Archives of Cardiovascular Diseases最新文献

{"title":"The impact of Hypoattenuated leaflet thickening (HALT) and hypoattenuation affecting motion (HAM) in percutaneous pulmonary valve implantation with Venus-P","authors":"Carlo Barsali, Raymond Haddad, Grégoire Albenque, Papa Momar Guissé, Lucie Mantes, Valentin Baland, Sarah Cohen, Guillaume Reverdito, Magalie Ladouceur, Clément Batteux, Sebastien Hascoet","doi":"10.1016/j.acvd.2026.06.051","DOIUrl":"10.1016/j.acvd.2026.06.051","url":null,"abstract":"<div><h3>Introduction</h3><div>Percutaneous pulmonary valve implantation (PPVI) with self-expanding valves, such as the VENUS P, has expanded treatment options for patients with large RVOT anatomies. However, concerns persist regarding valve durability and subclinical leaflet abnormalities, including hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (HAM) (<span><span>Fig. 1</span></span>). The incidence and clinical impact of these findings after PPVI remain poorly defined.</div></div><div>Percutaneous pulmonary valve implantation (PPVI) with self-expanding valves, such as the VENUS P, has expanded treatment options for patients with large RVOT anatomies. However, concerns persist regarding valve durability and subclinical leaflet abnormalities, including hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (HAM) (<span><span>Fig. 1</span></span>). The incidence and clinical impact of these findings after PPVI remain poorly defined.</div><div><h3>Methods</h3><div>Baseline, post-procedural and 6 months follow-up data were prospectively analyzed for 51 patients who underwent PPVI with Venus-P (Jan 2022–Dec 2025). At 6-month follow-up, all patients underwent cardiac CT to assess the presence of leaflet abnormalities (HALT and HAM).</div></div><div>Baseline, post-procedural and 6 months follow-up data were prospectively analyzed for 51 patients who underwent PPVI with Venus-P (Jan 2022–Dec 2025). At 6-month follow-up, all patients underwent cardiac CT to assess the presence of leaflet abnormalities (HALT and HAM).</div><div><h3>Results</h3><div>Of the 51 patients 49% were male with a mean age of 40.1<!--> <!-->±<!--> <!-->14.5 years. Thirty-seven patients had Tetralogy of Fallot. The main indication for percutaneous pulmonary valve implantation was pulmonary regurgitation (98%) associated with right heart chamber dilation.</div><div>The median valve diameter was 34<!--> <!-->mm (IQR: 32–36); At 6-month follow-up, HALT was detected in 25 patients (49%), whereas HAM was observed in 7 patients (13.7%). HAM was associated with impaired leaflet motion without any significant increase in transvalvular gradients on echocardiography. RVOT Vmax values were comparable between the two groups (no HALT versus HALT/HAM) at all time points(after PPVI T1: 1.64 vs 1.55, <em>P</em> <!-->=<!--> <!-->0.459; at 6 months T2: 1.69 vs 1.76, <em>P</em> <!-->=<!--> <!-->0.467).</div></div><div>Of the 51 patients 49% were male with a mean age of 40.1<!--> <!-->±<!--> <!-->14.5 years. Thirty-seven patients had Tetralogy of Fallot. The main indication for percutaneous pulmonary valve implantation was pulmonary regurgitation (98%) associated with right heart chamber dilation.</div><div>The median valve diameter was 34<!--> <!-->mm (IQR: 32–36); At 6-month follow-up, HALT was detected in 25 patients (49%), whereas HAM was observed in 7 patients (13.7%). HAM was associated with impaired leaflet motion without any significant increase in transvalvul","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S263"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstage outcomes in single ventricle neonates: Ductal stenting versus modified Blalock-Taussig shunt","authors":"Valentin Vescovo, Sophie-Guiti Malekzadeh Milani, Régis Gaudin, Olivier Raisky, Margaux Pontailler, Segolene Bernheim, Mathilde Méot, Alexander Moiroux-Sahraoui, Damien Bonnet, Neil Derridj","doi":"10.1016/j.acvd.2026.06.045","DOIUrl":"10.1016/j.acvd.2026.06.045","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>To compare outcomes of ductal stenting (DS) versus modified Blalock-Taussig shunt (mBTS) as initial palliation in neonates with functionally univentricular heart (FUH) and duct-dependent pulmonary blood flow, up to bidirectional cavo-pulmonary connection (BCPC).</div></div><div>To compare outcomes of ductal stenting (DS) versus modified Blalock-Taussig shunt (mBTS) as initial palliation in neonates with functionally univentricular heart (FUH) and duct-dependent pulmonary blood flow, up to bidirectional cavo-pulmonary connection (BCPC).</div><div><h3>Methods</h3><div>We retrospectively analysed 192 neonates with FUH and duct-dependent pulmonary blood flow undergoing initial palliation with DS (<em>n</em> <!-->=<!--> <!-->39) or mBTS (<em>n</em> <!-->=<!--> <!-->153) between 2005 and 2025, using Cox proportional hazards models.</div></div><div>We retrospectively analysed 192 neonates with FUH and duct-dependent pulmonary blood flow undergoing initial palliation with DS (<em>n</em> <!-->=<!--> <!-->39) or mBTS (<em>n</em> <!-->=<!--> <!-->153) between 2005 and 2025, using Cox proportional hazards models.</div><div><h3>Results</h3><div>Median follow-up was 6.3 months including the postoperative period of BCPC. Low birth weight was more frequent in the DS group (28.2% vs 11.1%; <em>P</em> <!-->=<!--> <!-->0.01). Survival at initial palliation, interstage, and post-BCPC was 85.7% (95% CI 81.9–91.5), 83.3% (95% CI 76.9–88.1), and 79.7% (95% CI 71.9–85.5), respectively, with no between-group differences (log-rank <em>P</em> <!-->><!--> <!-->0.8). Early postoperative morbidity, including NICU length of stay, duration of inotropic support, and mechanical ventilation was greater after mBTS (all <em>P</em> <!--><<!--> <!-->0.01). Reintervention rates were similar between DS and mBTS (≈<!--> <!-->23% overall), with no difference in time to reintervention, including when restricted to unplanned procedures. Patients initially palliated with DS underwent BCPC earlier (5.3[3.6–8.6] months vs 7.3[6.0–11.2] months, <em>P</em> <!-->=<!--> <!-->0.05) and at lower body weight (5.9[5.0–7.9]<!--> <!-->Kg vs 6.9[5.7–8.2]<!--> <!-->Kg, <em>P</em> <!-->=<!--> <!-->0.02). Branch pulmonary artery stenosis before BCPC was more frequent after mBTS (<em>P</em> <!--><<!--> <!-->0.01). After adjustment, mBTS showed a non-significant trend toward higher overall mortality and reintervention before BCPC.</div></div><div>Median follow-up was 6.3 months including the postoperative period of BCPC. Low birth weight was more frequent in the DS group (28.2% vs 11.1%; <em>P</em> <!-->=<!--> <!-->0.01). Survival at initial palliation, interstage, and post-BCPC was 85.7% (95% CI 81.9–91.5), 83.3% (95% CI 76.9–88.1), and 79.7% (95% CI 71.9–85.5), respectively, with no between-group differences (log-rank <em>P</em> <!-->><!--> <!-->0.8). Early postoperative morbidity, including NICU length of stay, duration of inotropic support, and mechani","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S260"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letters by Sathian et al. and Yue et al. regarding “Transfusion and coagulation management in acute type A aortic dissection”: Thromboelastography and intraoperative transfusion strategy","authors":"Philipp Pfeiffer, Daniel-Sebastian Dohle","doi":"10.1016/j.acvd.2025.09.002","DOIUrl":"10.1016/j.acvd.2025.09.002","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page 619"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of rheumatic heart disease among women of reproductive age: Socioeconomic and temporal trends, 1990 to 2021","authors":"Ran Li,&nbsp;Shuxiao Hou,&nbsp;Junhui Wu","doi":"10.1016/j.acvd.2026.01.003","DOIUrl":"10.1016/j.acvd.2026.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Women of reproductive age are an important group to consider in the global burden of rheumatic heart disease (RHD).</div></div><div><h3>Aim</h3><div>We aimed to systematically analyse the burden of RHD among women of reproductive age from 1990 to 2021.</div></div><div><h3>Methods</h3><div>We used Global Burden of Disease (GBD) 2021 to comprehensively analyse the global burden of RHD among women of reproductive age, including incidence, prevalence, mortality and disability-adjusted life years (DALY) and examined the relationship between the burden of disease and different regions, sociodemographic index (SDI) and age.</div></div><div><h3>Results</h3><div>The incidence and prevalence rates of RHD in women of reproductive age increased globally from 1990 to 2021. The incidence rate (per 100,000 population) increased from 60.37 (95% UI: 44.12–82.42) in 1990 to 64.06 (95% UI: 46.24–86.76) in 2021 and the prevalence rate increased from 951.74 (95% UI: 723.08–1197.48) to 1110.17 (95% UI: 843.45–1402.27). When countries were grouped by SDI, incidence rate and prevalence rate negatively correlated with SDI. Low SDI regions had the highest burden. In 2021, women of reproductive age 15–19<!--> <!-->years had the most incident cases, and the number of deaths and DALY connected positively with age.</div></div><div><h3>Conclusions</h3><div>The increasing incidence of RHD among women of reproductive age represents an important global health concern, particularly in low-SDI regions where the disease burden remains highest. The early onset of RHD highlights the need for preventive efforts targeting younger women. Prevention and management strategies should be adapted to disease patterns and health-system capacity, with an emphasis on early detection and effective secondary prevention in high-burden settings.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages 554-565"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146198250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the use of coronary revascularization in France and the United States: Divergent trends","authors":"Michael K. Gusmano,&nbsp;Victor G. Rodwin,&nbsp;Daniel Weisz,&nbsp;Jonathan Cottenet,&nbsp;Nicolas Danchin,&nbsp;Catherine Quantin","doi":"10.1016/j.acvd.2026.02.002","DOIUrl":"10.1016/j.acvd.2026.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Coronary revascularization is a key treatment for coronary artery disease (CAD). Over the past 15<!--> <!-->years, several randomized trials have shown that it failed to improve life expectancy in most patients with stable CAD.</div></div><div><h3>Aim</h3><div>To compare trends in the use of coronary revascularization from 2012 to 2018 in France and the United States (US).</div></div><div><h3>Methods</h3><div>Administrative databases were used in both countries to identify patients ≥<!--> <!-->35<!--> <!-->years of age, hospitalized for CAD or congestive heart failure (CHF) undergoing coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI), as identified from the International Classification of Diseases coding system. Independent correlates of the use of coronary revascularization were also investigated.</div></div><div><h3>Results</h3><div>In France, from 2012 to 2018, coronary revascularization increased by 13.3% among patients aged 35–64<!--> <!-->years and by 24.6% among those aged ≥<!--> <!-->65<!--> <!-->years. In contrast, in the US, it decreased by 16.3% and 19.6%, respectively. These trends were mainly related to the use of PCI: +15.8% and +28.8% in France versus–17.6% and–20.4% in the US. These divergent trends could not be explained solely by changes in the number of hospitalizations for CAD/CHF. In both countries and for both periods, use of revascularization was independently related to age, number of medical diagnoses, sex and income.</div></div><div><h3>Conclusion</h3><div>Divergent trends in the use of coronary revascularization were observed in France and the US that could not be explained by trends in the number of CAD/CHF hospitalizations, nor by differences in the correlates of its use.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages 572-578"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of prenatal diagnosis on outcomes of patients with congenitally corrected transposition of the great arteries: An international study of tertiary care institutions","authors":"Bénédicte Romefort,&nbsp;Lynne Nield,&nbsp;Mélanie Grasswill,&nbsp;Emre Belli,&nbsp;Sonya Babu-Narayan,&nbsp;Magalie Ladouceur,&nbsp;Paul Khairy,&nbsp;Ewa Kowalik,&nbsp;David Kalfa,&nbsp;David Barron,&nbsp;Emile Bacha,&nbsp;Michael A. Gatzoulis,&nbsp;Christopher Mcleod,&nbsp;Matilde Karakachoff,&nbsp;Alban-Elouen Baruteau","doi":"10.1016/j.acvd.2026.06.024","DOIUrl":"10.1016/j.acvd.2026.06.024","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Congenitally corrected transposition of the great arteries (ccTGA) with biventricular physiology is presumed to carry a favorable outcome. We aimed to better characterize the impact of prenatal diagnosis on conduction disorders, interventions, and mortality. Secondary objective was to examine outcomes in isolated ccTGA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Congenitally corrected transposition of the great arteries (ccTGA) with biventricular physiology is presumed to carry a favorable outcome. We aimed to better characterize the impact of prenatal diagnosis on conduction disorders, interventions, and mortality. Secondary objective was to examine outcomes in isolated ccTGA.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;An international, multicenter, retrospective cohort study was conducted in 29 tertiary hospitals (6 countries) from 1990–2018. Patients with a single ventricle, heterotaxy syndrome, or valvar atresia were excluded.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;An international, multicenter, retrospective cohort study was conducted in 29 tertiary hospitals (6 countries) from 1990–2018. Patients with a single ventricle, heterotaxy syndrome, or valvar atresia were excluded.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Of 331 ccTGA patients with a median follow-up of 8.6 years [IQR: 3.5–14.1], 128 (38.7%) were diagnosed prenatally at a median gestational age of 22 weeks. As compared to the postnatal group, prenatally diagnosed patients experienced earlier cardiac conduction disorders (median age at diagnosis of conduction disorders: 0.3 versus 2.7 years, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.010), earlier pacemaker implantation (median age at pacing: 6.5 years [2.5–11.6] versus 0.9 year [0.1–3.0], &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001) and earlier surgical intervention (intervention-free survival rate at 3 years: 50.3% versus 34.7%, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). The 3-year survival rate was significantly lower in patients diagnosed prenatally (91.1% versus 98.4%, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.002) and the median age at death was significantly younger among patients diagnosed prenatally (0.2 versus 7.0 years, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). In both groups, isolated ccTGA (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;63, 19%) was associated with superior outcomes with no intervention in 46.8% and only one death.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Of 331 ccTGA patients with a median follow-up of 8.6 years [IQR: 3.5–14.1], 128 (38.7%) were diagnosed prenatally at a median gestational age of 22 weeks. As compared to the postnatal group, prenatally diagnosed patients experienced earlier cardiac conduction disorders (median age at diagnosis of conduction disorders: 0.3 versus 2.7 years, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.010), earlier pacemaker implantation (median age at pacing: 6.5 years [2.5–11.6] versus 0.9 year [0.1–3.0], &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001) and earlier surgical intervention (intervention-free survival rate at 3 years: 50.3% versus 34.7%, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). The 3-year survival rate w","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S250"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalizing warfarin dose adjustment in pediatric cardiology using machine learning: A comparison with rule-based algorithms","authors":"Samon Abed-Nego,&nbsp;Caroline Ovaert,&nbsp;Sophie Quennelle","doi":"10.1016/j.acvd.2026.06.031","DOIUrl":"10.1016/j.acvd.2026.06.031","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Warfarin adjustment in pediatric cardiology is particularly challenging and requires frequent, individualized modifications based on international normalized ratio (INR) monitoring. While some adolescent patients are autonomous, most pediatric patients depend on caregivers and frequently contact their cardiologist to report INR values and contextual factors. Although rule-based dosing algorithms are available, clinicians often rely on experience, as these tools insufficiently account for inter- and intra-patient variability, including dietary changes, inflammatory status, and behavioral factors. We hypothesized that a machine learning (ML) model could learn from individual longitudinal INR monitoring data to personalize and fine-tune rule-based dose adjustment strategies at the patient level, thereby approximating clinician-driven decision-making in pediatric anticoagulation management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Warfarin adjustment in pediatric cardiology is particularly challenging and requires frequent, individualized modifications based on international normalized ratio (INR) monitoring. While some adolescent patients are autonomous, most pediatric patients depend on caregivers and frequently contact their cardiologist to report INR values and contextual factors. Although rule-based dosing algorithms are available, clinicians often rely on experience, as these tools insufficiently account for inter- and intra-patient variability, including dietary changes, inflammatory status, and behavioral factors. We hypothesized that a machine learning (ML) model could learn from individual longitudinal INR monitoring data to personalize and fine-tune rule-based dose adjustment strategies at the patient level, thereby approximating clinician-driven decision-making in pediatric anticoagulation management.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Monitoring data, including patient age, INR target, INR values, warfarin doses, and clinician dose adjustment decisions, from patients under 18 years of age receiving oral anticoagulation and followed at La Timone Hospital (Marseille) were analyzed. Clinician dose adjustment decisions served as the reference standard. The existing rule-based algorithm was evaluated. Four instead ML models were developed, trained, and evaluated to predict dose adjustments using longitudinal patient data. We calculated the Mean Squared Error (MSE) and the coefficient of determination (&lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt;) for each prediction of the model.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Monitoring data, including patient age, INR target, INR values, warfarin doses, and clinician dose adjustment decisions, from patients under 18 years of age receiving oral anticoagulation and followed at La Timone Hospital (Marseille) were analyzed. Clinician dose adjustment decisions served as the reference standard. The existing rule-based algorithm was evaluated. Four instead ML models were developed, trained, and evaluated to predict dose adjustments using longitudin","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S253"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a cardiovascular rehabilitation program on the quality of life of patients aged 8 to 25 years with sickle cell disease: A multicenter, randomized, controlled trial","authors":"Grégoire De La Villéon,&nbsp;Sophie Guillaumont,&nbsp;Marie Vincenti,&nbsp;Qualirehab Study Group Amedro","doi":"10.1016/j.acvd.2026.06.027","DOIUrl":"10.1016/j.acvd.2026.06.027","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Sickle cell disease (SCD) is the most common monogenic disorder worldwide and is now recognized as a systemic cardiovascular disease associated with chronic hemolysis, endothelial dysfunction, and progressive vasculopathy. Despite improved survival, patients exhibit early cardiovascular complications, reduced exercise capacity, and major impairment in quality of life (QoL). Sedentary behavior is highly prevalent, contributing to deconditioning, increased cardiovascular risk, and psychosocial burden. Although moderate physical activity is safe when supervised, no structured cardiovascular rehabilitation program currently exists for young SCD patients in France.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Sickle cell disease (SCD) is the most common monogenic disorder worldwide and is now recognized as a systemic cardiovascular disease associated with chronic hemolysis, endothelial dysfunction, and progressive vasculopathy. Despite improved survival, patients exhibit early cardiovascular complications, reduced exercise capacity, and major impairment in quality of life (QoL). Sedentary behavior is highly prevalent, contributing to deconditioning, increased cardiovascular risk, and psychosocial burden. Although moderate physical activity is safe when supervised, no structured cardiovascular rehabilitation program currently exists for young SCD patients in France.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate at 12 months the impact of a cardiovascular rehabilitation program compared with standard care on health-related QoL in children, adolescents, and young adults aged 8–25 years with SCD.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;To evaluate at 12 months the impact of a cardiovascular rehabilitation program compared with standard care on health-related QoL in children, adolescents, and young adults aged 8–25 years with SCD.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Multicenter, randomized, controlled, open-label trial with two parallel groups (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;228; 114 per group). Participants aged 8–25 years with SCD will be followed for 12 months; recruitment period is 24 months, total study duration 36 months. Primary endpoint: change in PedsQL™ 4.0 score between baseline and 12 months. Secondary outcomes include VO&lt;sub&gt;2max&lt;/sub&gt;, ventilatory parameters, muscle strength, physical activity, echocardiographic parameters, clinical specific evolution, pain scores, mental health and disease knowledge. The intervention group will undergo a 12-week hybrid rehabilitation program combining supervised exercise training and therapeutic education, delivered in-center and at home with digital support. All patients will receive standard care with assessments at baseline and 12 months; analyses will follow intention-to-treat and per-protocol approaches.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Multicenter, randomized, controlled, open-label trial with two parallel groups (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;228; 114 per group). Participants aged 8–25 years with SCD will be followed for 12 months; recruitment period","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S251-S252"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients implanted with a leadless pacemaker after transcatheter aortic valve implantation: Results from the MITAVI prospective study","authors":"Nicolas Lellouche,&nbsp;Eloi Marijon,&nbsp;Vincent Algalarrondo,&nbsp;Romain Gallet,&nbsp;Madjid Boukantar,&nbsp;Tarvinder Dhanjal,&nbsp;Thibaut Moulin,&nbsp;Marina Urena,&nbsp;Chekrallah Chamandi,&nbsp;Jean-Philippe Collet,&nbsp;Estelle Gandjbakhch,&nbsp;Emmanuel Teiger","doi":"10.1016/j.acvd.2026.02.004","DOIUrl":"10.1016/j.acvd.2026.02.004","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter aortic valve implantation is a well-established clinical procedure for treating severe aortic stenosis. High-grade atrioventricular block has been reported in 10–30% of patients following transcatheter aortic valve implantation. Traditional transvenous pacemakers are associated with several potential complications, including endocarditis, lead dislodgement or fracture, pocket haematoma and tricuspid regurgitation. These risks may be mitigated with the use of leadless pacemakers.</div></div><div><h3>Aim</h3><div>We proposed to evaluate the 1-year clinical and electrical outcomes of patients implanted with a leadless pacemaker following transcatheter aortic valve implantation.</div></div><div><h3>Methods</h3><div>From July 2019 to December 2022, 102 patients from four French centres who underwent transcatheter aortic valve implantation and subsequently required pacemaker implantation with a leadless pacemaker (Micra; Medtronic, Dublin, Ireland) were evaluated prospectively.</div></div><div><h3>Results</h3><div>The mean patient age was 82<!--> <!-->±<!--> <!-->9 years, and the mean baseline left ventricular ejection fraction was 58.4<!--> <!-->±<!--> <!-->10.6%. Major complications included one case of cardiac tamponade and one case of device migration. During 12-month follow-up, one patient required transvenous cardiac resynchronization therapy pacing because of severe heart failure. The all-cause death rate was 12%, and the heart failure hospitalization rate was also 12%. Compared with baseline, leadless pacemaker electrical variables improved at 1 year. Additionally, complete atrioventricular conduction restoration was observed in 38% of the cohort.</div></div><div><h3>Conclusions</h3><div>Leadless pacemakers can be implanted in patients following transcatheter aortic valve implantation, with low complication rates and excellent electrical variables at 1-year follow-up. The need for an upgrade to a transvenous pacemaker was low (&lt; 1%).</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages 579-585"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in outcomes after transcatheter pulmonary valve implantation: No impact on endocarditis but increased reintervention risk in males","authors":"Sebastien Hascoet,&nbsp;Aleksander Kempny,&nbsp;Ali Houeijeh,&nbsp;Maria Jesus Del-Cerro-Marin,&nbsp;James R. Bentham,&nbsp;Nicolas Combes,&nbsp;Clement Karsenty,&nbsp;Sophie-Guiti Malekzadeh Milani,&nbsp;Hélène Bouvaist,&nbsp;Zakaria Jalal,&nbsp;Patrice Guérin,&nbsp;Julie Lourtet-Hascoet,&nbsp;Philippe Aldebert,&nbsp;Anja Tengler,&nbsp;Stephane Morisset,&nbsp;Alain Fraisse","doi":"10.1016/j.acvd.2026.06.011","DOIUrl":"10.1016/j.acvd.2026.06.011","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Sex-related differences in outcomes after transcatheter pulmonary valve implantation (TPVI) remain incompletely understood, particularly regarding infective endocarditis (IE), valve durability, and survival.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Sex-related differences in outcomes after transcatheter pulmonary valve implantation (TPVI) remain incompletely understood, particularly regarding infective endocarditis (IE), valve durability, and survival.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This study is a sub-analysis of the ENDOCPULM international registry including 1200 patients undergoing TPVI between 2007 and 2021. The cohort comprised 486 females (40.5%) and 714 males (59.5%). Outcomes included IE, pulmonary valve reintervention (PVR), and overall survival.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;This study is a sub-analysis of the ENDOCPULM international registry including 1200 patients undergoing TPVI between 2007 and 2021. The cohort comprised 486 females (40.5%) and 714 males (59.5%). Outcomes included IE, pulmonary valve reintervention (PVR), and overall survival.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Males underwent TPVI at a younger age and exhibited higher post-procedural RVOT gradients. During a median follow-up of 2.3 years (3714 patient-years), 65 patients (5.4%) developed IE. Sex was not associated with IE risk in the overall cohort, and subgroup analyses showed limited and inconsistent signals without robust effect.&lt;/div&gt;&lt;div&gt;In contrast, male sex was associated with a higher risk of valve reintervention in specific subgroups (&lt;span&gt;&lt;span&gt;Fig. 1&lt;/span&gt;&lt;/span&gt;), particularly in patients with conotruncal defects and in those aged&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;40 years. These findings are consistent with a less favorable hemodynamic profile in males, combining earlier intervention and higher residual gradients.&lt;/div&gt;&lt;div&gt;No significant association between sex and overall survival was observed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Males underwent TPVI at a younger age and exhibited higher post-procedural RVOT gradients. During a median follow-up of 2.3 years (3714 patient-years), 65 patients (5.4%) developed IE. Sex was not associated with IE risk in the overall cohort, and subgroup analyses showed limited and inconsistent signals without robust effect.&lt;/div&gt;&lt;div&gt;In contrast, male sex was associated with a higher risk of valve reintervention in specific subgroups (&lt;span&gt;&lt;span&gt;Fig. 1&lt;/span&gt;&lt;/span&gt;), particularly in patients with conotruncal defects and in those aged&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;40 years. These findings are consistent with a less favorable hemodynamic profile in males, combining earlier intervention and higher residual gradients.&lt;/div&gt;&lt;div&gt;No significant association between sex and overall survival was observed.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In this large TPVI cohort, sex has no consistent impact on IE risk. However, male sex is associated with increased risk of valve reintervention in selected subgroups, likely driven by timing of intervention and residual hemodynamic burde","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S243"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}