Archives of Cardiovascular Diseases最新文献

{"title":"Impact of initial angiographic coronary flow on survival after out-of-hospital cardiac arrest","authors":"Emmie Lasik,&nbsp;Fabien Picard,&nbsp;Pierre Brami,&nbsp;Alain Cariou,&nbsp;Olivier Varenne,&nbsp;Vincent Pham","doi":"10.1016/j.acvd.2026.02.005","DOIUrl":"10.1016/j.acvd.2026.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital cardiac arrest (OHCA) remains associated with poor outcomes despite advances in care. Coronary artery disease is the leading cause, yet the prognostic role of initial coronary flow status, assessed by Thrombolysis In Myocardial Infarction (TIMI) grade at angiography, has not been fully explored in OHCA survivors.</div></div><div><h3>Aim</h3><div>To evaluate the prognostic impact of preprocedural TIMI flow in this population, and to identify predictive factors for reduced TIMI flow.</div></div><div><h3>Methods</h3><div>We analysed data from the prospective PROCAT registry, including consecutive patients with OHCA with no extracardiac cause who underwent early coronary angiography between May 2016 and August 2022 at Cochin Hospital, Paris. Patients were categorized into three groups: non-ischaemic OHCA (OHCAni); ischaemic OHCA with preserved flow (TIMI 2–3; OHCAi2–3); and ischaemic OHCA with reduced flow (TIMI 0–1; OHCAi0–1). The primary endpoint was 1-year death; secondary endpoints included in-hospital death, neurological outcome at discharge and major bleeding (Bleeding Academic Research Consortium types 3–5).</div></div><div><h3>Results</h3><div>Among 330 patients, 181 (55%) had OHCAni, 58 (18%) had OHCAi2–3 and 91 (27%) had OHCAi0–1. The 1-year death rate was significantly higher in the OHCAni group (66.7%) than in the ischaemic OHCA groups (OHCAi2–3, 34.5%; OHCAi0–1, 36.7%; <em>P</em> <!-->&lt;<!--> <!-->0.001). Favourable neurological outcome (Cerebral Performance Category 1–2) at hospital discharge was observed in 64.4% of the OHCAni group versus 64.9% and 58.9% in the OHCAi2–3 and OHCAi0–1 groups, respectively (<em>P</em> <!-->&lt;<!--> <!-->0.001). Major bleeding was more frequent in the OHCAi2–3 group (28.1%) than the OHCAi0–1 group (11.5%; <em>P</em> <!-->=<!--> <!-->0.02). In multivariable analysis restricted to ischaemic OHCA, reduced TIMI flow independently predicted 1-year death (odds ratio 2.58, 95% confidence interval 1.02–7.22; <em>P</em> <!-->=<!--> <!-->0.05), along with older age, longer low-flow duration and absence of shockable rhythm.</div></div><div><h3>Conclusions</h3><div>Ischaemic and non-ischaemic OHCA represent distinct clinical entities, with markedly poorer outcomes in the non-ischaemic group. In ischaemic OHCA, reduced preprocedural TIMI flow is an independent predictor of 1-year death despite high procedural success rates. Early assessment of coronary flow may thus provide important prognostic information, and should be integrated into risk stratification models for OHCA survivors.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages 586-593"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index","authors":"","doi":"10.1016/S1875-2136(26)00334-7","DOIUrl":"10.1016/S1875-2136(26)00334-7","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages I16-I18"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing patients’ knowledge and skills after pharmaceutical consultations in interventional cardiology: A competency framework-based approach","authors":"Nathalie Guillon,&nbsp;Cécile Auriault,&nbsp;Fabien Lindenberg,&nbsp;Patrice Guérin,&nbsp;Julien Plessis,&nbsp;Aurélie Fresselinat,&nbsp;Stéphanie Quéric,&nbsp;Pierre-Guillaume Piriou,&nbsp;Robin Le Ruz,&nbsp;Anais Aitgougam,&nbsp;Wissam Abi Khalil,&nbsp;Xavier Iriart,&nbsp;Johann Clouet,&nbsp;David Feldman,&nbsp;Fabien Nativel","doi":"10.1016/j.acvd.2025.12.012","DOIUrl":"10.1016/j.acvd.2025.12.012","url":null,"abstract":"<div><h3>Background</h3><div>Percutaneous closure of patent foramen ovale or atrial septal defect is associated with procedural risks and requires optimal care management. Providing tailored educational support to patients may help to improve their safety and engagement in the care.</div></div><div><h3>Aim</h3><div>To observe the effect of pharmaceutical consultations on the knowledge and skills of patients undergoing percutaneous closure of patent foramen ovale or atrial septal defect.</div></div><div><h3>Methods</h3><div>Multicentre meetings with healthcare professionals from university hospitals, as well as an expert patient, were organized to develop a patient-centred competency framework. Based on this framework, a consultation guide and information sheet were produced to support patients in acquiring key skills for managing their disease. A total of 31 patients were included in the study, 21 of whom attended both the preoperative and 6-month follow-up pharmaceutical consultations to assess changes in knowledge and skills. Patient satisfaction with the consultation and information sheet was evaluated.</div></div><div><h3>Results</h3><div>The competency framework includes 89 skills for patients with patent foramen ovale and 92 for patients with atrial septal defect. This observational study showed an improvement in knowledge and skills between consultations. For example, knowledge regarding cardiac follow-up improved between the preoperative consultation and the 6-month follow-up, increasing from 3 to 9 (<em>P</em> <!-->&lt;<!--> <!-->0.05). Most patients (90%) preferred to have the consultation before the procedure, as it reassured them and enhanced their engagement with care management. All patients expressed satisfaction with the educational tools provided.</div></div><div><h3>Conclusions</h3><div>Pharmaceutical consultations may support patients to acquire the knowledge and skills necessary for safe and autonomous management of their medical devices after returning home.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages 594-603"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental screening in children with congenital heart disease: The Necker Children's Hospital cardiac neurodevelopmental center follow-up","authors":"Neil Derridj,&nbsp;Helena Huguet,&nbsp;Alain Camacho,&nbsp;Anne Cyrielle Plassard,&nbsp;Sylvie Martins,&nbsp;Fanny Bajolle,&nbsp;Damien Bonnet,&nbsp;Johanna Calderon","doi":"10.1016/j.acvd.2026.06.030","DOIUrl":"10.1016/j.acvd.2026.06.030","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental impairments. A systematic neurodevelopmental screening program was implemented at the Necker Children's Hospital. We aimed to describe screening outcomes according to a previously published theoretical neurodevelopmental risk classification and to identify associated risk factors.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental impairments. A systematic neurodevelopmental screening program was implemented at the Necker Children's Hospital. We aimed to describe screening outcomes according to a previously published theoretical neurodevelopmental risk classification and to identify associated risk factors.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Neurodevelopmental screening was conducted during pediatric cardiology visits at Necker Children's Hospital (January 2024–September 2025) using parent-completed ASQ-3, M-CHAT, and SDQ questionnaires with standard cut-offs. Children were classified into four theoretical neurodevelopmental risk groups, and outcomes were compared across groups using multivariable logistic regression within risk strata.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Neurodevelopmental screening was conducted during pediatric cardiology visits at Necker Children's Hospital (January 2024–September 2025) using parent-completed ASQ-3, M-CHAT, and SDQ questionnaires with standard cut-offs. Children were classified into four theoretical neurodevelopmental risk groups, and outcomes were compared across groups using multivariable logistic regression within risk strata.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 255 children with isolated CHD were included (mean age 23&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;19 months; 55% male) and 21% were born preterm. Overall, 69% underwent open-heart surgery and 40% required neonatal surgery. According to theoretical neurodevelopmental risk, 29% were classified as very high risk, 27% high risk, 31% moderate risk, and 13% low risk. Overall, 68% screened positive on the ASQ-3 and 25% on the M-CHAT; among children completing the SDQ (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;31), 65% showed elevated behavioral risk. Screening outcomes did not differ across risk categories in the overall cohort; however, after exclusion of preterm-born children, severe ASQ impairment (≥1 severe domain) was observed in 49%, 35%, 36%, and 33% across the predefined neurodevelopmental risk groups, showing a non-significant trend toward higher rates in the very high-risk group (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.10). In the high/very high-risk no perinatal or surgical determinants were associated with increased neurodevelopmental impairment. In the moderate/low-risk groups, longer cardiopulmonary bypass duration was associated with positive ASQ-3 screening (OR 5.84, 95% CI [1.12–30.47], &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.04).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;A total of 255 children with isolated CHD were included (mean age 23&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S253"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding indications for transaxillary minimally invasive congenital heart surgery","authors":"Bastien Provost,&nbsp;Christoph Haller","doi":"10.1016/j.acvd.2026.06.062","DOIUrl":"10.1016/j.acvd.2026.06.062","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;The transaxillary approach is widely used for atrial-level defects, particularly atrial septal defect (ASD) closure, with outcomes comparable to sternotomy. We sought to describe procedural efficacy and expansion toward more complex lesions in a single-center cohort.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;The transaxillary approach is widely used for atrial-level defects, particularly atrial septal defect (ASD) closure, with outcomes comparable to sternotomy. We sought to describe procedural efficacy and expansion toward more complex lesions in a single-center cohort.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;All patients&lt;!--&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;18 years undergoing transaxillary MICS (minimally invasive cardiac surgery) between 2018 and 2025 were retrospectively included. We recorded demographics, procedure type, cardiopulmonary bypass (CPB) and aortic cross-clamp times, conversions, and early outcomes. Temporal trends and procedural efficiency were assessed across the study period. Postoperative outcomes included complications, conversion, mortality, and hospital length of stay (LOS).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;All patients&lt;!--&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;18 years undergoing transaxillary MICS (minimally invasive cardiac surgery) between 2018 and 2025 were retrospectively included. We recorded demographics, procedure type, cardiopulmonary bypass (CPB) and aortic cross-clamp times, conversions, and early outcomes. Temporal trends and procedural efficiency were assessed across the study period. Postoperative outcomes included complications, conversion, mortality, and hospital length of stay (LOS).&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 348 MICS patients were included (median age 5.63 years [4.01–9.48]). Twenty-nine (8.4%) were below 1 year of age. Procedures comprised ASD closure (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;168, 48.3%), partial anomalous pulmonary venous connection repair (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;72, 20.6%), ventricular septal defect closure (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;36, 10.3%), atrioventricular septal defect repair (partial: n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;45, 12.9%; complete: n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;9, 2.6%), atrioventricular valve repair (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;12, 3.4%), and cavopulmonary connection (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;6, 1.7%). Over time, the proportion of non-ASD procedures increased from 23.8% in the early period (2018–2019) to 54.8% in the late period (2024–2025) (&lt;span&gt;&lt;span&gt;Figure 1&lt;/span&gt;&lt;/span&gt;). When assessed by lesion, median CPB and cross-clamp times decreased over time (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.05). Median LOS was 2.8 days [1.4–4.0]. The overall complication rate was 8%, and conversion to sternotomy was 0.5%. No death occurred.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;A total of 348 MICS patients were included (median age 5.63 years [4.01–9.48]). Twenty-nine (8.4%) were below 1 year of age. Procedures comprised ASD closure (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;168, 48.3%), partial anomalous pulmonary venous connection repair (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;72, 20.6%), ventricular septal def","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S268-S269"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of post-traumatic stress symptoms and anxiety in parents of children with congenital and acquired heart diseases","authors":"Marion Larger,&nbsp;Helena Huguet,&nbsp;Johanna Calderon,&nbsp;Alain Camacho,&nbsp;Fanny Bajolle,&nbsp;Damien Bonnet,&nbsp;Neil Derridj","doi":"10.1016/j.acvd.2026.06.032","DOIUrl":"10.1016/j.acvd.2026.06.032","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Parents of children with congenital and acquired heart diseases (CAHD) are exposed to repeated hospitalizations and potentially traumatic medical events. Data on post-traumatic stress symptoms (PTSS), post-traumatic stress disorder (PTSD), and anxiety in this population remain limited.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Parents of children with congenital and acquired heart diseases (CAHD) are exposed to repeated hospitalizations and potentially traumatic medical events. Data on post-traumatic stress symptoms (PTSS), post-traumatic stress disorder (PTSD), and anxiety in this population remain limited.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This prospective, monocentric observational study was conducted at Necker–Enfants-Malades Hospital (Paris, France). Parents were invited to complete psychosocial questionnaires as part of a systematic neurocardiac follow-up program. Parents who completed questionnaires between February 2024 and June 2025 were included. Anxiety was assessed using the STAI-Y2 scale. PTSD was defined by a PCL-5 score&lt;!--&gt; &lt;!--&gt;≥&lt;!--&gt; &lt;!--&gt;31, and PTSS by the presence of significant symptoms across the four DSM-5 clusters (intrusion [B], avoidance [C], negative alterations in cognition and mood [D], and hyperarousal [E]). Univariate and multivariable logistic regression analyses were performed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;This prospective, monocentric observational study was conducted at Necker–Enfants-Malades Hospital (Paris, France). Parents were invited to complete psychosocial questionnaires as part of a systematic neurocardiac follow-up program. Parents who completed questionnaires between February 2024 and June 2025 were included. Anxiety was assessed using the STAI-Y2 scale. PTSD was defined by a PCL-5 score&lt;!--&gt; &lt;!--&gt;≥&lt;!--&gt; &lt;!--&gt;31, and PTSS by the presence of significant symptoms across the four DSM-5 clusters (intrusion [B], avoidance [C], negative alterations in cognition and mood [D], and hyperarousal [E]). Univariate and multivariable logistic regression analyses were performed.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 422 parents were included; 79% were mothers. Median child age was 4 months at hospital discharge and 2 years at psychosocial assessment. Overall, 322 parents completed the PCL-5 and 367 completed the STAI-Y2. Based on the PCL-5, 15% of parents met criteria for PTSD. Among parents completing the PCL-5, 50.6% reported intrusion symptoms (criterion B), 37.6% avoidance (criterion C), 28.0% negative alterations in cognition and mood (criterion D), and 31.7% hyperarousal symptoms (criterion E). A clinically significant anxious state was identified in 17% of parents overall. The composite outcome of PTSD or anxiety was present in 26% of parents. In multivariable analyses, no clinical or care-related variable was independently associated with PTSD. A family history of CAHD was independently associated with anxiety (adjusted OR 2.50, 95% CI 1.03–6.06) and showed a borderline association with the composite outcome of PTS","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S254"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GACH Study–Tolerability and efficacy of SGLT2 inhibitors in adults with congenital heart disease and heart failure","authors":"Olivia Domanski,&nbsp;Clement Karsenty,&nbsp;Jean Louchet,&nbsp;Reaksmei Ly,&nbsp;Nicolas Combes,&nbsp;Pascal Amédro,&nbsp;Mathieu Albertini,&nbsp;Fabien Labombarda,&nbsp;Jelena Radojevic,&nbsp;Laurianne Le Gloan,&nbsp;Alexandre Delarue,&nbsp;Claire Massardier,&nbsp;Bouzguenda Ivan,&nbsp;Marie Agness Bakhoum,&nbsp;Anne Claire Casalta,&nbsp;Sophie Guillaumont,&nbsp;Aurelien Capogna,&nbsp;Bruno Lefort,&nbsp;Sebastien Hascoet,&nbsp;Pamela Moceri","doi":"10.1016/j.acvd.2026.06.012","DOIUrl":"10.1016/j.acvd.2026.06.012","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Heart failure in patients with congenital heart disease increases with age. The effect of SGLT2 inhibitors in this population is poorly studied in literature.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Heart failure in patients with congenital heart disease increases with age. The effect of SGLT2 inhibitors in this population is poorly studied in literature.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods and objective&lt;/h3&gt;&lt;div&gt;To study the tolerability and efficacy of SGLT2 inhibitors in patients with heart failure due to congenital heart disease. The primary endpoint was a composite endpoint combining a significant decrease in NYHA class and/or BNP (or NT-proBNP) at 6–12 months.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;To study the tolerability and efficacy of SGLT2 inhibitors in patients with heart failure due to congenital heart disease. The primary endpoint was a composite endpoint combining a significant decrease in NYHA class and/or BNP (or NT-proBNP) at 6–12 months.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;140 patients were included in 14 French centers from December 2023 to May 2025 (including 20 Fontan patients, 37 transposition of the great arteries with atrial switch, and 13 Congenitally Corrected Transposition of the Great Arteries). Mean age was 47&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;13 years. 61% were male. Mean follow-up duration was 8.7&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;3.4 months. Mean BMI was 26&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;5. Thirty-nine (30%) patients were overweight (BMI 25 to 30), and 30 (23%) had moderate or severe obesity (BMI 30 to 40). Eighty-four patients (60%) had a history of arrhythmia (flutter, atrial fibrillation, ventricular tachycardia), 39 (28%) had a pacemaker (including 4 triple chamber), and 31 (22%) had a defibrillator. Regarding cardiovascular risk factors: 6 (4%) patients had diabetes, 13 (9%) hypertension, and 5 (3.6%) chronic kidney disease.&lt;/div&gt;&lt;div&gt;132 patients were treated with dapaglifozine, and 8 patients with empaglifozine. 88 patients (67%) (95% CI [59%; 76%]) met the primary endpoint (78% of systemic right ventricles, 59% of single ventricles). The presence of congestive signs in patients decreased significantly from 24% to 10% at 6–12 months (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.0015). Median NT-proBNP level at baseline was 1098&lt;!--&gt; &lt;!--&gt;ng/L [24; 1249] and decreased to 781&lt;!--&gt; &lt;!--&gt;ng/L [210; 1001] at 6–12 months. Echocardiographic ejection fraction of the systemic ventricle increased significantly from 41&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;12% to 42&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;12% (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.049). There was no significant difference in ejection fraction on MRI (but only 38 patients had MRI at inclusion) nor on peak VO&lt;sub&gt;2&lt;/sub&gt;.&lt;/div&gt;&lt;div&gt;Five patients (4%) experienced adverse event (3 urogenital infections, 2 fungal infections), leading to temporary discontinuation in 2 patients and permanent discontinuation in 1.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;140 patients were included in 14 French centers from December 2023 to May 2025 (including 20 Fontan patients, 37 transposition of the great arteries with","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S244"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of congenital heart disease, maternal environmental factors and neurodevelopmental outcomes: Evidence from a French multicenter cohort","authors":"Betty Bretin,&nbsp;Norbert Winer,&nbsp;Valerie Rouger,&nbsp;Garance Devarenne,&nbsp;Bénédicte Gaillard Le Roux,&nbsp;Marie Demonceaux,&nbsp;Thomas Moyon,&nbsp;Alban-Elouen Baruteau","doi":"10.1016/j.acvd.2026.06.015","DOIUrl":"10.1016/j.acvd.2026.06.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Congenital heart disease (CHD) is the leading cause of fetal malformations and remains a major determinant of morbidity in childhood. Children with CHD are at increased risk of neurodevelopmental disorders (NDD). The severity of CHD strongly influences clinical management and long-term outcomes, including neurodevelopment. Adverse maternal environment may play a major role in CHD and NDD induction. Additionally, contribution of CHD severity to NDD remains unclear.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Congenital heart disease (CHD) is the leading cause of fetal malformations and remains a major determinant of morbidity in childhood. Children with CHD are at increased risk of neurodevelopmental disorders (NDD). The severity of CHD strongly influences clinical management and long-term outcomes, including neurodevelopment. Adverse maternal environment may play a major role in CHD and NDD induction. Additionally, contribution of CHD severity to NDD remains unclear.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We analyzed obstetrical and pediatric data from a French multicenter retrospective cohort including 334 women who delivered infants with CHD between 2012 and 2023. Neurodevelopmental follow-up at 2, 5 or 7 years was available for a third of them. CHD severity was categorized as critical-complex, non-critical complex and non-complex according to the classification used by the French Reference Center for Complex Congenital Cardiac Malformations (M3C) and time to cardiac surgery. NDD were assessed using the Strengths and Difficulties Questionnaire (SDQ), the Ages and Stages Questionnaire (ASQ) and a standardized teacher-completed questionnaire. Multinomial multivariate logistic regression was used to evaluate associations between maternal environmental factors, CHD severity and NDD.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;We analyzed obstetrical and pediatric data from a French multicenter retrospective cohort including 334 women who delivered infants with CHD between 2012 and 2023. Neurodevelopmental follow-up at 2, 5 or 7 years was available for a third of them. CHD severity was categorized as critical-complex, non-critical complex and non-complex according to the classification used by the French Reference Center for Complex Congenital Cardiac Malformations (M3C) and time to cardiac surgery. NDD were assessed using the Strengths and Difficulties Questionnaire (SDQ), the Ages and Stages Questionnaire (ASQ) and a standardized teacher-completed questionnaire. Multinomial multivariate logistic regression was used to evaluate associations between maternal environmental factors, CHD severity and NDD.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Maternal psychological distress (OR 0.39, 95% CI [0.18–0.87]) and nulliparity (OR 1.77, 95% CI [1.08–2.90]) were associated with a lower probability of severe CHD. CHD severity was not significantly associated with NDD at 2, 5 or 7 years. Maternal age&lt;!--&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;25 years or&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;30 years, second parity and gestational w","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S245-S246"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmias in congenitally corrected transposition of the great arteries: An international study","authors":"Jean-Marc Sellal,&nbsp;Nabil Dib,&nbsp;Matilde Karakachoff,&nbsp;Christopher Mcleod,&nbsp;Lynne Nield,&nbsp;Sonya Babu-Narayan,&nbsp;Magalie Ladouceur,&nbsp;Ewa Kowalik,&nbsp;David Kalfa,&nbsp;David Barron,&nbsp;Emre Belli,&nbsp;Jean-Jacques Schott,&nbsp;Michael A. Gatzoulis,&nbsp;Paul Khairy,&nbsp;Alban-Elouen Baruteau","doi":"10.1016/j.acvd.2026.06.073","DOIUrl":"10.1016/j.acvd.2026.06.073","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;There is a paucity of data on arrhythmia burden in patients with congenitally corrected transposition of the great arteries (ccTGA). The present study sought to quantify the incidence of atrial arrhythmia (AA), ventricular arrhythmia (VA), and complete atrioventricular block (CAVB) in patients with ccTGA and identify associated factors.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;There is a paucity of data on arrhythmia burden in patients with congenitally corrected transposition of the great arteries (ccTGA). The present study sought to quantify the incidence of atrial arrhythmia (AA), ventricular arrhythmia (VA), and complete atrioventricular block (CAVB) in patients with ccTGA and identify associated factors.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;An international, multicenter, retrospective cohort study was conducted in 29 tertiary hospitals (6 countries) between 1990 and 2018. Primary analyses consisted of determining the incidence of a combined outcome consisting of AA, VA, or CAVB, along with its individual components. Factors associated with the different types of arrhythmias were assessed by univariable and multivariable Cox regression analyses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;An international, multicenter, retrospective cohort study was conducted in 29 tertiary hospitals (6 countries) between 1990 and 2018. Primary analyses consisted of determining the incidence of a combined outcome consisting of AA, VA, or CAVB, along with its individual components. Factors associated with the different types of arrhythmias were assessed by univariable and multivariable Cox regression analyses.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 1131 patients with ccTGA were followed for 9.0 (interquartile range 4.0–17.2) years. Cumulative rates of the primary endpoint at 10, 15, and 20 years were 44.5%, 51.0% and 58.8%, respectively. AA, VA, and CAVB occurred in 2.1, 1.4 and 2.0 cases per 100 person-years, respectively. In multivariable analyses, surgery/intervention conferred a greater than threefold higher risk of AA [HR: 3.01, 95% CI: 1.90–4.78, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001]. Furthermore, surgery/intervention was significantly associated with a greater risk of VA [HR: 1.73, 95% CI: 0.98–3.05, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.003] and CAVB [HR: 3.65, 95% CI: 2.20–6.05, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001]. Left and right bundle branch block were associated with a higher risk of VA [HR: 4.03, 95% CI: 1.59–10.23, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.003] and right bundle branch block with a higher risk of CAVB [HR: 3.71, 95% CI: 1.81–7.63, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;A total of 1131 patients with ccTGA were followed for 9.0 (interquartile range 4.0–17.2) years. Cumulative rates of the primary endpoint at 10, 15, and 20 years were 44.5%, 51.0% and 58.8%, respectively. AA, VA, and CAVB occurred in 2.1, 1.4 and 2.0 cases per 100 person-years, respectively. In multivariable analyses, surgery/intervention conferred a greater than threefold higher risk of AA [H","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S274-S275"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical stress response and O-GlcNAc regulation in children with congenital heart disease undergoing cardiopulmonary bypass","authors":"Eva Mélenchon,&nbsp;Martin Bouaud,&nbsp;Alexandre Moune,&nbsp;Amandine Vergnaud,&nbsp;Jerome Dauvergne,&nbsp;Alexy Henry,&nbsp;Elina Deneele,&nbsp;Angelique Erraud,&nbsp;Nolwenn Tessier,&nbsp;Aurélia Leroux,&nbsp;Bertrand Rozec,&nbsp;Jules Lecomte,&nbsp;Manon Denis,&nbsp;Benjamin Lauzier","doi":"10.1016/j.acvd.2026.06.022","DOIUrl":"10.1016/j.acvd.2026.06.022","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Congenital heart diseases require early reconstructive surgery involving cardiopulmonary bypass (CPB). Although life-saving, these procedures trigger a systemic and cellular stress response. This response remains poorly characterized in pediatric patients, whose metabolic profile and stress-adaptation mechanisms differ markedly from those of adults due to developmental immaturity. Protein O-GlcNAcylation, a post-translational modification linking cellular metabolism to stress-response signaling, has emerged as a regulator of cardiac stress adaptation, yet its role in the pediatric response to CPB remains unknown.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Congenital heart diseases require early reconstructive surgery involving cardiopulmonary bypass (CPB). Although life-saving, these procedures trigger a systemic and cellular stress response. This response remains poorly characterized in pediatric patients, whose metabolic profile and stress-adaptation mechanisms differ markedly from those of adults due to developmental immaturity. Protein O-GlcNAcylation, a post-translational modification linking cellular metabolism to stress-response signaling, has emerged as a regulator of cardiac stress adaptation, yet its role in the pediatric response to CPB remains unknown.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Pediatric (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;63) and adult (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;172) patients undergoing cardiac surgery with CPB were included. Blood samples were collected before CPB, at aortic declamping, and 6 and 12&lt;!--&gt; &lt;!--&gt;hours postoperatively. Global protein O-GlcNAcylation was measured by Western blot. In pediatric patients, O-GlcNAcylated proteins were isolated using a Click-iT–based immunoprecipitation approach followed by proteomic analysis. Associations between perioperative O-GlcNAcylation changes and postoperative outcomes (VIS, mechanical ventilation duration, bleeding, and fluid resuscitation) were assessed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Pediatric (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;63) and adult (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;172) patients undergoing cardiac surgery with CPB were included. Blood samples were collected before CPB, at aortic declamping, and 6 and 12&lt;!--&gt; &lt;!--&gt;hours postoperatively. Global protein O-GlcNAcylation was measured by Western blot. In pediatric patients, O-GlcNAcylated proteins were isolated using a Click-iT–based immunoprecipitation approach followed by proteomic analysis. Associations between perioperative O-GlcNAcylation changes and postoperative outcomes (VIS, mechanical ventilation duration, bleeding, and fluid resuscitation) were assessed.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In pediatric patients, global protein O-GlcNAcylation significantly decreased after CPB, with reduced levels at aortic declamping (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.05) that persisted at 6 and 12&lt;!--&gt; &lt;!--&gt;hours postoperatively (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). The magnitude of this decline correlated with greater postoperative severity, including high","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S249-S250"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}