory and interventions that increase sub-pulmonary left ventricle (LV) pressure load are associated with a reduction of tricuspid regurgitation (TR) and systemic right ventricle (RV) dysfunction, we began to use restrictive left ventricle-to-pulmonary artery (LV-PA) conduit without ventricular septal defect (VSD) closure as part of the physiological repair of ccTGA/VSD/LVOTO.</p></div><div><h3>Objective</h3><p>To report on the outcome of ccTGA/VSD/LVOTO patients treated with restrictive LV-PA conduit without VSD closure.</p></div><div><h3>Methods</h3><p>Between 1979 and 2024, 9 consecutive patients with ccTGA/non-restrictive VSD/LVOTO underwent restrictive LV-PA conduit interposition without VSD closure at Necker Sick Children's Hospitals (Paris, France).</p></div><div><h3>Results</h3><p>Six (66.7%) patients had pulmonary stenosis and 3 (33.3%) patients had pulmonary atresia. Median age and weight at surgery were 5 (IQR: 16.6) years and 18 (IQR: 36.5) kgs. Five (55.6%) patients had previously undergone surgical palliation. No patient died after surgery with a median follow-up of 9.8 (IQR: 13.4) years. No patient required permanent pacemaker implantation for complete AV block. Freedom from reintervention was 62.5% (95% CI: 22.9–86.1) at 10<!--> <!-->years. Late reintervention consisted in LV-PA conduit replacement (<em>n</em> <!-->=<!--> <!-->3), PA stenting (<em>n</em> <!-->=<!--> <!-->1) and one and half ventricle repair (hemi-Senning, Glenn, Rastelli, <em>n</em> <!-->=<!--> <!-->1). At last follow-up, only one patient was significantly limited in physical activity (NYHA class III). No patient developed atrial or ventricular arrythmia. No patients developed moderate or severe TR and only 2 (22.2%) patients had decreased RV function and dilatation.</p></div><div><h3>Conclusion</h3><p>We believe that restrictive LV-PA conduit placement without VSD closure represents a worthwhile biventricular alternative strategy to anatomic repair when it is deemed too risky and/or impractical.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and results of the ongoing French and Caribbean congenital cardiac catheterization program","authors":"H. Lucron ,&nbsp;M. Brard ,&nbsp;V. Atallah ,&nbsp;J. D’orazio ,&nbsp;S. Tuttle ,&nbsp;J. Yssap ,&nbsp;C. Isetta ,&nbsp;F. Lion ,&nbsp;A. Le Harrivel De Gonneville ,&nbsp;Y. Hatchuel ,&nbsp;J. Inamo ,&nbsp;F. Barbotin-Larrieu","doi":"10.1016/j.acvd.2024.07.045","DOIUrl":"10.1016/j.acvd.2024.07.045","url":null,"abstract":"<div><h3>Introduction</h3><p>Disparities persist regarding the access to pediatric and congenital cardiac catheterization procedures (PCCC). Developing capacities in French overseas territories located far away from mainland France remains essential to reducing inequalities and mortality.</p></div><div><h3>Objective</h3><p>To describe the characteristics of patients, procedures type risk categories (PTRC) and outcomes for all PCCC performed on the French island of Martinique (Caribbean).</p></div><div><h3>Methods</h3><p>Single center observational study. We recorded prospectively all consecutives PCCC performed in the catheter laboratory of the university Hospital of Martinique from January 2007 to December 2023. Demographics, procedures characteristics, PTRC, adverse events occurrence, as well as 24-hours mortality were documented. All results were retrospectively analysed.</p></div><div><h3>Results</h3><p>We performed 869 PCCC in 770 consecutives patients (31.3%<!--> <!-->&lt;<!--> <!-->1-year-old; 9.4% aged<!--> <!-->&lt;<!--> <!-->1<!--> <!-->month) living in French territories (90%) of Martinique, Guadeloupe, French Guiana, Saint-Martin, or natives from others Caribbean islands (10%). The median age and weight (IQR) were 4<!--> <!-->years (0.6–13) and 16<!--> <!-->kg (6.4–4.6). There were 126 urgent and 43 (4.9%) rescue procedures. PCCC were predominantly interventional (68.7%; success rate: 95.1%) covering all types of procedures, except revalvulation. The overall median PTRC was 2 (2–3) with a 24-h mortality of 1.1%. Complications occurred in 35 cases (4%), of which 18 were major, either procedure and anaesthesia-related (40%) or likely linked (40%) to the critical condition on admission at the cathlab. Overtime, the case-mix complexity continued to increase (PTRC<!--> <!-->&gt;<!--> <!-->3 in 25% of patients, with a median age and weight of 2.6<!--> <!-->years and 6.5<!--> <!-->kg, within the past 5<!--> <!-->years).</p></div><div><h3>Conclusion</h3><p>Developing permanent PCCC capabilities in French Martinique is efficient and safe. This ongoing international program is sustainable with the inclusion of patients coming from all French territories and neighbouring Caribbean islands and the continuous support of French Health Authorities.</p></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and design of the French Observatory of Acute Heart Failure (OFICA2)","authors":"Claire Bouleti ,&nbsp;Benjamin Alos ,&nbsp;Damien Legallois ,&nbsp;Romain Eschalier ,&nbsp;Jerome Costa ,&nbsp;Victoria Tea ,&nbsp;Jean-Noel Trochu ,&nbsp;Guillaume Turlotte ,&nbsp;Julie Perrin-Faurie ,&nbsp;Teodora Dutoiu ,&nbsp;François Picard ,&nbsp;Gregory Ducrocq ,&nbsp;Pascal de Groote ,&nbsp;Thierry Laperche ,&nbsp;Clement Delmas ,&nbsp;Ariel Cohen ,&nbsp;Maxime Doublet ,&nbsp;Damien Logeart","doi":"10.1016/j.acvd.2024.05.120","DOIUrl":"10.1016/j.acvd.2024.05.120","url":null,"abstract":"<div><h3>Background</h3><div>Acute heart failure (AHF) is a leading cause of hospitalization and mortality – especially in patients aged<!--> <!-->≥<!--> <!-->65 years in high-income countries – and represents a high healthcare burden. In the past decade, the epidemiology and management of heart failure (HF) has changed, with the emergence of new medical and interventional therapeutics, but up-to-date real-life data are scarce.</div></div><div><h3>Aims</h3><div>The main objectives are to describe baseline characteristics (with an emphasis on lifestyle, cognitive status, HF knowledge and treatment adherence), management, and in-hospital and mid-term outcomes of AHF patients in France. Secondary objectives are to investigate determinants of prognosis, modalities of treatment and follow-up, and identify gaps between guidelines and real-life management.</div></div><div><h3>Methods</h3><div>OFICA2 is a prospective multicentre observational survey that enrolled 1513 patients hospitalized for AHF in 80 participating centres in France during March and April 2021. The diagnosis of AHF was made according to the European Society of Cardiology guidelines definition. Inclusion criteria were age<!--> <!-->≥<!--> <!-->18<!--> <!-->years, health coverage and consent to participate. Detailed information was collected prospectively starting at admission. Thanks to direct linking with the French National Health Database, the anteriority up to 2<!--> <!-->years before inclusion, as well as a 3-year follow-up is specified for each patient and includes individual information on death, hospital admissions, major clinical events, drug delivery and use of reimbursed health resources.</div></div><div><h3>Conclusion</h3><div>This cohort provides a representative snapshot on contemporary AHF, with a particular focus on self-care determinants, and will improve knowledge about AHF presentation, management and outcomes.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific predictive factors of smoking cessation in subjects at high cardiovascular risk","authors":"Ingrid Allagbé ,&nbsp;Marianne Zeller ,&nbsp;Daniel Thomas ,&nbsp;Guillaume Airagnes ,&nbsp;Frédéric Limosin ,&nbsp;Abdelali Boussadi ,&nbsp;Frédéric Chagué ,&nbsp;Anne-Laurence Le Faou","doi":"10.1016/j.acvd.2024.06.001","DOIUrl":"10.1016/j.acvd.2024.06.001","url":null,"abstract":"<div><div>Smoking is a major risk factor for cardiovascular diseases (CVD), in particular in women, but smoking cessation (SC) reduces or even cancels the risk for both sexes. Using a nationwide SC services database, we aimed to determine the predictive factors of SC in men and women smokers with CV risk factors (CVRF) or CVD. A retrospective study from the French CDTnet database was conducted. Inclusion criteria were age ≥<!--> <!-->18<!--> <!-->years, and<!--> <!-->≥<!--> <!-->1 CVRF (Body Mass Index ≥<!--> <!-->25<!--> <!-->kg/m², hypertension, diabetes, hypercholesterolemia) or CVD (myocardial infarction (MI) or angina pectoris, stroke, peripheral arterial disease [PAD]). Self-reported smoking abstinence (≥<!--> <!-->28 consecutive days) was confirmed by exhaled carbon monoxide<!--> <!-->&lt;<!--> <!-->10<!--> <!-->ppm. Logistic regression analysis assessed the association between SC and sociodemographic, medical characteristics, and smoking profile. Among the 36,864 smokers at high CV risk, abstinence rate was slightly lower in women than in men, (52.6% [<em>n</em> <!-->=<!--> <!-->8,102] vs 55.0% [<em>n</em> <!-->=<!--> <!-->11,848], <em>P</em> <!-->&lt;<!--> <!-->0.001). For both sexes, factors associated with the lowest abstinence rates were diabetes, respiratory and psychiatric diseases, anxiolytic/antidepressant use, and cannabis consumption. In women, the factors associated with smoking abstinence were suffering from MI or angina and taking contraceptive pill and the factors associated with persistent smoking were alcohol disorder and high cigarette consumption. In men, there was a positive relationship between overweight and abstinence while being dual users of cigarettes and electronic cigarettes at first visit, having tobacco-related diseases (cancer and PAD) and taking opioid substitution treatment were associated with persistent smoking. Finally, in both sexes, the factors associated with abstinence were: age<!--> <!-->≥<!--> <!-->65<!--> <!-->years, having a diploma, being employed, self-referred or encouraged by entourage, ≥<!--> <!-->1 previous quit attempt, ≤<!--> <!-->20 cigarettes per day consumption, benefiting from SC medication prescription and ≥<!--> <!-->4 follow-up visits. In conclusion, our results suggest the relevance of SC intensive management in smokers at high CV risk, based on sociodemographic, medical, and smoking behaviour characteristics, as well as a gender-specific SC approach.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}