Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology最新文献

{"title":"Validity, internal consistency, and test-retest reliability of the Montenegrin 10-item Voice Handicap Index.","authors":"Elvir Zvrko,&nbsp;Muhedin Kadić","doi":"10.2478/aiht-2022-73-3624","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3624","url":null,"abstract":"<p><p>The purpose of the this cross-sectional study was to assess clinical validity, internal consistency, and test-retest reliability of the adapted Montenegrin translation of the Voice Handicap Index 10 (VHI-10). It included 50 patients with voice disorders, divided into three subgroups according disease aetiology: structural, neurological, and functional and a control group of 50 vocally healthy participants. Mean patient VHI-10 score of 21.1±7.6 was significantly higher than the 2.3±2.5 score of controls (p<0.001). Each of the three patient subgroups also scored significantly higher than control (p<0.001). Spearman's rank correlation coefficient of 0.90 (p<0.001) indicated a very strong correlation between the Montenegrin VHI-10 score and self-reported perception of the severity of voice disorder. Excellent internal consistency was found in the patient group, with a Cronbach's alpha of 0.94. Test-retest reliability was also excellent, with intra class correlation coefficient of 0.98. The translated Montenegrin version of VHI-10 is a valid, reliable, and clinically useful tool for self-assessment of the severity of voice disorders in individuals with voice problems in daily practice and in research projects.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"143-147"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/b9/aiht-73-143.PMC9287834.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to BTEX and styrene in West Asian countries: a brief review of current state and limits.","authors":"Razzagh Rahimpoor,&nbsp;Fatemeh Sarvi,&nbsp;Samira Rahimnejad,&nbsp;Seyed Mohammad Ebrahimi","doi":"10.2478/aiht-2022-73-3634","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3634","url":null,"abstract":"<p><p>The aim of introducing occupational exposure limits (OELs) is to use them as a risk management tool in order to protect workers' health and well-being against harmful agents at the workplace. In this review we identify OELs for benzene, toluene, ethylbenzene, xylene (BTEX), and styrene concentrations in air and assess occupational exposure to these compounds through a systematic literature search of publications published in West Asian countries from 1980 to 2021. OELs for BTEX and styrene have been set in Iran and Turkey to levels similar to those in European countries and the US. The search yielded 49 full-text articles that cover studies of exposure assessment in six countries, but most (n=40) regard Iran. Average occupational exposure to benzene of workers in oil-related industries is higher than recommended OEL, while average occupational exposure to other compounds is lower than local OELs (where they exist). Currently, information about levels of occupational exposure to BTEX and styrene is insufficient in West Asian countries, which should be remedied through OEL regulation and application. Furthermore, coherent research is also needed to determine actual levels of occupational exposure, dose-responses, and the economic and technical capacity of local industries to address current issues.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"107-118"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/c2/aiht-73-107.PMC9287831.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidative, cytotoxic, and antibacterial properties of self-assembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film.","authors":"Merve Eylul Kiymaci,&nbsp;Hakan Erdoğan,&nbsp;Merve Bacanlı","doi":"10.2478/aiht-2022-73-3658","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3658","url":null,"abstract":"<p><p>Recent years have seen much attention being given to self-assembly of dipeptide-based structures, especially to self-regulation of dipeptide structures with different amino acid sequences. In this study we investigated the effects of varying solvent environments on the self-assembly of glycine-histidine (Gly-His) dipeptide structures. First we determined the morphological properties of Gly-His films formed in different solvent environments with scanning electron microscopy and then structural properties with Fourier-transform infrared (FTIR) spectroscopy. In addition, we studied the effects of Gly-His films on silver nanoparticle (AgNP) formation and the antioxidant and cytotoxic properties of AgNPs obtained in this way. We also, assessed antibacterial activities of Gly-His films against Gram-negative <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> and Gram-positive <i>Staphylococcus aureus</i>. Silver nanoparticle-decorated Gly-His films were not significantly cytotoxic at concentrations below 2 mg/mL but had antibacterial activity. We therefore believe that AgNP-decorated Gly-His films at concentrations below 2 mg/mL can be used safely against bacteria.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"169-177"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/64/aiht-73-169.PMC9287833.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress.","authors":"Burcu Ünlü Endirlik,&nbsp;Ayşe Eken,&nbsp;Hande Canpınar,&nbsp;Figen Öztürk,&nbsp;Aylin Gürbay","doi":"10.2478/aiht-2022-73-3629","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3629","url":null,"abstract":"<p><p>The aim of this study was to investigate oxidative stress induced by perfluorooctanoic acid (PFOA) in the brain and liver tissues of Balb/c mice as well as protective effects of taurine and coenzyme Q₁₀ (CoQ₁₀) in both organs. For this purpose, animals were treated with PFOA (15 and 30 mg/kg) orally and their lipid peroxidation, total glutathione levels (GSH), and antioxidant enzyme activities measured and both tissues analysed for histopathological changes. Our results showed a dose-dependent decrease in body weight and increase in relative brain and liver weights, PFOA-induced lipid peroxidation and reduced glutathione peroxidase (GPx) activity in the brain tissue, and changes in GSH levels, GPx, superoxide dismutase (Cu-Zn SOD), and catalase (CAT) activities in the liver tissue. Pre-treatment with taurine or CoQ₁₀ provided protection against PFOA-induced Cu-Zn SOD reduction in the liver tissue. Our findings evidence the depleting effect of PFOA on antioxidative systems and confirm that PFOA exerts its (neuro)toxicity through oxidative stress, but further research is needed to identify the exact toxicity mechanisms, especially in the brain.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"148-157"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/9d/aiht-73-148.PMC9287837.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis.","authors":"Danijela Đukić-Ćosić,&nbsp;Katarina Baralić,&nbsp;Teodora Filipović,&nbsp;Dragica Božić,&nbsp;Katarina Živančević,&nbsp;Evica Antonijević Miljaković,&nbsp;Aleksandra Buha Đorđević,&nbsp;Zorica Bulat,&nbsp;Biljana Antonijević,&nbsp;Marijana Ćurčić","doi":"10.2478/aiht-2022-73-3631","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3631","url":null,"abstract":"<p><p>Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our <i>in silico</i> study was to determine the relationship between the key air pollutants [sulphur dioxide (SO), carbon monoxide (CO), ₂particulate matter (PM_x), nitrogen dioxide (NO₂), and ozone (O₃)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO₂, CO, PM_x, NO₂, and O₃ interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (<i>IL10</i>, <i>IL6</i>, <i>IL1B</i>, and <i>TNF</i>) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the <i>CEBPA</i> gene and acute myelocytic leukaemia and between <i>TNFRSF1A</i> and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"119-125"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/ca/aiht-73-119.PMC9287838.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption habits of pregnant women in Itaituba, Tapajós River basin, Brazil: risks of mercury contamination as assessed by measuring total mercury in highly consumed piscivore fish species and in hair of pregnant women.","authors":"Ricardo Bezerra de Oliveira,&nbsp;Domingas Machado da Silva,&nbsp;Thamilles Santa Bárbara Sousa Franco,&nbsp;Cláudio Ramon Sena Vasconcelos,&nbsp;Deise Juliane Dos Anjos de Sousa,&nbsp;Sandra Layse Ferreira Sarrazin,&nbsp;Mineshi Sakamoto,&nbsp;Jean-Paul Bourdineaud","doi":"10.2478/aiht-2022-73-3611","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3611","url":null,"abstract":"<p><p>The Tapajós River basin in the Amazon region, Brazil is one of the most active gold mining areas in the world. In this study, we evaluated fish consumption habits and mercury exposure in 110 pregnant women in the city of Itaituba by measuring their total hair mercury concentrations. In addition, we investigated seasonal differences in mercury concentrations in two highly consumed piscivorous fish species, tucunaré (<i>Cichla</i> spp.) and pescada (<i>Plagioscion squamosissimus</i>). Total fish mercury concentrations (THg) during the dry season were 0.62±0.07 mg/kg for <i>Cichla</i> spp. and 0.73±0.08 mg/kg for <i>P. squamosissimus</i>. During the rainy season they were 0.39±0.04 and 0.84±0.08 mg/ kg, respectively. Of our participants 44 % declared that they ate <i>Cichla</i> spp. and 67 % <i>P. squamosissimus</i>. Mean mercury concentration in their hair was 1.6±0.2 mg/kg and was above the US Environmental Protection Agency (US EPA) reference dose of 1 mg/kg in 48 % of them. Mean fish THg concentrations were also above the joint Food and Drug Administration and US EPA safety limit of 0.5 mg/kg for <i>P. squamosissimus</i> during both seasons and for <i>Cichla</i> spp. during the dry season only. These results show that pregnant women should avoid consumption of these piscivorous fish species during pregnancy and call for a regular programme to monitor Hg levels in that area.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 2","pages":"131-142"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/8b/aiht-73-131.PMC9287832.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to particulate matter: a brief review with a focus on cardiovascular effects, children, and research conducted in Turkey.","authors":"Aylin Elkama, Ayça Aktaş Şüküroğlu, Gonca Çakmak","doi":"10.2478/aiht-2021-72-3563","DOIUrl":"10.2478/aiht-2021-72-3563","url":null,"abstract":"<p><p>Exposure to environmental particulate matter (PM), outdoor air pollution in particular, has long been associated with adverse health effects. Today, PM has widely been accepted as a systemic toxicant showing adverse effects beyond the lungs. There are numerous studies, from those <i>in vitro</i> to epidemiological ones, suggesting various direct and indirect PM toxicity mechanisms associated with cardiovascular risks, including inflammatory responses, oxidative stress, changes in blood pressure, autonomic regulation of heart rate, suppression of endothelium-dependent vasodilation, thrombogenesis, myocardial infarction, and fibrinolysis. In addition to these and other health risks, considerations about air quality standards should include individual differences, lifestyle, and vulnerable populations such as children. Urban air pollution has been a major environmental issue for Turkey, and this review will also address current situation, research, and measures taken in our country.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"72 4","pages":"244-253"},"PeriodicalIF":1.7,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/55/aiht-72-4-244.PMC8785112.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9714891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Job demands, job control, and social support as predictors of job satisfaction and burnout in Croatian palliative care nurses.","authors":"Ivana Tucak Junaković,&nbsp;Ivana Macuka","doi":"10.2478/aiht-2021-72-3556","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3556","url":null,"abstract":"Abstract The Job Demands-Control-Support (JDCS) model has seldom been tested in palliative care settings, and occupational well-being of palliative care professionals has never before been investigated in Croatia. Our aim was therefore to fill that gap by testing the JDCS model among Croatian nurses providing palliative care. More specifically, we wanted to see how job demands, job control, and social support at work affect occupational well-being outcomes (i.e. job satisfaction and burnout dimensions of exhaustion and disengagement from work) in terms of the model’s iso-strain and buffer hypotheses. This cross-sectional study included 68 nurses working in various palliative care institutions across Croatia, who answered our online questionnaire. Overall, the nurses did not report high levels of burnout or low job satisfaction. The only significant effect was that of job control on job satisfaction (β=0.38; P<0.01) and disengagement (β=-0.45; P<0.01), while job demands and social support at work had a significant interaction effect on the burnout dimension of exhaustion (β=0.39; P<0.01) in the sense that high social support at work buffered the increase in exhaustion associated with high job demands. These findings suggest that interventions aimed at increasing perceived job control and social support at the workplace could improve occupational well-being of nurses working in palliative care.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"72 3","pages":"225-231"},"PeriodicalIF":2.1,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/09/aiht-72-225.PMC8576750.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of pumpkin pulp extract carotenoids against mycotoxin damage in the blood brain barrier <i>in vitro</i>.","authors":"Manuel Alonso-Garrido,&nbsp;Noelia Pallarés,&nbsp;Guillermina Font,&nbsp;Paola Tedeschi,&nbsp;Lara Manyes,&nbsp;Manuel Lozano","doi":"10.2478/aiht-2021-72-3541","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3541","url":null,"abstract":"<p><p>Some mycotoxins such as beauvericin (BEA), ochratoxin A (OTA), and zearalenone (ZEA) can cross the blood brain barrier, which is why we tested the anti-inflammatory action of a pumpkin carotenoid extract (from the pulp) against these mycotoxins and their combinations (OTA+ZEA and OTA+ZEA+BEA) on a blood brain barrier model with co-cultured ECV304 and C6 cells using an untargeted metabolomic approach. The cells were added with mycotoxins at a concentration of 100 nmol/L per mycotoxin and pumpkin carotenoid extract at 500 nmol/L. For control we used only vehicle solvent (cell control) or vehicle solvent with pumpkin extract (extract control). After two hours of exposure, samples were analysed with HPLC-ESI-QTOF-MS. Metabolites were identified against the Metlin database. The proinflammatory arachidonic acid metabolite eoxin (14,15-LTE4) showed lower abundance in ZEA and BEA+OTA+ZEA-treated cultures that also received the pumpkin extract than in cultures that were not treated with the extract. Another marker of inflammation, prostaglandin D2-glycerol ester, was only found in cultures treated with OTA+ZEA and BEA+OTA+ZEA but not in the ones that were also treated with the pumpkin extract. Furthermore, the concentration of the pumpkin extract metabolite dihydromorelloflavone significantly decreased in the presence of mycotoxins. In conclusion, the pumpkin extract showed protective activity against cellular inflammation triggered by mycotoxins thanks to the properties pertinent to flavonoids contained in the pulp.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"72 3","pages":"173-181"},"PeriodicalIF":2.1,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/ca/aiht-72-173.PMC8576748.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of <i>NLRP3</i> and <i>CARD8</i> gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study.","authors":"Anja Plemenitaš Ilješ, Blanka Kores Plesničar, Vita Dolžan","doi":"10.2478/aiht-2021-72-3432","DOIUrl":"10.2478/aiht-2021-72-3432","url":null,"abstract":"<p><p>We investigated two functional polymorphisms in NLRP3 inflammasome genes (<i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211) and their association with alcohol dependence and related anxiety, depression, obsession-compulsion, or aggression in 88 hospitalised alcohol-dependent patients, 99 abstinent alcohol-dependent participants, and 94 controls, all male Caucasian. Alcohol dependence-related psychiatric disorders were assessed with the Zung Depression and Anxiety scale, Buss-Durkee Hostility Inventory, Alcohol Use Disorders Identification Test, Brief Social Phobia Scale, Obsessive Compulsive Drinking Scale, and Yale-Brown Obsessive-Compulsive Scale. For genotyping we used the allele-specific quantitative polymerase chain reaction-based methods. The three groups differed significantly in <i>CARD8</i> rs2043211 distribution (P=0.049; chi-squared=9.557; df=4). The <i>NLPR3</i> rs35829419 polymorphism was not significantly associated with alcohol dependence. In hospitalised alcohol-dependent patients the investigated polymorphisms were not associated with scores indicating alcohol consumption or comorbid symptoms. In abstinent alcohol-dependent subjects homozygotes for the polymorphic <i>CARD8</i> allele presented with the highest scores on the Zung Anxiety Scale (p=0.048; df=2; F=3.140). Among controls, <i>CARD8</i> genotype was associated with high scores on the Obsessive Compulsive Drinking Scale (P=0.027; df=2; F=3.744). In conclusion, our results reveal that <i>CARD8</i> rs2043211 may play some role in susceptibility to alcohol dependence, expression of anxiety symptoms in abstinent alcohol-dependent subjects, and in obsessive compulsive drinking in healthy controls. However, further studies with larger cohorts are required to confirm these preliminary findings.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"72 3","pages":"191-197"},"PeriodicalIF":1.7,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/e4/aiht-72-191.PMC8576752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}