Archives of Cardiovascular Diseases最新文献

{"title":"Response to letter by Das et al. regarding \"Direct oral anticoagulants versus vitamin K antagonists after heart valve bioprosthetic replacement or repair: A systematic review and meta-analysis\".","authors":"Vito D Bruno, Tom Lester, Enrico Poletti, Bleri Celmeta, Tommaso Viva, Arturo Bisogno, Antonio Miceli, Mattia Glauber","doi":"10.1016/j.acvd.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.acvd.2026.08.002","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on the ESC consensus statement on inflammation in coronary syndromes: From mechanistic certainty to practical cardiology.","authors":"François Roubille, Mark Nidorf, Jean-Claude Tardif","doi":"10.1016/j.acvd.2026.08.001","DOIUrl":"https://doi.org/10.1016/j.acvd.2026.08.001","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models in clinical research: The widening transatlantic gap and a path towards compliant European artificial intelligence infrastructure.","authors":"Benoît Lequeux, Claire Gardent, Nicolas Girerd","doi":"10.1016/j.acvd.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.acvd.2026.07.002","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Staphylococcus aureus biofilm on material-associated infective endocarditis in congenital heart disease","authors":"Julie Lourtet-Hascoet, Sebastien Hascoet, Alexander Moiroux-Sahraoui, Régine Roussin, Emre Belli, Laurence Armand-Lefevre, Bernard Iung, Jean-Louis Herrmann, Yannis Arab, Nicolas Mirouze","doi":"10.1016/j.acvd.2026.06.016","DOIUrl":"10.1016/j.acvd.2026.06.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Infective endocarditis (IE) remains a major limitation of prosthetic materials in congenital heart disease (CHD), particularly after repeated interventions. Staphylococcus aureus is associated with severe outcomes, driven by its ability to form biofilms on implanted devices. However, the interaction between patient characteristics, bacterial phenotype and specific cardiac biomaterials remains poorly defined, limiting risk stratification and preventive strategies.</div></div><div>Infective endocarditis (IE) remains a major limitation of prosthetic materials in congenital heart disease (CHD), particularly after repeated interventions. Staphylococcus aureus is associated with severe outcomes, driven by its ability to form biofilms on implanted devices. However, the interaction between patient characteristics, bacterial phenotype and specific cardiac biomaterials remains poorly defined, limiting risk stratification and preventive strategies.</div><div><h3>Objective</h3><div>To identify bacterial and material determinants of IE by characterizing <em>Staphylococcus aureus</em> biofilm capacity and adhesion across biomaterials used in CHD, with the aim of informing clinical decision-making.</div></div><div>To identify bacterial and material determinants of IE by characterizing <em>Staphylococcus aureus</em> biofilm capacity and adhesion across biomaterials used in CHD, with the aim of informing clinical decision-making.</div><div><h3>Methods</h3><div>This pilot study part of a PhD program will include 50 <em>S</em>. <em>aureus</em> strains isolated from patients with prosthetic IE (with and without CHD), compared with 20 reference strains. Three complementary analyses will be performed: (1) quantitative assessment of biofilm formation, (2) whole-genome analysis to identify virulence and biofilm-associated genes, (3) evaluation of bacterial adhesion and biofilm formation on clinically used materials, including valved conduits, homograft, pericardial tissue, valves and metallic platforms.</div></div><div>This pilot study part of a PhD program will include 50 <em>S</em>. <em>aureus</em> strains isolated from patients with prosthetic IE (with and without CHD), compared with 20 reference strains. Three complementary analyses will be performed: (1) quantitative assessment of biofilm formation, (2) whole-genome analysis to identify virulence and biofilm-associated genes, (3) evaluation of bacterial adhesion and biofilm formation on clinically used materials, including valved conduits, homograft, pericardial tissue, valves and metallic platforms.</div><div><h3>Expected results</h3><div>We expect to identify high-risk bacterial profiles associated with enhanced biofilm formation and preferential adhesion to specific biomaterials. Differences in colonization between materials may also explain the heterogeneous risk of IE observed in clinical practice.</div></div><div>We expect to identify high-risk bacterial profiles associated with","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S246"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Fontan completion: A systematic literature review","authors":"Asmaa Benfreha, Sebastien Hascoet, Emre Belli, Damien Kenny, Raymond Haddad","doi":"10.1016/j.acvd.2026.06.059","DOIUrl":"10.1016/j.acvd.2026.06.059","url":null,"abstract":"<div><h3>Introduction</h3><div>Transcatheter Fontan completion (TFC) offers a less invasive alternative to surgery, but no technique has achieved routine adoption.</div></div><div>Transcatheter Fontan completion (TFC) offers a less invasive alternative to surgery, but no technique has achieved routine adoption.</div><div><h3>Methods</h3><div>A systematic review was conducted in accordance with PRISMA guidelines, including English-language TFC studies indexed in PubMed up to 01/12/2025. Records were screened by titles and abstracts, followed by full-text eligibility assessment. Data were extracted and synthesized. Methodological quality was classified as high, moderate, or low based on assessment of study design, outcome reporting, follow-up duration, and sample representativeness, with discrepancies resolved by consensus.</div></div><div>A systematic review was conducted in accordance with PRISMA guidelines, including English-language TFC studies indexed in PubMed up to 01/12/2025. Records were screened by titles and abstracts, followed by full-text eligibility assessment. Data were extracted and synthesized. Methodological quality was classified as high, moderate, or low based on assessment of study design, outcome reporting, follow-up duration, and sample representativeness, with discrepancies resolved by consensus.</div><div><h3>Results</h3><div>Six studies assessed Glenn-stage preconditioning strategies (extracardiac conduits (ECC) and intracardiac tunnels) for subsequent TFC in animal models. Eighteen studies reported outcomes in 115 patients: 94.8% underwent Glenn-stage preconditioning (96.3% with intracardiac tunnels using various techniques; 3.7% with ECCs), while 5.2% had subsequent stent-based TFC without preconditioning. Overall, TFC was attempted and completed in 85/115 (73.9%) patients aged 20 months–15 years, with minimum weights of 9–10<!--> <!-->kg, without procedure-related deaths or major adverse events. Hospital stay was 1–6 days. Antithrombotic strategies varied. Follow-up in 80 patients (1<!--> <!-->week–40<!--> <!-->months) showed 5 (6.2%) catheter reinterventions, 1 surgical revision, 1 neurological event, and 1 unexplained midterm death. Study quality was heterogeneous: only 11% were high quality, and 61% reported complete outcomes, limiting generalizability.</div></div><div>Six studies assessed Glenn-stage preconditioning strategies (extracardiac conduits (ECC) and intracardiac tunnels) for subsequent TFC in animal models. Eighteen studies reported outcomes in 115 patients: 94.8% underwent Glenn-stage preconditioning (96.3% with intracardiac tunnels using various techniques; 3.7% with ECCs), while 5.2% had subsequent stent-based TFC without preconditioning. Overall, TFC was attempted and completed in 85/115 (73.9%) patients aged 20 months–15 years, with minimum weights of 9–10<!--> <!-->kg, without procedure-related deaths or major adverse events. Hospital stay was 1–6 days. Antithrombotic strategies varied. Follow-up in ","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S266-S267"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent cardiovascular adverse event reporting with pathway-directed anticancer therapies in children and adults: A VigiBase disproportionality analysis","authors":"Fabien Labombarda, Damien Bodet, Jérémie Rouger, Camille Guérin, Marion Sassier, Basile Chrétien, Joachim Alexandre, Charles Dolladille","doi":"10.1016/j.acvd.2026.06.034","DOIUrl":"10.1016/j.acvd.2026.06.034","url":null,"abstract":"<div><h3>Introduction</h3><div>Cardiac monitoring in children receiving pathway-directed anticancer therapies is largely extrapolated from adult cardio-oncology practice. Developmental differences in cardiovascular physiology raise the possibility that treatment-related cardiovascular toxicity may not present similarly across ages. Whether the pattern of cardiovascular adverse events associated with these therapies differs between children and adults remains uncertain.</div></div><div>Cardiac monitoring in children receiving pathway-directed anticancer therapies is largely extrapolated from adult cardio-oncology practice. Developmental differences in cardiovascular physiology raise the possibility that treatment-related cardiovascular toxicity may not present similarly across ages. Whether the pattern of cardiovascular adverse events associated with these therapies differs between children and adults remains uncertain.</div><div><h3>Methods</h3><div>We conducted a retrospective pharmacovigilance study using VigiBase®, the World Health Organization global database of individual case safety reports (March 2025 extract). Reports involving pathway-directed anticancer therapies, including kinase and proteasome inhibitors, were classified as minors (<18 years) or adults (≥18 years). Cardiovascular adverse events were identified using predefined terms. Within-drug disproportionality analyses adjusted for sex were performed, with age-stratified and indication-matched sensitivity analyses.</div></div><div>We conducted a retrospective pharmacovigilance study using VigiBase®, the World Health Organization global database of individual case safety reports (March 2025 extract). Reports involving pathway-directed anticancer therapies, including kinase and proteasome inhibitors, were classified as minors (<18 years) or adults (≥18 years). Cardiovascular adverse events were identified using predefined terms. Within-drug disproportionality analyses adjusted for sex were performed, with age-stratified and indication-matched sensitivity analyses.</div><div><h3>Results</h3><div>A total of 5097 pediatric and 273,833 adult reports were analyzed. Cardiovascular reporting patterns differed markedly between age groups. Vascular and ischemic complications and supraventricular arrhythmias were rarely reported in children. In contrast, pediatric reports were predominantly characterized by myocardial dysfunction, including decreased ejection fraction and heart failure, with occasional repolarization abnormalities. Findings were consistent across pediatric age groups and after adjustment for concomitant cardiotoxic therapies, including anthracyclines. Limited drug–event associations were observed for selected agents, mainly involving myocardial dysfunction.</div></div><div>A total of 5097 pediatric and 273,833 adult reports were analyzed. Cardiovascular reporting patterns differed markedly between age groups. Vascular and ischemic complications and supraventricular arrh","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S255"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and executive function in toddlers with congenital heart disease: A multicenter controlled cross-sectionnal study","authors":"Marie Vincenti, Marion Audié, Helena Huguet, Marie-Christine Picot, Sophie Guillaumont, Oscar Werner, Cecile Jore, Lauriane Cornuault, Daniela Laux, Johanna Calderon, Pascal Amédro","doi":"10.1016/j.acvd.2026.06.028","DOIUrl":"10.1016/j.acvd.2026.06.028","url":null,"abstract":"<div><h3>Introduction</h3><div>Health-related quality of life (HRQoL) in toddlers with congenital heart disease (CHD) remains insufficiently characterized, particularly regarding the respective contributions of cardiac severity and neurodevelopmental functioning.</div></div><div>Health-related quality of life (HRQoL) in toddlers with congenital heart disease (CHD) remains insufficiently characterized, particularly regarding the respective contributions of cardiac severity and neurodevelopmental functioning.</div><div><h3>Methods</h3><div>In this cross-sectional study, 287 children aged 2–4 years (133 with CHD and 154 healthy controls) were assessed using the PedsQL™ 4.0 Generic Core Scales (parent proxy-report). Executive functioning was evaluated using the BRIEF Global Executive Composite score. Clinicaltrials.gov (<span><span>NCT04812210</span><svg><path></path></svg></span>).</div></div><div>In this cross-sectional study, 287 children aged 2–4 years (133 with CHD and 154 healthy controls) were assessed using the PedsQL™ 4.0 Generic Core Scales (parent proxy-report). Executive functioning was evaluated using the BRIEF Global Executive Composite score. Clinicaltrials.gov (<span><span>NCT04812210</span><svg><path></path></svg></span>).</div><div><h3>Results</h3><div>Compared with controls, children with CHD had lower overall HRQoL as reported by mothers (80.7<!--> <!-->±<!--> <!-->14.8 vs 85.0<!--> <!-->±<!--> <!-->11.4, <em>P</em> <!--><<!--> <!-->0.001) and fathers (82.8<!--> <!-->±<!--> <!-->13.6 vs 85.9<!--> <!-->±<!--> <!-->11.0, <em>P</em> <!-->=<!--> <!-->0.04). Physical functioning did not differ significantly between groups, whereas emotional, social, and school functioning were significantly lower in the CHD group. Within CHD, lower HRQoL was associated with greater disease burden, including single ventricle physiology and markers of medical complexity. Executive functioning was independently associated with HRQoL in multivariable analyses: higher executive difficulties were consistently related to lower HRQoL in both maternal and paternal reports. Agreement between caregivers was good (ICC 0.73–0.77 for total score).</div></div><div>Compared with controls, children with CHD had lower overall HRQoL as reported by mothers (80.7<!--> <!-->±<!--> <!-->14.8 vs 85.0<!--> <!-->±<!--> <!-->11.4, <em>P</em> <!--><<!--> <!-->0.001) and fathers (82.8<!--> <!-->±<!--> <!-->13.6 vs 85.9<!--> <!-->±<!--> <!-->11.0, <em>P</em> <!-->=<!--> <!-->0.04). Physical functioning did not differ significantly between groups, whereas emotional, social, and school functioning were significantly lower in the CHD group. Within CHD, lower HRQoL was associated with greater disease burden, including single ventricle physiology and markers of medical complexity. Executive functioning was independently associated with HRQoL in multivariable analyses: higher executive difficulties were consistently related to lower HRQoL in both maternal and paternal reports. Agre","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S252"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the PREMA-CHD 1-year mortality score in preterm infants with congenital heart disease: A multicenter cohort study","authors":"Illies Ouhab, Arthur Gavotto, Sophie Guillaumont","doi":"10.1016/j.acvd.2026.06.026","DOIUrl":"10.1016/j.acvd.2026.06.026","url":null,"abstract":"<div><h3>Introduction</h3><div>To describe 1-year mortality among preterm infants with hemodynamically significant CHD, identify associated risk factors, and develop a score to predict mortality at 1 year.</div></div><div>To describe 1-year mortality among preterm infants with hemodynamically significant CHD, identify associated risk factors, and develop a score to predict mortality at 1 year.</div><div><h3>Methods</h3><div>Retrospective multicenter cohort study conducted in 5 French tertiary M3<!--> <!-->C centers (Montpellier, Bordeaux, Marseille, Nantes, Toulouse). All infants born at<!--> <!--><<!--> <!-->37 weeks’ gestation with hemodynamically significant CHD managed between 2018 and 2023 were eligible. Minor lesions without expected hemodynamic impact were excluded. Severe neonatal morbidity was also assessed (IVH grade III/IV, NEC Bell stage<!--> <!-->≥<!--> <!-->2a, severe BPD, BPH).</div></div><div>Retrospective multicenter cohort study conducted in 5 French tertiary M3<!--> <!-->C centers (Montpellier, Bordeaux, Marseille, Nantes, Toulouse). All infants born at<!--> <!--><<!--> <!-->37 weeks’ gestation with hemodynamically significant CHD managed between 2018 and 2023 were eligible. Minor lesions without expected hemodynamic impact were excluded. Severe neonatal morbidity was also assessed (IVH grade III/IV, NEC Bell stage<!--> <!-->≥<!--> <!-->2a, severe BPD, BPH).</div><div><h3>Results</h3><div>Among 213 preterm infants with significant CHD (median gestational age, 34 weeks; mean birth weight, 1959<!--> <!-->g), 1-year mortality was 21.1%. The most frequent CHD categories were complex right ventricular outflow tract anomalies (40.9%) and extracardiac arterial trunk anomalies (14.6%). One-year survival without severe neonatal morbidity occurred in 69.0%. In multivariable survival analysis, one-year mortality remained associated with lower gestational age (aHR 0.88, 95% CI 0.79–0.98; <em>P</em> <!-->=<!--> <!-->0.02), lower 10-minute Apgar score (aHR 0.76, 95% CI 0.68–0.86; <em>P</em> <!--><<!--> <!-->0.001), genetic/syndromic anomalies (aHR 3.55, 95% CI 1.73–7.30; <em>P</em> <!-->=<!--> <!-->0.0006), mixing CHD physiology (aHR 4.64, 95% CI 2.32–9.30; <em>P</em> <!--><<!--> <!-->0.001), high-grade intraventricular hemorrhage (aHR 8.99, 95% CI 2.92–27.68; <em>P</em> <!-->=<!--> <!-->0.0001), and prostaglandin infusion (aHR 1.92, 95% CI 0.97–3.78; <em>P</em> <!-->=<!--> <!-->0.0596). A prediction score for 1-year mortality was derived from the final multivariable model.</div></div><div>Among 213 preterm infants with significant CHD (median gestational age, 34 weeks; mean birth weight, 1959<!--> <!-->g), 1-year mortality was 21.1%. The most frequent CHD categories were complex right ventricular outflow tract anomalies (40.9%) and extracardiac arterial trunk anomalies (14.6%). One-year survival without severe neonatal morbidity occurred in 69.0%. In multivariable survival analysis, one-year mortality remained associated with lo","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S251"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between neuropsychiatric symptoms and executive functioning in CHD","authors":"Anne-Cyrielle Plassard, Sylvie Martins, Fanny Bajolle, Neil Derridj, Noemie Derridj, Damien Bonnet, Johanna Calderon","doi":"10.1016/j.acvd.2026.06.042","DOIUrl":"10.1016/j.acvd.2026.06.042","url":null,"abstract":"<div><h3>Introduction</h3><div>Congenital heart disease (CHD) is associated with elevated neurodevelopmental risk. Data on mental health including anxiety and depression in children with CHD and their comorbidities remain unclear. We investigated neuropsychiatric internalizing and DSM-V autism spectrum symptoms and their association with executive functioning (EF) in children with CHD.</div></div><div>Congenital heart disease (CHD) is associated with elevated neurodevelopmental risk. Data on mental health including anxiety and depression in children with CHD and their comorbidities remain unclear. We investigated neuropsychiatric internalizing and DSM-V autism spectrum symptoms and their association with executive functioning (EF) in children with CHD.</div><div><h3>Methods</h3><div>Neurodevelopmental assessment was conducted at the Cardiac Neurodevelopmental Center Necker Children's Hospital between November 2025 and February 2026, following the European Neurodevelopmental follow-up guidelines for CHD. Cognitive outcomes were measured by the WISC-V, WPPSI-IV or the Bayley-4, and EF by the BRIEF-P/2. Parent-reported neuropsychiatric symptoms included BASC-3 Anxiety, Depression and Somatization as well as SRS-2 DSM-5 autism scales. Descriptive data and correlation analyses are reported.</div></div><div>Neurodevelopmental assessment was conducted at the Cardiac Neurodevelopmental Center Necker Children's Hospital between November 2025 and February 2026, following the European Neurodevelopmental follow-up guidelines for CHD. Cognitive outcomes were measured by the WISC-V, WPPSI-IV or the Bayley-4, and EF by the BRIEF-P/2. Parent-reported neuropsychiatric symptoms included BASC-3 Anxiety, Depression and Somatization as well as SRS-2 DSM-5 autism scales. Descriptive data and correlation analyses are reported.</div><div><h3>Results</h3><div>30 children with CHD were included (mean age 7<!--> <!-->y<!--> <!-->±<!--> <!-->2<!--> <!-->y; 50% male). 93% had cardiac surgery, including 57% as neonates. Cognitive scores were within norms (mean<!--> <!-->=<!--> <!-->95.6<!--> <!-->±<!--> <!-->13.2), however, executive dysfunction were frequent (BRIEF, mean<!--> <!-->=<!--> <!-->62<!--> <!-->±<!--> <!-->18.2, exceeding norms by<!--> <!-->≥<!--> <!-->1 SD). BASC-3 Anxiety (mean<!--> <!-->=<!--> <!-->47<!--> <!-->±<!--> <!-->10), Depression (mean<!--> <!-->=<!--> <!-->49<!--> <!-->±<!--> <!-->12.3), and Somatization (mean<!--> <!-->=<!--> <!-->52<!--> <!-->±<!--> <!-->10) matched expected norms. Both SRS-2 DSM-V scales (Communication: mean<!--> <!-->=<!--> <!-->63.8<!--> <!-->±<!--> <!-->13.7; Restricted interest: mean<!--> <!-->=<!--> <!-->67.4<!--> <!-->±<!--> <!-->15) were abovenormative means. No association was found between neuropsychiatric symptoms and cognitive functioning. EF was associated with Anxiety (<em>r</em> <!-->=<!--> <!-->0.45, <em>P</em> <!--><<!--> <!-->0.01), Depression (<em>r</em> <!-->=<!--> <!-->0.46, <em>P</em> <!--><<!--> <!-->0.0","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Pages S258-S259"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cardiorespiratory fitness on neurodevelopmental and mental health outcomes in youth with congenital long QT syndrome","authors":"Sylvie Martins, Luc Souilla, Helena Huguet, Sophie Guillaumont, Marie Vincenti, Grégoire de La Villéon, Marie-Christine Picot, Damien Bonnet, Pascal Amédro, Johanna Calderon","doi":"10.1016/j.acvd.2026.06.074","DOIUrl":"10.1016/j.acvd.2026.06.074","url":null,"abstract":"<div><h3>Introduction</h3><div>Congenital long QT syndrome (LQTS) is an inherited heart rhythm disorder characterized by abnormal myocardial repolarization with potential ventricular arrhythmias and risks for sudden cardiac arrest. LQTS is linked to reduced cardiorespiratory fitness (CRF) and mental health vulnerability. We investigated associations between CRF and neurodevelopmental and mental health in pediatric LQTS.</div></div><div>Congenital long QT syndrome (LQTS) is an inherited heart rhythm disorder characterized by abnormal myocardial repolarization with potential ventricular arrhythmias and risks for sudden cardiac arrest. LQTS is linked to reduced cardiorespiratory fitness (CRF) and mental health vulnerability. We investigated associations between CRF and neurodevelopmental and mental health in pediatric LQTS.</div><div><h3>Methods</h3><div>This multicenter study enrolled children with congenital LQTS. CRF was assessed using the Ventilatory Anaerobic Threshold (VAT) and maximal oxygen uptake (VO2max). Neurodevelopment was assessed <em>via</em> standardized mean scores from the Wechsler Intelligence Scale for Children V, and the Behavior Rating Inventory of Executive Function, proxy-report. Anxiety and depression were measured <em>via</em> self-reports from the Revised Children's Manifest Anxiety Scale, and the Multiscore Depression Inventory for Children. Pearson correlations were computed independently between VAT and VO2max z-scores and neuropsychological indices, adjusted for IQ.</div></div><div>This multicenter study enrolled children with congenital LQTS. CRF was assessed using the Ventilatory Anaerobic Threshold (VAT) and maximal oxygen uptake (VO2max). Neurodevelopment was assessed <em>via</em> standardized mean scores from the Wechsler Intelligence Scale for Children V, and the Behavior Rating Inventory of Executive Function, proxy-report. Anxiety and depression were measured <em>via</em> self-reports from the Revised Children's Manifest Anxiety Scale, and the Multiscore Depression Inventory for Children. Pearson correlations were computed independently between VAT and VO2max z-scores and neuropsychological indices, adjusted for IQ.</div><div><h3>Results</h3><div>Twenty-three participants (mean age<!--> <!-->=<!--> <!-->11 y<!--> <!-->±<!--> <!-->3.5 mo; 70% male) were enrolled. VAT correlated with working memory (<em>r</em> <!-->=<!--> <!-->0.44, <em>p</em> <!-->=<!--> <!-->0.04) and processing speed (<em>r</em> <!-->=<!--> <!-->0.57, <em>p</em> <!-->=<!--> <!-->0.01), whereas VO2max correlated with processing speed only (<em>r</em> <!-->=<!--> <!-->0.51, <em>p</em> <!-->=<!--> <!-->0.02). None of the CRF measures were associated with executive functioning. Anxiety symptoms were related to lower VO2max (social concerns, <em>r</em> <!-->=<!--> <!-->−0.53, <em>p</em> <!-->=<!--> <!-->0.01). Depression scores were related to both VAT and VO2max. Indeed, lower VAT and VO2max were associated with poorer scores on Sad Mood, Helpless","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 8","pages":"Page S275"},"PeriodicalIF":2.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}