Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology最新文献

筛选
英文 中文
Does organisational myopia mediate the effect of occupational health and safety practices on the risk of occupational accidents in Turkish healthcare institutions? 组织近视是否对土耳其医疗机构职业健康与安全实践对工伤事故风险的影响起中介作用?
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3796
Hasan Sadık Tatli, Kübra Sezen Erküvün, Mesut Can Türkoğlu
{"title":"Does organisational myopia mediate the effect of occupational health and safety practices on the risk of occupational accidents in Turkish healthcare institutions?","authors":"Hasan Sadık Tatli, Kübra Sezen Erküvün, Mesut Can Türkoğlu","doi":"10.2478/aiht-2024-75-3796","DOIUrl":"10.2478/aiht-2024-75-3796","url":null,"abstract":"<p><p>Occupational health and safety (OHS) policies in healthcare institutions must be well managed, because healthcare practice involves many physical, biological, ergonomic, chemical, and psychosocial hazards that can affect the health of healthcare workers. In addition, their work performance may be affected by the so-called organisational myopia. In this context, the aim of our study was to determine how organisational myopia affects OHS practices in healthcare institutions and whether it increases the risk of occupational accidents. The study population consisted of a convenience sample of 420 healthcare professionals working throughout Turkey who completed a questionnaire addressing these three domains: organisational myopia, OHS practices, and risk of occupational accidents. Their responses were analysed with exploratory factor analysis, reliability analysis, and Spearman's correlation to assess the adequacy of measurement tools and identify relationships between variables, followed by mediation analysis. We found that OHS practices mitigate organisational myopia and the risk of occupational accidents. We also found no significant effect of organisational myopia on the risk of occupational accidents. Our findings underscore the importance of OHS practices in healthcare institutions and that organisational myopia should be evaluated in special contexts such as working time, experience, or routinisation.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"180-190"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors predicting the level of vaccine protection against hepatitis B virus infection among physicians and nurses in Šabac, Serbia. 预测塞尔维亚萨巴茨医生和护士接种疫苗预防乙型肝炎病毒感染水平的因素。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3828
Slobodanka Bogdanović Vasić, Branislava Brestovački Svitlica, Dragana Milutinović, Goran Stevanović, Jelena Stojčević Maletić, Nikola Savić, Branimirka Aranđelović, Maja Ružić
{"title":"Factors predicting the level of vaccine protection against hepatitis B virus infection among physicians and nurses in Šabac, Serbia.","authors":"Slobodanka Bogdanović Vasić, Branislava Brestovački Svitlica, Dragana Milutinović, Goran Stevanović, Jelena Stojčević Maletić, Nikola Savić, Branimirka Aranđelović, Maja Ružić","doi":"10.2478/aiht-2024-75-3828","DOIUrl":"10.2478/aiht-2024-75-3828","url":null,"abstract":"<p><p>As healthcare workers run a high and constant occupational risk of hepatitis B virus (HBV) infection through exposure to biological material, vaccination is mandatory as well as the monitoring of antibody levels one to two months after complete immunisation. The aim of this descriptive cross-sectional study was to determine HBV vaccine coverage of 200 primary and secondary healthcare workers (100 each) from Šabac, Serbia and their blood anti-HBs titre. We also wanted to identify factors that could predict the titre. Anti-HBV vaccination covered all participants, of whom 89.5 % were fully vaccinated, and 85 % had a protective antibody titre. We found a statistically significant association between antibody titre and the number of received vaccine doses, chronic jaundice, autoimmune disease, and cancer in our participants. The fact that 15 % did not achieve the protective antibody titre confirms the necessity of its control after immunisation, which is not routinely carried out in most countries, Serbia included. It is, therefore, necessary to develop a detailed strategy for monitoring vaccination and serological status of healthcare workers in order to improve their safety at work. An important role should also be given to continuous education of healthcare workers from the beginning of schooling to the end of their professional career.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"191-199"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bis(amino acidato)copper(II) compounds in blood plasma: a review of computed structural properties and amino acid affinities for Cu2+ informing further pharmacological research. 血浆中的双(氨基酸)铜(II)化合物:计算结构特性和氨基酸对 Cu2+ 的亲和力综述,为进一步的药理学研究提供信息。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3871
Jasmina Sabolović
{"title":"Bis(amino acidato)copper(II) compounds in blood plasma: a review of computed structural properties and amino acid affinities for Cu<sup>2+</sup> informing further pharmacological research.","authors":"Jasmina Sabolović","doi":"10.2478/aiht-2024-75-3871","DOIUrl":"10.2478/aiht-2024-75-3871","url":null,"abstract":"<p><p>Neutral bis(amino acidato)copper(II) [Cu(aa)<sub>2</sub>] coordination compounds are the physiological species of copper(II) amino acid compounds in blood plasma taking the form of bis(l-histidinato)copper(II) and mixed ternary copper(II)-l-histidine complexes, preferably with l-glutamine, l-threonine, l-asparagine, and l-cysteine. These amino acids have three functional groups that can bind metal ions: the common α-amino and carboxylate groups and a side-chain polar group. In Cu(aa)<sub>2</sub>, two coordinating groups per amino acid bind to copper(II) in-plane, while the third group can bind apically, which yields many possibilities for axial and planar bonds, that is, for bidentate and tridentate binding. So far, the experimental studies of physiological Cu(aa)<sub>2</sub> compounds in solutions have not specified their complete geometries. This paper provides a brief review of my group's research on structural properties of physiological Cu(aa)<sub>2</sub> calculated using the density functional theory (DFT) to locate low-energy conformers that can coexist in aqueous solutions. These DFT investigations have revealed high conformational flexibility of ternary Cu(aa)<sub>2</sub> compounds for tridentate or bidentate chelation, which may explain copper(II) exchange reactions in the plasma and inform the development of small multifunctional copper(II)-binding drugs with several possible copper(II)-binding groups. Furthermore, our prediction of metal ion affinities for Cu<sup>2+</sup> binding with amino-acid ligands in low-energy conformers with different coordination modes of five physiological Cu(aa)<sub>2</sub> in aqueous solution supports the findings of their abundance in human plasma obtained with chemical speciation modelling.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"159-171"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urine levels of nicotine and its metabolites in young population exposed to second-hand smoke in nightclubs: a pilot study. 接触夜总会二手烟的年轻人尿液中尼古丁及其代谢物的水平:一项试验性研究。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3846
Antonia Zečić, Bernarda Vazdar, Livia Slišković, Davorka Sutlović
{"title":"Urine levels of nicotine and its metabolites in young population exposed to second-hand smoke in nightclubs: a pilot study.","authors":"Antonia Zečić, Bernarda Vazdar, Livia Slišković, Davorka Sutlović","doi":"10.2478/aiht-2024-75-3846","DOIUrl":"10.2478/aiht-2024-75-3846","url":null,"abstract":"<p><p>The aim of this study was to investigate the extent of second-hand smoke exposure in younger population visiting nightclubs in Croatia by comparing the levels of nicotine and its main metabolites cotinine and trans-3'-hydroxycotinine (3HC) in urine samples taken from 22 participants before and after spending about three hours in a nightclub, stratified by smoking status (smokers and non-smokers). The samples were prepared by liquid-liquid extraction and analysed with gas chromatography-mass spectrometry. The presence of nicotine, cotinine, and 3HC was confirmed in all urine samples. Their median concentrations significantly differed between the two measurements in non-smokers. Our findings show that even a three-hour exposure to second-hand smoke can significantly increase the levels of nicotine and its metabolites in urine, which are indicative of exposure to other, harmful tobacco smoke substances. They also call for raising awareness of the health risks of exposure to second-hand smoke in the general population and among individuals who frequent nightclubs in particular.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"211-216"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difference between hand and forearm transepidermal water loss and skin pH as an improved method to biomonitor occupational hand eczema: our findings in healthcare workers. 手部和前臂经表皮失水和皮肤 pH 值之间的差异是职业性手部湿疹生物监测的一种改进方法:我们在医护人员中的发现。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3885
Željka Babić, Franka Šakić, Iva Japudžić Rapić, Liborija Lugović-Mihić, Jelena Macan
{"title":"Difference between hand and forearm transepidermal water loss and skin pH as an improved method to biomonitor occupational hand eczema: our findings in healthcare workers.","authors":"Željka Babić, Franka Šakić, Iva Japudžić Rapić, Liborija Lugović-Mihić, Jelena Macan","doi":"10.2478/aiht-2024-75-3885","DOIUrl":"10.2478/aiht-2024-75-3885","url":null,"abstract":"<p><p>The aim of this cross-sectional field study was to establish the condition of hand and forearm skin barrier among dentists and physicians and how it may be associated with personal and work-related factors. The study consisted of an occupational questionnaire, clinical examination of skin on hands, and transepidermal water loss (TEWL) and pH measurements on hands and forearms. The participants were divided in the following groups (N=37 each, N=148 in total): physicians, medical surgeons, dentists, and dental surgeons. We calculated the difference between hand and forearm TEWL and pH (ΔTEWL and ΔpH, respectively) and divided it by the forearm values (ΔTEWL% and ΔpH%, respectively). There was a clear trend of increasing median ΔTEWL%, starting from physicians with non-surgical specialisation (56 %) to medical surgeons (65 %), dentists (104 %), and dental surgeons (108 %), with the latter two groups showing particularly worrisome signs of work-related skin barrier impairment, since they had double the TEWL on hands than on forearms. Although less prominent, the same worsening trend was noted for skin pH, with dental surgeons having on average a 0.3 points higher skin pH on hands than on forearms. These findings were mainly associated with prolonged glove use and male sex. Our findings also suggest that comparing TEWL and pH between hands and forearms can better establish occupational skin barrier impairment on hands.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"172-179"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Justice sensitivity among nurses and physiotherapists in a Croatian rehabilitation hospital. 克罗地亚康复医院护士和理疗师的司法敏感性。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3829
Irena Canjuga, Dragana Sakač, Melita Sajko, Marija Arapović, Dijana Vuković, Anica Hunjet, Ivana Herak
{"title":"Justice sensitivity among nurses and physiotherapists in a Croatian rehabilitation hospital.","authors":"Irena Canjuga, Dragana Sakač, Melita Sajko, Marija Arapović, Dijana Vuković, Anica Hunjet, Ivana Herak","doi":"10.2478/aiht-2024-75-3829","DOIUrl":"10.2478/aiht-2024-75-3829","url":null,"abstract":"<p><p>The aim of this study was to investigate and compare justice sensitivity between self-perceived beneficiaries, victims, and observers in a sample of 90 healthcare workers (nurses and physiotherapists) at the Varaždinske Toplice Special Medical Rehabilitation Hospital, Croatia. For this purpose we used a questionnaire consisting of demographic data and the Croatian version of the justice sensitivity inventory developed by Schmitt. Regardless of its limitations, our study clearly shows that healthcare professionals at Varaždinske Toplice are most sensitive to injustice from the beneficiary's perspective, that is, as persons who personally benefitted from injustice, although they may not have been instrumental to this effect. They are less sensitive to injustice perceived on the outside (observer's perspective) or to injustice suffered by themselves (victim's perspective). Another important finding is that participants of female gender, rural residence, and nurses (who are all women) are significantly more sensitive to injustice, whereas age and marital status do not seem to contribute to justice sensitivity. Future research should investigate the perception of injustice over a longer timeframe and involve all healthcare workers. It could also address different approaches to management, especially in terms of worker rewards and career advancement. Qualitative research among healthcare workers could provide a broader and clearer idea of social injustice at their workplace.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"200-210"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peculiarities of 7-hydroxyflavone oxidation in relation to our model for the estimation of the first oxidation potential of flavonoids. 7- 羟基黄酮氧化的特殊性与我们估算黄酮类化合物第一氧化潜能的模型有关。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI: 10.2478/aiht-2024-75-3891
Ante Miličević
{"title":"Peculiarities of 7-hydroxyflavone oxidation in relation to our model for the estimation of the first oxidation potential of flavonoids.","authors":"Ante Miličević","doi":"10.2478/aiht-2024-75-3891","DOIUrl":"10.2478/aiht-2024-75-3891","url":null,"abstract":"","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 3","pages":"217-218"},"PeriodicalIF":1.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sick leaves among healthy pregnant Croatian healthcare workers during the COVID-19 pandemic due to loopholes in the occupational safety system. 在 COVID-19 大流行期间,由于职业安全系统的漏洞,克罗地亚健康的怀孕医护人员请病假。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-06-29 eCollection Date: 2024-06-01 DOI: 10.2478/aiht-2024-75-3851
Tea Samardžić, Roko Žaja, Jelena Macan
{"title":"Sick leaves among healthy pregnant Croatian healthcare workers during the COVID-19 pandemic due to loopholes in the occupational safety system.","authors":"Tea Samardžić, Roko Žaja, Jelena Macan","doi":"10.2478/aiht-2024-75-3851","DOIUrl":"10.2478/aiht-2024-75-3851","url":null,"abstract":"<p><p>The aim of this study was to explore occupational safety in pregnant Croatian healthcare workers (HCWs) during the coronavirus disease 2019 (COVID-19) pandemic. To this end we composed an anonymous questionnaire that included pregnancy data, risk assessment and mitigation, and workplace intervention and distributed it to HCWs through social media of their groups and associations. The study includes a total of 173 respondents (71.1 % physicians, 19.7 % nurses, 9.2 % other HCWs) diagnosed with pregnancy in 2020 and 2021. Employers were notified about HCWs' pregnancy at the eighth (IQR 7.0-11.0) week of pregnancy, which delayed workplace risk assessment and mitigation beyond the first trimester. Only 19.6 % of the participants had the risk assessed and mitigated, mostly on their own initiative (76.5 %). After notifying employers about pregnancy, 37.0 % of participants opted for temporary work incapacity (TWI) due to \"pregnancy complications\" despite healthy pregnancy, 16.8 % were granted a pregnant worker's paid leave at the expense of the employer, while 5.8 % continued to work at the same workplace. Nurses used the TWI benefit more frequently than physicians (58.8 % vs 30.1 %, P=0.004). Our findings suggest that occupational safety of pregnant HCWs in Croatia lacks clear-cut and transparent strategies to protect pregnant HCWs, forcing them to misuse the healthcare system.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 2","pages":"110-115"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiocaesium in mosses from the Kopački rit Nature Park in Croatia: searching for undeclared releases from nuclear facilities in war-torn Ukraine. 克罗地亚 Kopački rit 自然公园苔藓中的放射性铯:寻找饱受战争蹂躏的乌克兰未申报的核设施释放物。
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-06-29 eCollection Date: 2024-06-01 DOI: 10.2478/aiht-2024-75-3853
Nora Miljanić, Branimir Zauner, Dinko Babić, Branko Petrinec
{"title":"Radiocaesium in mosses from the Kopački rit Nature Park in Croatia: searching for undeclared releases from nuclear facilities in war-torn Ukraine.","authors":"Nora Miljanić, Branimir Zauner, Dinko Babić, Branko Petrinec","doi":"10.2478/aiht-2024-75-3853","DOIUrl":"10.2478/aiht-2024-75-3853","url":null,"abstract":"<p><p>The invasion of Ukraine and military operations around Ukrainian nuclear power plants and other nuclear facilities have prompted us to search for radiocaesium in mosses from the Kopački Rit Nature Park in Croatia, since mosses are known bioindicators of airborne radioactive pollution, and Kopački Rit is a known low radiocaesium background area. Sampling was finished in August 2023, and our analysis found no elevated radiocaesium levels. Kopački Rit therefore remains a suitable place for future detection of anthropogenic radioactive pollutants.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 2","pages":"155-158"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay between mistranslation and oxidative stress in Escherichia coli. 大肠杆菌中错误翻译与氧化应激之间的相互作用
IF 1.7 4区 医学
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2024-06-29 eCollection Date: 2024-06-01 DOI: 10.2478/aiht-2024-75-3834
Valentina Ević, Jasmina Rokov-Plavec
{"title":"Interplay between mistranslation and oxidative stress in <i>Escherichia coli</i>.","authors":"Valentina Ević, Jasmina Rokov-Plavec","doi":"10.2478/aiht-2024-75-3834","DOIUrl":"10.2478/aiht-2024-75-3834","url":null,"abstract":"<p><p>Mistakes in translation are mostly associated with toxic effects in the cell due to the production of functionally aberrant and misfolded proteins. However, under certain circumstances mistranslation can have beneficial effects and enable cells to preadapt to other stress conditions. Mistranslation may be caused by mistakes made by aminoacyl-tRNA synthetases, essential enzymes that link amino acids to cognate tRNAs. There is an <i>Escherichia coli</i> strain expressing isoleucyl-tRNA synthetase mutant variant with inactivated editing domain which produces mistranslated proteomes where valine (Val) and norvaline (Nva) are misincorporated into proteins instead of isoleucine. We compared this strain with the wild-type to determine the effects of such mistranslation on bacterial growth in oxidative stress conditions. When the cells were pre-incubated with 0.75 mmol/L Nva or 1.5 mmol/L Val or Nva and exposed to hydrogen peroxide, no beneficial effect of mistranslation was observed. However, when the editing-deficient strain was cultivated in medium supplemented with 0.75 mmol/L Val up to the early or mid-exponential phase of growth and then exposed to oxidative stress, it slightly outgrew the wild-type grown in the same conditions. Our results therefore show a modest adaptive effect of isoleucine mistranslation on bacterial growth in oxidative stress, but only in specific conditions. This points to a delicate balance between deleterious and beneficial effects of mistranslation.</p>","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"75 2","pages":"147-154"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信